EP0650358A4 - 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors. - Google Patents

17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors.

Info

Publication number: EP0650358A4
Authority: EP; European Patent Office
Prior art keywords: aza; steroid; acyl; alpha; reductase inhibitors
Prior art date: 1992-06-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93916878A

Other versions

EP0650358A1 (en

Inventor

Dennis Alan Holt

Mark Alan Levy

Hye-Ja Oh

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-30

Filing date

1993-06-30

Publication date

1995-06-07

1993-06-30 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1995-05-03 Publication of EP0650358A1 publication Critical patent/EP0650358A1/en

1995-06-07 Publication of EP0650358A4 publication Critical patent/EP0650358A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

EP93916878A 1992-06-30 1993-06-30 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors. Withdrawn EP0650358A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB929213901A GB9213901D0 (en)	1992-06-30	1992-06-30	Compounds
GB9213901		1992-06-30
PCT/US1993/006233 WO1994000121A1 (en)	1992-06-30	1993-06-30	17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors

Publications (2)

Publication Number	Publication Date
EP0650358A1 EP0650358A1 (en)	1995-05-03
EP0650358A4 true EP0650358A4 (en)	1995-06-07

Family

ID=10717969

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93916878A Withdrawn EP0650358A4 (en)	1992-06-30	1993-06-30	17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors.

Country Status (4)

Country	Link
EP (1)	EP0650358A4 (en)
JP (1)	JPH07508524A (en)
GB (1)	GB9213901D0 (en)
WO (1)	WO1994000121A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) *	1994-10-25	1997-01-21	Merck & Co., Inc.	7-substituted 4-aza cholanic acid derivatives and their use
GB201102913D0 (en)	2011-02-18	2011-04-06	Univ Birmingham	Novel therapeutic

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0277002A2 (en) *	1987-01-28	1988-08-03	Smithkline Beecham Corporation	Steroid-5-alpha-reductase inhibitors
WO1992000010A1 (en) *	1990-06-27	1992-01-09	Smithkline Beecham Corporation	Method of treating human prostatic adenocarcinoma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4760071A (en) *	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US5049562A (en) *	1984-02-27	1991-09-17	Merck & Co., Inc.	17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4859681A (en) *	1984-02-27	1989-08-22	Merck & Co., Inc.	17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
GB8505862D0 (en) *	1985-03-07	1985-04-11	Erba Farmitalia	Steroidic 5alpha-reductase inhibitors
US5110939A (en) *	1987-01-28	1992-05-05	Smithkline Beecham Corporation	Intermediates in the preparation of steriod 5-alpha-reductase inhibitors
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
US5116983A (en) *	1988-04-18	1992-05-26	Merck & Co., Inc.	Dehydrogenation process intermediates
US4882319A (en) *	1988-12-23	1989-11-21	Smithkline Beckman Corporation	Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5061803A (en) *	1990-09-24	1991-10-29	Merck & Co., Inc.	Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes

1992
- 1992-06-30 GB GB929213901A patent/GB9213901D0/en active Pending
1993
- 1993-06-30 JP JP6502657A patent/JPH07508524A/en active Pending
- 1993-06-30 WO PCT/US1993/006233 patent/WO1994000121A1/en not_active Application Discontinuation
- 1993-06-30 EP EP93916878A patent/EP0650358A4/en not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0277002A2 (en) *	1987-01-28	1988-08-03	Smithkline Beecham Corporation	Steroid-5-alpha-reductase inhibitors
WO1992000010A1 (en) *	1990-06-27	1992-01-09	Smithkline Beecham Corporation	Method of treating human prostatic adenocarcinoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9400121A1 *

Also Published As

Publication number	Publication date
GB9213901D0 (en)	1992-08-12
WO1994000121A1 (en)	1994-01-06
JPH07508524A (en)	1995-09-21
EP0650358A1 (en)	1995-05-03

Legal Events

Date	Code	Title	Description
1995-03-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-05-03	17P	Request for examination filed	Effective date: 19950112
1995-05-03	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI NL
1995-06-07	A4	Supplementary search report drawn up and despatched
1995-06-07	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): BE CH DE FR GB IT LI NL
1995-06-07	RHK1	Main classification (correction)	Ipc: C07J 73/00
1997-09-17	17Q	First examination report despatched	Effective date: 19970804
1998-04-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1998-06-17	18D	Application deemed to be withdrawn	Effective date: 19971216

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EP0624089A4 (en)	1994-12-14	Methods.
ZA939480B (en)	1995-06-19	Enzyme inhibitor
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GB9303051D0 (en)	1993-03-31	17b-nmonosubstituted carbamoyl-11-oxo-4-aza-5-a-androst-en-3-one testosterone-5-alpha reductase inhibitors
ZA935828B (en)	1994-03-10	New insobutyl-substituted methanesulphonyl-quinolyl-methoxyphenyl-cycloalkylacetamides.