EP0428615A4 - Method for stabilizing heterologous protein expression and vectors for use therein - Google Patents
Method for stabilizing heterologous protein expression and vectors for use thereinInfo
- Publication number
- EP0428615A4 EP0428615A4 EP19890910335 EP89910335A EP0428615A4 EP 0428615 A4 EP0428615 A4 EP 0428615A4 EP 19890910335 EP19890910335 EP 19890910335 EP 89910335 A EP89910335 A EP 89910335A EP 0428615 A4 EP0428615 A4 EP 0428615A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- vectors
- protein expression
- heterologous protein
- stabilizing
- stabilizing heterologous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23122488A | 1988-08-11 | 1988-08-11 | |
US231224 | 1988-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0428615A1 EP0428615A1 (en) | 1991-05-29 |
EP0428615A4 true EP0428615A4 (en) | 1991-11-13 |
Family
ID=22868276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19890910335 Withdrawn EP0428615A4 (en) | 1988-08-11 | 1989-08-09 | Method for stabilizing heterologous protein expression and vectors for use therein |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0428615A4 (en) |
JP (1) | JPH04501204A (en) |
AU (1) | AU4216689A (en) |
CA (1) | CA1320162C (en) |
IL (1) | IL91272A0 (en) |
WO (1) | WO1990001540A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
NL9201173A (en) * | 1992-07-01 | 1994-02-01 | Leuven K U Res & Dev | Vector for positive selection of recombinants |
DK144093D0 (en) * | 1993-12-23 | 1993-12-23 | Novo Nordisk As | |
US6031075A (en) * | 1996-02-05 | 2000-02-29 | Children's Hospital Medical Center | Mature alveolar SP-B and a process for producing the same |
PT1095141E (en) * | 1998-07-10 | 2006-07-31 | Scios Inc | METHOD FOR PRODUCING A PEPTIDE WITH A PI ABOVE 8 OR BELOW 5 |
AT410444B (en) * | 2001-03-02 | 2003-04-25 | Oesterr Forsch Seibersdorf | METHOD FOR DETECTING NUCLEIC ACID MOLECULES |
ES2545090T3 (en) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Albumin and GCSF fusion proteins |
HUE027902T2 (en) | 2004-02-09 | 2016-11-28 | Human Genome Sciences Inc Corp Service Company | Albumin fusion proteins |
CA2744940A1 (en) | 2008-12-10 | 2010-06-17 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
CN117343200B (en) * | 2023-12-04 | 2024-01-30 | 北京质肽生物医药科技有限公司 | Fusion protein containing amyloid core polypeptide, preparation method and application thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0131363A1 (en) * | 1983-05-24 | 1985-01-16 | Celltech Limited | Polypeptide and protein products, and processes for their production and use |
EP0207402A2 (en) * | 1985-07-03 | 1987-01-07 | Bayer Ag | Process for producing proteins and polypeptides |
GB2180539A (en) * | 1985-07-24 | 1987-04-01 | Glaxo Group Ltd | Microbiological products |
WO1987006588A1 (en) * | 1986-04-30 | 1987-11-05 | California Biotechnology Inc. | Recombinant alveolar surfactant protein |
WO1988003170A1 (en) * | 1986-10-24 | 1988-05-05 | Whitsett Jeffrey A | Pulmonary hydrophobic surfactant-associated proteins |
WO1988003951A1 (en) * | 1986-11-17 | 1988-06-02 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
WO1989004326A1 (en) * | 1987-11-04 | 1989-05-18 | California Biotechnology Inc. | Alveolar surfactant proteins |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3682104D1 (en) * | 1985-04-22 | 1991-11-28 | Genentech Inc | PLASMINOGENACTIVATOR MUTANT OF HUMAN TISSUE, METHODS AND INTERMEDIATE PRODUCTS THEREFOR AND COMPOSITIONS USING THIS MUTANT. |
-
1989
- 1989-08-09 EP EP19890910335 patent/EP0428615A4/en not_active Withdrawn
- 1989-08-09 JP JP1509538A patent/JPH04501204A/en active Pending
- 1989-08-09 CA CA000607908A patent/CA1320162C/en not_active Expired - Fee Related
- 1989-08-09 WO PCT/US1989/003417 patent/WO1990001540A1/en not_active Application Discontinuation
- 1989-08-09 AU AU42166/89A patent/AU4216689A/en not_active Abandoned
- 1989-08-10 IL IL91272A patent/IL91272A0/en unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0131363A1 (en) * | 1983-05-24 | 1985-01-16 | Celltech Limited | Polypeptide and protein products, and processes for their production and use |
EP0207402A2 (en) * | 1985-07-03 | 1987-01-07 | Bayer Ag | Process for producing proteins and polypeptides |
GB2180539A (en) * | 1985-07-24 | 1987-04-01 | Glaxo Group Ltd | Microbiological products |
WO1987006588A1 (en) * | 1986-04-30 | 1987-11-05 | California Biotechnology Inc. | Recombinant alveolar surfactant protein |
WO1988003170A1 (en) * | 1986-10-24 | 1988-05-05 | Whitsett Jeffrey A | Pulmonary hydrophobic surfactant-associated proteins |
WO1988003951A1 (en) * | 1986-11-17 | 1988-06-02 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
WO1989004326A1 (en) * | 1987-11-04 | 1989-05-18 | California Biotechnology Inc. | Alveolar surfactant proteins |
Non-Patent Citations (1)
Title |
---|
See also references of WO9001540A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH04501204A (en) | 1992-03-05 |
CA1320162C (en) | 1993-07-13 |
EP0428615A1 (en) | 1991-05-29 |
AU4216689A (en) | 1990-03-05 |
WO1990001540A1 (en) | 1990-02-22 |
IL91272A0 (en) | 1990-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19910206 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19910923 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
17Q | First examination report despatched |
Effective date: 19930617 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19931228 |