EP0919215B1 - Glasampulle zur Aufnahme einer Flüssigkeit - Google Patents
Glasampulle zur Aufnahme einer Flüssigkeit Download PDFInfo
- Publication number
- EP0919215B1 EP0919215B1 EP97890231A EP97890231A EP0919215B1 EP 0919215 B1 EP0919215 B1 EP 0919215B1 EP 97890231 A EP97890231 A EP 97890231A EP 97890231 A EP97890231 A EP 97890231A EP 0919215 B1 EP0919215 B1 EP 0919215B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ampoule
- area
- glass ampoule
- coating
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Definitions
- the invention relates to a glass ampoule for holding a liquid, for example a drug, a calibration or quality control fluid, with a substantially flat floor or with an inside of the Ampoule retracted bottom area, the bottom area due to its shape has a defined predetermined breaking area, which requires little effort is mechanically destructible.
- a liquid for example a drug, a calibration or quality control fluid
- Such ampoules are used in large numbers, especially in medical laboratories as well as used in medical practices and clinics, with the glass ampoules for removal their contents are usually broken open by hand and used for their purpose Need to become.
- EP 0 694 498 B1 describes a device for automatic removal of a liquid from a sealed glass ampoule became known, in which the glass ampoule in an upright, the bottom the ampoule is held upward in a holder. The The bottom of the glass ampoule becomes mechanical through a rigid-walled, single-lumen cannula destroyed, this cannula at the same time to aspirate the liquid serves a splinter-free area of the glass ampoule.
- FR 1 241 230 A is a glass ampoule with one on the inside the ampoule retracted bottom area, which due to its Forming has a defined predetermined breaking area.
- the object of the invention is to provide known glass ampoules for holding liquids to further develop such that problem-free opening through the floor area is guaranteed by automatically operating removal devices.
- the floor area preferably a coating of the center of the drawn-in area a material, for example ceramic, which has tension forces between the coated floor area and the coating.
- a coating of a material which has tensile forces between the coated floor area and the coating.
- This ceramic coating for example, can also be in a punctiform formation on the center of the drawn-in area or limit the point of attack of a removal element.
- the floor area is asymmetrical, conical Has depression, the lowest point is arranged off-center.
- Such asymmetrical, conical depressions can, for example, with a blower is manufactured during the manufacturing process, wherein Wall parts of the ampoule bottom in a reproducible form and depth inside of the ampoule. Arches of approximately half the diameter the ampoule has proven to be advantageous. To strengthen the Wall area can be specifically cooled during the blowing and the optimal arching can be subjected to an automatic optical control. The reduced rigidity of the floor area due to the asymmetry allows es, a withdrawal cannula with much less effort in the glass ampoule introduce, the splintering essentially on the asymmetrical shaped area remains limited.
- Targeted asymmetries naturally have advantages over manufacturing-related asymmetries, such as e.g. known from GB 198,993 A, on.
- the indented floor area is a comparison reduced to the wall thickness of the glass ampoule, preferably reduced by 30 to 60% Has wall thickness.
- the wall thickness of the glass ampoule preferably reduced by 30 to 60% Has wall thickness.
- glass ampoules with an to provide essential flat ground, again for local weakening the surface tension of the soil preferably in its central Area has a ceramic coating, and possibly also the Bottom of the glass ampoule, especially in its central area, one in comparison reduced to the wall thickness of the glass ampoule, preferably by 30 to 60% reduced wall thickness.
- the glass ampoule 1 shown in Fig. 1a for receiving a liquid has a bottom region 2 drawn in to the inside of the ampoule.
- the cylindrical Shank area 3 of the ampoule 1 goes into a neck area 4 and this into a head area 5 over.
- the areas 3 to 4 can essentially be any be carried out, it only has to be guaranteed that the ampoule in one Device for automatic withdrawal of ampoule liquid - such as this is known from EP 0 694 498 B1 - can be used.
- the bottom region 2 of the ampoule according to FIG. 1a has a conical depression on, which in the center of the retracted area 2 a punctiform ceramic Has coating 7 (see also Fig. 1b).
- the embodiment according to FIGS. 2a and 2b has an asymmetrical, conical recess 6 'with reduced wall thickness, which means a central in the direction of the axis 1 'of the ampoule removal element 12 a reduced mechanical resistance when opening the floor.
- the ceramic coating 7 is also asymmetrical here, namely arranged at the deepest point of the conical recess 6 '.
- the base region 2 of the ampoule 1 executed with a substantially cylindrical recess 8, which a has flat or slightly curved floor 9.
- the wall thickness of the fed Floor area 2 can be entirely or only in a central area a reduced wall thickness compared to the wall thickness of the glass ampoule 1 exhibit.
- a glass ampoule 1 which has a substantially flat bottom 10, this for Whole or in its central area for easier penetration of the removal element has a reduced wall thickness (30 - 60%).
- Such floors can, for example, be welded or melted onto the shaft of the ampoule become.
- a ceramic one can also be found in the central area Coating 7 can be applied in the form of a ceramic point. It is also possible that the bottom area or the bottom 10 of the glass ampoule 1 is scored, preferably has a circular scoring 12.
- an elastomer coating indicated in FIG. 4a can be used in all design variants 11 can be provided, which on a to the floor 10 (or Bottom region 2) of the cylindrical shaft region 3 adjoining the glass ampoule 1 is applied. This elastomer coating serves to prevent any splinters in the to hold the lower shaft area.
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Description
- Fig. 1a
- eine erfindungsgemäße Ampulle in einem teilweisen Axialschnitt,
- Fig.
- 1b eine Draufsicht auf den Bodenbereich der Ampulle nach Fig. 1a sowie die
- Fig.
- 2a bis 4a bzw. 2b bis 4b Ausführungsvarianten der erfindungsgemäßen Ampulle.
Claims (7)
- Glasampulle (1) zur Aufnahme einer Flüssigkeit, vorzugsweise eines Arzneimittels, einer Kalibrier- oder einer Qualitätskontrollflüssigkeit, mit einem zur Innenseite der Ampulle eingezogenen Bodenbereich (2), wobei der Bodenbereich (2) durch seine Formgebung (6') einen definierten Sollbruchbereich aufweist, welcher mit geringem Kraftaufwand mechanisch zerstörbar ist, dadurch gekennzeichnet, dass der Bodenbereich (2), vorzugsweise das Zentrum des eingezogenen Bereiches eine Beschichtung (7) aus einem Material, beispielsweise Keramik, aufweist, welches Spannungskräfte zwischen dem beschichteten Bodenbereich (2) und der Beschichtung (7) hervorruft.
- Glasampulle nach Anspruch 1, dadurch gekennzeichnet, dass der Bodenbereich (2) eine asymmetrische, konische Vertiefung (6') aufweist, deren tiefste Stelle außermittig angeordnet ist.
- Glasampulle nach Anspruch 2, dadurch gekennzeichnet, dass der eingezogene Bodenbereich (2) eine im Vergleich zur Wandstärke der Glasampulle (1) verminderte, vorzugsweise um 30 bis 60% verringerte Wandstärke aufweist.
- Glasampulle (1) zur Aufnahme einer Flüssigkeit, beispielsweise eines Arzneimittels, einer Kalibrier- oder einer Qualitätskontrollflüssigkeit, mit einem im wesentlichen ebenen Boden (10), dadurch gekennzeichnet, dass der Boden (10) in seinem zentralen Bereich, eine Beschichtung (7) aus einem Material, beispielsweise Keramik, aufweist, welches Spannungskräfte zwischen dem Boden (10) und der Beschichtung (7) hervorruft.
- Glasampulle nach Anspruch 4, dadurch gekennzeichnet, dass der Boden (10) der Glasampulle, insbesondere in seinem zentralen Bereich, eine im Vergleich zur Wandstärke der Glasampulle verminderte, vorzugsweise um 30 bis 60% verringerte, Wandstärke aufweist.
- Glasampulle nach Anspruch 4, dadurch gekennzeichnet, dass der Boden (10) der Glasampulle (1) eine Anritzung, vorzugsweise eine kreisförmige Anritzung (12) aufweist.
- Glasampulle nach einem der Ansprüche 2 bis 6, dadurch gekennzeichnet, dass der an den Bodenbereich (2) bzw. Boden (10) der Glasampulle (1) anschließende zylindrische Schaftbereich (3) eine Elastomerbeschichtung (11) aufweist.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97890231A EP0919215B1 (de) | 1997-11-24 | 1997-11-24 | Glasampulle zur Aufnahme einer Flüssigkeit |
DE59706326T DE59706326D1 (de) | 1997-11-24 | 1997-11-24 | Glasampulle zur Aufnahme einer Flüssigkeit |
US09/000,948 US5948366A (en) | 1997-11-24 | 1997-12-30 | Glass ampoule for holding a drug a calibration liquid or a quality control liquid |
JP10332133A JP3062687B2 (ja) | 1997-11-24 | 1998-11-24 | 薬剤、較正用液又は品質管理用液用ガラス製アンプル |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97890231A EP0919215B1 (de) | 1997-11-24 | 1997-11-24 | Glasampulle zur Aufnahme einer Flüssigkeit |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0919215A1 EP0919215A1 (de) | 1999-06-02 |
EP0919215B1 true EP0919215B1 (de) | 2002-02-06 |
Family
ID=8231126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97890231A Expired - Lifetime EP0919215B1 (de) | 1997-11-24 | 1997-11-24 | Glasampulle zur Aufnahme einer Flüssigkeit |
Country Status (4)
Country | Link |
---|---|
US (1) | US5948366A (de) |
EP (1) | EP0919215B1 (de) |
JP (1) | JP3062687B2 (de) |
DE (1) | DE59706326D1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6340097B1 (en) | 1998-10-22 | 2002-01-22 | Closure Medical Corporation | Applicator with protective barrier |
US20060042373A1 (en) * | 2004-08-25 | 2006-03-02 | Kirollos Kirollos S | Smoke generating device |
CA2578724A1 (en) * | 2004-09-08 | 2006-03-16 | The Dial Corporation | Methods and apparatus for a low-cost vapor-dispersing device |
EP2288900B1 (de) | 2008-06-06 | 2012-11-21 | Capitol Plastic Products, L.l.c. | Gestell mit fläschchen |
DE102009013211B4 (de) | 2009-03-17 | 2012-04-19 | Aap Biomaterials Gmbh | Vakuum-Mischvorrichtung für Knochenzement sowie Verfahren zum Mischen von Knochenzement |
DE102011112516B4 (de) * | 2011-09-07 | 2024-02-29 | Stryker European Operations Holdings Llc | Gebinde mit einem Behälter zur Aufnahme einer Flüssigkeit und einer Flüssigkeitsentnahmeeinrichtung |
EP3647781B1 (de) | 2018-10-29 | 2024-05-01 | EXIAS Medical GmbH | Messkartusche zur messung einer flüssigkeitsprobe |
WO2022155812A1 (en) | 2021-01-20 | 2022-07-28 | L'oreal | Glass syringe dropper |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB191501531A (en) * | 1914-12-02 | 1915-12-30 | Wilfred Ambrose Whatmough | Improved Construction of Ampoule or the like with Means for Applying the Contents to the Body. |
GB198993A (en) * | 1922-06-06 | 1924-08-13 | Friedrich Wilhelm Horst | Improvements in flasks for containing chemicals, and in means for opening the same and discharging their contents |
US1951743A (en) * | 1930-04-25 | 1934-03-20 | Iso Ges M B H | Method of producing a prepared breaking point in ampulle |
FR721646A (fr) | 1930-11-14 | 1932-03-05 | Negoce Et Ind | Ampoule destinée à contenir de l'anhydride sulfureux ou tout autre gaz liquéfié sous pression. et appareil pour briser cette ampoule et diffuser le gaz qu'elle contient dans un liquide quelconque |
CH287394A (fr) * | 1950-07-07 | 1952-11-30 | Owens Illinois Glass Co | Récipient en verre et procédé pour sa fabrication. |
FR1241230A (fr) * | 1959-08-04 | 1960-09-16 | Prolabo Sa | Ampoule pour le conditionnement de réactifs |
US3535070A (en) * | 1966-02-03 | 1970-10-20 | Owens Illinois Inc | Method of inducing stress in glass containers and container made with a stressed zone |
US3749271A (en) * | 1971-06-22 | 1973-07-31 | Becton Dickinson Co | Resealable ampoule closure |
FR2237643B1 (de) * | 1973-07-17 | 1978-03-17 | Steiner Maurice | |
SU607138A1 (ru) * | 1975-10-27 | 1978-05-15 | Предприятие П/Я Г-4236 | Ампула дл инжектировани в хроматограф продуктов реакции |
US4096683A (en) * | 1977-02-16 | 1978-06-27 | Cozzoli Machine Company | Ampoule filling and sealing machine |
US4266681A (en) * | 1977-02-28 | 1981-05-12 | Oceanography International Corporation | Multiple breakpoint resealable ampoule |
IL60740A (en) * | 1980-08-01 | 1983-06-15 | Tadiran Israel Elect Ind Ltd | Electrolyte container for use in reserve cells |
ES8504055A1 (es) * | 1983-03-10 | 1985-04-16 | Dehais Claude | Perfeccionamientos en las maquinas para elaborar ampollas farmaceuticas y similares y anpolla obtenida. |
SE8505542L (sv) * | 1985-11-25 | 1987-05-26 | Vestsvensk Medicinteknik Ab | Anordning for brytning av ampuller |
US5179024A (en) * | 1991-05-30 | 1993-01-12 | Harald Dahms | Sealed vials containing improved karl fischer solutions, and process for water determination using these vials |
US5221311A (en) * | 1992-01-10 | 1993-06-22 | Rising Peter E | Evacuated sampling vial |
AT404827B (de) * | 1994-07-28 | 1999-03-25 | Avl Verbrennungskraft Messtech | Verfahren und vorrichtung zur entnahme einer flüssigkeit aus einer verschlossenen glasampulle |
-
1997
- 1997-11-24 DE DE59706326T patent/DE59706326D1/de not_active Expired - Lifetime
- 1997-11-24 EP EP97890231A patent/EP0919215B1/de not_active Expired - Lifetime
- 1997-12-30 US US09/000,948 patent/US5948366A/en not_active Expired - Lifetime
-
1998
- 1998-11-24 JP JP10332133A patent/JP3062687B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5948366A (en) | 1999-09-07 |
JPH11221266A (ja) | 1999-08-17 |
EP0919215A1 (de) | 1999-06-02 |
JP3062687B2 (ja) | 2000-07-12 |
DE59706326D1 (de) | 2002-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1741397B1 (de) | Knochenplatte | |
DE102005005746B4 (de) | Zahnimplantat | |
DE69001289T2 (de) | Vorrichtung zum zentralisieren des stieles einer intramedulaeren prothese. | |
EP2525737B2 (de) | Abutment für ein Zahnimplantat und Kombination aus Abutment und Implantat | |
DE69515885T2 (de) | Behälter für pharmazeutische Produkte mit zwei gesonderten Komponenten, mit Mitteln zu deren Mischung und dosierter Ausgabe sowie Verfahren zum Zusammenstellen des Behälters | |
EP2440147B1 (de) | Chirurgieinstrument mit knochenschraube | |
DE19829228C1 (de) | Vorrichtung zur Versorgung von Knochenbrüchen | |
CH651747A5 (de) | Implantat zur befestigung eines kuenstlichen zahnersatzes. | |
DE1965761B2 (de) | Zur einmaligen benutzung bestimmte vorrichtung fuer die aufnahme und ausgabe einer dosis von verunreinigungsempfindlichen behandlungsfluessigkeiten | |
EP0919215B1 (de) | Glasampulle zur Aufnahme einer Flüssigkeit | |
DE3425737C2 (de) | ||
DE2834298B2 (de) | Femurkopfkappe für eine zementfrei zu implantierende Hüftgelenkendoprothese | |
EP2015684B1 (de) | Bohrer zur herstellung von bohrungen im knochengewebe mit einem halteteil und einem bohraufsatz | |
EP1018319B1 (de) | Kieferimplantat | |
WO2021198052A1 (de) | Medizinisches instrument und verfahren zum herstellen eines medizinischen instruments | |
EP0091499B1 (de) | Profilierter intramedullärer Unterschenkelnagel | |
EP0339320B1 (de) | Prothesenschaft | |
EP0263938B1 (de) | Zugschraube fuer die Osteosynthese | |
WO1996018354A2 (de) | Werkzeug zum präparieren von hohlräumen in knochen | |
WO2003074438A1 (de) | Flasche, verfahren zu deren herstellung, verfahren zum abfüllen in eine flasche und verfahren zum öffnen einer flasche | |
EP2893888A1 (de) | Ampullensystem mit medizinischer Flüssigkeit und Kappe mit Filtereinrichtung | |
EP2767254A2 (de) | Keramikimplantatsystem | |
EP3914188B1 (de) | Okklusalschraube, dentalimplantatsystem und set | |
DE19935256C1 (de) | Glasampulle | |
EP1393693B1 (de) | Instrument zur Abgabe eines Arzneimittels |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19981219 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE FR GB IT |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
17Q | First examination report despatched |
Effective date: 19991008 |
|
AKX | Designation fees paid |
Free format text: DE FR GB IT |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: F.HOFFMANN-LA ROCHE AG |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: IF02 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): DE FR GB IT |
|
GBT | Gb: translation of ep patent filed (gb section 77(6)(a)/1977) |
Effective date: 20020206 |
|
REF | Corresponds to: |
Ref document number: 59706326 Country of ref document: DE Date of ref document: 20020321 |
|
ET | Fr: translation filed | ||
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20021107 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20131129 Year of fee payment: 17 Ref country code: GB Payment date: 20131028 Year of fee payment: 17 Ref country code: FR Payment date: 20131025 Year of fee payment: 17 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20131121 Year of fee payment: 17 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 59706326 Country of ref document: DE |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20141124 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: ST Effective date: 20150731 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20141124 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20150602 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20141201 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20141124 |