EP0959925A1 - Nebuliseur - Google Patents

Nebuliseur

Info

Publication number
EP0959925A1
EP0959925A1 EP96943222A EP96943222A EP0959925A1 EP 0959925 A1 EP0959925 A1 EP 0959925A1 EP 96943222 A EP96943222 A EP 96943222A EP 96943222 A EP96943222 A EP 96943222A EP 0959925 A1 EP0959925 A1 EP 0959925A1
Authority
EP
European Patent Office
Prior art keywords
gas
nebuliser
supply
liquid
nebulizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96943222A
Other languages
German (de)
English (en)
Inventor
Surinderjit Kumar Jassell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intersurgical Ltd
Original Assignee
Intersurgical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intersurgical Ltd filed Critical Intersurgical Ltd
Publication of EP0959925A1 publication Critical patent/EP0959925A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles

Definitions

  • Nebulizers are becoming widely used in hospitals and other medical situations. Such as
  • nebulizers have particular application in the delivery of drugs for the treatment of lung diseases.
  • ⁇ e drug may be given as an inhaled drug aerosol, and this has many advantages over drugs which are taken systemically. It has become apparent that the size of the droplets plays an important role in how the drug is received by
  • the present invention provides a nebulizer comprising a pressure gas inlet, means for passing liquid medication to nebulising means associated with said pressure gas inlet
  • the nebulizer may include a reservoir for said liquid medication, and the control means may include means to vary the size of the supply means so as to vary the amount of further gas passing through said further gas supply means.
  • the control means may be in the form of a variable aperture, which may be provided by an aperture with a plate with a cooperating aperture therein, the plate being moveable.
  • the control means may also include a one way valve.
  • An advantage of the arrangement of the invention is that the quantity and relative constitution of the nebulized mixture may be changed by varying the control means to control the supply of further gas.
  • Figure 3 is a view similar to Figure 2 of the nebulizer with the air controller in a second position
  • Figure 4 is a view corresponding to Figures 2 and 3 of the nebulizer, with the air controller missing, showing the inlet air valve,
  • Figure 5 is a pan view showing one line of ratchet teeth mounted on the nebul ⁇ zer( with air controller missing), and,
  • Figure 6 is rear view of the air controller showing the teeth to engage the ratchet shown in Figure 5.
  • FIG. 1 there is shown an axial section through a nebulizer (10).
  • the section shown in Figure 1 comp ⁇ ses, on the left hand side of the Figure 1 , a first ve ⁇ ical section, and on the ⁇ ght hand side of the Figure a second ve ⁇ icaJ section at ⁇ ght angles to the first
  • the nebulizer is manufactured of ⁇ gid moulded plastics mate ⁇ al.
  • the nebulizer compnses a base section (1 1) which includes an inlet tube ( 12) for connection to a flexible plastic tube supplying pressurized gas, such as oxygen or air.
  • the inlet tube (12) is sunounded by a threaded collar (13).
  • Forming pan of the base section ( 1 1) but separately moulded is a second moulding ( 16) which includes; (a) a cylindncal stem portion (17) which closely sunounds the
  • a jet mounting portion which includes a jet (20A) which overlies a jet (20B) in the upper end of the inlet (12); and (c) a collar portion (21 ) which comprises a frusto conical plate (22) surrounding the jet mounting po ⁇ ion (19) and
  • the inner generally cylindrical surface (21A) of the collar portion (21) immediately sunounding the jet comprises a frusto-conical surface of the apex of which is below the collar and is at an angle of about 8° to the axis.
  • the jet (20A) and jet (20B) combine to provide a gas/liquid mixing jet (20).
  • the collar (32) communicates via pathways (33, 34) with an ambient air inlet (36) mounted on the side of the outer housing (27).
  • the ambient air inlet (36) is closed by a one way valve (37) in the form of a flexible diaphragm (38) of plastic, neoprene, or rubber mounted centrally at (39) and which engages with a rim (41) sunounding the ambient air inlet (36).
  • the ambient air inlet (36) includes a circular opening (42) defined by the rim (41) and an adjustable air controller (43) is provided
  • the adjustable air controller (43) comprises a plate like member (44) mounted to slide vertically with respect to the housing (27) and includes an aperture (46) which, as the plate (44) slides, may selectively align with the circular opening (42).
  • Figure 2 shows the general arrangement of the plate (44), in a first position in which the air inlet (36) is closed and
  • Figure 3 shows the plate (44) in a second position in which the air inlet (36) is open.
  • Figures 4 shows the nebulizer with the plate (44) removed thereby showing more clearly the circular opening (42).
  • each side of the opening (42) there is moulded into the outer housing (27) a pair of vertically extending edges (47, 48) which each include a respective ratchet track (51 , 52) which are illustrated in more detail in Figure 5.
  • the plate (44) Spaced from and aligned into the conesponding vertically extending edges (47, 48), the plate (44) has ve ⁇ ically extending faces (53, 54) illustrated in Figure 6.
  • Each face (53.54) includes a respective upper and lower tooth (56, 57) for engaging with the respective adjacent ratchet track (51 , 52).
  • inlet tube (12) is connected by means of a flexible plastic pipe to a suitable pressurised supply of air or oxygen and the outlet (28) is connected, usually by tubes, to a patient.
  • the plate (44) is slid up or down so that the aperture (46) coincides with the circular opening (42) to a desired extent and is held in the desired position by engagement of the teeth (56,57) with their respective ratchet tracks (51 ,52).
  • the liquid medication passes from top reservoir (14) up the capillary path (18) and as the pressurised air or oxygen passes through the jet (20B), mixes with the liquid passing
  • air is drawn into the ambient air inlet (36) via the one way valve (37), through the pathways (33,34) to join and mix with the nebulized stream assisting in the breaking up of the gas liquid stream into finer droplets and in increasing the aerosol output being delivered through the outlet (28).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nozzles (AREA)

Abstract

Ce nébuliseur comporte un orifice d'entrée (12) de gaz sous pression, un moyen (18) permettant de faire passer un liquide thérapeutique vers un dispositif (20) de nébulisation associé à l'orifice d'entrée de gaz sous pression pour mélanger le gaz provenant de l'orifice d'entrée de gaz sous pression avec ledit liquide thérapeutique, afin de produire un mélange nébulisé de liquide et de gaz, un moyen (36) destiné à fournir du gaz supplémentaire, à mélanger avec ledit mélange nébulisé, ledit moyen d'apport de gaz supplémentaire comportant un dispositif de régulation (43) destiné à réguler l'apport en gaz supplémentaire.
EP96943222A 1995-12-20 1996-12-20 Nebuliseur Withdrawn EP0959925A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9526100 1995-12-20
GB9526100A GB9526100D0 (en) 1995-12-20 1995-12-20 Nebulizer
PCT/GB1996/003201 WO1997022376A1 (fr) 1995-12-20 1996-12-20 Nebuliseur

Publications (1)

Publication Number Publication Date
EP0959925A1 true EP0959925A1 (fr) 1999-12-01

Family

ID=10785782

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96943222A Withdrawn EP0959925A1 (fr) 1995-12-20 1996-12-20 Nebuliseur

Country Status (4)

Country Link
EP (1) EP0959925A1 (fr)
AU (1) AU1201797A (fr)
GB (1) GB9526100D0 (fr)
WO (1) WO1997022376A1 (fr)

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UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
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AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
UA89481C2 (uk) 2003-09-30 2010-02-10 Центокор, Инк. Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
AU2005231359A1 (en) 2004-03-31 2005-10-20 Centocor, Inc. Human GLP-1 mimetibodies, compositions, methods and uses
US7393662B2 (en) 2004-09-03 2008-07-01 Centocor, Inc. Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
DK1896073T3 (da) 2005-06-30 2013-06-03 Janssen Biotech Inc Anti-il-antistoffer, sammensætninger, fremgangsmåder og anvendelser
SI3219328T1 (sl) 2005-12-29 2020-10-30 Janssen Biotech, Inc. Človeška protitelesa proti-IL-23, sestavki, postopki in uporabe
CA3177366A1 (fr) 2006-08-10 2008-02-21 Roy C. Levitt Therapie locale de troubles inflammatoires des voies aeriennes inferieures avec des inhibiteurs de cytokine proinflammatoire
AR064623A1 (es) 2006-12-21 2009-04-15 Centocor Inc Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos
EP2326668B1 (fr) 2008-08-14 2018-01-17 Teva Pharmaceuticals Australia Pty Ltd Anticorps anti-il-12/il-23
ES2705714T3 (es) 2008-10-31 2019-03-26 Janssen Biotech Inc Métodos y usos de dominio de Fibronectina tipo III basado en estructuras de composiciones
DK2396011T3 (en) 2009-02-12 2016-04-25 Janssen Biotech Inc Fibronectin TYPE III DOMAIN-BASED SCAFFOLD COMPOSITIONS, METHODS AND USES
JP5841072B2 (ja) 2010-02-10 2016-01-06 イミュノジェン・インコーポレーテッド Ｃｄ２０抗体およびその使用
CN103347894B (zh) 2010-06-19 2017-05-10 纪念斯隆-凯特林癌症中心 抗gd2抗体
TWI726291B (zh) 2013-01-07 2021-05-01 英屬維爾京群島商遠東超級實驗室有限公司 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物
KR102207859B1 (ko) 2013-03-15 2021-01-27 메모리얼 슬로안 케터링 캔서 센터 고 친화도 항-gd2 항체
WO2018140026A1 (fr) 2017-01-27 2018-08-02 Memorial Sloan Kettering Cancer Center Molécules bispécifiques de liaison à her2 et cd3
CN107667120B (zh) 2015-03-17 2022-03-08 纪念斯隆-凯特林癌症中心 抗muc16抗体及其应用
US20190177421A1 (en) 2016-07-15 2019-06-13 Poseida Therapeutics, Inc. Chimeric antigen receptors and methods for use
US20190328784A1 (en) 2016-07-15 2019-10-31 Poseida Therapeutics, Inc. Chimeric antigen receptors (cars) specific for muc1 and methods for their use
KR20240038146A (ko) 2017-01-30 2024-03-22 얀센 바이오테크 인코포레이티드 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
KR20190115042A (ko) 2017-02-07 2019-10-10 얀센 바이오테크 인코포레이티드 활성 강직성 척추염의 치료를 위한 항-tnf 항체, 조성물, 및 방법
CN112218885B (zh) 2017-12-20 2024-06-18 波赛达治疗公司 Vcar组合物和使用方法
JP2021523138A (ja) 2018-05-11 2021-09-02 ヤンセン バイオテツク，インコーポレーテツド Ｉｌ−２３抗体を使用してうつを治療する方法
US20220153827A1 (en) 2019-01-15 2022-05-19 Janssen Biotech, Inc. Anti-TNF Antibody Compositions and Methods for the Treatment of Juvenile Idiopathic Arthritis
US20220064278A1 (en) 2019-01-23 2022-03-03 Janssen Biotech, Inc. Anti-TNF Antibody Compositions for Use in Methods for the Treatment of Psoriatic Arthritis
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Also Published As

Publication number Publication date
GB9526100D0 (en) 1996-02-21
WO1997022376A1 (fr) 1997-06-26
AU1201797A (en) 1997-07-14

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