EP0721015A4 - Monoclonal antibody that induces apoptosis - Google Patents

Monoclonal antibody that induces apoptosis

Info

Publication number
EP0721015A4
EP0721015A4 EP94925618A EP94925618A EP0721015A4 EP 0721015 A4 EP0721015 A4 EP 0721015A4 EP 94925618 A EP94925618 A EP 94925618A EP 94925618 A EP94925618 A EP 94925618A EP 0721015 A4 EP0721015 A4 EP 0721015A4
Authority
EP
European Patent Office
Prior art keywords
antibody
monoclonal antibody
induces apoptosis
myelocytic
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP94925618A
Other languages
German (de)
French (fr)
Other versions
EP0721015A1 (en
EP0721015B1 (en
Inventor
Naoshi Fukushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of EP0721015A1 publication Critical patent/EP0721015A1/en
Publication of EP0721015A4 publication Critical patent/EP0721015A4/en
Application granted granted Critical
Publication of EP0721015B1 publication Critical patent/EP0721015B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A monoclonal antibody that induces apoptosis in the myelocytic cell, a fragment of the antibody, and a hybridoma that produces the antibody. The antibody is useful as an antibody that specifically recognizes an antigen or the like inducing apoptosis in the myelocytic cell and discriminates and identifies the same. Further it is useable as a useful drug in the field of, for example, treating myelocytic leukemia by utilizing the activity of inducing apoptosis in the myelocytic cell.
EP94925618A 1993-09-03 1994-09-02 Monoclonal antibody that induces apoptosis Expired - Lifetime EP0721015B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24211093 1993-09-03
JP242110/93 1993-09-03
JP05242110 1993-09-03
PCT/JP1994/001453 WO1995006748A1 (en) 1993-09-03 1994-09-02 Monoclonal antibody that induces apoptosis

Publications (3)

Publication Number Publication Date
EP0721015A1 EP0721015A1 (en) 1996-07-10
EP0721015A4 true EP0721015A4 (en) 1999-03-31
EP0721015B1 EP0721015B1 (en) 2004-10-27

Family

ID=17084452

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94925618A Expired - Lifetime EP0721015B1 (en) 1993-09-03 1994-09-02 Monoclonal antibody that induces apoptosis

Country Status (19)

Country Link
US (4) US5840344A (en)
EP (1) EP0721015B1 (en)
KR (1) KR100241863B1 (en)
CN (1) CN1046314C (en)
AT (1) ATE280835T1 (en)
AU (1) AU692466B2 (en)
CA (1) CA2169950A1 (en)
CZ (1) CZ294359B6 (en)
DE (1) DE69434097T2 (en)
FI (1) FI960567A0 (en)
HU (1) HU222989B1 (en)
NO (1) NO960684D0 (en)
PL (1) PL181783B1 (en)
RU (1) RU2202615C2 (en)
SK (1) SK281964B6 (en)
TW (1) TW426687B (en)
UA (1) UA50708C2 (en)
WO (1) WO1995006748A1 (en)
ZA (1) ZA946767B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181783B1 (en) * 1993-09-03 2001-09-28 Chugai Pharmaceutical Co Ltd Monoclonal antibodies having properties making them able to cause apoptosis
AU2232597A (en) * 1996-03-06 1997-09-22 Chugai Seiyaku Kabushiki Kaisha Method of screening apoptosis inducing substances
AU733322B2 (en) 1996-07-15 2001-05-10 Chugai Seiyaku Kabushiki Kaisha Novel VEGF-like factor
US7531643B2 (en) 1997-09-11 2009-05-12 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
WO1999012973A1 (en) * 1997-09-11 1999-03-18 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
US7696325B2 (en) * 1999-03-10 2010-04-13 Chugai Seiyaku Kabushiki Kaisha Polypeptide inducing apoptosis
WO2000053634A1 (en) * 1999-03-10 2000-09-14 Chugai Seiyaku Kabushiki Kaisha Single-stranded fv inducing apoptosis
US20040058393A1 (en) * 2000-04-17 2004-03-25 Naoshi Fukishima Agonist antibodies
US20040242847A1 (en) * 2000-10-20 2004-12-02 Naoshi Fukushima Degraded agonist antibody
US8034903B2 (en) * 2000-10-20 2011-10-11 Chugai Seiyaku Kabushiki Kaisha Degraded TPO agonist antibody
US7195771B1 (en) 2000-11-21 2007-03-27 Kimberly-Clark Worldwide, Inc. Water-soluble lotions for paper products
US20030138419A1 (en) * 2001-11-16 2003-07-24 The University Of Tennessee Research Corporation Recombinant antibody fusion proteins and methods for detection of apoptotic cells
DE60324700D1 (en) * 2002-10-11 2008-12-24 Chugai Pharmaceutical Co Ltd CELL TOD INDUCTIVE ACTIVE SUBSTANCE
JP2004279086A (en) 2003-03-13 2004-10-07 Konica Minolta Holdings Inc Radiation image conversion panel and method for manufacturing it
EP1609803A4 (en) * 2003-03-31 2006-05-24 Chugai Pharmaceutical Co Ltd Modified antibody against cd22 and utilization thereof
WO2005056602A1 (en) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha Method of screening modified antibody having agonistic activity
TW200530269A (en) * 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Anti-Mpl antibodies
WO2005056603A1 (en) * 2003-12-12 2005-06-23 Chugai Seiyaku Kabushiki Kaisha Cell death inducing agent
TW200530266A (en) * 2003-12-12 2005-09-16 Chugai Pharmaceutical Co Ltd Method of reinforcing antibody activity
TW200722518A (en) * 2005-03-31 2007-06-16 Chugai Pharmaceutical Co Ltd Sc(fv)2 structural isomers
EP1927367A4 (en) * 2005-05-18 2009-08-12 Univ Tokushima Novel pharmaceutical using anti-hla antibody
JP5068167B2 (en) 2005-06-10 2012-11-07 中外製薬株式会社 Stabilizer for protein preparation containing meglumine and use thereof
JP5085322B2 (en) 2005-06-10 2012-11-28 中外製薬株式会社 Pharmaceutical composition containing sc (Fv) 2
WO2007100892A2 (en) * 2006-02-28 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Trojan horse immunotherapy
TW200808351A (en) * 2006-07-13 2008-02-16 Chugai Pharmaceutical Co Ltd Cell death-inducing agents
CL2008000719A1 (en) * 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku THERAPEUTIC AGENT FOR CANCER RESISTANT TO CHEMOTHERAPEUTIC AGENTS THAT UNDERSTAND AN ANTIBODY THAT RECOGNIZES IT CLASS I AS ACTIVE INGREDIENT; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH ANTIBODY; AND METHOD TO TREAT CANCER RESISTANT TO
MX2017007249A (en) 2014-12-05 2018-01-25 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof.
EP3383913A4 (en) 2015-12-04 2019-10-30 Memorial Sloan-Kettering Cancer Center Antibodies targeting fc receptor-like 5 and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181783B1 (en) * 1993-09-03 2001-09-28 Chugai Pharmaceutical Co Ltd Monoclonal antibodies having properties making them able to cause apoptosis
AU2232597A (en) * 1996-03-06 1997-09-22 Chugai Seiyaku Kabushiki Kaisha Method of screening apoptosis inducing substances
WO1999012973A1 (en) * 1997-09-11 1999-03-18 Chugai Seiyaku Kabushiki Kaisha Monoclonal antibody inducing apoptosis
WO2000053634A1 (en) * 1999-03-10 2000-09-14 Chugai Seiyaku Kabushiki Kaisha Single-stranded fv inducing apoptosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B. TRAUTH ET AL.: "Monoclonal antibody-mediated tumor regression by induction of apoptosis.", SCIENCE, vol. 245, no. 4915, 21 July 1989 (1989-07-21), Washington, DC, USA, pages 301 - 305, XP000749873 *
S. YONEHARA ET AL.: "A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 169, May 1989 (1989-05-01), New York, NY, USA, pages 1747 - 1756, XP000560316 *

Also Published As

Publication number Publication date
DE69434097D1 (en) 2004-12-02
SK281964B6 (en) 2001-09-11
HUT74594A (en) 1997-01-28
FI960567A (en) 1996-02-07
AU692466B2 (en) 1998-06-11
EP0721015A1 (en) 1996-07-10
HU222989B1 (en) 2004-01-28
DE69434097T2 (en) 2006-02-02
UA50708C2 (en) 2002-11-15
EP0721015B1 (en) 2004-10-27
ATE280835T1 (en) 2004-11-15
US5840344A (en) 1998-11-24
NO960684L (en) 1996-02-21
AU7546694A (en) 1995-03-22
NO960684D0 (en) 1996-02-21
PL313260A1 (en) 1996-06-24
US6267959B1 (en) 2001-07-31
CA2169950A1 (en) 1995-03-09
KR100241863B1 (en) 2000-03-02
CN1130405A (en) 1996-09-04
US20010001712A1 (en) 2001-05-24
CN1046314C (en) 1999-11-10
PL181783B1 (en) 2001-09-28
RU2202615C2 (en) 2003-04-20
HU9600206D0 (en) 1996-03-28
SK25596A3 (en) 1996-10-02
WO1995006748A1 (en) 1995-03-09
CZ61796A3 (en) 1996-06-12
CZ294359B6 (en) 2004-12-15
ZA946767B (en) 1995-04-03
US20030147894A1 (en) 2003-08-07
US6759043B2 (en) 2004-07-06
FI960567A0 (en) 1996-02-07
TW426687B (en) 2001-03-21

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