EP0528951A4 - Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof - Google Patents

Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof

Info

Publication number
EP0528951A4
EP0528951A4 EP19910910051 EP91910051A EP0528951A4 EP 0528951 A4 EP0528951 A4 EP 0528951A4 EP 19910910051 EP19910910051 EP 19910910051 EP 91910051 A EP91910051 A EP 91910051A EP 0528951 A4 EP0528951 A4 EP 0528951A4
Authority
EP
European Patent Office
Prior art keywords
icam
antibodies
usage
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910910051
Other versions
EP0528951A1 (en
Inventor
John Robert Adair
Diljeet Singh Athwal
Robert A. Rothlein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Celltech Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Celltech R&D Ltd
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Celltech R&D Ltd
Publication of EP0528951A1 publication Critical patent/EP0528951A1/en
Publication of EP0528951A4 publication Critical patent/EP0528951A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
EP19910910051 1990-04-27 1991-04-29 Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof Withdrawn EP0528951A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909009549A GB9009549D0 (en) 1990-04-27 1990-04-27 Recombinant antibody and method
GB9009549 1990-04-27

Publications (2)

Publication Number Publication Date
EP0528951A1 EP0528951A1 (en) 1993-03-03
EP0528951A4 true EP0528951A4 (en) 1993-05-26

Family

ID=10675134

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910910051 Withdrawn EP0528951A4 (en) 1990-04-27 1991-04-29 Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof

Country Status (8)

Country Link
EP (1) EP0528951A4 (en)
JP (1) JPH06500229A (en)
AU (1) AU7900191A (en)
BR (1) BR9106392A (en)
CA (1) CA2081478A1 (en)
GB (1) GB9009549D0 (en)
HU (2) HUT62652A (en)
WO (1) WO1991016927A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
GB9009548D0 (en) * 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
EP0459577A3 (en) * 1990-06-01 1992-08-05 Merck & Co. Inc. Microbially expressed portions of a monoclonal antibody block rhinovirus attachment to cell receptors
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5223396A (en) * 1991-05-03 1993-06-29 Boehringer Ingelheim Pharmaceuticals, Inc. Method for detecting organ transplant rejection
EP0610298A1 (en) * 1991-10-01 1994-08-17 The General Hospital Corporation Preventing allograft rejection with antibodies to adhesion molecules
US5635177A (en) 1992-01-22 1997-06-03 Genentech, Inc. Protein tyrosine kinase agonist antibodies
WO1994004188A1 (en) * 1992-08-21 1994-03-03 Genentech, Inc. Method for treating an lfa-1-mediated disorder
EP0672068A4 (en) * 1992-09-25 1997-02-26 Commw Scient Ind Res Org Target binding polypeptide.
US5484892A (en) * 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US5695760A (en) * 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US6037454A (en) * 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
US6670321B1 (en) 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
DK1163003T3 (en) 1999-03-19 2009-11-30 Genentech Inc Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
ATE429518T1 (en) 1999-06-24 2009-05-15 Univ Johns Hopkins COMPOSITIONS AND METHODS FOR PREVENTING TRANSEPITHELIAL TRANSMISSION OF HIV
US20030158382A1 (en) 2000-04-21 2003-08-21 Nobutaka Wakamiya Novel collectins
CN102659946A (en) * 2002-03-13 2012-09-12 拜奥根Idec马萨诸塞公司 Anti-alpha v beta 6 antibodies
AU2005254980A1 (en) 2004-06-09 2005-12-29 Genentech, Inc. Method of treating granuloma annulare or sarcoid
CN104072614B (en) 2005-07-08 2017-04-26 生物基因Ma公司 Anti-alpha[v]beta[6] antibodies and uses thereof
ES2602781T3 (en) * 2011-07-05 2017-02-22 Dinona Inc. An antibody that induces antigen-specific T lymphocyte tolerance and use thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
KR102063341B1 (en) * 2018-12-31 2020-01-07 다이노나(주) Antibody specifically binding to ICAM-1 and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314863A2 (en) * 1987-11-02 1989-05-10 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8720833D0 (en) * 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314863A2 (en) * 1987-11-02 1989-05-10 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NATURE vol. 332, 24 March 1988, LONDON, GB pages 323 - 327 L. RIECHMANN ET AL. 'Reshaping human antibodies for therapy.' *
See also references of WO9116927A1 *

Also Published As

Publication number Publication date
CA2081478A1 (en) 1991-10-28
HUT62652A (en) 1993-05-28
AU7900191A (en) 1991-11-27
WO1991016927A1 (en) 1991-11-14
GB9009549D0 (en) 1990-06-20
EP0528951A1 (en) 1993-03-03
BR9106392A (en) 1993-04-27
HU9203371D0 (en) 1993-01-28
JPH06500229A (en) 1994-01-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19921030

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

Effective date: 19930405

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STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19941101