EP0787014A4 - Use of flea proteases and protease inhibitors to protect animals from flea infestation - Google Patents

Use of flea proteases and protease inhibitors to protect animals from flea infestation

Info

Publication number
EP0787014A4
EP0787014A4 EP95939081A EP95939081A EP0787014A4 EP 0787014 A4 EP0787014 A4 EP 0787014A4 EP 95939081 A EP95939081 A EP 95939081A EP 95939081 A EP95939081 A EP 95939081A EP 0787014 A4 EP0787014 A4 EP 0787014A4
Authority
EP
European Patent Office
Prior art keywords
flea
protease inhibitors
proteases
protect animals
infestation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95939081A
Other languages
German (de)
French (fr)
Other versions
EP0787014A1 (en
Inventor
Robert B Grieve
Keith E Rushlow
Shirley Wu Hunter
Glenn R Frank
Gary L Stiegler
Andrew Heath
Miles Yamanaka
Ann Arfsten
Beverly Dale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heska Corp
Original Assignee
Heska Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/326,773 external-priority patent/US5766609A/en
Priority claimed from US08/484,211 external-priority patent/US5972645A/en
Priority claimed from US08/485,443 external-priority patent/US6146870A/en
Priority claimed from US08/485,455 external-priority patent/US5712143A/en
Priority claimed from US08/482,130 external-priority patent/US5962257A/en
Application filed by Heska Corp filed Critical Heska Corp
Publication of EP0787014A1 publication Critical patent/EP0787014A1/en
Publication of EP0787014A4 publication Critical patent/EP0787014A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP95939081A 1994-10-18 1995-10-18 Use of flea proteases and protease inhibitors to protect animals from flea infestation Withdrawn EP0787014A4 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US08/326,773 US5766609A (en) 1991-12-13 1994-10-18 Use of protease inhibitors and protease vaccines to protect animals from flea infestation
US326773 1994-10-18
US08/484,211 US5972645A (en) 1991-12-13 1995-06-07 Flea serine protease nucleic acid molecules
US08/485,443 US6146870A (en) 1991-12-13 1995-06-07 Flea protease proteins
US485455 1995-06-07
US484211 1995-06-07
US08/485,455 US5712143A (en) 1991-12-13 1995-06-07 Flea protease proteins, nucleic acid molecules, and uses thereof
US485443 1995-06-07
US08/482,130 US5962257A (en) 1991-12-13 1995-06-07 Flea aminopeptidase nucleic acid molecules
US482130 1995-06-07
PCT/US1995/014442 WO1996011706A1 (en) 1994-10-18 1995-10-18 Use of flea proteases and protease inhibitors to protect animals from flea infestation

Publications (2)

Publication Number Publication Date
EP0787014A1 EP0787014A1 (en) 1997-08-06
EP0787014A4 true EP0787014A4 (en) 2001-01-10

Family

ID=27541069

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95939081A Withdrawn EP0787014A4 (en) 1994-10-18 1995-10-18 Use of flea proteases and protease inhibitors to protect animals from flea infestation

Country Status (8)

Country Link
EP (1) EP0787014A4 (en)
JP (1) JPH10507455A (en)
AU (1) AU705715B2 (en)
CA (1) CA2202622A1 (en)
IL (1) IL115671A0 (en)
MX (1) MX9702776A (en)
NZ (1) NZ296424A (en)
WO (1) WO1996011706A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210920B1 (en) * 1991-12-13 2001-04-03 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
WO1998045408A2 (en) * 1996-04-10 1998-10-15 Heska Corporation Novel ectoparasite saliva proteins and apparatus to collect such proteins
US6204010B1 (en) * 1995-06-07 2001-03-20 Heska Corporation Flea protease proteins, nucleic acid molecules, and uses thereof
FR2750865B1 (en) * 1996-06-27 1998-12-04 Rhone Merieux RECOMBINANT LIVING VACCINE BASED ON CANINE HERPESVIRUS, IN PARTICULAR FOR SQUARE DISEASE, RABIES OR TYPE 2 PARAINFLUENZA VIRUS
US6596291B2 (en) 1997-12-05 2003-07-22 Thomas A. Bell Compositions and methods for treating surfaces infected with ectoparasitic insects
EP1947112B1 (en) 1999-04-09 2012-05-16 Heska Corporation Flea head, nerve cord, hindgut and malpighian tubule nucleic acid molecules, proteins and uses thereof
US6399759B1 (en) * 1999-05-27 2002-06-04 University Of Georgia Research Foundation, Inc. Ant proteases and methods of inhibition
US7812163B2 (en) 2003-07-16 2010-10-12 Hatchtech Pty Ltd. Methods and compositions for controlling ectoparasites
AU2003903686A0 (en) * 2003-07-16 2003-07-31 Hatchtech Pty Ltd Methods and compositions for controlling ectoparasites
JP4710001B2 (en) * 2005-03-09 2011-06-29 国立大学法人帯広畜産大学 Tick leucine aminopeptidase
CN104039812A (en) 2011-05-31 2014-09-10 和黄生物膜医疗解决方案有限公司 Dispersion and detachment of cell aggregates
CA2933081C (en) 2013-12-17 2023-04-04 Hatchtech Pty Ltd. Pediculicidal composition

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011790A1 (en) * 1991-12-13 1993-06-24 Paravax, Inc. Flea midgut-supernatant vaccines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011790A1 (en) * 1991-12-13 1993-06-24 Paravax, Inc. Flea midgut-supernatant vaccines

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; BRYUKHANOVA L.V. ET AL.,: "DIGESTION OF BLOOD BY THE FLEA LEPTOPSYLLA-SEGNIS", XP002143760 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; RIDDOCH B.J. ET AL.,: "ASPECTS OF THE POPULATION STRUCTURE OF THE SAND MARTIN FLEA CERATOPHYLLUS-STYX IN BRITAIN UK", XP002143762 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; SHCHEDRIN V.I. ET AL.,: "BLOOD DIGESTION AND PLAGUE BLOK FORMATION IN FLEAS CERATOPHYLLUS-TESQUORUM", XP002143759 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; SHCHEDRIN V.I. ET AL.,: "HISTOENZYMATIC ANALYSIS OF FLEAS", XP002143761 *
MULLER M.H. ET AL.,: "Members of a trypsin gene family in Anopheles gambiae are induced in the gut by blood meal", EMBO J., vol. 12, no. 7, July 1993 (1993-07-01), pages 2891 - 2900, XP000919311 *
See also references of WO9611706A1 *
SMITH W.A. ET AL.,: "Cloning and sequencing of the Dermatophagoides pteronyssinus group III allergen, Der p III.", CLIN. EXP. ALLERGY, vol. 24, no. 3, March 1994 (1994-03-01), pages 220 - 228, XP000917275 *

Also Published As

Publication number Publication date
WO1996011706A1 (en) 1996-04-25
NZ296424A (en) 1999-01-28
EP0787014A1 (en) 1997-08-06
AU705715B2 (en) 1999-05-27
CA2202622A1 (en) 1996-04-25
JPH10507455A (en) 1998-07-21
AU4103896A (en) 1996-05-06
IL115671A0 (en) 1996-01-19
MX9702776A (en) 1998-07-31

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