EP0341303A4 - Monoclonal antibody against the rgd-directed adhesion receptor of endothelial cells. - Google Patents

Monoclonal antibody against the rgd-directed adhesion receptor of endothelial cells.

Info

Publication number
EP0341303A4
EP0341303A4 EP19890900512 EP89900512A EP0341303A4 EP 0341303 A4 EP0341303 A4 EP 0341303A4 EP 19890900512 EP19890900512 EP 19890900512 EP 89900512 A EP89900512 A EP 89900512A EP 0341303 A4 EP0341303 A4 EP 0341303A4
Authority
EP
European Patent Office
Prior art keywords
rgd
monoclonal antibody
endothelial cells
antibody against
adhesion receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890900512
Other languages
German (de)
French (fr)
Other versions
EP0341303A1 (en
Inventor
David A Cheresh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of EP0341303A1 publication Critical patent/EP0341303A1/en
Publication of EP0341303A4 publication Critical patent/EP0341303A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP19890900512 1987-11-19 1988-11-17 Monoclonal antibody against the rgd-directed adhesion receptor of endothelial cells. Withdrawn EP0341303A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12304587A 1987-11-19 1987-11-19
US123045 1987-11-19

Publications (2)

Publication Number Publication Date
EP0341303A1 EP0341303A1 (en) 1989-11-15
EP0341303A4 true EP0341303A4 (en) 1990-06-27

Family

ID=22406412

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890900512 Withdrawn EP0341303A4 (en) 1987-11-19 1988-11-17 Monoclonal antibody against the rgd-directed adhesion receptor of endothelial cells.

Country Status (5)

Country Link
EP (1) EP0341303A4 (en)
JP (1) JPH02502156A (en)
AU (1) AU2807189A (en)
FI (1) FI893475A (en)
WO (1) WO1989005155A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DE69322860T2 (en) * 1992-04-03 1999-07-01 Genentech Inc ANTIBODIES AGAINST ALPHA V BETA 3 INTEGRIN
JP3490443B2 (en) † 1992-10-29 2004-01-26 ジ・オーストラリアン・ナショナル・ユニバーシティ Anti-angiogenic antibody
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US6056958A (en) * 1994-12-09 2000-05-02 Dupont Pharmaceuticals Method of treatment of arterial and venous thromboembolic disorders
RU2195312C2 (en) 1996-05-31 2002-12-27 Дзе Скриппс Рисерч Инститьют TECHNIQUES AND COMPOSITIONS USED TO INHIBIT αvβ5-CAUSED ANGIOGENESIS
ES2234099T3 (en) 1997-03-12 2005-06-16 Smithkline Beecham Corporation ANTI-ALFA BETA 3 HUMANIZED MONOCLANAL ANTIBODIES 3.
DK0973550T3 (en) * 1997-04-11 2003-02-10 Searle & Co Antagonistic anti-AVB3 integrin antibodies
US6193968B1 (en) 1997-04-11 2001-02-27 The Burnham Institute Methods for using anti-αvβ3 integrin antibody
US6160099A (en) * 1998-11-24 2000-12-12 Jonak; Zdenka Ludmila Anti-human αv β3 and αv β5 antibodies
AU2006261920A1 (en) 2005-06-23 2007-01-04 Medimmune, Llc Antibody formulations having optimized aggregation and fragmentation profiles
EP2467401B1 (en) 2009-08-19 2017-01-18 Merck Patent GmbH Antibodies for the detection of integrin complexes in ffpe material

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Proc. Natl. Acad. Sci. USA, Vol. 84, September 1987, pages 6471-6475; D.A. CHERESH: "Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor", the whole article. *
See also references of WO8905155A1 *

Also Published As

Publication number Publication date
WO1989005155A1 (en) 1989-06-15
AU2807189A (en) 1989-07-05
FI893475A0 (en) 1989-07-18
FI893475A (en) 1989-07-18
JPH02502156A (en) 1990-07-19
EP0341303A1 (en) 1989-11-15

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19890707

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19900627

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19900915