EP0796322A4 - Production and use of human and plant methyltransferases - Google Patents

Production and use of human and plant methyltransferases

Info

Publication number
EP0796322A4
EP0796322A4 EP95939576A EP95939576A EP0796322A4 EP 0796322 A4 EP0796322 A4 EP 0796322A4 EP 95939576 A EP95939576 A EP 95939576A EP 95939576 A EP95939576 A EP 95939576A EP 0796322 A4 EP0796322 A4 EP 0796322A4
Authority
EP
European Patent Office
Prior art keywords
human
production
methyltransferases
plant
plant methyltransferases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95939576A
Other languages
German (de)
French (fr)
Other versions
EP0796322A1 (en
Inventor
Duncan C Maclaren
Mary Beth Mudgett
Steven Clarke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP0796322A1 publication Critical patent/EP0796322A1/en
Publication of EP0796322A4 publication Critical patent/EP0796322A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP95939576A 1994-10-19 1995-10-19 Production and use of human and plant methyltransferases Withdrawn EP0796322A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32677494A 1994-10-19 1994-10-19
US326774 1994-10-19
PCT/US1995/013691 WO1996012797A1 (en) 1994-10-19 1995-10-19 Production and use of human and plant methyltransferases

Publications (2)

Publication Number Publication Date
EP0796322A1 EP0796322A1 (en) 1997-09-24
EP0796322A4 true EP0796322A4 (en) 2000-04-26

Family

ID=23273666

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95939576A Withdrawn EP0796322A4 (en) 1994-10-19 1995-10-19 Production and use of human and plant methyltransferases

Country Status (5)

Country Link
EP (1) EP0796322A4 (en)
JP (1) JPH10507919A (en)
AU (1) AU4134196A (en)
CA (1) CA2203265A1 (en)
WO (1) WO1996012797A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4944297A (en) * 1996-10-08 1998-05-05 Novartis Ag Modulation of apoptosis
WO2002052016A2 (en) * 2000-12-26 2002-07-04 Bayer Aktiengesellschaft Regulation of human protein l-isoaspartate o-methyltransferase-like enzyme
EP1667699B1 (en) * 2003-10-03 2010-08-18 Green Meadows Research. LLC. Compositions comprising lotus extracts and methyl donors
FR2862661B1 (en) * 2003-11-26 2007-10-05 Agronomique Inst Nat Rech USE OF L-ISOASPARTYL METHYLTRANSFERASE AS A MARKER FOR LONGEVITY OF SEEDS.
JP2007300802A (en) * 2006-01-31 2007-11-22 Nippon Sheet Glass Co Ltd Extract composition and method for detoxifying toxic compound by using the same
JP6944957B2 (en) * 2016-12-28 2021-10-06 サントリーホールディングス株式会社 Composition for activation of protein L-isoaspartate methyltransferase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273886A (en) * 1990-08-24 1993-12-28 The Reagents Of The University Of California Determination of isoaspartate in proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273886A (en) * 1990-08-24 1993-12-28 The Reagents Of The University Of California Determination of isoaspartate in proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
INGROSSO, D. ET AL.,: "Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.", J. BIOL. CHEM., vol. 264, 1989, pages 20131-20139, XP002121864 *
MIZOBUCHI M. ET AL.,: "Tissue-specific expression of isoaspartyl protein carboxyl methyltransferase gene in rat brain and testis", J. NEUROCHEM., vol. 62, 1994, pages 322-328, XP002121863 *
MUDGETT M.B., CLARKE S.: "Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: Purification, cloning, and sequence analysis of the wheat germ enzyme", BIOCHEMISTRY, vol. 32, 1993, pages 11100-11111, XP000867677 *
ROMANIK E.A. ET AL.,: "Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase", GENE, vol. 118, 1992, pages 217-222, XP002121865 *
SATO M. ET AL.,: "Primary structure of rat brain protein carboxyl methyltransferase deduced from cDNA sequence", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 161, 1989, pages 342-347, XP002121862 *
See also references of WO9612797A1 *
W.J. HENZEL ET AL.,: "The primary structure of a protein carboxyl methyltransferase from bovine brain that selectively methylates L-isoaspartyl sites", J. BIOL. CHEM., vol. 264, no. 27, 1989, pages 15905 - 15911, XP002121866 *

Also Published As

Publication number Publication date
CA2203265A1 (en) 1996-05-02
AU4134196A (en) 1996-05-15
JPH10507919A (en) 1998-08-04
WO1996012797A1 (en) 1996-05-02
EP0796322A1 (en) 1997-09-24

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Legal Events

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