EP0516636A1 - Dispenser for media. - Google Patents
Dispenser for media.Info
- Publication number
- EP0516636A1 EP0516636A1 EP91902680A EP91902680A EP0516636A1 EP 0516636 A1 EP0516636 A1 EP 0516636A1 EP 91902680 A EP91902680 A EP 91902680A EP 91902680 A EP91902680 A EP 91902680A EP 0516636 A1 EP0516636 A1 EP 0516636A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- discharge device
- valve body
- channel
- piston
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
- B05B11/007—Outlet valves actuated by the pressure of the fluid to be sprayed being opened by deformation of a sealing element made of resiliently deformable material, e.g. flaps, skirts, duck-bill valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
Definitions
- Discharge device for media
- the invention relates to a discharge for f technicallyfä ⁇ hige and similar media, gaseous, liquid, pasty, pulverfö 'RMI g or the like. could be.
- the discharge device can have a pressure chamber connected via an outlet channel to a discharge opening, such as a nozzle, and / or at least one valve, which can be an inlet valve, an outlet valve or another valve, so that it can be reliably controlled operation is possible.
- the invention is further based on the object of avoiding disadvantages of known designs and, in particular, of achieving a high degree of positional security or a very secure closure by the respective valve.
- At least one valve is in at least one position, in particular in the closed position, by at least one type of detent or inhibition The like. Specified so that it can be held immovably in the case of an open position or in the case of a closed position so that it only overcomes the inhibition by applying a predetermined disengagement force and then suddenly, in order to move into a further location to succeed.
- the catch is expediently formed directly by the contact between a valve body and a valve seat.
- the valve body is axially symmetrical or centrically symmetrical, and it can be used as a self-contained unit with pretension in a channel section which forms a valve seat lying in its jacket.
- the escapement or detent can also be generated by a fluid against which the valve works when changing between two positions under pressure changes, so that a kind of fluid suspension or damping results.
- the valve body when changing the position, can narrow a pressure chamber, which e.g. is formed by a gas or air-filled blind hole section adjoining the valve seat.
- the inhibiting force can be adjusted by changing the ratio between the two volumes of the pressure chamber associated with the two valves.
- the fluid pressure can also be used as a return spring for returning the valve to at least one position, in particular the closed position.
- the valve as an outlet valve can also only be hermetically sealed tight closure of the media or pump chamber in the area of the off! auxiliarykanales form. This closure is then transferred to its open position under the pump pressure, in which it is secured by clamping, detent or stop.
- the Venti 1 ausbi 1 fertilizer is particularly suitable for discharge devices according to DE-OS 35 32 890, to which reference is made for further details and effects.
- the discharge device is designed according to patent application P 39 09 031.0, to which reference is made accordingly, it can be advantageous to form a displacement or valve body, which is mechanically connected to a pump cylinder, by a separate component , which consists of a different material than the cylinder and with this, for example is connected via a fixed connecting member.
- a separate component which consists of a different material than the cylinder and with this, for example is connected via a fixed connecting member.
- the cylinder e.g. can be formed in a simple manner as a container made of glass or a material having similar properties that would be too inelastic for the valve or displacement body.
- the more elastic displacement body forms a self-contained structural unit with the harder glass container.
- FIG. 1 shows a discharge device according to the invention essentially in Axi al section
- FIG. 2 shows the discharge device according to FIG. 1 in plan view with the closure cap removed
- FIG. 1 shows a detail of FIG. 1 in an enlarged representation and valve open position
- FIG. 4 shows a further embodiment in a representation corresponding to FIG. 3.
- the discharge device 1 has a one-piece base body 2 which essentially forms its entire outer boundary and has at one end a cap-shaped housing 3 which is flat oval in longitudinal view and a connecting piece 4 projecting beyond the outside of its end wall .
- the nozzle 4 is formed by an end connected to the end wall of the housing 3 outer sleeve 5 and an inner sleeve 6 which integrally connects in the region of the free end to the outer sleeve 5, otherwise essentially contact-free inside the outer sleeve 5 and over the inside the cap end wall protrudes into the housing 3.
- the inner sleeve 6 carries an essentially completely inside the housing 3 or the outer sleeve 5 thrust piston pump 7, which essentially consists of one
- a piston 8 and a cup-shaped cylinder 9 which is closed in one piece on the bottom and which, with the piston 8, delimits a pump chamber which is hermetically sealed to the outside.
- the piston 8, which rests with a plurality of sawtooth-shaped piston lips under prestress on the cylinder track and essentially connects directly to the associated end of the inner sleeve 6 protruding into the cylinder 9, is in one piece with an essentially through cylindrical cylindrical stem 10 extending to the inner end of a discharge opening 11.
- the discharge opening 11 is provided at the free end of the connecting piece 4 in the end wall of a nozzle cap which is formed by the transition region between the two sleeves 5, 6 and on the end wall of which the piston skirt 10 with its end face remote from the piston 8 connects.
- outlet channel 12 From the pressure chamber leads through the piston 8 and along the outer circumference of the piston shaft 10, an outlet channel 12 into a swirl device located at the end of the piston shaft 10 and from there approximately radially inward directly into the discharge opening 11.
- a swirl device located at the end of the piston shaft 10 and from there approximately radially inward directly into the discharge opening 11.
- an outlet valve 13 In the outlet channel 12, and although lying completely within the piston skirt 10 or the piston 8 and the cylinder 9 in the initial position and the inner sleeve 6, an outlet valve 13 is provided which forms a tight seal in the initial position.
- a channel 14 designed as a blind hole extends into the piston skirt 10, which is connected at a distance from its blind hole bottom via a transverse channel 16 to a channel section 15 which runs along the associated section of the Kol shaft 10 between its outer circumference and the inner circumference of the inner sleeve 6 to the Dral 1einrich- tung runs.
- valve seat 18 which is ring-shaped on an imaginary spherical surface for a preferably completely spherical valve body which is spherically curved at least in its area on the outer circumference 17, whose spherical radius is slightly larger than that of the valve seat 18 or as the radius of the channel section 14.
- the valve body 17 is pressed through the channel section 14 to the slightly prestressed contact with the valve seat 18, is supported on the jacket region of the channel section 14 opposite the valve seat 18, and then lies at a distance from the floor corresponding at least approximately to its outer diameter the blind hole.
- a receiving chamber 19 for the valve body 17 is formed between this base and the valve body 17, which is completely sealed off from the outlet channel 12 or the channel section 14 and the transverse channel 16 by the valve body 17.
- the control movement of the valve body is approximately the same direction as or a continuation of the assembly insertion direction, without a separate securing part against falling out or a valve spring being required.
- the resilient position catch 20 of the valve body 17 formed by the described design is overcome, which then acts like a Venti 1 kol bens rolling and / or displacing out of the valve seat 18 and is pressed into the receiving chamber 19 as shown in FIG. 3.
- the volume of the receiving chamber 19 can be chosen so large that its gas filling of the opening movement of the valve body 17 is none noteworthy resistance or the receiving chamber 19 can be provided with a suitable ventilation for this purpose. Essentially all of the components mentioned are expediently located in a common central axis 21.
- the outer width of the inner sleeve 6 corresponds at least in the area of the cylinder 9 to the inner width, so that the cylinder 9 is guided on the inner sleeve 6 essentially without play or tilting.
- the outer periphery of the inner sleeve 6 in the region of the valve 13 is supported radially on the cylinder wall via the sleeve-shaped piston shaft 10 in this region.
- the piston skirt At least in the area of the valve body 17 and the valve seat 18, the piston skirt consists of a material that is resilient to compression, while the inner sleeve 6 is made of a material that is substantially harder.
- the valve body can be rigid or resilient.
- the end wall of the housing 3 forms an actuating handle 22 in the form of finger pressure surfaces on both sides of the connecting piece 4.
- two mutually opposite, approximately identical and mutually aligned cutouts 23 are provided for the simultaneous engagement of a thumb, which start from the fully open end of the housing shell 3 and through which one acts as a finger pressure surface on the cylinder 9 provided handle 24 is accessible, which is formed by the bottom of the cylinder 9.
- the connecting piece 4 can lie essentially completely in a removable cap 25 which extends approximately to the end wall of the housing 3 and lies with the associated end in a sealed manner on the outer circumference of the outer sleeve 5.
- a further seal is advantageously provided closer to or in the area of the nozzle cap and is formed by an inner sleeve 26 protruding freely from the inside of the cap end wall, which rests with an annular bead under prestress on the outer surface of the nozzle 4.
- the discharge opening 11 lies in a relatively small, separate cap chamber, and moreover the outer end of the otherwise non-contact cap 25 is exactly centered with respect to the associated end of the nozzle 4.
- a valve body 17a which rests elastically and radially in the manner of a cup sleeve or ring lip, is located at the end of a shaft 27 and forms a displacement body with the shaft 27, which at the end of the pump stroke almost completely fills the channel section 14a except for a narrow annular gap.
- the shaft 27 is formed in one piece with an enlarged collar 28, which is expediently inserted with pressure from the open end into the cylinder 9a and abuts the entire surface of the cylinder 9a.
- the collar 28 forms the annular bottom boundary of the pump chamber opposite the piston 8a.
- the component 30 having the displacement body can be inserted into the cylinder 9a as desired are or not, so that one and the same cylinder can optionally be equipped differently.
- the valve body 17a forms on its end face a depression or a sleeve interior which is flared conically in the direction of movement, into which, at the end of the pump stroke, a displacement projection 31 which is adapted thereto and which projects from the blind hole bottom of the channel section 14a against the valve body 17a is immersed.
- the transverse channel 16a is provided adjacent to the jacket of the displacement projection 31 or immediately following the bottom of the blind hole, so that the medium displaced from the valve body 17a is pressed directly into the transverse channel 16a at the end of the pump stroke in a last volume surge.
- the floor delimitation 29 is adapted to the spherically hollowed out associated end face of the pump piston 8a and to the cone stumpfförmi jacket of its foremost piston lip, so that here too a complete emptying takes place.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4005528 | 1990-02-22 | ||
DE4005528A DE4005528C2 (en) | 1990-02-22 | 1990-02-22 | Discharge device for media |
PCT/EP1990/002280 WO1991013281A1 (en) | 1990-02-22 | 1990-12-21 | Dispenser for media |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0516636A1 true EP0516636A1 (en) | 1992-12-09 |
EP0516636B1 EP0516636B1 (en) | 1994-09-14 |
Family
ID=6400693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91902680A Expired - Lifetime EP0516636B1 (en) | 1990-02-22 | 1990-12-21 | Dispenser for media |
Country Status (7)
Country | Link |
---|---|
US (1) | US5368201A (en) |
EP (1) | EP0516636B1 (en) |
AT (1) | ATE111577T1 (en) |
AU (1) | AU7064591A (en) |
DE (2) | DE4005528C2 (en) |
ES (1) | ES2060361T3 (en) |
WO (1) | WO1991013281A1 (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007068907A2 (en) | 2005-12-13 | 2007-06-21 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising a saponin adjuvant |
WO2011051445A1 (en) | 2009-10-30 | 2011-05-05 | Glaxosmithkline Biologicals S.A. | Process for preparing an influenza seed virus for vaccine manufacture |
EP2397153A1 (en) | 2005-03-23 | 2011-12-21 | GlaxoSmithKline Biologicals S.A. | Novel composition |
EP2422810A1 (en) | 2006-07-17 | 2012-02-29 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine |
WO2012055951A2 (en) | 2010-10-27 | 2012-05-03 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
EP2455101A2 (en) | 2007-04-20 | 2012-05-23 | GlaxoSmithKline Biologicals S.A. | Influenza vaccine with oil-in-water emulsion adjuvant |
WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
WO2013139655A1 (en) | 2012-03-23 | 2013-09-26 | Glaxosmithkline Biologicals S.A. | Influenza vaccines |
WO2017149054A1 (en) | 2016-03-02 | 2017-09-08 | Glaxosmithkline Biologicals S.A. | Novel influenza antigens |
WO2017167768A1 (en) | 2016-03-28 | 2017-10-05 | Glaxosmithkline Biologicals S.A. | Novel vaccine composition |
WO2017216286A1 (en) | 2016-06-17 | 2017-12-21 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
WO2019121924A1 (en) | 2017-12-21 | 2019-06-27 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
WO2019121926A1 (en) | 2017-12-21 | 2019-06-27 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
WO2021142238A1 (en) | 2020-01-10 | 2021-07-15 | First Wave Bio, Inc. | Deuterated niclosamide |
WO2021188564A1 (en) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Methods of treating covid-19 with a niclosamide compound |
WO2022212365A1 (en) | 2021-03-29 | 2022-10-06 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides for treating or preventing a sars-cov-2 infection |
WO2023274860A1 (en) | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
US11744812B2 (en) | 2020-03-16 | 2023-09-05 | First Wave Bio, Inc. | Methods of treatment |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69206988T2 (en) * | 1991-06-26 | 1996-07-04 | Valois Sa | Device for injecting a predetermined dose of a medium and method for filling this device |
DE19525734A1 (en) | 1995-07-14 | 1997-01-16 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for flowable media, in particular for discharge in just one stroke |
DE19604626A1 (en) * | 1996-02-08 | 1997-08-14 | Uhu Gmbh | Glue stick with piston-shaped holding device for the stick mass |
FR2746676B1 (en) * | 1996-04-02 | 1998-05-22 | Valois | DEVICE FOR DISPENSING A SINGLE DOSE OF FLUID PRODUCT |
DE19749514A1 (en) | 1997-11-08 | 1999-05-12 | Pfeiffer Erich Gmbh & Co Kg | Delivery of a mixture of media for e.g. pharmaceutical products |
US6398074B1 (en) * | 1998-03-10 | 2002-06-04 | Valois S.A. | Reservoir, reservoir filling method and device for dispensing fluid contained in the reservoir |
US6276568B1 (en) | 1998-08-21 | 2001-08-21 | Pharmacia & Upjohn Company | Spray bottle grip |
USD421120S (en) * | 1998-08-21 | 2000-02-22 | Pharmacia & Upjohn Company | Spray bottle grip |
USD428141S (en) * | 1999-08-04 | 2000-07-11 | Pharmacia & Upjohn Company | Spray bottle grip |
DE10006368A1 (en) * | 2000-02-12 | 2001-08-16 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
FR2817847B1 (en) * | 2000-12-08 | 2003-03-28 | Tebro | DEVICE FOR DISPENSING FLUID OR POWDERY PRODUCT |
JP5208347B2 (en) | 2001-02-23 | 2013-06-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | New vaccine |
GB0302536D0 (en) * | 2003-02-04 | 2003-03-12 | Bespak Plc | Container |
DE102004034629A1 (en) * | 2004-06-14 | 2006-01-05 | Seaquist Perfect Dispensing Gmbh | Device and spray head for atomizing a preferably cosmetic liquid and method for producing such a device |
US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
FR2916429B1 (en) * | 2007-05-22 | 2012-10-05 | Valois Sas | PROTECTIVE COVER FOR FLUID PRODUCT DISPENSING HEAD. |
WO2011026198A1 (en) * | 2009-09-07 | 2011-03-10 | Mk International Pty Ltd | Nasal spray pump |
FR3004128B1 (en) * | 2013-04-08 | 2017-01-13 | Aptar France Sas | IMPROVED SPRAY HEAD. |
CN109562137A (en) | 2015-09-01 | 2019-04-02 | 第波生物公司 | For treating the method and composition for reacting the related patient's condition with abnormal inflammatory |
DE102016212893A1 (en) * | 2016-07-14 | 2018-01-18 | F. Holzer Gmbh | Pump head and metering device |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US2574744A (en) * | 1950-03-31 | 1951-11-13 | Henry J Koepke | Lubricator |
US3344963A (en) * | 1965-05-07 | 1967-10-03 | Robinson E S & A Ltd | Plastic tubes for dispensing pasty or liquid substances |
US3907174A (en) * | 1971-04-13 | 1975-09-23 | Vca Corp | Dispensing pump construction with foldable discharge nozzle |
US3908870A (en) * | 1973-11-15 | 1975-09-30 | Yoshino Kogyosho Co Ltd | Manual-type miniature atomizer |
US4022354A (en) * | 1976-02-17 | 1977-05-10 | The Risdon Manufacturing Company | Accumulator release pump |
US4034900A (en) * | 1976-05-03 | 1977-07-12 | Ethyl Corporation | Spray pump assembly |
US4154374A (en) * | 1977-10-03 | 1979-05-15 | Ethyl Products Company | Finger operated spray pump |
US4494680A (en) * | 1980-02-13 | 1985-01-22 | Corsette Douglas Frank | Manually operated dispensing pump |
US4371097A (en) * | 1980-05-07 | 1983-02-01 | Diamond International Corporation | Liquid dispensing pump |
US4440325A (en) * | 1981-07-24 | 1984-04-03 | Treuhaft Martin B | Actuator |
DE3513575A1 (en) * | 1985-04-16 | 1986-10-16 | Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell | MANUAL DISCHARGE DEVICE FOR MEDIA |
DE3530486A1 (en) * | 1985-08-27 | 1987-03-05 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
DE8526339U1 (en) * | 1985-09-14 | 1987-05-07 | Ing. Erich Pfeiffer Gmbh & Co Kg, 7760 Radolfzell, De | |
FR2612890B1 (en) * | 1987-03-26 | 1989-12-29 | Step Soc Tech Pulverisation | DOSER ASSEMBLY FOR PASTY OR SEMI-LIQUID PRODUCT |
DE3734306A1 (en) * | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR FLOWABLE MEDIA |
EP0378935B1 (en) * | 1988-12-20 | 1992-09-23 | Societe Technique De Pulverisation (S.T.E.P.) | Device to dispense a liquid or cream in droplets having small volumes |
DE3909031A1 (en) * | 1989-03-18 | 1990-09-27 | Pfeiffer Erich Gmbh & Co Kg | DISCHARGE DEVICE FOR MEDIA |
-
1990
- 1990-02-22 DE DE4005528A patent/DE4005528C2/en not_active Expired - Fee Related
- 1990-12-21 WO PCT/EP1990/002280 patent/WO1991013281A1/en active IP Right Grant
- 1990-12-21 EP EP91902680A patent/EP0516636B1/en not_active Expired - Lifetime
- 1990-12-21 AT AT91902680T patent/ATE111577T1/en active
- 1990-12-21 DE DE59007175T patent/DE59007175D1/en not_active Expired - Fee Related
- 1990-12-21 AU AU70645/91A patent/AU7064591A/en not_active Abandoned
- 1990-12-21 ES ES91902680T patent/ES2060361T3/en not_active Expired - Lifetime
- 1990-12-21 US US07/934,617 patent/US5368201A/en not_active Expired - Lifetime
Non-Patent Citations (1)
Title |
---|
See references of WO9113281A1 * |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2397153A1 (en) | 2005-03-23 | 2011-12-21 | GlaxoSmithKline Biologicals S.A. | Novel composition |
EP2364723A1 (en) | 2005-12-13 | 2011-09-14 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising a saponin adjuvant |
EP2364721A1 (en) | 2005-12-13 | 2011-09-14 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising a saponin adjuvant |
EP2364722A1 (en) | 2005-12-13 | 2011-09-14 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising a saponin adjuvant |
EP2364724A1 (en) | 2005-12-13 | 2011-09-14 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising a saponin adjuvant |
EP2364720A1 (en) | 2005-12-13 | 2011-09-14 | GlaxoSmithKline Biologicals S.A. | Vaccine compositions comprising a saponin adjuvant |
WO2007068907A2 (en) | 2005-12-13 | 2007-06-21 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising a saponin adjuvant |
EP2422810A1 (en) | 2006-07-17 | 2012-02-29 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine |
EP2455101A2 (en) | 2007-04-20 | 2012-05-23 | GlaxoSmithKline Biologicals S.A. | Influenza vaccine with oil-in-water emulsion adjuvant |
WO2011051445A1 (en) | 2009-10-30 | 2011-05-05 | Glaxosmithkline Biologicals S.A. | Process for preparing an influenza seed virus for vaccine manufacture |
EP3560511A2 (en) | 2010-10-27 | 2019-10-30 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
WO2012055951A2 (en) | 2010-10-27 | 2012-05-03 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
WO2012156391A1 (en) | 2011-05-17 | 2012-11-22 | Glaxosmithkline Biologicals S.A. | Vaccine against streptococcus pneumoniae |
WO2013139655A1 (en) | 2012-03-23 | 2013-09-26 | Glaxosmithkline Biologicals S.A. | Influenza vaccines |
WO2017149054A1 (en) | 2016-03-02 | 2017-09-08 | Glaxosmithkline Biologicals S.A. | Novel influenza antigens |
WO2017167768A1 (en) | 2016-03-28 | 2017-10-05 | Glaxosmithkline Biologicals S.A. | Novel vaccine composition |
WO2017216286A1 (en) | 2016-06-17 | 2017-12-21 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
WO2019121926A1 (en) | 2017-12-21 | 2019-06-27 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
WO2019121924A1 (en) | 2017-12-21 | 2019-06-27 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
WO2021142238A1 (en) | 2020-01-10 | 2021-07-15 | First Wave Bio, Inc. | Deuterated niclosamide |
WO2021188564A1 (en) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Methods of treating covid-19 with a niclosamide compound |
US11744812B2 (en) | 2020-03-16 | 2023-09-05 | First Wave Bio, Inc. | Methods of treatment |
WO2022212365A1 (en) | 2021-03-29 | 2022-10-06 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides for treating or preventing a sars-cov-2 infection |
WO2023274860A1 (en) | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
Also Published As
Publication number | Publication date |
---|---|
EP0516636B1 (en) | 1994-09-14 |
WO1991013281A1 (en) | 1991-09-05 |
AU7064591A (en) | 1991-09-18 |
DE59007175D1 (en) | 1994-10-20 |
DE4005528C2 (en) | 1998-01-15 |
ATE111577T1 (en) | 1994-09-15 |
US5368201A (en) | 1994-11-29 |
DE4005528A1 (en) | 1991-08-29 |
ES2060361T3 (en) | 1994-11-16 |
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