EP0444156A4 - Method for treating vascular diseases - Google Patents

Method for treating vascular diseases

Info

Publication number
EP0444156A4
EP0444156A4 EP19900901238 EP90901238A EP0444156A4 EP 0444156 A4 EP0444156 A4 EP 0444156A4 EP 19900901238 EP19900901238 EP 19900901238 EP 90901238 A EP90901238 A EP 90901238A EP 0444156 A4 EP0444156 A4 EP 0444156A4
Authority
EP
European Patent Office
Prior art keywords
vascular diseases
treating vascular
treating
diseases
vascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900901238
Other versions
EP0444156A1 (en
Inventor
Hollis D. Kleinert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0444156A1 publication Critical patent/EP0444156A1/en
Publication of EP0444156A4 publication Critical patent/EP0444156A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19900901238 1988-11-21 1989-11-20 Method for treating vascular diseases Withdrawn EP0444156A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27515188A 1988-11-21 1988-11-21
US275151 1988-11-21

Publications (2)

Publication Number Publication Date
EP0444156A1 EP0444156A1 (en) 1991-09-04
EP0444156A4 true EP0444156A4 (en) 1992-12-09

Family

ID=23051068

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900901238 Withdrawn EP0444156A4 (en) 1988-11-21 1989-11-20 Method for treating vascular diseases

Country Status (4)

Country Link
EP (1) EP0444156A4 (en)
CA (1) CA2003382A1 (en)
GR (1) GR1001145B (en)
WO (1) WO1990005531A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
US5244910A (en) * 1990-08-15 1993-09-14 Abbott Laboratories Renin inhibitors
ZA921381B (en) * 1991-03-01 1992-11-25 Fujisawa Pharmaceutical Co New use of amino acid derivatives
SE9903028D0 (en) * 1999-08-27 1999-08-27 Astra Ab New use
PL353199A1 (en) * 1999-08-30 2003-11-03 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
CA2436774A1 (en) 2001-01-30 2002-08-08 R. Michael Lawrence Sulfonamide lactam inhibitors of factor xa
PL3464336T3 (en) 2016-06-01 2022-05-16 Athira Pharma, Inc. Compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161588A2 (en) * 1984-05-18 1985-11-21 MERCK PATENT GmbH Diamino acid derivatives
EP0179352A2 (en) * 1984-10-20 1986-04-30 MERCK PATENT GmbH Peptides
DE3626130A1 (en) * 1986-08-01 1988-02-11 Merck Patent Gmbh AMINO ACID DERIVATIVES
EP0272444A2 (en) * 1986-11-27 1988-06-29 MERCK PATENT GmbH Renin-inhibiting peptides
EP1610588A2 (en) * 2004-06-08 2005-12-28 Bose Corporation Audio signal processing

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (en) * 1985-10-31 1987-05-07 Merck Patent Gmbh PEPTIDE

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161588A2 (en) * 1984-05-18 1985-11-21 MERCK PATENT GmbH Diamino acid derivatives
EP0179352A2 (en) * 1984-10-20 1986-04-30 MERCK PATENT GmbH Peptides
DE3626130A1 (en) * 1986-08-01 1988-02-11 Merck Patent Gmbh AMINO ACID DERIVATIVES
EP0272444A2 (en) * 1986-11-27 1988-06-29 MERCK PATENT GmbH Renin-inhibiting peptides
EP1610588A2 (en) * 2004-06-08 2005-12-28 Bose Corporation Audio signal processing

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ENDOCRINOL. JPN., vol. 30, no. 2, April 1983, pages 147-153, JP; N. SHIMOJO: "Plasma inactive renin in patients with diabetes mellitus: effects of standing and the relation to serum protease inhibitor" *
HYPERTENSION, vol. 12, no. 3, September 1988, page 341, US; M. BURSZTYN et al.: "Dissociation between plasma renin inhibition and blood pressure response to a renin inhibitor in hypertensive patients", (Council for high blood pressure research; 42nd Annual fall conference and scientific sessions, San Francisco, California, September 1988) *
HYPERTENSION, vol. 12, no. 3, September 1988, page 360, US; A. DELABAYS et al.: "Effects of a new renin inhibitor (ABBOTT-64662) in normal volunteers", (Council for high blood pressure research; 42nd Annual fall conference and scientific sessions, San Francisco, California, September 1988) *
JOURNAL OF NARA MEDICAL ASSOCIATION, vol. 35, no. 1, 29th February 1984, pages 59-75; T. HIJIOKA: "Studies on the inhibitory effect of serine protease inhibitors/in human blood on trypsin-activated plasma prorenin; with special reference to hemodialyzed patients with diabetic nephropathy" *
KLINISCHE WOCHEN-SCHRIFT, vol. 66, no. 18, 15th September 1988, pages 883-891, DE; J. MANN et al.: "Renin-Angiotensin System beim diabetischen Patienten" *
See also references of WO9005531A1 *
THE AMERICAN JOURNAL OF CARDIOLOGY, vol. 37, no. 4, 31st March 1976, pages 667-674, US; R.P. DAY et al.: "Big renin: identification, chemical properties and clinical implications" *

Also Published As

Publication number Publication date
CA2003382A1 (en) 1990-05-21
WO1990005531A1 (en) 1990-05-31
GR890100773A (en) 1990-12-31
GR1001145B (en) 1993-05-24
EP0444156A1 (en) 1991-09-04

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Legal Events

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