EP0238551A4 - Methods for the recovery of tissue plasminogen activator. - Google Patents

Methods for the recovery of tissue plasminogen activator.

Info

Publication number: EP0238551A4
Authority: EP; European Patent Office
Prior art keywords: recovery; methods; plasminogen activator; tissue plasminogen; tissue
Prior art date: 1985-09-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19860905624

Other languages

German (de)

French (fr)

Other versions

EP0238551A1 (en

Inventor

Craig W Rice

Michael John Morser

Peter Donner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Berlex Laboratories Inc

Original Assignee

Codon

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-09-06

Filing date

1986-09-05

Publication date

1988-02-01

1986-09-05 Application filed by Codon filed Critical Codon

1987-09-30 Publication of EP0238551A1 publication Critical patent/EP0238551A1/en

1988-02-01 Publication of EP0238551A4 publication Critical patent/EP0238551A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP19860905624 1985-09-06 1986-09-05 Methods for the recovery of tissue plasminogen activator. Withdrawn EP0238551A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77333485A	1985-09-06	1985-09-06
US773334		1985-09-06

Publications (2)

Publication Number	Publication Date
EP0238551A1 EP0238551A1 (en)	1987-09-30
EP0238551A4 true EP0238551A4 (en)	1988-02-01

Family

ID=25097914

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19860905624 Withdrawn EP0238551A4 (en)	1985-09-06	1986-09-05	Methods for the recovery of tissue plasminogen activator.

Country Status (3)

Country	Link
EP (1)	EP0238551A4 (en)
AU (1)	AU606582B2 (en)
WO (1)	WO1987001389A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3512910A1 (en) *	1985-04-11	1986-10-16	Behringwerke Ag, 3550 Marburg	METHOD FOR CLEANING PLASMINOGEN ACTIVATORS
US4960702A (en) *	1985-09-06	1990-10-02	Codon	Methods for recovery of tissue plasminogen activator
US4898825A (en) *	1986-05-07	1990-02-06	Mitsui Toatsu Chemicals, Incorporated	Methods for purification of single-chain and double-chain tissue plasminogen activator
IL82746A (en) *	1986-06-06	1994-10-07	Genentech Inc	Process for producing biologically active tissue-type plasminogen activator
JPH01500563A (en) *	1986-07-16	1989-03-01	セルテック　リミテッド	Purification method
JPS6463378A (en) *	1986-08-11	1989-03-09	Mitsui Toatsu Chemicals	Separation of single stranded tpa and double standard tpa
JPS6379591A (en) *	1986-09-22	1988-04-09	Mitsui Toatsu Chem Inc	Purification of tpa
AU1668988A (en) *	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
US4929560A (en) *	1988-02-03	1990-05-29	Damon Biotech, Inc.	Recovery of tissue plasminogen activator
WO1990002175A1 (en) *	1988-08-16	1990-03-08	Novo Nordisk A/S	A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
US4980165A (en) *	1989-01-27	1990-12-25	Genetics Institute, Inc.	Pharmaceutical formulations of plasminogen activator proteins
EP0485504B1 (en) *	1989-08-11	1993-12-01	Zymogenetics, Inc.	Cell culture methods for producing activated protein c

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4245051A (en) *	1978-03-30	1981-01-13	Rockefeller University	Human serum plasminogen activator
NL8003402A (en) *	1980-06-11	1982-01-04	Leuven Res & Dev Vzw	NEW PLASMINOGEN ACTIVATOR AND PHARMACEUTICAL PREPARATION WITH THROMBOLYTIC ACTION.
DE3584902D1 (en) *	1984-02-29	1992-01-30	Asahi Chemical Ind	AQUEOUS SOLUTION OF AN INCREASED CONCENTRATION OF TISSUE PLASMINOGEN ACTIVATOR AND PRODUCTION METHOD.
AU593264B2 (en) *	1985-07-10	1990-02-08	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor

1986
- 1986-09-05 WO PCT/US1986/001831 patent/WO1987001389A1/en not_active Application Discontinuation
- 1986-09-05 EP EP19860905624 patent/EP0238551A4/en not_active Withdrawn
- 1986-09-05 AU AU63369/86A patent/AU606582B2/en not_active Ceased

Also Published As

Publication number	Publication date
WO1987001389A1 (en)	1987-03-12
AU6336986A (en)	1987-03-24
AU606582B2 (en)	1991-02-14
EP0238551A1 (en)	1987-09-30

Legal Events

Date	Code	Title	Description
1987-08-15	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1987-09-30	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1987-11-04	17P	Request for examination filed	Effective date: 19870909
1988-03-23	A4	Supplementary search report drawn up and despatched	Effective date: 19880201
1991-06-26	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: BERLEX LABORATORIES, INC.
1992-11-04	17Q	First examination report despatched	Effective date: 19920918
1994-11-19	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1995-01-11	18D	Application deemed to be withdrawn	Effective date: 19940708
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: RICE, CRAIG, W. Inventor name: MORSER, MICHAEL, JOHN Inventor name: DONNER, PETER

Publication	Publication Date	Title
GB2179948B (en)	1989-08-16	Poly-kringle plasminogen activator
AU4777785A (en)	1986-03-24	Modified tissue plasminogen activators
GB8312221D0 (en)	1983-06-08	Human tissue plasminogen activator
ES553651A0 (en)	1988-01-01	A PROCEDURE FOR PREPARING AN ACTIVATOR OF PLASMINOGEN.
AU5330286A (en)	1986-08-14	Modified tissue-type plasminogen activator
ZA833174B (en)	1984-08-29	Human tissue plasminogen activator
AU6806487A (en)	1987-07-30	Tissue plasminogen activator
EP0238551A4 (en)	1988-02-01	Methods for the recovery of tissue plasminogen activator.
AU6180486A (en)	1987-03-05	Novel tissue plasminogen activator derivatives
OA08402A (en)	1988-06-30	Method for the treatment of natural rubber field latex.
EP0208486A3 (en)	1988-01-20	Process for producing tissue plasminogen activator
AU602681B2 (en)	1990-10-25	Modified plasminogen activators
GB8414992D0 (en)	1984-07-18	Plasminogen activator
NZ219920A (en)	1989-08-29	Purification of t.p.a. (tissue plasminogen activator)
AU1103588A (en)	1988-07-15	New plasminogen activators
EP0251806A3 (en)	1989-04-12	Plasminogen activator production
AU7090787A (en)	1987-10-08	Tissue plasminogen activator
EP0225177A3 (en)	1987-11-25	Dna sequence coding for human tissue plasminogen activator
AU608232C (en)	1992-05-07	Modified tissue plasminogen activator
IE861388L (en)	1986-11-28	Tissue plasminogen activator
ZA866053B (en)	1988-03-30	Poly-kringle plasminogen activator
IE860861L (en)	1986-10-03	Plasminogen activator
GB8901422D0 (en)	1989-03-15	New tissue plasminogen activator
GB8815245D0 (en)	1988-08-03	New tissue plasminogen activator
AU7554687A (en)	1988-01-14	Modified tissue plasminogen activator