EP0785992A4 - Conditional transformation of genetically engineered cells - Google Patents

Conditional transformation of genetically engineered cells

Info

Publication number
EP0785992A4
EP0785992A4 EP95937629A EP95937629A EP0785992A4 EP 0785992 A4 EP0785992 A4 EP 0785992A4 EP 95937629 A EP95937629 A EP 95937629A EP 95937629 A EP95937629 A EP 95937629A EP 0785992 A4 EP0785992 A4 EP 0785992A4
Authority
EP
European Patent Office
Prior art keywords
genetically engineered
engineered cells
conditional transformation
conditional
transformation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95937629A
Other languages
German (de)
French (fr)
Other versions
EP0785992A1 (en
Inventor
Gerald R Crabtree
David Spencer
Leslie Holsinger
Isabella Graef
Stuart Schreiber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Leland Stanford Junior University
Original Assignee
Harvard College
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Leland Stanford Junior University filed Critical Harvard College
Publication of EP0785992A1 publication Critical patent/EP0785992A1/en
Publication of EP0785992A4 publication Critical patent/EP0785992A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/72—Fusion polypeptide containing domain for protein-protein interaction containing SH2 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP95937629A 1994-10-25 1995-10-25 Conditional transformation of genetically engineered cells Withdrawn EP0785992A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32893194A 1994-10-25 1994-10-25
US328931 1994-10-25
PCT/US1995/013776 WO1996012796A1 (en) 1994-10-25 1995-10-25 Conditional transformation of genetically engineered cells

Publications (2)

Publication Number Publication Date
EP0785992A1 EP0785992A1 (en) 1997-07-30
EP0785992A4 true EP0785992A4 (en) 1999-12-22

Family

ID=23283095

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95937629A Withdrawn EP0785992A4 (en) 1994-10-25 1995-10-25 Conditional transformation of genetically engineered cells

Country Status (4)

Country Link
EP (1) EP0785992A4 (en)
JP (1) JPH11511643A (en)
AU (1) AU3968595A (en)
WO (1) WO1996012796A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE388724T1 (en) * 1998-01-08 2008-03-15 Univ Washington METHODS FOR CONTROLLING CELL DIFFERENTIATION AND GROWTH BY USING A FUSION PROTEIN AND AN ACTIVE SUBSTANCE
EP1079859B1 (en) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
AU2044001A (en) 1999-11-19 2001-05-30 Board Of Trustees Of The Leland Stanford Junior University Targeted bifunctional molecules and therapies based thereon
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
AU2002317841A1 (en) 2001-06-22 2003-01-08 Roche Diagnostics Gmbh Use of fkbp chaperones as expression tool
EP1641927B1 (en) 2003-02-18 2015-07-08 Baylor College of Medicine Induced activation in dendritic cells
WO2008049113A2 (en) 2006-10-19 2008-04-24 Baylor College Of Medicine Generating an immune response by inducing cd40 and pattern recognition receptors
AU2009292996B2 (en) 2008-09-22 2015-04-23 Baylor College Of Medicine Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
US10634668B2 (en) 2012-09-13 2020-04-28 Takara Bio Usa, Inc. Modifiable chemical inducers of proximity and methods of using the same
US9434935B2 (en) 2013-03-10 2016-09-06 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof
WO2014151960A2 (en) 2013-03-14 2014-09-25 Bellicum Pharmaceuticals, Inc. Methods for controlling t cell proliferation
AU2014274916B2 (en) 2013-06-05 2019-10-31 Bellicum Pharmaceuticals, Inc. Methods for inducing partial apoptosis using caspase polypeptides
CA2905229C (en) 2013-06-11 2023-10-10 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
CN111849912B (en) 2014-02-14 2024-03-15 贝里坤制药股份有限公司 Method for activating T cells using inducible chimeric polypeptides
JP6868554B2 (en) 2014-09-02 2021-05-12 ベリカム ファーマシューティカルズ， インコーポレイテッド Co-stimulation of chimeric antigen receptor with MyD88 and CD40 polypeptides
EP3215522B1 (en) 2014-11-03 2021-12-01 Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum T cell receptors directed against bob1 and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023550A2 (en) * 1992-05-18 1993-11-25 Genentech, Inc. Activation of oligomerizing receptors by using fused receptor ligands
WO1994018317A1 (en) * 1993-02-12 1994-08-18 The Board Of Trustees Of The Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
WO1995002684A1 (en) * 1993-07-16 1995-01-26 The Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
WO1996006111A1 (en) * 1994-08-18 1996-02-29 Ariad Gene Therapeutics, Inc. Regulatable elimination of gene expression, gene product function and engineered host cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023550A2 (en) * 1992-05-18 1993-11-25 Genentech, Inc. Activation of oligomerizing receptors by using fused receptor ligands
WO1994018317A1 (en) * 1993-02-12 1994-08-18 The Board Of Trustees Of The Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
WO1995002684A1 (en) * 1993-07-16 1995-01-26 The Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
WO1996006111A1 (en) * 1994-08-18 1996-02-29 Ariad Gene Therapeutics, Inc. Regulatable elimination of gene expression, gene product function and engineered host cells

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ARONHEIM A ET AL: "Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the ras signaling pathway", CELL, vol. 78, 23 September 1994 (1994-09-23), NA US, pages 949 - 961, XP002117493 *
HOLSINGER L J ET AL: "Signal transduction in T lymphocytes using a conditional allele of Sos.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995 OCT 10) 92 (21) 9810-4., XP002117491 *
KOLANUS, WALDEMAR ET AL: "T cell activation by clustered tyrosine kinases", CELL (CAMBRIDGE, MASS.) ( 1993 ), 74(1), 171-83, XP002117494 *
PRUSCHY M N ET AL: "Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012.", CHEMISTRY AND BIOLOGY, (1994 NOV) 1 (3) 163-72., XP002117492 *
See also references of WO9612796A1 *
SPENCER D M ET AL: "A general strategy for producing conditional alleles of Src-like tyrosine kinases.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995 OCT 10) 92 (21) 9805-9., XP002117490 *

Also Published As

Publication number Publication date
JPH11511643A (en) 1999-10-12
EP0785992A1 (en) 1997-07-30
WO1996012796A1 (en) 1996-05-02
AU3968595A (en) 1996-05-15

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