EP0341681A3 - 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols - Google Patents

6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols Download PDF

Info

Publication number
EP0341681A3
EP0341681A3 EP89108378A EP89108378A EP0341681A3 EP 0341681 A3 EP0341681 A3 EP 0341681A3 EP 89108378 A EP89108378 A EP 89108378A EP 89108378 A EP89108378 A EP 89108378A EP 0341681 A3 EP0341681 A3 EP 0341681A3
Authority
EP
European Patent Office
Prior art keywords
hydroxytetrahydropyran
ones
dihydrocarboxylic
thiophenoxymethyl
thiophenols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP89108378A
Other languages
German (de)
Other versions
EP0341681A2 (en
EP0341681B1 (en
Inventor
Heiner Dr. Jendralla
Gunther Dr. Wess
Wilhelm Prof. Dr. Bartmann
Gerhard Dr. Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3816388A external-priority patent/DE3816388A1/en
Priority claimed from DE19883819999 external-priority patent/DE3819999A1/en
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to AT89108378T priority Critical patent/ATE99301T1/en
Publication of EP0341681A2 publication Critical patent/EP0341681A2/en
Publication of EP0341681A3 publication Critical patent/EP0341681A3/en
Application granted granted Critical
Publication of EP0341681B1 publication Critical patent/EP0341681B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
EP89108378A 1988-05-13 1989-05-10 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols Expired - Lifetime EP0341681B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89108378T ATE99301T1 (en) 1988-05-13 1989-05-10 NEW 6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2ONE AND 6-THIOPHENOXYMETHYL-4HYDROXYTETRAHYDROPYRAN-2-ONE, AND THE CORRESPONDING DIHYDROXYCARBONIC ACID DERIVATIVES, SALTS AND ESTERS, PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS, THEIR USE AS PHARMACEUTICALS, PH ARMACEUTICAL PREPARATIONS AND NEW PHENOLS AND THIOPHENOLS.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3816388A DE3816388A1 (en) 1988-05-13 1988-05-13 Novel 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, processes for their preparation, their use as drugs (medicaments, pharmaceuticals), pharmaceutical preparations and novel phenols and thiophenols
DE3816388 1988-05-13
DE3819999 1988-06-11
DE19883819999 DE3819999A1 (en) 1988-06-11 1988-06-11 Novel 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for the preparation of these compounds, their use as medicaments, pharmaceutical preparations and novel phenols and thiophenols

Publications (3)

Publication Number Publication Date
EP0341681A2 EP0341681A2 (en) 1989-11-15
EP0341681A3 true EP0341681A3 (en) 1990-05-16
EP0341681B1 EP0341681B1 (en) 1993-12-29

Family

ID=25868078

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89108378A Expired - Lifetime EP0341681B1 (en) 1988-05-13 1989-05-10 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols

Country Status (16)

Country Link
EP (1) EP0341681B1 (en)
JP (1) JP2833779B2 (en)
KR (1) KR900018062A (en)
AU (1) AU615060B2 (en)
CA (1) CA1338018C (en)
DE (1) DE58906520D1 (en)
DK (1) DK235389A (en)
ES (1) ES2061779T3 (en)
FI (1) FI96684C (en)
HU (1) HU206312B (en)
IE (1) IE63298B1 (en)
IL (1) IL90249A (en)
NO (1) NO172538C (en)
NZ (1) NZ229083A (en)
PH (1) PH26257A (en)
PT (1) PT90532B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929913A1 (en) * 1989-09-08 1991-04-04 Hoechst Ag 4-HYDROXYTETRAHYDROPYRAN-2-ONE AND THE CORRESPONDING DIHYDROXYCARBONSAEUREDERIVATES, SALTS AND ESTERS, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT, PHARMACEUTICAL PREPARATES AND PREPARED PRODUCTS
KR950005791A (en) * 1993-08-09 1995-03-20 후꾸야마 마사루 Method for preparing carboxylic ester-derivative and 4-fluorobiphenyl derivative used in the method
US9045684B2 (en) * 2012-07-30 2015-06-02 Jnc Corporation Liquid crystal composition, antioxidant and liquid crystal display device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0216127A2 (en) * 1985-08-29 1987-04-01 Hoechst Aktiengesellschaft 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates
DE3632893A1 (en) * 1986-09-27 1988-04-07 Hoechst Ag 4-(R)-Hydroxy-6-(S)-arylthiomethyltetrahydropyran-2-ones, their corresponding sulphoxides and sulphones, processes for their preparation, their use as medicaments, pharmaceutical preparations and intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3530798A1 (en) * 1985-08-29 1987-03-05 Hoechst Ag 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, processes for their preparation, their use as medicaments, pharmaceutical preparations and intermediates
DE3929913A1 (en) * 1989-09-08 1991-04-04 Hoechst Ag 4-HYDROXYTETRAHYDROPYRAN-2-ONE AND THE CORRESPONDING DIHYDROXYCARBONSAEUREDERIVATES, SALTS AND ESTERS, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT, PHARMACEUTICAL PREPARATES AND PREPARED PRODUCTS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0216127A2 (en) * 1985-08-29 1987-04-01 Hoechst Aktiengesellschaft 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones, process for their preparation, their use as medicines, pharmaceutical compositions and intermediates
DE3632893A1 (en) * 1986-09-27 1988-04-07 Hoechst Ag 4-(R)-Hydroxy-6-(S)-arylthiomethyltetrahydropyran-2-ones, their corresponding sulphoxides and sulphones, processes for their preparation, their use as medicaments, pharmaceutical preparations and intermediates

Also Published As

Publication number Publication date
JP2833779B2 (en) 1998-12-09
AU3471589A (en) 1989-12-21
IL90249A0 (en) 1989-12-15
HUT58309A (en) 1992-02-28
FI96684C (en) 1996-08-12
FI892291A0 (en) 1989-05-11
DK235389A (en) 1989-11-14
PT90532A (en) 1989-11-30
AU615060B2 (en) 1991-09-19
EP0341681A2 (en) 1989-11-15
EP0341681B1 (en) 1993-12-29
DE58906520D1 (en) 1994-02-10
IE891554L (en) 1989-11-13
IE63298B1 (en) 1995-04-05
HU206312B (en) 1992-10-28
PH26257A (en) 1992-04-01
JPH01319472A (en) 1989-12-25
ES2061779T3 (en) 1994-12-16
NO891937L (en) 1989-11-14
PT90532B (en) 1994-11-30
FI892291A (en) 1989-11-14
NO891937D0 (en) 1989-05-12
KR900018062A (en) 1990-12-20
FI96684B (en) 1996-04-30
CA1338018C (en) 1996-01-30
NZ229083A (en) 1990-12-21
IL90249A (en) 1994-01-25
NO172538B (en) 1993-04-26
DK235389D0 (en) 1989-05-12
NO172538C (en) 1993-08-04

Similar Documents

Publication Publication Date Title
ZA916583B (en) 3-amidopyrazole derivatives,process for preparing these and pharmaceutical compositions containing them
HUT50339A (en) Process for producing benzoxazole derivatives and pharmaceutical compositions comprising the compounds
ZA895588B (en) Intravenou pharmaceutical composition and process for preparing the same
AU3707889A (en) Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
AR243515A1 (en) Thiazole derivatives active on the cholinergic system, process for their preparation and pharmaceutical compositions containing them
IL87731A0 (en) Cephem derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
IL99393A0 (en) Thiazolidine derivatives,methods for the preparation thereof and pharmaceutical composition containing the same
AU3746489A (en) Glycosaminoglycan salts, processes for the preparation thereof and pharmaceutical compositions containing them
IL98864A0 (en) Oxazolyl derivatives,process for their preparation and pharmaceutical compositions containing them
IL88903A0 (en) Indolylpiperidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA897541B (en) Benzoxazolinone derivatives,process for the preparation thereof and pharmaceutical compositions containing them
IL95548A0 (en) Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
IL87563A0 (en) Isoxazole-beta-carboline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ZA901543B (en) Benzoxazolinone derivatives,process for preparing them and pharmaceutical compositions containing them
IL87921A0 (en) Pharmaceutical composition for piperidinoalkanol derivatives
AU8808791A (en) New benzoselenazolinone compounds, process for preparing these and pharmaceutical compositions containing them
ZA886160B (en) Cephalosporin compounds,process for their preparation and their pharmaceutical compositions
EP0341681A3 (en) 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols
AU1563388A (en) New macrolide derivatives, process for the preparation thereof and pharmaceutical compositions containing them
EP0329563A3 (en) Benzocyclohexane and benzocycloheptane derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
DE3664635D1 (en) 7-hydroxyguanine compounds, process for preparing said compounds, pharmaceutical composition, and use thereof
HU9503345D0 (en) Substituted benzoyl-guanidine derivatives, process for producing them their use as medicine and diagnosticum and pharmaceutical composition containing them
ZA898179B (en) Tylosin derivatives,process for the preparation thereof and pharmaceutical compositions containing them
GB9004407D0 (en) New uronic acid derivatives,a process for their production and a pharmaceutical composition containing the same
HUT49870A (en) Process for producing new 1,2-dithiolo-3-thion-s-oxide derivatives and pharmaceutical compositions comprising these compounds

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE

17P Request for examination filed

Effective date: 19900718

17Q First examination report despatched

Effective date: 19920601

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE

REF Corresponds to:

Ref document number: 99301

Country of ref document: AT

Date of ref document: 19940115

Kind code of ref document: T

REF Corresponds to:

Ref document number: 58906520

Country of ref document: DE

Date of ref document: 19940210

ITF It: translation for a ep patent filed

Owner name: ING. C. GREGORJ S.P.A.

ET Fr: translation filed
GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 19940307

REG Reference to a national code

Ref country code: GR

Ref legal event code: FG4A

Free format text: 3010724

EPTA Lu: last paid annual fee
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2061779

Country of ref document: ES

Kind code of ref document: T3

26N No opposition filed
EAL Se: european patent in force in sweden

Ref document number: 89108378.4

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20080619

Year of fee payment: 20

Ref country code: LU

Payment date: 20080519

Year of fee payment: 20

Ref country code: CH

Payment date: 20080616

Year of fee payment: 20

Ref country code: DE

Payment date: 20080531

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20080514

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20080527

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20080509

Year of fee payment: 20

Ref country code: NL

Payment date: 20080403

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20080514

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20080709

Year of fee payment: 20

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20080410

Year of fee payment: 20

BE20 Be: patent expired

Owner name: *HOECHST A.G.

Effective date: 20090510

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20090509

NLV7 Nl: ceased due to reaching the maximum lifetime of a patent

Effective date: 20090510

EUG Se: european patent has lapsed
REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20090511

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20090510

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20090511

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20090509

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20080514

Year of fee payment: 20