EP0603314A4 - Chemical compounds. - Google Patents

Chemical compounds.

Info

Publication number
EP0603314A4
EP0603314A4 EP9292920317A EP92920317A EP0603314A4 EP 0603314 A4 EP0603314 A4 EP 0603314A4 EP 9292920317 A EP9292920317 A EP 9292920317A EP 92920317 A EP92920317 A EP 92920317A EP 0603314 A4 EP0603314 A4 EP 0603314A4
Authority
EP
European Patent Office
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP9292920317A
Other versions
EP0603314A1 (en
Inventor
Robert Michael Demarinis
Francis Richard Pfeiffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0603314A1 publication Critical patent/EP0603314A1/en
Publication of EP0603314A4 publication Critical patent/EP0603314A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP9292920317A 1991-09-12 1992-09-11 Chemical compounds. Ceased EP0603314A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919119467A GB9119467D0 (en) 1991-09-12 1991-09-12 Chemical compounds
GB9119467 1991-09-12
PCT/US1992/007694 WO1993004686A1 (en) 1991-09-12 1992-09-11 Chemical compounds

Publications (2)

Publication Number Publication Date
EP0603314A1 EP0603314A1 (en) 1994-06-29
EP0603314A4 true EP0603314A4 (en) 1994-08-24

Family

ID=10701273

Family Applications (1)

Application Number Title Priority Date Filing Date
EP9292920317A Ceased EP0603314A4 (en) 1991-09-12 1992-09-11 Chemical compounds.

Country Status (5)

Country Link
EP (1) EP0603314A4 (en)
JP (1) JPH06510545A (en)
AU (1) AU2654792A (en)
GB (1) GB9119467D0 (en)
WO (1) WO1993004686A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007353A1 (en) * 1997-08-05 1999-02-18 The Mount Sinai School Of Medicine Of The City University Of New York USE OF α1A-ADRENERGIC RECEPTOR ANTAGONISTS IN GLAUCOMA THERAPY
US6395736B1 (en) * 1998-12-14 2002-05-28 Cellegy Pharmaceuticals, Inc. Compositions and methods for the treatment of anorectal disorders
WO2003042190A1 (en) 2001-11-12 2003-05-22 Pfizer Products Inc. N-alkyl-adamantyl derivatives as p2x7-receptor antagonists
PA8557501A1 (en) 2001-11-12 2003-06-30 Pfizer Prod Inc BENZAMIDA, HETEROARILAMIDA AND INVESTED AMIDAS
RU2423353C1 (en) 2002-12-20 2011-07-10 Глэксо Груп Лимитед New benzazepin derivatives
PA8591801A1 (en) 2002-12-31 2004-07-26 Pfizer Prod Inc BENZAMID INHIBITORS OF THE P2X7 RECEIVER.
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
JP4731468B2 (en) 2003-05-12 2011-07-27 ファイザー・プロダクツ・インク Benzamide inhibitor of P2X7 receptor
AU2004283452A1 (en) * 2003-10-23 2005-05-06 F. Hoffmann-La Roche Ag Benzazepine derivatives as MAO-B inhibitors
EP1720836B1 (en) 2004-02-25 2014-04-16 Eli Lilly And Company 6-substituted 2,3,4,5-tetrahydro-1h-benzo [d]azepines as 5-ht2c receptor agonists
AU2005258911A1 (en) 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3H`1,2,4!triazin-2-YL!-benzamide derivatives by deprotecting the hydroxyl-protected precursers
ES2397400T3 (en) 2005-09-01 2013-03-06 Eli Lilly & Company 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo [D] azepines as 5-HT2C receptor agonists
PT1926712E (en) 2005-09-01 2009-10-06 Lilly Co Eli 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
WO2007028082A1 (en) * 2005-09-01 2007-03-08 Eli Lilly And Company 6-substituted- 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
ES2440483T3 (en) 2005-09-01 2014-01-29 Eli Lilly And Company 2,3,4,5-Tetrahydro-1H-benzo [d] azepines substituted with 6-N-linked heterocycle as 5-HT2C receptor agonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285287A2 (en) * 1987-03-23 1988-10-05 Smithkline Beecham Corporation 3-Benzazepine compounds for use in treating gastrointestinal motility disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285287A2 (en) * 1987-03-23 1988-10-05 Smithkline Beecham Corporation 3-Benzazepine compounds for use in treating gastrointestinal motility disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LADD, DAVID L.; WEINSTOCK, JOSEPH; WISE, MARGARET; GESSNER, GEORGE W.; SAWYER, JOHN L.; FLAIM, KATHRYN E.: "Synthesis and dopaminergic binding of 2-aryldopamine analogs: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes", JOURNAL OF MEDICINAL CHEMISTRY., vol. 29, no. 10, WASHINGTON US, pages 1904 - 1912, XP002031848, DOI: doi:10.1021/jm00160a018 *
See also references of WO9304686A1 *

Also Published As

Publication number Publication date
AU2654792A (en) 1993-04-05
EP0603314A1 (en) 1994-06-29
WO1993004686A1 (en) 1993-03-18
GB9119467D0 (en) 1991-10-23
JPH06510545A (en) 1994-11-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19940316

AK Designated contracting states

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Designated state(s): BE CH DE FR GB IT LI NL

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Ipc: C07D223/16

A4 Supplementary search report drawn up and despatched

Effective date: 19940705

AK Designated contracting states

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Effective date: 19981205