EP0481003A2 - Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates. - Google Patents
Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates.Info
- Publication number
- EP0481003A2 EP0481003A2 EP90911357A EP90911357A EP0481003A2 EP 0481003 A2 EP0481003 A2 EP 0481003A2 EP 90911357 A EP90911357 A EP 90911357A EP 90911357 A EP90911357 A EP 90911357A EP 0481003 A2 EP0481003 A2 EP 0481003A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- enzyme hydrolysis
- via enzyme
- producing antibacterial
- intermediates via
- racemic substrates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Selon un nouveau procédé de préparation d'intermédiaires bactéricides, par exemple de préparation du composé bactéricide thiamphénicol, on utilise une hydrolase de gamma-glutamyle afin d'hydrolyser sélectivement un mélange racémique de D-thréophénylsérines et de L-thréophénylsérines.According to a new process for the preparation of bactericidal intermediates, for example of the preparation of the bactericidal compound thiamphenicol, a gamma-glutamyl hydrolase is used in order to selectively hydrolyze a racemic mixture of D-threophenylserines and L-threophenylserines.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37644889A | 1989-07-07 | 1989-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0481003A2 true EP0481003A2 (en) | 1992-04-22 |
Family
ID=23485070
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900307347 Withdrawn EP0407190A3 (en) | 1989-07-07 | 1990-07-05 | Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates |
EP90911357A Pending EP0481003A2 (en) | 1989-07-07 | 1990-07-05 | Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900307347 Withdrawn EP0407190A3 (en) | 1989-07-07 | 1990-07-05 | Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP0407190A3 (en) |
KR (1) | KR920701470A (en) |
AU (1) | AU6052090A (en) |
WO (1) | WO1991000923A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5346828A (en) * | 1991-03-27 | 1994-09-13 | Celgene Corporation | Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase |
TW397866B (en) * | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
WO1995016786A1 (en) * | 1993-12-17 | 1995-06-22 | Dsm N.V. | Phenylserine amides and the preparation of phenylserines/phenylserine amides |
US6686296B1 (en) | 2000-11-28 | 2004-02-03 | International Business Machines Corp. | Nitrogen-based highly polymerizing plasma process for etching of organic materials in semiconductor manufacturing |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3347752A (en) * | 1965-03-26 | 1967-10-17 | Merck & Co Inc | Microbiological cleavage process for resolving racemic alpha-methyl-beta-(3, 4,-dihydroxyphenyl)-alanine |
US3733352A (en) * | 1969-07-29 | 1973-05-15 | Sumitomo Chemical Co | Preparation of d-threo-1-p-methyl-sulfonylphenyl-2-dichloro-acet-amidopropane-1,3-diol |
JPS5133550B2 (en) * | 1974-05-01 | 1976-09-20 | ||
EP0678506A3 (en) * | 1983-06-02 | 1996-07-24 | Zambon Spa | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives. |
JPS6098995A (en) * | 1983-11-04 | 1985-06-01 | Microbial Chem Res Found | Production of optically active 3-(3,4-dihydroxyphenyl) serine and its derivative |
JPS60248192A (en) * | 1984-05-23 | 1985-12-07 | Sumitomo Chem Co Ltd | Preparation of optically active threo-3-phenylserine derivative |
-
1990
- 1990-07-05 EP EP19900307347 patent/EP0407190A3/en not_active Withdrawn
- 1990-07-05 AU AU60520/90A patent/AU6052090A/en not_active Abandoned
- 1990-07-05 EP EP90911357A patent/EP0481003A2/en active Pending
- 1990-07-05 WO PCT/US1990/003688 patent/WO1991000923A2/en unknown
-
1991
- 1991-03-07 KR KR1019910700252A patent/KR920701470A/en not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO9100923A2 * |
Also Published As
Publication number | Publication date |
---|---|
AU6052090A (en) | 1991-02-06 |
EP0407190A2 (en) | 1991-01-09 |
KR920701470A (en) | 1992-08-11 |
EP0407190A3 (en) | 1991-03-13 |
WO1991000923A3 (en) | 1991-03-07 |
WO1991000923A2 (en) | 1991-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
17P | Request for examination filed |
Effective date: 19911219 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
D17D | Deferred search report published (deleted) | ||
D17P | Request for examination filed (deleted) | ||
DA1 | Application published (deleted) |