EP0901476A4 - Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives - Google Patents

Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives

Info

Publication number: EP0901476A4
Authority: EP; European Patent Office
Prior art keywords: pyrimidines; arylthio; aryloxy; derivatives; fused pyridines
Prior art date: 1996-03-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97916985A

Other languages

German (de)

French (fr)

Other versions

EP0901476A1 (en

Inventor

Parthasarathi Rajagopalan

Robert John Chorvat

Rajagopal Bakthavatchalam

James Peter Beck

Paul Joseph Gilligan

Richard Eric Olson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Pharma Co

Original Assignee

DuPont Merck Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-26

Filing date

1997-03-25

Publication date

2001-08-16

1997-03-25 Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co

1999-03-17 Publication of EP0901476A1 publication Critical patent/EP0901476A1/en

2001-08-16 Publication of EP0901476A4 publication Critical patent/EP0901476A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

EP97916985A 1996-03-26 1997-03-25 Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives Withdrawn EP0901476A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1409096P	1996-03-26	1996-03-26
US14090P		1996-03-26
US64661196A	1996-05-08	1996-05-08
US646611		1996-05-08
PCT/US1997/004828 WO1997035846A1 (en)	1996-03-26	1997-03-25	Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives

Publications (2)

Publication Number	Publication Date
EP0901476A1 EP0901476A1 (en)	1999-03-17
EP0901476A4 true EP0901476A4 (en)	2001-08-16

Family

ID=26685647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97916985A Withdrawn EP0901476A4 (en)	1996-03-26	1997-03-25	Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives

Country Status (6)

Country	Link
EP (1)	EP0901476A4 (en)
JP (1)	JP2000507552A (en)
AU (1)	AU725254B2 (en)
CA (1)	CA2249598A1 (en)
NZ (1)	NZ331647A (en)
WO (1)	WO1997035846A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19653646A1 (en) *	1996-12-20	1998-06-25	Hoechst Ag	Substituted purine derivatives, processes for their preparation, agents containing them and their use
BR9915129A (en)	1998-11-12	2001-08-07	Neurocrine Biosciences Inc	Crf receptor antagonists and related processes
DK1129091T3 (en)	1998-11-12	2002-11-04	Neurocrine Biosciences Inc	Antagonists of CRF receptors and their associated methods
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
US6589952B2 (en)	2000-07-14	2003-07-08	Bristol-Myers Squibb Pharma Company	Imidazo[1,2-a]pyrazines for the treatment of neurological disorders
MXPA03008185A (en)	2001-03-13	2004-01-29	Bristol Myers Squibb Pharma Co	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3, 5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands.
CZ20033053A3 (en)	2001-05-14	2004-05-12	Bristol@Myersásquibbápharmaácompany	Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands
US6894045B2 (en)	2001-07-12	2005-05-17	Bristol-Myers Squibb Pharma Company	Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands
WO2003006015A1 (en)	2001-07-13	2003-01-23	Bristol-Myers Squibb Pharma Company	Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands
US20030119831A1 (en)	2001-11-20	2003-06-26	Hartz Richard A.	3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands
GB0219746D0 (en) *	2002-08-23	2002-10-02	Inst Of Ex Botany Ascr	Azapurine derivatives
KR20210061202A (en) *	2019-11-19	2021-05-27	일동제약(주)	Benzonitrile-substituted Fused pyrimidine derivatives and their pharmaceutical use

Citations (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
JPS56131587A (en) *	1980-03-18	1981-10-15	Ss Pharmaceut Co Ltd	7-substituted triazolopyrimidine derivative and its preparation
JPS5962595A (en) *	1982-09-30	1984-04-10	Ss Pharmaceut Co Ltd	3,5,7-trisubstituted-triazolopyrimidine derivative and its preparation
EP0298467A2 (en) *	1987-07-10	1989-01-11	Hoechst Aktiengesellschaft	2-Amino-8-aza purines substituted in positions 6 and 9, their use, medicaments containing these purines and process for the preparation of the purines
EP0458519A2 (en) *	1990-05-24	1991-11-27	Efamol Holdings Plc	Synthesis of nucleotide and nucleoside derivatives
US5075445A (en) *	1983-08-18	1991-12-24	Beecham Group P.L.C.	Guanine derivatives
WO1994013677A1 (en) *	1992-12-17	1994-06-23	Pfizer Inc.	Pyrazolopyrimidines as crf antagonists
WO1994013676A1 (en) *	1992-12-17	1994-06-23	Pfizer Inc.	Pyrrolopyrimidines as crf antagonists
WO1995010506A1 (en) *	1993-10-12	1995-04-20	The Du Pont Merck Pharmaceutical Company	1n-alkyl-n-arylpyrimidinamines and derivatives thereof
EP0664294A1 (en) *	1994-01-19	1995-07-26	Colin Reese	Production of nucleoside analogues
WO1995033750A1 (en) *	1994-06-08	1995-12-14	Pfizer Inc.	Corticotropin releasing factor antagonists
WO1995033727A1 (en) *	1994-06-06	1995-12-14	Pfizer Inc.	Substituted pyrazoles having corticotropin-releasing factor (crf) antagonist activity
WO1995034563A1 (en) *	1994-06-16	1995-12-21	Pfizer Inc.	Pyrazolo and pyrrolopyridines
EP0778277A1 (en) *	1995-12-08	1997-06-11	Pfizer Inc.	Substituted heterocyclic derivatives as CRF antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS56131586A (en) *	1980-03-18	1981-10-15	Ss Pharmaceut Co Ltd	Triazolopyrimidine derivative and its preparation
US4916224A (en) *	1988-01-20	1990-04-10	Regents Of The University Of Minnesota	Dideoxycarbocyclic nucleosides

1997
- 1997-03-25 CA CA002249598A patent/CA2249598A1/en not_active Abandoned
- 1997-03-25 EP EP97916985A patent/EP0901476A4/en not_active Withdrawn
- 1997-03-25 JP JP9534562A patent/JP2000507552A/en active Pending
- 1997-03-25 NZ NZ331647A patent/NZ331647A/en unknown
- 1997-03-25 WO PCT/US1997/004828 patent/WO1997035846A1/en not_active Application Discontinuation
- 1997-03-25 AU AU25453/97A patent/AU725254B2/en not_active Ceased

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
JPS56131587A (en) *	1980-03-18	1981-10-15	Ss Pharmaceut Co Ltd	7-substituted triazolopyrimidine derivative and its preparation
JPS5962595A (en) *	1982-09-30	1984-04-10	Ss Pharmaceut Co Ltd	3,5,7-trisubstituted-triazolopyrimidine derivative and its preparation
US5075445A (en) *	1983-08-18	1991-12-24	Beecham Group P.L.C.	Guanine derivatives
EP0298467A2 (en) *	1987-07-10	1989-01-11	Hoechst Aktiengesellschaft	2-Amino-8-aza purines substituted in positions 6 and 9, their use, medicaments containing these purines and process for the preparation of the purines
EP0458519A2 (en) *	1990-05-24	1991-11-27	Efamol Holdings Plc	Synthesis of nucleotide and nucleoside derivatives
WO1994013677A1 (en) *	1992-12-17	1994-06-23	Pfizer Inc.	Pyrazolopyrimidines as crf antagonists
WO1994013676A1 (en) *	1992-12-17	1994-06-23	Pfizer Inc.	Pyrrolopyrimidines as crf antagonists
WO1995010506A1 (en) *	1993-10-12	1995-04-20	The Du Pont Merck Pharmaceutical Company	1n-alkyl-n-arylpyrimidinamines and derivatives thereof
EP0664294A1 (en) *	1994-01-19	1995-07-26	Colin Reese	Production of nucleoside analogues
WO1995033727A1 (en) *	1994-06-06	1995-12-14	Pfizer Inc.	Substituted pyrazoles having corticotropin-releasing factor (crf) antagonist activity
WO1995033750A1 (en) *	1994-06-08	1995-12-14	Pfizer Inc.	Corticotropin releasing factor antagonists
WO1995034563A1 (en) *	1994-06-16	1995-12-21	Pfizer Inc.	Pyrazolo and pyrrolopyridines
EP0778277A1 (en) *	1995-12-08	1997-06-11	Pfizer Inc.	Substituted heterocyclic derivatives as CRF antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 006, no. 007 (C - 087) 16 January 1982 (1982-01-16) *
PATENT ABSTRACTS OF JAPAN vol. 008, no. 162 (C - 235) 26 July 1984 (1984-07-26) *
See also references of WO9735846A1 *

Also Published As

Publication number	Publication date
WO1997035846A1 (en)	1997-10-02
CA2249598A1 (en)	1997-10-02
EP0901476A1 (en)	1999-03-17
NZ331647A (en)	2000-03-27
AU725254B2 (en)	2000-10-12
JP2000507552A (en)	2000-06-20
AU2545397A (en)	1997-10-17

Legal Events

Date	Code	Title	Description
1999-01-29	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1999-03-17	17P	Request for examination filed	Effective date: 19980914
1999-03-17	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1999-03-31	RIN1	Information on inventor provided before grant (corrected)	Inventor name: OLSON, RICHARD, ERIC Inventor name: GILLIGAN, PAUL, JOSEPH Inventor name: BECK, JAMES, PETER Inventor name: BAKTHAVATCHALAM, RAJAGOPAL Inventor name: CHORVAT, ROBERT, JOHN Inventor name: RAJAGOPALAN, PARTHASARATHI
2001-05-09	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07D 487/04 A, 7C 07D 471/04 B, 7C 07D 473/30 B, 7C 07D 473/00 B, 7C 07D 239/46 B, 7C 07D 239/48 B, 7A 61K 31/44 B, 7A 61K 31/505 B, 7A 61K 31/52 B, 7A 61K 31/53 B, 7C 07D 487/04 J, 7C 07D 249:00 J, 7C 07D 239:00 J, 7C 07D 487/04 K, 7C 07D 239:00 K, 7C 07D 231:00 K, 7C 07D 471/04 L, 7C 07D 235:00 L, 7C 07D 221:00 L, 7C 07D 471/04 M, 7C 07D 231:00 M, 7C 07D 221:00 M, 7C 07D 471/04 N, 7C 07D 249:00 N, 7C 07D 221:00 N
2001-08-16	A4	Supplementary search report drawn up and despatched	Effective date: 20010625
2001-08-16	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
2002-10-02	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: BRISTOL-MYERS SQUIBB PHARMA COMPANY
2003-11-12	17Q	First examination report despatched	Effective date: 20030930
2004-07-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-08-18	18D	Application deemed to be withdrawn	Effective date: 20040211

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