EP0451730A1 - Vorrichtung zum Dosieren von pharmazeutischen Produkten, insbesondere in Kapseln - Google Patents

Vorrichtung zum Dosieren von pharmazeutischen Produkten, insbesondere in Kapseln Download PDF

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Publication number
EP0451730A1
EP0451730A1 EP91105443A EP91105443A EP0451730A1 EP 0451730 A1 EP0451730 A1 EP 0451730A1 EP 91105443 A EP91105443 A EP 91105443A EP 91105443 A EP91105443 A EP 91105443A EP 0451730 A1 EP0451730 A1 EP 0451730A1
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EP
European Patent Office
Prior art keywords
machine
fact
hole
container
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP91105443A
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English (en)
French (fr)
Inventor
Ernesto Gamberini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MG 2 SpA
MG2 SpA
Original Assignee
MG 2 SpA
MG2 SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MG 2 SpA, MG2 SpA filed Critical MG 2 SpA
Publication of EP0451730A1 publication Critical patent/EP0451730A1/de
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations

Definitions

  • the present invention relates to a machine for metering pharmaceutical products in liquid or paste form into hard gelatine capsules or bottles.
  • Known machines for metering pharmaceutical products currently differ in design according to the nature of product, i.e. powder, liquid, paste, granules, etc.
  • Those currently used for metering liquid products operate on an indexing basis, and substantially present an indexing body radially supporting a number of capsules; a feeder filled with liquid; a second internally-channelled body rotating between two operating positions; and a number of hydraulic pistons.
  • Said second body in a first position, connects the feeder to the pistons for withdrawing a given amount of liquid, and, in a second position, connects the pistons to respective capsules arrested underneath the second body for a given period of time in which the pistons inject the liquid into the capsules.
  • Liquid metering machines of the aforementioned type present numerous drawbacks.
  • indexing machines provide for lower output as compared with continuous types.
  • each operating step is accompanied by severe vibration resulting, not only in wear of the machine components, but also in spillage of the liquid from the capsules.
  • This results in further equally serious drawbacks, such as inaccurate filling of the capsules and fouling of the machine to the extent that it eventually grinds to a halt.
  • control devices for ensuring the presence of the capsules inside their seats are often dispensed with, thus resulting in possible further spillage and arrest of the machine.
  • the aim of the present invention is to provide a machine for metering pharmaceutical products, designed to overcome the aforementioned drawbacks, i.e. which operates continuously; features straightforward, reliable devices for detecting the presence of the capsules; and is easily adaptable for metering both liquid and paste products.
  • a machine for metering, particularly into capsules, a predetermined quantity of a pharmaceutical product in substantially liquid or paste form characterised by the fact that it comprises: a bottom portion connected to a drive shaft so as to rotate about a vertical longitudinal axis; at least a first vertical axial hole open at the top and formed in said bottom portion; at least one piston moved back and forth by a first cam along said first hole; a conveyor belt supporting said capsules, meshing with a portion of said bottom portion, and traveling along the entire plant of which said machine forms part; a rotary top portion having a container fed with said pharmaceutical product; a rotary center portion coaxial and angularly integral with said bottom portion and said top portion; at least a second hole associated with said first hole and formed radially along said center portion; at least one valve housed inside said second hole, having an inner chamber with three openings, and designed, for each turn of said center portion, to travel along said second hole between a first position, wherein said inner
  • Number 1 in Fig.1 indicates a continuously-operating machine for metering liquid pharmaceutical products in general into hard gelatine capsules.
  • liquid products is intended to mean actual liquids, thixotropic liquids, heat-melt liquids (fed in the form of paste or very thick liquids) and liquids with suspended particles.
  • machine 1 can be divided along its vertical longitudinal axis into three coaxial, substantially cylindrical, rotary portions 3, 4 and 5.
  • Top portion 3 comprises a cylindrical container 6 fed with liquid by a feeder 7 at the top, as shown partially by the dotted line.
  • Center portion 4 comprises a number of substantially slide type valves 8 designed, for each turn of machine 1, to receive a given quantity of liquid from container 6 and then feed it to a respective capsule.
  • Bottom portion 5 comprises a number of hydraulic pistons 11, one for each valve 8, for generating the thrust required for feeding the liquid to the capsule.
  • Bottom portion 5 also presents a toothed portion 12 with which meshes a belt 13 having a number of bushes 14 engaged by respective bottoms 15 of said capsules.
  • Machine 1 normally forms part of a system comprising various types of machines, e.g. for supplying the capsules, positioning and separating the top and bottom halves of the capsules, metering pharmaceutical products of various types and/or in other forms, closing and packing the capsules, etc.. All these machines are usually driven by one means, e.g. belts, pulleys or direct gearing, present a toothed portion similar to 12, and are usually tangent to one another so that belt 13 runs through the entire system.
  • Bottom portion 5 is driven by a vertical shaft 16 connected in known manner to the output shaft 17 of a motor 18 as shown schematically by the dotted line in Fig.1.
  • bottom portion 5 is formed in a number of coaxial parts connected integral with one another by means of screws 21.
  • Bottom portion 5 is in the form of a rotary drum having an intermediate ring of equally-spaced through holes 22 inside each of which a respective piston 11 slides in reciprocating manner. Travel of piston 11 is controlled by a fixed cylindrical cam 23 in which is formed an annular track 24 engaged by a wheel 25 supported on the bottom end portion of piston 11 projecting downwards from portion 5.
  • center portion 4 comprises a substantially cylindrical body 31, the center portion of the bottom face of which presents a cylindrical recess 32 engaged by the cylindrical top end 33 of portion 5.
  • Body 31 is secured to portion 5 by means of screws (not shown), and presents a number of cylindrical radial holes 34 each housing a valve 8.
  • the top face of body 31 constitutes the bottom wall of container 6, which presents a lateral wall composed of a bottom portion consisting of a ring 35 extending coaxially upwards from the top face of body 31, and a longer top portion consisting of an annular body 36 supported coaxially on ring 35 by means of screws 37.
  • the top and bottom faces of body 31 present respective vertical holes 38 and 41 coming out inside hole 34. Holes 38 and 41 are formed along the same ring, and are therefore coaxial with one other. Holes 38 constitute the outlets of container 6, and holes 41 connect the inside of valve 8 with hole 22 of respective piston 11, so that holes 41 are coaxial with holes 22.
  • Valve 8 travels along respective hole 34, between two limit positions, by virtue of a lever 44 operated by cams described in detail later on.
  • Valve 8 comprises a cylindrical body 45 having a horizontal longitudinal axis and inside which is defined, along said axis, a chamber 46 having three vertical openings 47, 48 and 51.
  • top opening 47 provides for connecting respective hole 38 hydraulically to chamber 46.
  • Wide bottom opening 48 provides for constantly connecting chamber 46 to respective hole 22.
  • Opening 51 is also formed at the bottom but with its axis further outwards in relation to opening 48.
  • the ring defined by holes 52 is the same as that defined by toothed portion 12, so that, on the portion of said portion 12 meshing with belt 13, each nozzle 53 is coaxial with a respective capsule bottom 15 underneath.
  • opening 51 is coaxial and communicates hydraulically with a respective hole 52.
  • a passage 54 between hole 34 and recess 32.
  • Lever 44 is shaped in the form of a downturned L, and comprises a substantially vertical arm 55 extending downwards inside respective recess 42, and a substantially horizontal arm 56 extending radially outwards of center portion 4.
  • the center portion of lever 44 pivots about a horizontal pin 57 on a respective appendix 43, and the end of arm 55 presents a recess 58 engaged by a horizontal pin 61 on an appendix 62 extending coaxially from body 45. Rotation of lever 44 therefore causes respective valve 8 to slide along hole 34.
  • lever 44 On the end of arm 56, lever 44 is fitted with a wheel 63 designed to contact two cams 64 and 65.
  • lever 44 When wheel 63 contacts cam 64, lever 44 is turned (clockwise in Fig.1) so as to slide valve 8 towards the innermost portion of hole 34 corresponding to a first limit position, wherein hole 38 communicates with respective opening 47, thus enabling liquid input into chamber 46, and hole 52 is closed at the top by the outer surface of body 45, thus preventing liquid from flowing out through opening 51.
  • the outer lateral surface of body 45 presents respective hydraulic sealing assemblies.
  • lever 44 When wheel 63 contacts cam 65, lever 44 is turned (anticlockwise in Fig.1) so as to slide valve 8 towards the outermost portion of hole 34 corresponding to a second limit position, wherein chamber 46 is prevented from communicating with container 6, and opening 51 communicates with respective hole 52, thus enabling fluid to flow out of hole 52 into capsule 15.
  • Machine 1 also comprises a fixed column 66 supporting, over container 6, a plate 67 in turn supporting a second plate 68 covering container 6, and the casing of a variable-speed electric motor 71.
  • Container 6 houses a mixing device 72 having blades 73 turned about the longitudinal axis of machine 1 by a shaft 74 connected mechanically to the output shaft of motor 71.
  • Container 6 also houses a heating device 75 consisting, in the embodiment shown, of an annular, externally finned body inside which is formed a substantially helical heating fluid circuit.
  • a system shown schematically by block 76, provides for heating the fluid to a predetermined temperature and feeding it to device 75.
  • Casing 6 also houses three sensors 77, 78 and 81 supported on plate 68, and which provide respectively for detecting the top and bottom level and the temperature of the liquid inside container 6.
  • Machine 1 also comprises an electronic control system for controlling motors 18 and 71 and system 76, and to which sensors 77, 78 and 81 are connected. Via a gate valve 83 (shown schematically in Fig.1), control system 82 also provides for controlling supply of said pharmaceutical product from feeder 7 to container 6. Finally, control system 82 is connected to a sensor 84 for detecting the presence of capsules 15 on belt 13, particularly prior to the capsule filling stage. For better illustrating operation of sensor 84, this is shown in Fig.1 to be located to the side of belt 13 meshing with machine 1, whereas, in actual fact, it is preferably installed upstream from machine 1. A device 85 (e.g.
  • a capsule 15 is aligned beneath nozzle 53, ready to receive a predetermined quantity of liquid, and respective piston 11 is moved upwards so as to expel the liquid from the top portion of hole 22.
  • the liquid is forced towards the only possible outlet, i.e. opening 51, from which it is fed into capsule 15.
  • the amount of liquid fed into capsule 15 is directly proportional to the stroke of piston 11, i.e. to the length of the top portion of hole 22 filled with liquid at the drawing-in stage.
  • piston 11 actually only draws in the amount of liquid for filling the top portion of hole 22 and which is then fed into capsule 15.
  • Control system 82 provides for overall control of machine 1, and particularly for maintaining a suitable liquid level inside container 6 via gate valve 83; for controlling the temperature of the liquid inside container 6, especially in the case of heat-melt liquids requiring a constant predetermined temperature (normally defined in a map stored in a memory block of system 82) during the metering process; and for controlling mixing device 72, which provides for both blending the product (e.g. liquids with suspended particles) and ensuring uniform temperature.
  • the variable speed of motor 71 enables operation of mixer 72 to be regulated according to the current and predetermined characteristics of the product, for ensuring correct metering of the same.
  • control system 82 upon detecting the absence of capsule 15, provides for detaching cam 65 from lever 44 of respective valve 8, thus preventing the liquid from being expelled through opening 51, which remains closed, while at the same time permitting upward movement of piston 11 for feeding the liquid back into container 6.
  • amount of liquid fed into capsule 15 is proportional to the stroke of piston 11, said amount may obviously be varied by simply replacing cam 23 with another providing for a different stroke of piston 11, or by providing for an adjustable cam 23.
  • Holes 54 provide for expelling any air inside holes 34 and so preventing it from obstructing travel of valves 8.
  • Number 101 in Fig.s 3 and 4 indicates a machine for metering pharmaceutical products in paste form.
  • machine 101 may be divided schematically, along its vertical longitudinal axis, into three coaxial, substantially cylindrical, rotary portions 102, 103 and 104.
  • Top portion 102 comprises a container 105 fed with cubes 106 of paste on a conveyor belt 107 (shown partially).
  • Center portion 103 which is similar to portion 4 of machine 1, comprises a number of valves 8 designed, at each turn of machine 101, to receive a given amount of paste from container 105 and feed it to a respective capsule 15.
  • Bottom portion 104 is substantially similar to portion 5 of machine 1. Any other parts of machine 101 similar to those of machine 1 will be indicated using the same numbering system.
  • portion 103 differs from portion 4 of machine 1 substantially as regards two characteristics. Firstly, the portion of body 45 of valve 8 in which openings 48 and 51 are formed is flattened for better cutting the thread of paste issuing from opening 51, as described in more detail later on. Naturally, the corresponding portion of hole 34 is also flattened. Secondly, the bottom face of body 31 presents a smaller outside diameter than in Fig.1, and, instead of holes 52, an equal number of peripheral V-shaped radial recesses 108, as shown in Fig.5.
  • machine 101 operates in the same way as machine 1, except that the product issuing from opening 51 is in the form of a thread of paste which, as valve 8 travels inwards of hole 34, is cut by virtue of the flat design of the mating surfaces of bodies 31 and 45.
  • capsule 15 is pressed against the edge of opening 51, at respective recess 108, and is lifted from respective bush 14 into recess 108. Subsequently, the upward thrust on capsule 15 is removed, and contact between the walls of recess 108 and capsule 15 prevents this from adhering to valve 8 (as a result of the "adhesive" effect of the paste).
  • capsule 15 is carried off by belt 13 as this abandons machine 101 tangentially to mesh with a follow-up machine, and it is precisely at this point that capsule 15, if still attached to valve 8, is detached from the same by virtue of contacting the walls of recess 108.
  • portion 104 differs in only one respect from portion 5 of machine 1, which characteristic, however, may and is preferably also adopted on machine 1.
  • Portion 104 comprises an annular flange 111 in which are formed a number of vertical through holes 112 equal in number to valves 8 and coaxial with a respective capsule 15.
  • Each hole 112 is engaged by a cylindrical sleeve 113 along which a vertical pin 115 slides by virtue of a cam 114 similar to cam 23.
  • Pin 115 is formed in two coaxial parts 116 and 117 with a spring 118 in between.
  • pin 115 moves upwards to press capsule 15 against the edge of opening 51 and through respective recess 108, thus ensuring the paste thread centers capsule 15.
  • the above system provides for avoiding spillage of the liquid outside capsule 15.
  • container 105 presents a bottom wall defined by the top face of body 31, and a lateral wall defined by an annular body 121 secured coaxially to body 31 by screws 122, and by a funnel-shaped body 123 secured coaxially to the top end of body 121 by screws 124.
  • a fixed plate 125 over container 105, is fitted integral with a hollow, cylindrical, vertical column 126 coaxial with container 105 and the bottom portion of which is actually housed inside the same.
  • the bottom end of column 126 is fitted coaxially, by means of screws 127, with a centrally-drilled, cylindrical body 128, the lateral surface of which presents a downward-winding channel 131.
  • Body 128 is located close to the top face of body 31, and presents an outside diameter slightly smaller than the inside diameter of body 121. Body 128 therefore acts as a short-pitch screw for determining a constant paste pressure inwards of valves 8.
  • Shaft 16 is connected angularly and coaxially in known manner (not shown) with a second rotary shaft 132 extending vertically upwards through body 31 and, via the interposition of bearings 133, through body 128. Via the interposition of further bearings 134, shaft 132 extends through the whole of column 126 and, on the top end outside column 126, is fitted with a gear 135.
  • column 126 Via the interposition of bearings 136, column 126 is housed inside a second rotary column 137, the lateral surface of a portion of which, inside container 105, is fitted integral with a screw 138, and the top end of which is fitted with a gear 141.
  • a reduction device 142 on plate 125 transmits motion from gear 135 to gear 141 and from shaft 16 to screw 138, which therefore turns at a slower speed than shaft 16.
  • machine 101 also presents an electronic control system 143 for controlling overall operation of machine 101.
  • system 143 controls means 144 (shown by the dotted line) for driving conveyor belt 107, motor 18 and device 85.
  • System 143 is connected to sensor 84 already described in connection with machine 1; a temperature sensor 145 on a cooling fin 146 extending radially from the outer lateral surface of body 121; and a microswitch 147 activated by a built-in device on reduction device 142, for detecting an increase in pressure inside container 105 over and above a predetermined threshold.
  • System 148 shown schematically for blowing cold air on to the outer surface of container 105.
  • System 148 is controlled by system 143 on the basis of the temperature detected by sensor 145, so as to maintain the temperature inside container 105 at a level acceptable by both the container components and the paste housed inside the same.
  • reduction device 142 comprises a vertical rotary shaft 151 fitted centrally, via the interposition of bearings 152, with a gear 153 meshing with gear 135; fitted integrally at the bottom with a gear 154 meshing with gear 141; and fitted in idle manner, over gear 153, with an axially-sliding annular body 155.
  • the top face of gear 153 is fitted integrally and coaxially with a ring 156 about which are formed a number of equally-spaced notches 157.
  • Body 155 supports, at the bottom, a number of horizontal rollers 158 cooperating with notches 157 (Fig.7).
  • the top face of body 155 presents an integral ring 161 having two diametrically-opposed, open-topped recesses 162.
  • shaft 151 is connected integral, via a pin (Fig.6), with a block 163 from which two arms 164 extend radially in opposite directions, and are fitted with respective horizontal rollers 165 engaging respective recesses 162.
  • the assembly consisting of block 163, arms 164 and rollers 165 is housed inside an axially-sliding, upside down cup-shaped body 166 mounted in idle manner on shaft 151 and secured to ring 161 and body 155 by means of screws 167 (shown by the dotted lines in Fig.3).
  • the top end of shaft 151 outside body 166 is threaded and engaged by a nut 168, and spring means 171 are provided between nut 168 and the top face of body 166.
  • a fixed plate 172 integral with plate 125, supports microswitch 147, the operating stem 173 of which is normally pressed downwards by an outer annular shoulder 174 formed on body 166.
  • shaft 16 In actual use, the motion of shaft 16 is transmitted by gear 135 to gear 153, which, via the connection of notches 157 and rollers 158, drives body 155. This in turn drives body 166 directly, and block 163 together with shaft 151 via the connection of recesses 162 and rollers 165. Finally, shaft 151 drives screw 138 via the connection of gears 154 and 141.
  • the transmission ratio of gear pairs 135-153 and 154-141 determines the rotation speed of screw 138 which, as stated, is less than that of container 105.
  • an undesired increase in pressure may occur inside container 105, mainly due to an excessive number of cubes 106 or to the hardness of the paste.
  • the pressure inside container 105 exceeds a given value determined by the setting of spring means 171
  • the rotation speed of screw 138 is gradually slowed down by the pressure exerted by the same on the paste. Consequently, shaft 151 also tends to turn at a slower speed than that imposed by gear 153, which speed is also imposed on body 155.
  • rollers 158 travel up the mating surface of respective notches 157, which surface (Fig.7) is inclined for facilitating upward travel of rollers 158.
  • a continuously operating machine the major advantages of which include greater output, as compared with indexing machines of comparable overall size, reduced vibration and, consequently, reduced wear of machine components.
  • said reduction in vibration also prevents fouling of the machine and ensures correct, accurate metering of the product into capsules 15.
  • a continuously operating machine enables troublefree, low-cost installation of sensors for detecting the presence of capsules 15, thus preventing possible spillage of the liquid from valves 8, as well as for performing other, e.g. temperature control, functions.
  • the machine according to the present invention provides for a greater degree of reliability as compared with currently used types.
  • machines 1 and 101 differ solely as regards the top portion, which may easily be changed for switching from one product to another.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Basic Packing Technique (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP91105443A 1990-04-12 1991-04-05 Vorrichtung zum Dosieren von pharmazeutischen Produkten, insbesondere in Kapseln Ceased EP0451730A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT3443A IT1238551B (it) 1990-04-12 1990-04-12 Macchina per il dosaggio di prodotti farmaceutici particolarmente in capsule.
IT344390 1990-04-12

Publications (1)

Publication Number Publication Date
EP0451730A1 true EP0451730A1 (de) 1991-10-16

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ID=11107476

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91105443A Ceased EP0451730A1 (de) 1990-04-12 1991-04-05 Vorrichtung zum Dosieren von pharmazeutischen Produkten, insbesondere in Kapseln

Country Status (4)

Country Link
EP (1) EP0451730A1 (de)
JP (1) JPH0692393A (de)
BR (1) BR9101476A (de)
IT (1) IT1238551B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018330A2 (de) * 1999-01-05 2000-07-12 Mg2 S.P.A. Maschine zum Dosieren von flüssigen pharmazeutischen Produkten

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5033147B2 (ja) 2009-02-04 2012-09-26 株式会社 ノサカテック 容器蓋体の結合方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403471A1 (fr) * 1977-09-20 1979-04-13 Bosch Gmbh Robert Pompe a piston pour remplir des gelules dures avec un liquide
DE3318810A1 (de) * 1982-05-25 1983-12-01 MG 2 S.p.A., 40065 Pian di Macina-Pianoro, Bologna Vorrichtung zum dosierten abfuellen pharmazeutischer pasten
DE3432992A1 (de) * 1983-09-08 1985-03-28 MG 2 S.p.A., Pian di Macina-Pianoro, Bologna Vorrichtung zum zumessen einer vorgegebenen pulvermenge
WO1990007695A2 (fr) * 1989-01-06 1990-07-12 Unisabi S.A. Dispositif de dosage de produits pateux, notamment d'emulsions de viande ou d'autres proteines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403471A1 (fr) * 1977-09-20 1979-04-13 Bosch Gmbh Robert Pompe a piston pour remplir des gelules dures avec un liquide
DE3318810A1 (de) * 1982-05-25 1983-12-01 MG 2 S.p.A., 40065 Pian di Macina-Pianoro, Bologna Vorrichtung zum dosierten abfuellen pharmazeutischer pasten
DE3432992A1 (de) * 1983-09-08 1985-03-28 MG 2 S.p.A., Pian di Macina-Pianoro, Bologna Vorrichtung zum zumessen einer vorgegebenen pulvermenge
WO1990007695A2 (fr) * 1989-01-06 1990-07-12 Unisabi S.A. Dispositif de dosage de produits pateux, notamment d'emulsions de viande ou d'autres proteines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018330A2 (de) * 1999-01-05 2000-07-12 Mg2 S.P.A. Maschine zum Dosieren von flüssigen pharmazeutischen Produkten
EP1018330A3 (de) * 1999-01-05 2001-01-17 Mg2 S.P.A. Maschine zum Dosieren von flüssigen pharmazeutischen Produkten

Also Published As

Publication number Publication date
JPH0692393A (ja) 1994-04-05
IT9003443A1 (it) 1991-10-12
IT1238551B (it) 1993-08-18
BR9101476A (pt) 1991-11-26
IT9003443A0 (it) 1990-04-12

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