EP0249103A3 - Triaryl and triheteroaryl methane derivatives as redox indicators, and their use - Google Patents

Triaryl and triheteroaryl methane derivatives as redox indicators, and their use Download PDF

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Publication number
EP0249103A3
EP0249103A3 EP87107786A EP87107786A EP0249103A3 EP 0249103 A3 EP0249103 A3 EP 0249103A3 EP 87107786 A EP87107786 A EP 87107786A EP 87107786 A EP87107786 A EP 87107786A EP 0249103 A3 EP0249103 A3 EP 0249103A3
Authority
EP
European Patent Office
Prior art keywords
triaryl
triheteroaryl
redox indicators
methane derivatives
redox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87107786A
Other languages
German (de)
French (fr)
Other versions
EP0249103A2 (en
Inventor
Holger Dr. Heidenreich
Gerhard Dr. Wolfrum
Klaus Dr. Wehling
Herbert Dr. Hugl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of EP0249103A2 publication Critical patent/EP0249103A2/en
Publication of EP0249103A3 publication Critical patent/EP0249103A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)

Abstract

Die Erfindung betrifft Mittel zum Nachweis von Redoxreakionen enthaltend Verbindungen der allgemeinen Formel I in der A, B, D, G, m und X die in der Beschreibung angege­ bene Bedeutung haben, Triaryl- und Trihetarylmethanderivate als Redoxindikatoren. Diese Redoxindikatoren können sehr gut zum Nachweis von Waserstoffperoxid eingesetzt werden insbesondere unter Zuhilfenahme von Peroxidasen oder von peroxidativ-aktiven Substanzen. The invention relates to agents for the detection of redox reactions containing compounds of general formula I. in which A, B, D, G, m and X have the meaning given in the description, triaryl and trihetarylmethane derivatives as redox indicators. These redox indicators can be used very well for the detection of hydrogen peroxide, in particular with the help of peroxidases or of peroxidatively active substances.

EP87107786A 1986-06-10 1987-05-29 Triaryl and triheteroaryl methane derivatives as redox indicators, and their use Withdrawn EP0249103A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3619436 1986-06-10
DE19863619436 DE3619436A1 (en) 1986-06-10 1986-06-10 TRIARYL AND TRIHETARYLMETHANE DERIVATIVES AS REDOX INDICATORS AND THEIR USE

Publications (2)

Publication Number Publication Date
EP0249103A2 EP0249103A2 (en) 1987-12-16
EP0249103A3 true EP0249103A3 (en) 1990-01-17

Family

ID=6302658

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87107786A Withdrawn EP0249103A3 (en) 1986-06-10 1987-05-29 Triaryl and triheteroaryl methane derivatives as redox indicators, and their use

Country Status (5)

Country Link
US (1) US4988616A (en)
EP (1) EP0249103A3 (en)
JP (1) JPS62298573A (en)
AU (1) AU592440B2 (en)
DE (1) DE3619436A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012251A1 (en) * 1990-02-19 1991-08-22 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
GB9027131D0 (en) * 1990-12-14 1991-02-06 Rice Evans Catherine Diagnostic test
US5290682A (en) * 1991-05-31 1994-03-01 Polaroid Corporation Enzyme controlled processes and products
US20040157280A1 (en) * 2001-09-17 2004-08-12 Paul Wentworth Antibody mediated ozone generation
US20050129680A1 (en) * 2001-09-17 2005-06-16 Paul Wentworth Antimicrobial activity of antibodies
US20040116350A1 (en) * 2001-09-17 2004-06-17 Paul Wentworth Jr Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies
CA2505923A1 (en) * 2002-11-14 2004-05-27 Novartis Ag Antibody-or neutrophil-mediated ozone generation
US20070218562A1 (en) * 2006-03-20 2007-09-20 Shulong Li Color indicator for halamine treated fabric
JP5491203B2 (en) * 2007-03-05 2014-05-14 アドヴァンスト リキッド ロジック インコーポレイテッド Hydrogen peroxide droplet-based assay
TW201321371A (en) 2011-10-14 2013-06-01 Incyte Corp Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
CN105837496A (en) * 2016-04-22 2016-08-10 浙江大学 Preparation method of spiro[indenylisoindoline] compounds and derivatives thereof
CN107266351A (en) * 2017-06-26 2017-10-20 成都理工大学 Content of nitrite based on crystal violet hydrazides is determined
CN108640939A (en) * 2018-04-26 2018-10-12 福建师范大学泉港石化研究院 A kind of rhodamine base H2O2Fluorescence probe and its synthetic method
CN108409791A (en) * 2018-04-26 2018-08-17 福建师范大学泉港石化研究院 A kind of detection H2O2Fluorescence probe and preparation method thereof
CN109053750B (en) * 2018-08-21 2020-11-17 辽宁大学 Rhodamine hydrazine Schiff base derivative and preparation method and application thereof
CN109142342B (en) * 2018-08-29 2020-06-26 四川大学 Method for detecting elemental sulfur
CN109540884B (en) * 2018-12-29 2020-02-18 四川大学 Method for detecting hydrazine hydrate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110682A2 (en) * 1982-11-26 1984-06-13 Syva Company Activated aryl capped fluorescent compounds, and assay methods and systems using them as fluorogenic precursors
EP0141962A1 (en) * 1983-09-15 1985-05-22 The Hilton - Davis Chemical Company Hydrazine derivatives of fluorans and use thereof in electrochromic recording systems

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5631641A (en) * 1979-08-24 1981-03-31 Yatoron:Kk New quantitative determination method for hydrogen peroxide
US4407960A (en) * 1980-06-25 1983-10-04 American Sterilizer Company Visual chemical indicating composition for monitoring sterilization
US4539579A (en) * 1982-11-05 1985-09-03 The Hilton-Davis Chemical Co. Compounds, processes and marking systems
JPH0764986B2 (en) * 1984-03-02 1995-07-12 和光純薬工業株式会社 New coloring reagent
US4670385A (en) * 1984-05-21 1987-06-02 Eastman Kodak Company Compositions and elements containing triarylmethane leuco dyes and methods using same
JPS62296A (en) * 1985-06-26 1987-01-06 Kyowa Medetsukusu Kk Method of determining hydrogen peroxide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0110682A2 (en) * 1982-11-26 1984-06-13 Syva Company Activated aryl capped fluorescent compounds, and assay methods and systems using them as fluorogenic precursors
EP0141962A1 (en) * 1983-09-15 1985-05-22 The Hilton - Davis Chemical Company Hydrazine derivatives of fluorans and use thereof in electrochromic recording systems

Also Published As

Publication number Publication date
DE3619436A1 (en) 1987-12-17
JPS62298573A (en) 1987-12-25
AU592440B2 (en) 1990-01-11
EP0249103A2 (en) 1987-12-16
US4988616A (en) 1991-01-29
AU7382987A (en) 1987-12-17

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Inventor name: HUGL, HERBERT, DR.

Inventor name: HEIDENREICH, HOLGER, DR.

Inventor name: WOLFRUM, GERHARD, DR.

Inventor name: WEHLING, KLAUS, DR.