EP0501006A3 - Flow imaging cytometer - Google Patents

Flow imaging cytometer Download PDF

Info

Publication number: EP0501006A3
Authority: EP; European Patent Office
Prior art keywords: flow imaging; imaging cytometer; cytometer; flow; imaging
Prior art date: 1991-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP19910115005

Other versions

EP0501006B1 (en

EP0501006A2 (en

Inventor

Shinichi Ogino

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sysmex Corp

Original Assignee

Sysmex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-27

Filing date

1991-09-05

Publication date

1992-12-02

1991-09-05 Application filed by Sysmex Corp filed Critical Sysmex Corp

1992-09-02 Publication of EP0501006A2 publication Critical patent/EP0501006A2/en

1992-12-02 Publication of EP0501006A3 publication Critical patent/EP0501006A3/en

1995-12-27 Application granted granted Critical

1995-12-27 Publication of EP0501006B1 publication Critical patent/EP0501006B1/en

2011-09-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000003384 imaging method Methods 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1425—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement
- G01N15/1427—Optical investigation techniques, e.g. flow cytometry using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
- G01N2015/144—Imaging characterised by its optical setup
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence

Landscapes

Chemical & Material Sciences (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Dispersion Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Engineering & Computer Science (AREA)
Signal Processing (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Investigating Or Analysing Biological Materials (AREA)
Eye Examination Apparatus (AREA)

EP91115005A 1991-02-27 1991-09-05 Flow imaging cytometer Expired - Lifetime EP0501006B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP33189/91		1991-02-27
JP03033189A JP3084296B2 (en)	1991-02-27	1991-02-27	Flow image cytometer

Publications (3)

Publication Number	Publication Date
EP0501006A2 EP0501006A2 (en)	1992-09-02
EP0501006A3 true EP0501006A3 (en)	1992-12-02
EP0501006B1 EP0501006B1 (en)	1995-12-27

Family

ID=12379543

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP91115005A Expired - Lifetime EP0501006B1 (en)	1991-02-27	1991-09-05	Flow imaging cytometer

Country Status (5)

Country	Link
US (1)	US5247340A (en)
EP (1)	EP0501006B1 (en)
JP (1)	JP3084296B2 (en)
CA (1)	CA2050760A1 (en)
DE (1)	DE69115876T2 (en)

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US6115119A (en) *	1997-10-21	2000-09-05	Bigelow Laboratory For Ocean Science	Device and method for studying particles in a fluid
US6087182A (en) *	1998-08-27	2000-07-11	Abbott Laboratories	Reagentless analysis of biological samples
US8885913B2 (en)	1999-01-25	2014-11-11	Amnis Corporation	Detection of circulating tumor cells using imaging flow cytometry
US7057732B2 (en) *	1999-01-25	2006-06-06	Amnis Corporation	Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US20060257884A1 (en) *	2004-05-20	2006-11-16	Amnis Corporation	Methods for preparing and analyzing cells having chromosomal abnormalities
US7450229B2 (en) *	1999-01-25	2008-11-11	Amnis Corporation	Methods for analyzing inter-cellular phenomena
US8406498B2 (en)	1999-01-25	2013-03-26	Amnis Corporation	Blood and cell analysis using an imaging flow cytometer
US8131053B2 (en)	1999-01-25	2012-03-06	Amnis Corporation	Detection of circulating tumor cells using imaging flow cytometry
US6975400B2 (en) *	1999-01-25	2005-12-13	Amnis Corporation	Imaging and analyzing parameters of small moving objects such as cells
US6778263B2 (en) *	2000-08-25	2004-08-17	Amnis Corporation	Methods of calibrating an imaging system using calibration beads
US6875973B2 (en) *	2000-08-25	2005-04-05	Amnis Corporation	Auto focus for a flow imaging system
US7009651B2 (en)	2000-10-12	2006-03-07	Amnis Corporation	System and method for high numeric aperture imaging systems
CA2445044C (en) *	2001-04-25	2011-02-15	Amnis Corporation	Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
US7345758B2 (en) *	2001-05-17	2008-03-18	Cytopeia	Apparatus for analyzing and sorting biological particles
US6519033B1 (en)	2001-11-19	2003-02-11	Point Source Technologies, Llc	Identification of particles in fluid
US6774995B2 (en)	2001-08-03	2004-08-10	Pointsource Technologies, Llc	Identification of particles in fluid
US6573992B1 (en)	2001-11-13	2003-06-03	Pointsource Technologies, Llc	Plano convex fluid carrier for scattering correction
US6590652B2 (en)	2001-11-02	2003-07-08	Pointsource Technologies, Inc.	Flow through light scattering device
US6628386B2 (en)	2001-12-12	2003-09-30	Pointsource Technologies, Llc	Particle detection beam
US7057724B1 (en)	2002-03-21	2006-06-06	Institute Of Critical Care Medicine	Particulate info to field units
US6930769B1 (en)	2002-03-21	2005-08-16	Pointsource Technologies, Llc	Optical sensor module tester
US6972424B1 (en)	2002-04-16	2005-12-06	Pointsource Technologies, Llc	High detection rate particle identifier
US6819421B1 (en)	2003-04-11	2004-11-16	Point Source Technologies, Llc	Detection of new species of particles
WO2005090945A1 (en)	2004-03-16	2005-09-29	Amnis Corporation	Method for imaging and differential analysis of cells
US8953866B2 (en)	2004-03-16	2015-02-10	Amnis Corporation	Method for imaging and differential analysis of cells
US8150136B2 (en)	2004-03-16	2012-04-03	Amnis Corporation	Image based quantitation of molecular translocation
US7295306B2 (en) *	2004-04-22	2007-11-13	Kowa Company, Ltd.	Microchip and fluorescent particle counter with microchip
WO2007067999A2 (en) *	2005-12-09	2007-06-14	Amnis Corporation	Extended depth of field imaging for high speed object analysis
JP2008249804A (en) *	2007-03-29	2008-10-16	Fujifilm Corp	Confocal fluorescence microscope
US7796256B2 (en) *	2008-05-05	2010-09-14	Fluid Imaging Technologies, Inc.	Oil-immersion enhanced imaging flow cytometer
US20090283697A1 (en) *	2008-05-16	2009-11-19	Fluid Imaging Technologies, Inc.	System and method for monitoring blue-green algae in a fluid
US8345239B1 (en)	2008-08-04	2013-01-01	Fluid Imaging Technologies, Inc.	System and method for monitoring birefringent particles in a fluid
US9151943B2 (en)	2008-08-04	2015-10-06	Fluid Imaging Technologies, Inc.	System and method for monitoring birefringent particles in a fluid
JP2010085194A (en) *	2008-09-30	2010-04-15	Sysmex Corp	Sample analyzer
US8451524B2 (en)	2009-09-29	2013-05-28	Amnis Corporation	Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
FR2956207B1 (en) *	2010-02-10	2012-05-04	Horiba Abx Sas	DEVICE AND METHOD FOR MULTIPARAMETRIC MEASUREMENTS OF MICROPARTICLES IN A FLUID
US8817115B1 (en)	2010-05-05	2014-08-26	Amnis Corporation	Spatial alignment of image data from a multichannel detector using a reference image
CN102809551B (en) *	2011-06-01	2015-06-24	陈亮嘉	Stroboscopic optical image mapping system
US8976352B2 (en) *	2011-08-30	2015-03-10	Sony Corporation	Microparticle analysis apparatus
US8994945B2 (en)	2011-10-27	2015-03-31	Fluid Imaging Technologies, Inc.	Method of treatment analysis with particle imaging
US8879797B2 (en)	2012-05-25	2014-11-04	Fluid Imaging Technologies, Inc.	System and method for total internal reflection enhanced imaging flow cytometry
US8582100B1 (en) *	2012-06-19	2013-11-12	The United States Of America, As Represented By The Secretary Of The Navy	Remote multisensor optical particle monitor for flowing fluid systems
DK3004838T3 (en)	2013-05-28	2022-06-20	Chemometec As	Imaging cytometer
CN103852409B (en) *	2014-03-18	2016-09-14	江西科技师范大学	The imaging system of hemocyte in flow cytometer
JP2016080563A (en)	2014-10-20	2016-05-16	日本光電工業株式会社	Analysis system and analyzer
US9983115B2 (en)	2015-09-21	2018-05-29	Fluid Imaging Technologies, Inc.	System and method for monitoring particles in a fluid using ratiometric cytometry
CN115931687A (en)	2017-03-31	2023-04-07	生命技术公司	Apparatus, system and method for imaging flow cytometry
CN109709025B (en) *	2019-02-12	2021-07-16	军事科学院***工程研究院卫勤保障技术研究所	Multimode imaging optical system
CN114778419B (en) *	2022-02-28	2024-06-11	山东大学	High-magnification optical amplification imaging flow cytometer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU467714B2 (en) *	1972-12-07	1975-12-11	Cognos Corporation	Method and apparatus for counting and classifying microscopic particles
DE3705876A1 (en) *	1986-10-07	1988-04-14	Toa Medical Electronics	Process and apparatus for flow cytometry
US4887721A (en) *	1987-11-30	1989-12-19	The United States Of America As Represented By The United States Department Of Energy	Laser particle sorter

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US3826364A (en) *	1972-05-22	1974-07-30	Univ Leland Stanford Junior	Particle sorting method and apparatus
DE2732272C2 (en) *	1977-07-16	1979-07-05	Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts, 6900 Heidelberg	Method and device for fluorescence analysis of colored particles, in particular biological cells
US4338024A (en) *	1980-05-02	1982-07-06	International Remote Imaging Systems, Inc.	Flow analyzer and system for analysis of fluids with particles
US4573796A (en) *	1984-01-06	1986-03-04	The United States Of America As Represented By The United States Department Of Energy	Apparatus for eliminating background interference in fluorescence measurements
US4643566A (en) *	1984-07-20	1987-02-17	Canon Kabushiki Kaisha	Particle analyzing apparatus
US4786165A (en) *	1986-07-10	1988-11-22	Toa Medical Electronics Co., Ltd.	Flow cytometry and apparatus therefor
US5053626A (en) *	1989-09-29	1991-10-01	Boston University	Dual wavelength spectrofluorometer
JPH0734012B2 (en) *	1991-02-27	1995-04-12	東亜医用電子株式会社	Flow image cytometer
JP3084295B2 (en) *	1991-02-27	2000-09-04	シスメックス株式会社	Flow image cytometer

1991
- 1991-02-27 JP JP03033189A patent/JP3084296B2/en not_active Expired - Fee Related
- 1991-09-05 DE DE69115876T patent/DE69115876T2/en not_active Expired - Fee Related
- 1991-09-05 CA CA002050760A patent/CA2050760A1/en not_active Abandoned
- 1991-09-05 EP EP91115005A patent/EP0501006B1/en not_active Expired - Lifetime
- 1991-09-05 US US07/755,303 patent/US5247340A/en not_active Expired - Fee Related

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU467714B2 (en) *	1972-12-07	1975-12-11	Cognos Corporation	Method and apparatus for counting and classifying microscopic particles
DE3705876A1 (en) *	1986-10-07	1988-04-14	Toa Medical Electronics	Process and apparatus for flow cytometry
US4887721A (en) *	1987-11-30	1989-12-19	The United States Of America As Represented By The United States Department Of Energy	Laser particle sorter

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CYTOMETRY. vol. 9, no. 6, November 1988, NEW YORK US pages 566 - 572; B. JAGGI ET AL.: 'Imaging System for Morphometric Assessment of Absorption or Fluorescence in Stained Cells' *

Also Published As

Publication number	Publication date
EP0501006B1 (en)	1995-12-27
EP0501006A2 (en)	1992-09-02
DE69115876D1 (en)	1996-02-08
US5247340A (en)	1993-09-21
CA2050760A1 (en)	1992-08-28
JP3084296B2 (en)	2000-09-04
DE69115876T2 (en)	1996-06-05
JPH04270940A (en)	1992-09-28

Legal Events

Date	Code	Title	Description
1992-07-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-09-02	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): DE FR GB IT NL
1992-10-15	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
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1993-03-31	17P	Request for examination filed	Effective date: 19930202
1995-05-03	17Q	First examination report despatched	Effective date: 19950320
1995-11-10	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
1995-12-27	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): DE FR GB IT NL
1995-12-27	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED. Effective date: 19951227 Ref country code: FR Effective date: 19951227
1996-02-08	REF	Corresponds to:	Ref document number: 69115876 Country of ref document: DE Date of ref document: 19960208
1996-05-24	EN	Fr: translation not filed
1996-11-01	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
1996-11-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
1996-12-18	26N	No opposition filed
1997-08-27	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 19970827 Year of fee payment: 7
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1999-04-28	GBPC	Gb: european patent ceased through non-payment of renewal fee	Effective date: 19980905
1999-06-01	NLV4	Nl: lapsed or anulled due to non-payment of the annual fee	Effective date: 19990401
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Publication	Publication Date	Title
EP0501008A3 (en)	1992-11-04	Flow imaging cytometer
EP0501005A3 (en)	1992-12-09	Flow imaging cytometer
EP0538551A3 (en)	1993-08-04	Flow imaging cytometer
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