EP0813415A4 - Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
EP0813415A4
EP0813415A4 EP95942875A EP95942875A EP0813415A4 EP 0813415 A4 EP0813415 A4 EP 0813415A4 EP 95942875 A EP95942875 A EP 95942875A EP 95942875 A EP95942875 A EP 95942875A EP 0813415 A4 EP0813415 A4 EP 0813415A4
Authority
EP
European Patent Office
Prior art keywords
thionophosphate
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95942875A
Other languages
German (de)
French (fr)
Other versions
EP0813415A1 (en
Inventor
Oren Tirosh
Joshua Katzhendler
Isaac Ginsburg
Yehezkel Barenholz
Ron Kohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of EP0813415A1 publication Critical patent/EP0813415A1/en
Publication of EP0813415A4 publication Critical patent/EP0813415A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95942875A 1994-11-28 1995-11-13 Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them Withdrawn EP0813415A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11179794A IL111797A0 (en) 1994-11-28 1994-11-28 Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them
IL11179794 1994-11-28
PCT/US1995/015199 WO1996016663A1 (en) 1994-11-28 1995-11-13 Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
EP0813415A1 EP0813415A1 (en) 1997-12-29
EP0813415A4 true EP0813415A4 (en) 1998-05-06

Family

ID=11066823

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95942875A Withdrawn EP0813415A4 (en) 1994-11-28 1995-11-13 Thionophosphate derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (5)

Country Link
EP (1) EP0813415A4 (en)
AU (1) AU4408196A (en)
CA (1) CA2206374A1 (en)
IL (1) IL111797A0 (en)
WO (1) WO1996016663A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10051983A1 (en) * 2000-10-20 2002-06-13 Beate Kehrel Medicaments useful e.g. for preventing thrombosis, inhibiting transplant rejection or treating chronic inflammatory reactions comprises agents inhibiting binding of oxidized proteins to CD36,

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670057A (en) * 1969-11-10 1972-06-13 Sumitomo Chemical Co S(alkllthio ethyl) phosphorothioamidate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3087955A (en) * 1960-02-08 1963-04-30 Dow Chemical Co O-haloalkyl o-alkyl phosphoramidothioates
US3251675A (en) * 1961-12-28 1966-05-17 Dow Chemical Co Method of inhibiting plant growth
US3207661A (en) * 1963-01-11 1965-09-21 American Agricultural Chem Co Bis-(aziridinyl)-phosphinothioic esters as chemical sterilants for insects and mites
US3531550A (en) * 1965-08-12 1970-09-29 Monsanto Co Phosphorus ester amides
US3597476A (en) * 1968-12-04 1971-08-03 Dow Chemical Co Process for preparing tris (2-mercaptoethylamino) phophine oxides and sulfides
FR2034207A1 (en) * 1969-02-20 1970-12-11 Pepro

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3670057A (en) * 1969-11-10 1972-06-13 Sumitomo Chemical Co S(alkllthio ethyl) phosphorothioamidate

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 071, no. 1, 7 July 1969, Columbus, Ohio, US; abstract no. 003242, KAS'YANOVA E F ET AL: "Synthesis of some derivatives of monothiophosphoric acid for the flotation of ores of heavy nonferrous metals" XP002055305 *
CHEMICAL ABSTRACTS, vol. 085, no. 17, 25 October 1976, Columbus, Ohio, US; abstract no. 123267, MANDEL'BAUM Y A ET AL: "Reaction of phosphorus thio acid chlorides with ethanolamine" XP002055307 *
CHEMICAL ABSTRACTS, vol. 092, no. 13, 31 March 1980, Columbus, Ohio, US; abstract no. 110472, KRONGAUZ Y I ET AL: "Reaction of thiophosphoric acid chlorides with ethanolamine" XP002055306 *
CHEMICAL ABSTRACTS, vol. 121, no. 9, 29 August 1994, Columbus, Ohio, US; abstract no. 109001, GUO D ET AL: "N-substituted-O,O-diethylphosphoramidothioates" XP002055304 *
GUO D ET AL: "Phase transfer catalytic synthesis of O,O-diethyl-N-hydrocarbyl phosphoramidothioates", POLYM. MATER. SCI. ENG. (PMSEDG,07430515);93; VOL.69,; PP.482-3, SHANDONG TEACHER'S UNIV.;DEP. OF CHEMISTRY; JINAN; 250014; PEOP. REP. CHINA (CN), XP002055302 *
HECHENG HUAXUE (HEHUE2);94; VOL.2 (2); PP.185-9, SHANDONG NORMAL UNIV.;DEP. CHEM.; JINAN; 250014; PEOP. REP. CHINA (CN) *
KELNER M.J.: "Thioureas react with superoxide radicals to yield a sulfhydril compound", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 265, no. 3, 1990, MD US, pages 1306 - 1311, XP002057035 *
NOV. KHIM. SREDSTVA ZASHCH. RAST. (42DUA7);79; PP.11-15, USSR *
See also references of WO9616663A1 *
TIROSH O ET AL: "Antioxidant properties of amidothionophosphates: novel antioxidant molecules", FREE RADICAL BIOL. MED. (FRBMEH,08915849);96; VOL.20 (3); PP.421-32, HEBREW UNIV. JERUSALEM;DEP. PHARM.; JERUSALEM; ISRAEL (IL), XP002055303 *
ZH. OBSHCH. KHIM. (ZOKHA4);69; VOL.39 (2); PP.365-6, USSR *
ZH. OBSHCH. KHIM. (ZOKHA4);76; VOL.46 (8); PP.1757-8, USSR *

Also Published As

Publication number Publication date
CA2206374A1 (en) 1996-06-06
IL111797A0 (en) 1995-01-24
AU4408196A (en) 1996-06-19
WO1996016663A1 (en) 1996-06-06
EP0813415A1 (en) 1997-12-29

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Legal Events

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