EP0672054A4 - Nouvelle molecule inhibant la fonction biologique du neuropeptide tyrosine. - Google Patents
Nouvelle molecule inhibant la fonction biologique du neuropeptide tyrosine.Info
- Publication number
- EP0672054A4 EP0672054A4 EP93901575A EP93901575A EP0672054A4 EP 0672054 A4 EP0672054 A4 EP 0672054A4 EP 93901575 A EP93901575 A EP 93901575A EP 93901575 A EP93901575 A EP 93901575A EP 0672054 A4 EP0672054 A4 EP 0672054A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- biological function
- novel molecule
- neuropeptide tyrosine
- inhibits
- inhibits neuropeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPL010691 | 1991-12-19 | ||
AU106/91 | 1991-12-19 | ||
PCT/AU1992/000673 WO1993012139A1 (fr) | 1991-12-19 | 1992-12-21 | Nouvelle molecule inhibant la fonction biologique du neuropeptide tyrosine |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0672054A1 EP0672054A1 (fr) | 1995-09-20 |
EP0672054A4 true EP0672054A4 (fr) | 1996-02-07 |
Family
ID=3775895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93901575A Withdrawn EP0672054A4 (fr) | 1991-12-19 | 1992-12-21 | Nouvelle molecule inhibant la fonction biologique du neuropeptide tyrosine. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0672054A4 (fr) |
JP (1) | JPH08501055A (fr) |
CA (1) | CA2126212A1 (fr) |
WO (1) | WO1993012139A1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
US5989920A (en) | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
CA2249222C (fr) * | 1996-03-21 | 2005-11-08 | Banyu Pharmaceutical Co., Ltd. | Derives d'aminopyridine |
US5965392A (en) | 1996-04-08 | 1999-10-12 | Bayer Corporation | Neuropeptide Y receptor Y5 and nucleic acid sequences |
FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
US6713265B1 (en) | 1997-06-04 | 2004-03-30 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) |
DE602004026289D1 (de) | 2003-05-05 | 2010-05-12 | Probiodrug Ag | Glutaminylcyclase-hemmer |
WO2005049027A2 (fr) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinaisons utiles au traitement de troubles neuronaux |
CA2554809C (fr) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Nouveaux inhibiteurs de la glutaminyl-cyclase comportant de la n thiouree alkyle et de l'imidazolyl substitue par thioamide |
EP2089383B1 (fr) | 2006-11-09 | 2015-09-16 | Probiodrug AG | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
WO2008128985A1 (fr) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
EP2542549B1 (fr) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibiteurs de glutaminyl cyclase |
EA022420B1 (ru) | 2010-03-10 | 2015-12-30 | Пробиодруг Аг | Гетероциклические ингибиторы глутаминилциклазы (qc, ec 2.3.2.5) |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
EP3461819B1 (fr) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibiteurs de la glutaminyl-cyclase |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH490338A (de) * | 1967-04-13 | 1970-05-15 | Ciba Geigy | Verfahren zur Herstellung von ACTH-wirksamen Peptiden mit verlängerter Wirkung |
EP0225020A2 (fr) * | 1985-10-19 | 1987-06-10 | Beecham Group Plc | Peptides comprenant dans leur séquence des unités sélectionnées parmi les restes d'acides aminés 17 à 24 du VIP |
WO1991008223A1 (fr) * | 1989-12-01 | 1991-06-13 | Basf Aktiengesellschaft | Nouveaux peptides derives du neuropeptide y |
WO1993009227A1 (fr) * | 1991-11-06 | 1993-05-13 | Garvan Institute Of Medical Research | Recepteur de neuropeptide y-y1 humain |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4839343A (en) * | 1987-03-13 | 1989-06-13 | Debiopharm, S.A. | Preparation containing hexatriacontapeptides and methods of use |
DE3811193A1 (de) * | 1988-04-01 | 1989-10-19 | Boehringer Ingelheim Kg | Neue peptide, verfahren zu ihrer herstellung und diese peptide enthaltende pharmazeutische zusammensetzungen |
ZA896376B (en) * | 1988-08-26 | 1990-05-30 | Merrell Dow Pharma | Neuropeptide y agonists |
ATE109979T1 (de) * | 1990-03-30 | 1994-09-15 | Heumann Pharma Gmbh & Co | Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung. |
SE467340B (sv) * | 1990-07-04 | 1992-07-06 | Perstorp Ab | Anvaendning av inositolmonofosfat foer framstaellning av ett laekemedel effektivt som en neuropeptid y-(npy-)antagonist |
-
1992
- 1992-12-21 CA CA002126212A patent/CA2126212A1/fr not_active Abandoned
- 1992-12-21 EP EP93901575A patent/EP0672054A4/fr not_active Withdrawn
- 1992-12-21 JP JP5510467A patent/JPH08501055A/ja active Pending
- 1992-12-21 WO PCT/AU1992/000673 patent/WO1993012139A1/fr not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH490338A (de) * | 1967-04-13 | 1970-05-15 | Ciba Geigy | Verfahren zur Herstellung von ACTH-wirksamen Peptiden mit verlängerter Wirkung |
EP0225020A2 (fr) * | 1985-10-19 | 1987-06-10 | Beecham Group Plc | Peptides comprenant dans leur séquence des unités sélectionnées parmi les restes d'acides aminés 17 à 24 du VIP |
WO1991008223A1 (fr) * | 1989-12-01 | 1991-06-13 | Basf Aktiengesellschaft | Nouveaux peptides derives du neuropeptide y |
WO1993009227A1 (fr) * | 1991-11-06 | 1993-05-13 | Garvan Institute Of Medical Research | Recepteur de neuropeptide y-y1 humain |
Non-Patent Citations (4)
Title |
---|
BALASUBRAMANIAN, A. ET AL.: "Synthseis and receptor affinities of partial sequences of peptide YY (PYY)", PEPTIDE RESEARCH, vol. 1, no. 1, pages 32 - 35, XP002039197 * |
LACOMBE, J.M. ET AL.: "Malaria invasion of human erythrocytes", INT. J. PEPTIDE PROTEIN RES., vol. 32, pages 104 - 116, XP009038013 * |
See also references of WO9312139A1 * |
SERVIN, A.L. ET AL.: "Peptide-YY and Neuropeptide-Y inhibit vasoactive intestinal peptide-stimulated ...", ENDOCRINOLOGY, vol. 124, no. 2, pages 692 - 700 * |
Also Published As
Publication number | Publication date |
---|---|
EP0672054A1 (fr) | 1995-09-20 |
JPH08501055A (ja) | 1996-02-06 |
CA2126212A1 (fr) | 1993-07-08 |
WO1993012139A1 (fr) | 1993-06-24 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19940714 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19951227 |
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Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 19960104 |