EP0491851A4 - Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy - Google Patents

Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy

Info

Publication number: EP0491851A4
Authority: EP; European Patent Office
Prior art keywords: production; lymphoid cells; adoptive immunotherapy; vitro expanded; expanded lymphoid
Prior art date: 1989-09-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19900914826

Other versions

EP0491851A1 (en

Inventor

Richard A. Knazek

William R. Kidwell

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Cellco Inc

Original Assignee

Cellco Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-14

Filing date

1990-09-11

Publication date

1993-02-17

1990-09-11 Application filed by Cellco Inc filed Critical Cellco Inc

1992-07-01 Publication of EP0491851A1 publication Critical patent/EP0491851A1/en

1993-02-17 Publication of EP0491851A4 publication Critical patent/EP0491851A4/en

Status Withdrawn legal-status Critical Current

Links

238000009169 immunotherapy Methods 0.000 title 1
238000000338 in vitro Methods 0.000 title 1
210000004698 lymphocyte Anatomy 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Sustainable Development (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP19900914826 1989-09-14 1990-09-11 Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy Withdrawn EP0491851A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40745689A	1989-09-14	1989-09-14
US407456		1989-09-14

Publications (2)

Publication Number	Publication Date
EP0491851A1 EP0491851A1 (en)	1992-07-01
EP0491851A4 true EP0491851A4 (en)	1993-02-17

Family

ID=23612175

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19900914826 Withdrawn EP0491851A4 (en)	1989-09-14	1990-09-11	Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy

Country Status (5)

Country	Link
EP (1)	EP0491851A4 (en)
JP (1)	JPH05502369A (en)
AU (1)	AU652725B2 (en)
CA (1)	CA2066645A1 (en)
WO (1)	WO1991004317A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2098510A1 (en) *	1990-12-13	1992-06-14	Kenneth W. Culver	Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
IT1261180B (en) *	1993-02-10	1996-05-09		IN VITRO PROPAGATION METHOD OF TIL CELLS.
PT879282E (en)	1996-01-17	2003-11-28	Imp College Innovations Ltd	IMMUNOTHERAPY USING CITOTOXIC T-LYMPHOCYTES (CTL)
DE10021627B4 (en) *	2000-05-04	2009-11-19	Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich	Method for producing a vascularized bioartificial tissue and associated experimental reactor
DE60218173T2 (en) *	2002-10-11	2007-11-22	Sentoclone Ab	Immunotherapy for cancer
EP1479760A1 (en) *	2003-05-19	2004-11-24	ProBioGen AG	Artificial immune organ
US10577585B2 (en) *	2015-05-13	2020-03-03	Terumo Bct, Inc.	Cell expansion
US20170056448A1 (en) *	2015-09-01	2017-03-02	Ifm Therapeutics, Inc	Immune cells having increased immunity or resistance to an immunosuppressive cytokine and use of the same
EP3216861A1 (en) *	2016-03-11	2017-09-13	Fropharm GmbH	Immunoregulatory cells and methods for their production
EP3510136A1 (en) *	2016-09-12	2019-07-17	Juno Therapeutics, Inc.	Perfusion bioreactor bag assemblies
CN109536444B (en) *	2018-12-11	2022-06-28	吉林省拓华生物科技有限公司	Separation induction method suitable for malignant solid tumor infiltrating T lymphocytes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987006610A1 (en) *	1986-04-28	1987-11-05	Endotronics, Inc.	Method of culturing leukocytes
WO1990014097A1 (en) *	1989-05-15	1990-11-29	E.I. Du Pont De Nemours And Company	Improved culture of human tumor-infiltrating lymphocytes by combining gas permeable bags and a primary culture container

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3883393A (en) *	1972-05-18	1975-05-13	Us Health Education & Welfare	Cell culture on semi-permeable tubular membranes
JPS5642584A (en) *	1979-09-18	1981-04-20	Asahi Chem Ind Co Ltd	Cell cultivation method
US4690915A (en) *	1985-08-08	1987-09-01	The United States Of America As Represented By The Department Of Health And Human Services	Adoptive immunotherapy as a treatment modality in humans

1990
- 1990-09-11 JP JP2513730A patent/JPH05502369A/en active Pending
- 1990-09-11 AU AU65008/90A patent/AU652725B2/en not_active Ceased
- 1990-09-11 EP EP19900914826 patent/EP0491851A4/en not_active Withdrawn
- 1990-09-11 CA CA002066645A patent/CA2066645A1/en not_active Abandoned
- 1990-09-11 WO PCT/US1990/005051 patent/WO1991004317A1/en not_active Application Discontinuation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987006610A1 (en) *	1986-04-28	1987-11-05	Endotronics, Inc.	Method of culturing leukocytes
WO1990014097A1 (en) *	1989-05-15	1990-11-29	E.I. Du Pont De Nemours And Company	Improved culture of human tumor-infiltrating lymphocytes by combining gas permeable bags and a primary culture container

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF IMMUNOLOGICAL METHODS vol. 127, no. 1, 1990, AMSTERDAM pages 29 - 37 KNAZEK R.A. ET AL 'Culture of human tumor infiltrating lymphocytes in hollow fiber bioreactors' *
SCIENCE vol. 244, no. 4910, 16 June 1989, LANCASTER, PA US pages 1430 - 1433 CULLITON B.J. 'Fighting cancer with designer cells' *
See also references of WO9104317A1 *

Also Published As

Publication number	Publication date
JPH05502369A (en)	1993-04-28
CA2066645A1 (en)	1991-03-15
WO1991004317A1 (en)	1991-04-04
AU652725B2 (en)	1994-09-08
EP0491851A1 (en)	1992-07-01
AU6500890A (en)	1991-04-18

Legal Events

Date	Code	Title	Description
1992-05-15	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1992-07-01	17P	Request for examination filed	Effective date: 19920317
1992-07-01	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1993-02-17	A4	Supplementary search report drawn up and despatched	Effective date: 19921230
1993-02-17	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE
1994-04-13	17Q	First examination report despatched	Effective date: 19940224
1996-01-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1996-03-06	18W	Application withdrawn	Withdrawal date: 19960109

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