EP0733122A4 - Fusionsproteine, die das rep-protein des adeno-assoziierten virus enthalten, und proteine aus bakterien - Google Patents

Fusionsproteine, die das rep-protein des adeno-assoziierten virus enthalten, und proteine aus bakterien

Info

Publication number
EP0733122A4
EP0733122A4 EP94919252A EP94919252A EP0733122A4 EP 0733122 A4 EP0733122 A4 EP 0733122A4 EP 94919252 A EP94919252 A EP 94919252A EP 94919252 A EP94919252 A EP 94919252A EP 0733122 A4 EP0733122 A4 EP 0733122A4
Authority
EP
European Patent Office
Prior art keywords
protein
fusion proteins
associated virus
proteins containing
virus rep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94919252A
Other languages
English (en)
French (fr)
Other versions
EP0733122A1 (de
Inventor
Robert Kotin
Brian Safer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Genetic Therapy Inc
Original Assignee
US Department of Health and Human Services
Genetic Therapy Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, Genetic Therapy Inc filed Critical US Department of Health and Human Services
Publication of EP0733122A1 publication Critical patent/EP0733122A1/de
Publication of EP0733122A4 publication Critical patent/EP0733122A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP94919252A 1993-05-26 1994-05-26 Fusionsproteine, die das rep-protein des adeno-assoziierten virus enthalten, und proteine aus bakterien Withdrawn EP0733122A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6723693A 1993-05-26 1993-05-26
US67236 1993-05-26
PCT/US1994/005940 WO1994028157A1 (en) 1993-05-26 1994-05-26 Fusion proteins containing adeno-associated virus rep protein and bacterial protein

Publications (2)

Publication Number Publication Date
EP0733122A1 EP0733122A1 (de) 1996-09-25
EP0733122A4 true EP0733122A4 (de) 1998-06-10

Family

ID=22074622

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94919252A Withdrawn EP0733122A4 (de) 1993-05-26 1994-05-26 Fusionsproteine, die das rep-protein des adeno-assoziierten virus enthalten, und proteine aus bakterien

Country Status (4)

Country Link
EP (1) EP0733122A4 (de)
JP (1) JPH09501309A (de)
CA (1) CA2162271A1 (de)
WO (1) WO1994028157A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342390B1 (en) 1994-11-23 2002-01-29 The United States Of America As Represented By The Secretary Of Health And Human Services Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
US5843742A (en) * 1994-12-16 1998-12-01 Avigen Incorporated Adeno-associated derived vector systems for gene delivery and integration into target cells
US5756283A (en) * 1995-06-05 1998-05-26 The Trustees Of The University Of Pennsylvania Method for improved production of recombinant adeno-associated viruses for gene therapy
US6281010B1 (en) 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
DE19545126A1 (de) 1995-12-04 1997-06-05 Hoechst Ag ATP- und Nukleinsäure-bindendes Protein mit Helikase-Eigenschaften
EP0933997A4 (de) * 1996-09-06 2000-08-16 Chiron Corp Verfahren und zusammensetzungen für die leberspezifische verabreichung von therapeutischen molekülen unter verwendung rekombinanter aav vektoren
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
AU9363798A (en) 1997-11-06 1999-05-31 Chiron S.P.A. Neisserial antigens
CA2317815A1 (en) 1998-01-14 1999-07-22 Chiron S.P.A. Neisseria meningitidis antigens
ES2304065T3 (es) 1998-05-01 2008-09-01 Novartis Vaccines And Diagnostics, Inc. Antigenos y composiciones de neisseria meningitidis.
NZ581940A (en) 1999-04-30 2011-07-29 Novartis Vaccines & Diagnostic Conserved neisserial antigens
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
RU2281956C2 (ru) 1999-10-29 2006-08-20 Чирон С.Р.Л. Антигенные пептиды neisseria
DK2289545T3 (en) 2000-01-17 2016-09-05 Glaxosmithkline Biologicals Sa Supplemented OMV vaccine against meningococcus
EP2189473A3 (de) 2000-10-27 2010-08-11 Novartis Vaccines and Diagnostics S.r.l. Nukleinsäure und Proteine von Gruppen A und B Streptokokken
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
JP4413617B2 (ja) 2001-12-12 2010-02-10 カイロン ソチエタ ア レスポンサビリタ リミタータ Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓに対する免疫化
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
JP4792390B2 (ja) 2004-03-29 2011-10-12 株式会社ガルファーマ 新規ガレクチン９改変体タンパク質及びその用途
PT2054431E (pt) 2006-06-09 2011-11-03 Novartis Ag Confórmeros de adesinas bacterianas

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (de) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Antivirale Aktivität des vom adeno-assoziierten Virus Typ 2 codierten rep-Gens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) * 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (de) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Antivirale Aktivität des vom adeno-assoziierten Virus Typ 2 codierten rep-Gens

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIORINI J A ET AL: "BIOLOGICALLY ACTIVE REP PROTEINS OF ADENO-ASSOCIATED VIRUS TYPE 2 PRODUCED AS FUSION PROTEINS IN ESCHERICHIA COLI", JOURNAL OF VIROLOGY, vol. 68, no. 2, February 1994 (1994-02-01), pages 797 - 804, XP000608411 *
IM D.S: & MUZYCZKA N.: "The AAV origin bvinding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity.", CELL, vol. 61, 4 May 1990 (1990-05-04), pages 447 - 457, XP002060793 *
NEW ENGLAND BIOLABS CATALOG, 1992, pages 96 - 97, XP002061117 *
See also references of WO9428157A1 *

Also Published As

Publication number Publication date
JPH09501309A (ja) 1997-02-10
EP0733122A1 (de) 1996-09-25
WO1994028157A1 (en) 1994-12-08
CA2162271A1 (en) 1994-12-08

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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A4 Supplementary search report drawn up and despatched

Effective date: 19980428

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Effective date: 19980723