EP0695368A4 - Procede aleatoire de production de nouveaux composes chimiques - Google Patents

Procede aleatoire de production de nouveaux composes chimiques

Info

Publication number
EP0695368A4
EP0695368A4 EP94916542A EP94916542A EP0695368A4 EP 0695368 A4 EP0695368 A4 EP 0695368A4 EP 94916542 A EP94916542 A EP 94916542A EP 94916542 A EP94916542 A EP 94916542A EP 0695368 A4 EP0695368 A4 EP 0695368A4
Authority
EP
European Patent Office
Prior art keywords
generation
new compounds
random chemistry
chemistry
random
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94916542A
Other languages
German (de)
English (en)
Other versions
EP0695368A1 (fr
Inventor
Stuart A Kauffman
Julius Rebek Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0695368A1 publication Critical patent/EP0695368A1/fr
Publication of EP0695368A4 publication Critical patent/EP0695368A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1093General methods of preparing gene libraries, not provided for in other subgroups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002Antibodies with enzymatic activity, e.g. abzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP94916542A 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques Withdrawn EP0695368A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4926893A 1993-04-19 1993-04-19
US49268 1993-04-19
PCT/US1994/004314 WO1994024314A1 (fr) 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques

Publications (2)

Publication Number Publication Date
EP0695368A1 EP0695368A1 (fr) 1996-02-07
EP0695368A4 true EP0695368A4 (fr) 1996-05-08

Family

ID=21958942

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94916542A Withdrawn EP0695368A4 (fr) 1993-04-19 1994-04-19 Procede aleatoire de production de nouveaux composes chimiques

Country Status (5)

Country Link
EP (1) EP0695368A4 (fr)
JP (1) JPH09500007A (fr)
AU (1) AU6815894A (fr)
CA (1) CA2160457A1 (fr)
WO (1) WO1994024314A1 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
AU4424496A (en) * 1995-03-27 1996-10-16 Warner-Lambert Company A method for the synthesis of mixtures of compounds
EP0817787A4 (fr) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc Composes macrocycliques azotes
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US5780241A (en) * 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
DK1801214T3 (da) * 1997-07-07 2011-01-24 Medical Res Council In vitro sorteringsfremgangsmåde
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
US6455263B2 (en) 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
US6100035A (en) * 1998-07-14 2000-08-08 Cistem Molecular Corporation Method of identifying cis acting nucleic acid elements
DE19843242A1 (de) * 1998-09-11 2000-03-23 Inst Angewandte Chemie Berlin Verfahren zur Herstellung aktiver und/oder selektiver Feststoff-Katalysatoren aus anorganischen oder metallorganischen Feststoffen oder Gemischen davon
DE19902378A1 (de) * 1999-01-21 2000-08-03 Morphochem Gmbh Verfahren zur Auffindung und Herstellung von biologisch wirksamen chemischen Verbindungen
AU3517400A (en) * 1999-03-10 2000-09-28 Axys Pharmaceuticals, Inc. Proline derivatives and synthesis thereof
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
EP1590477B1 (fr) 2003-01-29 2009-07-29 454 Corporation PROCÉDÉ D'AMPLIFICATION ET DE SÉQUENçAGE D'ACIDES NUCLÉIQUES
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US8048627B2 (en) 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US20060063208A1 (en) 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7968091B2 (en) 2005-02-16 2011-06-28 The General Hospital Corporation Methods and compositions to regulate iron metabolism
EP1801212A1 (fr) * 2005-12-21 2007-06-27 Eidgenössische Technische Hochschule Zürich Sélection de biocatalyseurs pour la synthèse chimique
CA2636855C (fr) 2006-01-11 2016-09-27 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procedes d'utilisation dans la formation et le controle de nanoreacteurs
EP3031918B1 (fr) 2006-05-11 2018-03-14 Raindance Technologies Inc. Dispositifs microfluidiques
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
WO2008097559A2 (fr) 2007-02-06 2008-08-14 Brandeis University Manipulation de fluides et de réactions dans des systèmes microfluidiques
US8895002B2 (en) 2007-04-09 2014-11-25 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
WO2008130623A1 (fr) 2007-04-19 2008-10-30 Brandeis University Manipulation de fluides, composants fluidiques et réactions dans des systèmes microfluidiques
CN101802182A (zh) 2007-08-21 2010-08-11 诺达利蒂公司 用于诊断、预后和治疗方法的方法
EP2315629B1 (fr) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Bibliothèque de gouttelettes
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
WO2010111231A1 (fr) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
US8187885B2 (en) 2009-05-07 2012-05-29 Nodality, Inc. Microbead kit and method for quantitative calibration and performance monitoring of a fluorescence instrument
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (fr) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Procédés pour réduire l'échange de molécules entre des gouttelettes
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
CA2789425C (fr) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Analyse numerique d'analyte comportant la correction d'erreur de polymerase
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US20130288373A1 (en) 2010-12-20 2013-10-31 Kenneth Verstraete Crystal structure of flt3 ligand-receptor complex
EP2673614B1 (fr) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Procédé de formation de gouttelettes mélangées
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP2714970B1 (fr) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Quantification d'enzyme
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
CN104066432B (zh) 2011-12-06 2017-06-13 小利兰·斯坦福大学董事会 用于治疗病毒性疾病的方法和组合物
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
EP3331536A4 (fr) 2015-08-03 2019-03-27 The Regents of The University of California Compositions et procédés pour moduler l'activité d'abhd2
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
WO2020229300A1 (fr) 2019-05-10 2020-11-19 Griessinger Emmanuel Méthode de mesure et de ciblage du métabolisme dependant de la phosphorylation oxydative
BR112022007375A2 (pt) 2019-10-18 2022-07-05 Univ Leland Stanford Junior Sequenciamento de tecido intacto em escala clínica e industrial
CN111493208B (zh) * 2020-04-29 2023-11-21 无锡金农生物科技有限公司 一种植物双蛋白的制备方法及其产品

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968619A (en) * 1976-09-27 1990-11-06 Research Corporation Modified microorganisms and method of preparing and using same

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
B. GONG ET AL.: "A chromogenic assay for screening large antibody libraries", J. AM. CHEM. SOC., vol. 114, no. 4, 12 February 1992 (1992-02-12), AM. CHEM. SOC., US, pages 1486 - 1487 *
C. TUERK AND L GOLD: "Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage tç DNA polymerase", SCIENCE, vol. 249, 3 August 1990 (1990-08-03), AAAS,WASHINGTON,DC,US, pages 505 - 510, XP002547963, DOI: doi:10.1126/science.2200121 *
D.S. TAWFIK ET AL.: "catELISA: A facile general route to catalytic antibodies", PROC. NATL.ACAD SCI., vol. 90, NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 373 - 377, XP002044712, DOI: doi:10.1073/pnas.90.2.373 *
KAUFFMAN, STUART: "Random Chemistry", BER. BUNSEN-GES. PHYS. CHEM. (1994), 98(9), 1142-7 CODEN: BBPCAX;ISSN: 0005-9021 *
LAM K S ET AL: "A NEW TYPE OF SYNTHETIC PEPTIDE LIBRARY FOR IDENTIFYING LIGAND-BINDING ACTIVITY", NATURE, vol. 354, no. 6348, 7 November 1991 (1991-11-07), pages 82 - 84, XP000371736 *
M. EIGEN ET AL.: "Ursprung der genetischen Information", SPEKTRUM DER WISSENSCHAFT, no. 6, HEIDELBERG, BRD, pages 37 - 56 *
R.A. HOUGHTEN ET AL.: "Generation and use of synthetic peptide libraries for basic research and drug discovery", NATURE, vol. 354, 7 November 1991 (1991-11-07), MACMILLAN JOURNALS LTD., LONDON,UK, pages 84 - 86, XP000371737, DOI: doi:10.1038/354084a0 *
S.A. KAUFFMAN: "Autocatalytic sets of proteins", J. THEORETICAL BIOLOGY, vol. 119, no. 1, 7 March 1986 (1986-03-07), ACADEMIC PRESS INC., LONDON, UK, pages 1 - 24, XP000564567 *
See also references of WO9424314A1 *
Y.-C.J. CHEN ET AL.: "Catalytic antibodies from combinatorial libraries", J. AM. CHEM. SOC., vol. 115, no. 1, 13 January 1993 (1993-01-13), AM. CHEM. SOC.,US, pages 357 - 358 *

Also Published As

Publication number Publication date
CA2160457A1 (fr) 1994-10-27
WO1994024314A1 (fr) 1994-10-27
JPH09500007A (ja) 1997-01-07
EP0695368A1 (fr) 1996-02-07
AU6815894A (en) 1994-11-08

Similar Documents

Publication Publication Date Title
EP0695368A4 (fr) Procede aleatoire de production de nouveaux composes chimiques
GB9315595D0 (en) New compounds
GB9304618D0 (en) Chemical compounds
GB9301000D0 (en) Chemical compounds
GB9311682D0 (en) Chemical compounds
GB9305468D0 (en) Chemical compounds
GB9310635D0 (en) Chemical compounds
GB2280677B (en) Chemical compounds
GB9308421D0 (en) Chemical compounds
GB9307749D0 (en) Chemical compounds
GB9305523D0 (en) Chemical compounds
GB9305459D0 (en) Chemical compounds
AU8002098A (en) Random chemistry for the generation of new compounds
GB9305806D0 (en) Chemical compounds
GB9306941D0 (en) Chemical compounds
PL315061A1 (en) Di-ter-butylophenolic compounds suitable as anti-inflammatory agents
GB9302797D0 (en) New compounds
GB9304499D0 (en) Chemical compounds
GB9303987D0 (en) Chemical compounds
GB9317988D0 (en) Chemical compounds
GB9303572D0 (en) Chemical compounds
GB9302844D0 (en) Chemical compounds
GB9302801D0 (en) Chemical compounds
GB9301092D0 (en) Chemical compounds
GB9307398D0 (en) Chemical compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19951012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

RHK1 Main classification (correction)

Ipc: C12N 15/10

A4 Supplementary search report drawn up and despatched

Effective date: 19960320

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19970627

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20011101