EP0544668A4 - 6-halo- and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents. - Google Patents

6-halo- and 2-amino-6-halo-purine 2',3'-dideoxy nucleosides and their use as antiviral agents.

Info

Publication number
EP0544668A4
EP0544668A4 EP19910904744 EP91904744A EP0544668A4 EP 0544668 A4 EP0544668 A4 EP 0544668A4 EP 19910904744 EP19910904744 EP 19910904744 EP 91904744 A EP91904744 A EP 91904744A EP 0544668 A4 EP0544668 A4 EP 0544668A4
Authority
EP
European Patent Office
Prior art keywords
halo
purine
amino
antiviral agents
dideoxy nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910904744
Other languages
German (de)
French (fr)
Other versions
EP0544668A1 (en
Inventor
Hiroaki Mitsuya
Takuma Shirasaka
Samuel Broder
Kunichika Murakami
Hidetoshi Sanyo-Kokus Yoshioka
Eiji Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanyo Kokusaku Pulp Co Ltd
US Department of Commerce
Original Assignee
Sanyo Kokusaku Pulp Co Ltd
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanyo Kokusaku Pulp Co Ltd, US Department of Commerce filed Critical Sanyo Kokusaku Pulp Co Ltd
Publication of EP0544668A4 publication Critical patent/EP0544668A4/en
Publication of EP0544668A1 publication Critical patent/EP0544668A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP91904744A 1990-02-09 1991-02-08 -6-fluoro-9-(2,3-dideoxy-b-d-glycero-pentofuranosyl)-9h-purines and their use asantiviral agents Ceased EP0544668A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47740690A 1990-02-09 1990-02-09
US477406 1990-02-09

Publications (2)

Publication Number Publication Date
EP0544668A4 true EP0544668A4 (en) 1993-03-03
EP0544668A1 EP0544668A1 (en) 1993-06-09

Family

ID=23895790

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91904744A Ceased EP0544668A1 (en) 1990-02-09 1991-02-08 -6-fluoro-9-(2,3-dideoxy-b-d-glycero-pentofuranosyl)-9h-purines and their use asantiviral agents

Country Status (4)

Country Link
EP (1) EP0544668A1 (en)
JP (1) JPH05506211A (en)
CA (1) CA2075490A1 (en)
WO (1) WO1991012260A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006671A2 (en) * 1988-12-12 1990-06-28 Palese Peter M Methods and compositions for the prophylaxis and treatment of hepatitis b virus infections
GB2228479A (en) * 1989-02-27 1990-08-29 Sanyo Kokusaku Pulp Co 2', 3'-dideoxy purine nucleosides and process for the preparation thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86007A0 (en) * 1987-04-09 1988-09-30 Wellcome Found 6-substituted purine nucleosides,their preparation and pharmaceutical compositions containing them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006671A2 (en) * 1988-12-12 1990-06-28 Palese Peter M Methods and compositions for the prophylaxis and treatment of hepatitis b virus infections
GB2228479A (en) * 1989-02-27 1990-08-29 Sanyo Kokusaku Pulp Co 2', 3'-dideoxy purine nucleosides and process for the preparation thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 87, no. 23, December 1990, pages 9426-9430, Washington, DC, US; T. SHIRASAKA et al.: "Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro" *
See also references of WO9112260A1 *

Also Published As

Publication number Publication date
CA2075490A1 (en) 1991-08-10
EP0544668A1 (en) 1993-06-09
WO1991012260A1 (en) 1991-08-22
JPH05506211A (en) 1993-09-16

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19920807

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19931221

RTI1 Title (correction)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19951118