EP0907661A4 - METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF alpha v beta 5 MEDIATED ANGIOGENESIS - Google Patents
METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF alpha v beta 5 MEDIATED ANGIOGENESISInfo
- Publication number
- EP0907661A4 EP0907661A4 EP97927814A EP97927814A EP0907661A4 EP 0907661 A4 EP0907661 A4 EP 0907661A4 EP 97927814 A EP97927814 A EP 97927814A EP 97927814 A EP97927814 A EP 97927814A EP 0907661 A4 EP0907661 A4 EP 0907661A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- alpha
- beta
- inhibition
- mediated angiogenesis
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1586996P | 1996-05-31 | 1996-05-31 | |
US1873396P | 1996-05-31 | 1996-05-31 | |
US15869P | 1996-05-31 | ||
US18733P | 1996-05-31 | ||
PCT/US1997/009099 WO1997045447A1 (en) | 1996-05-31 | 1997-05-30 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0907661A1 EP0907661A1 (en) | 1999-04-14 |
EP0907661A4 true EP0907661A4 (en) | 2000-07-26 |
Family
ID=26687899
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97928698A Expired - Lifetime EP0951295B1 (en) | 1996-05-31 | 1997-05-30 | Compositions for use in inhibiting of alpha-v-beta3 mediated angiogenesis |
EP97927814A Withdrawn EP0907661A4 (en) | 1996-05-31 | 1997-05-30 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF alpha v beta 5 MEDIATED ANGIOGENESIS |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97928698A Expired - Lifetime EP0951295B1 (en) | 1996-05-31 | 1997-05-30 | Compositions for use in inhibiting of alpha-v-beta3 mediated angiogenesis |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0951295B1 (en) |
JP (1) | JP2002515036A (en) |
KR (2) | KR20000016301A (en) |
CN (1) | CN1226254A (en) |
AT (1) | ATE470450T1 (en) |
BR (1) | BR9709514A (en) |
CA (2) | CA2256588A1 (en) |
CZ (2) | CZ383498A3 (en) |
DE (1) | DE69739907D1 (en) |
DK (1) | DK0951295T3 (en) |
HU (2) | HUP9901628A3 (en) |
NO (2) | NO985574L (en) |
PL (2) | PL330241A1 (en) |
WO (2) | WO1997045447A1 (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
PL345544A1 (en) * | 1998-07-14 | 2001-12-17 | Upjohn Co | Oxazolidinones to treat eye infections |
DE19842415A1 (en) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmaceutical preparation for treating e.g. tumors, thrombosis or inflammation, contains cyclic pentapeptide integrin inhibitor and chemotherapeutic agent and/or angiogenesis inhibitor |
US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
DK1156823T3 (en) * | 1999-02-12 | 2009-01-19 | Scripps Research Inst | Methods for treating tumors and metastases using a combination of anti-angiogenic therapies and immunotherapies |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
UA71608C2 (en) * | 1999-03-11 | 2004-12-15 | Merck Patent Gmbh | A method for producing the cyclic pentapeptide |
WO2001090186A1 (en) * | 2000-05-26 | 2001-11-29 | Glaxo Group Limited | Methods for identifying modulators of the interaction between lap (latency associated peptide) and intergrin alpha.v.beta.3 and medical use thereof |
CN1329167A (en) * | 2000-06-19 | 2002-01-02 | 上海博德基因开发有限公司 | A novel polypeptide-human non-integral protein-metalloprotease 10.67 and polynucleotide for coding this polypeptide |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
JP5054274B2 (en) | 2000-11-01 | 2012-10-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Methods and compositions for treating eye diseases |
KR100854424B1 (en) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | Substituted indoles and their use as integrin antagonists |
CN1247258C (en) | 2001-04-24 | 2006-03-29 | 默克专利有限公司 | Combination therapy using anti-angiogenic agents and tnfa |
US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
US7019108B2 (en) * | 2001-06-01 | 2006-03-28 | University Of Southern California | Method and composition for inhibition of angiogenesis and tumor growth using compounds based on a sequence within MMP-2 |
EP1411926B1 (en) * | 2001-08-01 | 2005-06-01 | MERCK PATENT GmbH | Integrin inhibitors for the treatment of eye diseases |
DE10159453A1 (en) * | 2001-12-04 | 2003-06-18 | Merck Patent Gmbh | Use of 1-phenyl-oxazolidin-2-one compounds as a protease |
GB0217017D0 (en) * | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 2 |
FR2856598B1 (en) * | 2003-06-25 | 2005-10-28 | Inst Nat Sante Rech Med | PEPTIDES DERIVED FROM THE MMP-2 PROTEIN AND THEIR USE IN ANTI-TUMOR IMMUNOTHERAPY |
US7196061B2 (en) | 2003-09-10 | 2007-03-27 | Wyeth | Compounds that modulate neuronal growth and their uses |
EP1973569B1 (en) | 2006-01-18 | 2013-05-22 | Merck Patent GmbH | Specific therapy using integrin ligands for treating cancer |
EP1862541A1 (en) * | 2006-06-01 | 2007-12-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Polypeptides derived from the hemopexin-like domain of metalloproteinase MMP-2 |
US20100069302A1 (en) | 2007-07-18 | 2010-03-18 | Stefan Krueger | Specific therapy and medicament using integrin ligands for treating cancer |
CA2697070A1 (en) * | 2007-08-24 | 2009-03-05 | University Health Network | Methods of inhibiting tumor growth using beta 5 integrin antagonists |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
JP2012528079A (en) | 2009-05-25 | 2012-11-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Continuous administration of integrin ligand to treat cancer |
US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
KR102237243B1 (en) | 2009-11-10 | 2021-04-07 | 알레그로 파마슈티칼스, 인코포레이티드. | Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites |
WO2014163156A1 (en) * | 2013-04-04 | 2014-10-09 | 味の素株式会社 | Deprotection method |
CN107001469A (en) * | 2014-09-12 | 2017-08-01 | 比奥根Ma公司 | Antibody of humanized anti-alpha v β 5 and application thereof |
CN111748041B (en) * | 2019-03-11 | 2021-09-14 | 中国科学院苏州纳米技术与纳米仿生研究所 | Microenvironment controlled-release type functional hydrogel, and preparation method and application thereof |
CN116239704B (en) * | 2023-05-09 | 2023-07-14 | 北京青云智创科技有限公司 | Polypeptide for treating neovascular eye disease and preparation thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028426A2 (en) * | 1994-04-13 | 1995-10-26 | La Jolla Cancer Research Foundation | Peptides for reducing or inhibiting bone resorption, angiogenesis and restenosis |
WO1997014716A1 (en) * | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Cyclopeptide derivatives |
EP0770622A2 (en) * | 1995-09-15 | 1997-05-02 | MERCK PATENT GmbH | Cyclic adhesion inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4903921B2 (en) * | 1995-08-14 | 2012-03-28 | ザ スクリプス リサーチ インスティチュート | Methods and compositions effective for inhibiting αVβ5-mediated angiogenesis |
-
1997
- 1997-05-30 PL PL97330241A patent/PL330241A1/en unknown
- 1997-05-30 HU HU9901628A patent/HUP9901628A3/en unknown
- 1997-05-30 CA CA002256588A patent/CA2256588A1/en not_active Abandoned
- 1997-05-30 KR KR1019980709874A patent/KR20000016301A/en not_active Application Discontinuation
- 1997-05-30 AT AT97928698T patent/ATE470450T1/en active
- 1997-05-30 DK DK97928698.6T patent/DK0951295T3/en active
- 1997-05-30 JP JP54291497A patent/JP2002515036A/en not_active Abandoned
- 1997-05-30 WO PCT/US1997/009099 patent/WO1997045447A1/en not_active Application Discontinuation
- 1997-05-30 DE DE69739907T patent/DE69739907D1/en not_active Expired - Lifetime
- 1997-05-30 CA CA2256543A patent/CA2256543C/en not_active Expired - Fee Related
- 1997-05-30 HU HU9902099A patent/HUP9902099A3/en unknown
- 1997-05-30 EP EP97928698A patent/EP0951295B1/en not_active Expired - Lifetime
- 1997-05-30 PL PL97330240A patent/PL330240A1/en unknown
- 1997-05-30 CN CN97196818A patent/CN1226254A/en active Pending
- 1997-05-30 WO PCT/US1997/009158 patent/WO1997045137A1/en not_active Application Discontinuation
- 1997-05-30 EP EP97927814A patent/EP0907661A4/en not_active Withdrawn
- 1997-05-30 CZ CZ983834A patent/CZ383498A3/en unknown
- 1997-05-30 KR KR1019980709875A patent/KR20000016302A/en not_active Application Discontinuation
- 1997-05-30 CZ CZ983800A patent/CZ380098A3/en unknown
- 1997-05-30 BR BR9709514A patent/BR9709514A/en not_active IP Right Cessation
-
1998
- 1998-11-27 NO NO985574A patent/NO985574L/en not_active Application Discontinuation
- 1998-11-27 NO NO985575A patent/NO985575L/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028426A2 (en) * | 1994-04-13 | 1995-10-26 | La Jolla Cancer Research Foundation | Peptides for reducing or inhibiting bone resorption, angiogenesis and restenosis |
EP0770622A2 (en) * | 1995-09-15 | 1997-05-02 | MERCK PATENT GmbH | Cyclic adhesion inhibitors |
WO1997014716A1 (en) * | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Cyclopeptide derivatives |
Non-Patent Citations (5)
Title |
---|
AM. J. PATHOL., vol. 148, no. 5, May 1996 (1996-05-01), pages 1407 - 1421 * |
CHEMICAL ABSTRACTS, vol. 125, no. 1, 1 July 1996, Columbus, Ohio, US; abstract no. 7248, R A CLARK ET AL.: "Transient functional expression of alpha.v.beta.3 on vascular cells during wound repair" XP002138525 * |
H P HAMMES ET AL.: "Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization", NATURE MEDICINE., vol. 2, no. 5, May 1996 (1996-05-01), NATURE PUBLISHING, CO., US, pages 529 - 533, XP002138522, ISSN: 1078-8956 * |
P C BROOKS ET AL.: "Integrin alphaV beta3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels", CELL, vol. 79, 30 December 1994 (1994-12-30), NA US, pages 1157 - 1164, XP002138523 * |
P C BROOKS ET AL.: "Requirement of vascular integrin alphaV beta3 for angiogenesis", SCIENCE., vol. 264, 22 April 1994 (1994-04-22), AAAS. LANCASTER, PA., US, pages 569 - 571, XP002138524 * |
Also Published As
Publication number | Publication date |
---|---|
EP0907661A1 (en) | 1999-04-14 |
EP0951295B1 (en) | 2010-06-09 |
BR9709514A (en) | 1999-08-10 |
CZ380098A3 (en) | 1999-05-12 |
HUP9902099A3 (en) | 2001-10-29 |
HUP9901628A2 (en) | 1999-08-30 |
CA2256543C (en) | 2010-12-07 |
NO985574L (en) | 1999-02-01 |
NO985574D0 (en) | 1998-11-27 |
JP2002515036A (en) | 2002-05-21 |
HUP9901628A3 (en) | 2002-11-28 |
CZ383498A3 (en) | 1999-05-12 |
PL330241A1 (en) | 1999-05-10 |
ATE470450T1 (en) | 2010-06-15 |
WO1997045137A1 (en) | 1997-12-04 |
NO985575L (en) | 1999-02-01 |
KR20000016302A (en) | 2000-03-25 |
WO1997045137A8 (en) | 2001-02-01 |
PL330240A1 (en) | 1999-05-10 |
CA2256543A1 (en) | 1997-12-04 |
EP0951295A1 (en) | 1999-10-27 |
DE69739907D1 (en) | 2010-07-22 |
CN1226254A (en) | 1999-08-18 |
DK0951295T3 (en) | 2010-09-13 |
HUP9902099A2 (en) | 1999-09-28 |
CA2256588A1 (en) | 1997-12-04 |
EP0951295A4 (en) | 2000-07-26 |
NO985575D0 (en) | 1998-11-27 |
WO1997045447A1 (en) | 1997-12-04 |
KR20000016301A (en) | 2000-03-25 |
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