EP0594586A4 - Hiv protease inhibitors - Google Patents
Hiv protease inhibitorsInfo
- Publication number
- EP0594586A4 EP0594586A4 EP9191903689A EP91903689A EP0594586A4 EP 0594586 A4 EP0594586 A4 EP 0594586A4 EP 9191903689 A EP9191903689 A EP 9191903689A EP 91903689 A EP91903689 A EP 91903689A EP 0594586 A4 EP0594586 A4 EP 0594586A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- protease inhibitors
- hiv protease
- hiv
- inhibitors
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46266990A | 1990-01-09 | 1990-01-09 | |
US462669 | 1990-01-09 | ||
US46989190A | 1990-01-23 | 1990-01-23 | |
US469891 | 1990-01-23 | ||
PCT/US1991/000178 WO1991010442A1 (en) | 1990-01-09 | 1991-01-09 | Hiv protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0594586A1 EP0594586A1 (de) | 1994-05-04 |
EP0594586A4 true EP0594586A4 (en) | 1994-08-17 |
Family
ID=27040413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP9191903689A Withdrawn EP0594586A4 (en) | 1990-01-09 | 1991-01-09 | Hiv protease inhibitors |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0594586A4 (de) |
JP (1) | JPH05503703A (de) |
WO (1) | WO1991010442A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0487270A3 (en) * | 1990-11-19 | 1992-11-25 | Merck & Co. Inc. | Hiv protease inhibitors having polyether substituents |
US5436339A (en) * | 1991-03-06 | 1995-07-25 | Abbott Laboratories | Process for the preparation of a substituted diaminoalcohol |
JPH06510766A (ja) * | 1991-09-11 | 1994-12-01 | スミスクライン・ビーチャム・コーポレイション | H.i.v.阻害剤としてのヘテロ環含有ペプチド同配体 |
DE4215874A1 (de) * | 1992-05-14 | 1993-11-18 | Bayer Ag | Dithiolanylglycinhaltige HIV-Proteaseinhibitoren vom Hydroxyethylenisostertyp |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
ES2068739B1 (es) * | 1993-01-21 | 1995-11-01 | Smithkline Beecham Corp | Inhibidores retrovirables de proteasas. |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
ATE220661T1 (de) * | 1994-10-19 | 2002-08-15 | Novartis Erfind Verwalt Gmbh | Antivirale ether von aspartat-protease-substrat- isosteren |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337714A2 (de) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV-Protease-Inhibitoren zur Behandlung von AIDS |
EP0352000A2 (de) * | 1988-07-08 | 1990-01-24 | Smithkline Beecham Corporation | Retrovirale, Protease bindende Peptide |
EP0386611A2 (de) * | 1989-03-06 | 1990-09-12 | F. Hoffmann-La Roche Ag | Aminosäure-Derivate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8322414D0 (en) * | 1983-08-19 | 1983-09-21 | Szelke M | Renin inhibitors |
-
1991
- 1991-01-09 WO PCT/US1991/000178 patent/WO1991010442A1/en active Search and Examination
- 1991-01-09 EP EP9191903689A patent/EP0594586A4/en not_active Withdrawn
- 1991-01-09 JP JP3503872A patent/JPH05503703A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337714A2 (de) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV-Protease-Inhibitoren zur Behandlung von AIDS |
EP0352000A2 (de) * | 1988-07-08 | 1990-01-24 | Smithkline Beecham Corporation | Retrovirale, Protease bindende Peptide |
EP0386611A2 (de) * | 1989-03-06 | 1990-09-12 | F. Hoffmann-La Roche Ag | Aminosäure-Derivate |
Non-Patent Citations (2)
Title |
---|
G.B.DREYER ET AL: "Inhibition of HIV 1 protease in vitro; Rational design of substrate analogue inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 86, December 1989 (1989-12-01), WASHINGTON US, pages 9752 - 9756, XP000151090, DOI: doi:10.1073/pnas.86.24.9752 * |
See also references of WO9110442A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1991010442A1 (en) | 1991-07-25 |
JPH05503703A (ja) | 1993-06-17 |
EP0594586A1 (de) | 1994-05-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920702 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
RHK1 | Main classification (correction) |
Ipc: C07K 5/02 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19940630 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19940922 |