EP0210153A2 - Device for transferring a substance between at least two vessels in a closed system - Google Patents

Device for transferring a substance between at least two vessels in a closed system Download PDF

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Publication number
EP0210153A2
EP0210153A2 EP86850262A EP86850262A EP0210153A2 EP 0210153 A2 EP0210153 A2 EP 0210153A2 EP 86850262 A EP86850262 A EP 86850262A EP 86850262 A EP86850262 A EP 86850262A EP 0210153 A2 EP0210153 A2 EP 0210153A2
Authority
EP
European Patent Office
Prior art keywords
collection container
plunger
cannula
rod
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86850262A
Other languages
German (de)
French (fr)
Other versions
EP0210153A3 (en
Inventor
Erik Ekholmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediplast AB
Original Assignee
Mediplast AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediplast AB filed Critical Mediplast AB
Publication of EP0210153A2 publication Critical patent/EP0210153A2/en
Publication of EP0210153A3 publication Critical patent/EP0210153A3/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0657—Pipetting powder

Definitions

  • the present invention relates to a device for transferring a liquid from a vessel e.g. a bloodvessel, a ampoule or the like to a collection container, both of which can be attached to each other via a connecting apparatus with a two sided cannula, where at least the collecting container is closed at one end by a sealing cap which can be penetrated by the cannula, the collection container being in the shape of a cylinder for a plunger equipped with consist of a transparent tube an axial penetrating canal.
  • a vessel e.g. a bloodvessel, a ampoule or the like
  • a collection container both of which can be attached to each other via a connecting apparatus with a two sided cannula, where at least the collecting container is closed at one end by a sealing cap which can be penetrated by the cannula, the collection container being in the shape of a cylinder for a plunger equipped with consist of a transparent tube an axial penetrating canal.
  • the blood is mixed in a test tube with a citrate solution, after which the solution is transferred to a pipette up to a certain level.
  • the pipette is placed in a holder with a length scale.
  • US-4.037.464 an apparatus used as a plunger in the test tube
  • the purpose of the present invention is to achieve an apparatus of the above mentioned type with which the substance can be transferred between different vessels, for example transfer of a blood sample from a blood vessel to a pipette, in a closed system without contamination risk, and which apparatus is simpleand inexpensive to produce. This has been achieved according to the invention
  • FIGS 1-3 a conventional cannula set is shown which used for blood sample extracton according to the vacuum system.
  • the set consists of a cannula case 1 one end of which is equipped with an attachment to a cannula with punctation points 3 and 4 at both ends.
  • the cannula point 3 inside the case 1 is apporpriately surrounded by a self sealing membrane 5 in the form of a rubber cap which prevents blood leakage.
  • a vein is punctured by the outer point 4 of the cannula 2, while the inner point 3 is used for puncturing the rubber stopper 7 to a collection container 6.
  • the collection container 6 consists of a cylinder open at both ends, one end of which is sealed by a rubber stopper 7 intended to be punctured by the cannula 2.
  • a plunger 8 is fitted, to which is attached a rod 9, e.g. a transparent pipette tube or the like both of which are provided with an axial penetrating canal 21.
  • a rod 9 e.g. a transparent pipette tube or the like both of which are provided with an axial penetrating canal 21.
  • the collection container 6 contains shoulders 10, which prevent the plunger 8 from being removed from the container 6.
  • the free end of the pipette tube 9 away from the plunger 8 is closed with a stopper 11, for example a plug, and withit it a blood filter 12 is placed.
  • a valve can be used which can open and close the passage in the pipette tube 9.
  • Transfer of the blood-citrate mixture from the container 6 to the pipette 9 is accomplished by removing the stopper 11 and attaching the pipette 9 to a holder 13 (figure 4) by its upper part.
  • the container 6 with blood-citrate solution is moved upward in the direction of the plunger 8, whereby a blood column is pressed up in the pipette 9.
  • the pipette is fixed in the lower part of the holder 13 the pipette is fixed in the lower part of the holder in attachments 14 for that purpose, between which the pipette tube is gripped so that the tube is closed.
  • both the pipette tube 9 and the collection container 6 can be discarded as a unit.
  • FIG. 5-7 The exemplification shown in figures 5-7 is designed primarily for transfer of a liquid enclosed in an ampule 14 to the collection container 6 and thereafter fruther to its intended use, for example injection into a patient.
  • the outer part of the cannula 2 equipped with a point 4 contains a self sealing membrane 15 in the form of a rubber cap, which seals the cannula point 4 after it has penetrated the ampule's 14 rubber stopper 16.
  • the tube has a coupling member 17 on its end away from the plunger 8, to which a multi-ported valve is 18 is attachable.
  • a flexible pressure equalization chamber 19 is attached to one of the valve's 18 connectors for equalization of the pressure in the ampule 14, when liquid is sucked up from it to the collection container 6.
  • a non-wettable filter can be arranged in front of the pressure equalization chamber 19.
  • the plunger 8 In use the plunger 8 is moved toward the rubber stopper 7, whereby teh valve 18 is adjusted to allow air from the collection container 6 to be transferred to the pressure equalization chamber 19. The valve 18 is then closed.
  • the collection container 6 can now be attached to the ampule 14 via the cannula set 1, 2 and liquid can be transferred to the collection container 6 by moving the plunger 8 downwards away from the rubber stopper 7.
  • the reduced pressure in the ampule 14 is so large that the pressure equalization chamber 19 is attached to the tube 9. Air can now rise up in the container 6, and be pressed by the plunger 8 up into the ampule 14 and achieve a pressure equalization in it. This procedure can be repeated when necessary.
  • the collection container 6 can be designed as a delivery container for certain medications in powder form, for example freeze dried cell poisons, which are dissolved by teh liquid which is taken from the ampule 14.
  • teh liquid which is taken from the ampule 14.
  • a liquid or air pereable filter (not shown) can be placed in teh tube or attached to it.
  • type teh valve 18 is appropriately permanently attached to the tube 9, as well as the pressure equalization chamber 19 to the valve.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)

Abstract

An arrangement for a closed system for transferring a liquid from a vessel to a collection container (6) which are attachable to each other via a coupling member (17) with a two sided cannula (2). One end of the collection container (6) is closed by a seal (7) which can be penetrated by the cannula (2). Behind the seal inside the container is a plunger (8) with an axial penetrating canal to which a tube (9) is attached. At the tube end away from the plunger (8) an openable stopper (11) is attached. By axial motion of the plunger (8) in the collection container (6) away from the seal reduced pressure is achieved in the container for sucking up the liquid through the cannula (2). After opening the stopper (11) the liquid can be forced out into the tube (9) by axial motion of the plunger toward the seal (7).

Description

  • The present invention relates to a device for transferring a liquid from a vessel e.g. a bloodvessel, a ampoule or the like to a collection container, both of which can be attached to each other via a connecting apparatus with a two sided cannula, where at least the collecting container is closed at one end by a sealing cap which can be penetrated by the cannula, the collection container being in the shape of a cylinder for a plunger equipped with consist of a transparent tube an axial penetrating canal.
    • Background of the invention
  • In determining blood's sinking reaction the blood is mixed in a test tube with a citrate solution, after which the solution is transferred to a pipette up to a certain level. The pipette is placed in a holder with a length scale. The transfer of the blood-citrate mixture from the test tube to the pipette as a suction tube or by equipping the pipette with an apparatus used as a plunger in the test tube (US-4.037.464). In all cases there is a certain risk of contamination during transfer of the blood sample to the pipette. The problem has recently been accentuated because of the debate about AIDS risks and the personnel concerned must be protected from all contact with contaminated blood samples.
  • Also in other situations, for example during transfer of a substance contained in an ampule to another vessel and subsequently to its intended use an injection into a patient, one wants to protect the personnel concerned from contamination. Examples of such poisonous substances are cell poisons, isotope solutions and allergy inducing substances of different types.
    • The purpose of the invention and its most important characteristics
  • The purpose of the present invention is to achieve an apparatus of the above mentioned type with which the substance can be transferred between different vessels, for example transfer of a blood sample from a blood vessel to a pipette, in a closed system without contamination risk, and which apparatus is simpleand inexpensive to produce. This has been achieved according to the invention
    • Description of the drawings
  • In the following the invention will be described in detail with reference to a pair of exemplifications shown on the attached drawings.
    • Figures 1-3 show sections through an exemplification of the apparatus according to the invention designed for determination of the sinking reaction, to which apparatus is attached a cannula set for vein punctuation during three different stages of the sample extraction procedure.
    • Figure 4 shows in perspective a part of a holder for determination of the sinking reaction with inserted pipettes equipped with apparatus according to the invention.
    • Figure 5 shows a section through a second exemplification of the apparatus according to the invention designed for transfer of a substance stored in an ampule.
    • Figure 6 shows the apparatus according to figures 5 and 6 which is uncoupled from the ampule and cannula set and attached to an injection needle for subsequent transfer of the substance to its intended use.
    Description of the exemplifications
  • In figures 1-3 a conventional cannula set is shown which used for blood sample extracton according to the vacuum system. The set consists of a cannula case 1 one end of which is equipped with an attachment to a cannula with punctation points 3 and 4 at both ends. The cannula point 3 inside the case 1 is apporpriately surrounded by a self sealing membrane 5 in the form of a rubber cap which prevents blood leakage. During sample extraction a vein is punctured by the outer point 4 of the cannula 2, while the inner point 3 is used for puncturing the rubber stopper 7 to a collection container 6.
  • The collection container 6 according to the invention consists of a cylinder open at both ends, one end of which is sealed by a rubber stopper 7 intended to be punctured by the cannula 2. In the cylindrical collection container 6, which can be made of plastic or glass, a plunger 8 is fitted, to which is attached a rod 9, e.g. a transparent pipette tube or the like both of which are provided with an axial penetrating canal 21. Inside its open end the collection container 6 contains shoulders 10, which prevent the plunger 8 from being removed from the container 6. The free end of the pipette tube 9 away from the plunger 8 is closed with a stopper 11, for example a plug, and withit it a blood filter 12 is placed. Instead of the stopper 11 a valve can be used which can open and close the passage in the pipette tube 9.
  • In use to the collection container 6 with attached pipette tube 9 is guided in the cannula set's case 1, as is shown in figure 1. Reduced pressure is created in the container 6 by drawing the plunger 8 toward the open end of the container. After vein punctuation by the outer point 4 of the cannula 2 the rubber stopper 7 is punctured by the inner point 3 as is shown in figure 2, whereby the reduced pressure in the container 6 draws blood into it. In the container 6 a certain amount of citrate solution is appropriately contained. The container 6 with attached pipette tube 9 is them removed from the case 1, as shown in figure 3, whereby the membrane 5 reseals itself around the inner cannula point 3.
  • Transfer of the blood-citrate mixture from the container 6 to the pipette 9 is accomplished by removing the stopper 11 and attaching the pipette 9 to a holder 13 (figure 4) by its upper part. The container 6 with blood-citrate solution is moved upward in the direction of the plunger 8, whereby a blood column is pressed up in the pipette 9. When the blood has reached a designated level on the holder 13 the pipette is fixed in the lower part of the holder 13 the pipette is fixed in the lower part of the holder in attachments 14 for that purpose, between which the pipette tube is gripped so that the tube is closed. After the test has been completed both the pipette tube 9 and the collection container 6 can be discarded as a unit.
  • Thus a completely closed system from blood sample extraction to sinking reaction without contamination risk in any step is ahcieved using the arrangement according to the invention. If desired the outer part of the cannula 2 wiht point 4 can be enclosed by a rubber cap.
  • The exemplification shown in figures 5-7 is designed primarily for transfer of a liquid enclosed in an ampule 14 to the collection container 6 and thereafter fruther to its intended use, for example injection into a patient. The outer part of the cannula 2 equipped with a point 4 contains a self sealing membrane 15 in the form of a rubber cap, which seals the cannula point 4 after it has penetrated the ampule's 14 rubber stopper 16. The tube has a coupling member 17 on its end away from the plunger 8, to which a multi-ported valve is 18 is attachable. A flexible pressure equalization chamber 19 is attached to one of the valve's 18 connectors for equalization of the pressure in the ampule 14, when liquid is sucked up from it to the collection container 6. A non-wettable filter can be arranged in front of the pressure equalization chamber 19.
  • In use the plunger 8 is moved toward the rubber stopper 7, whereby teh valve 18 is adjusted to allow air from the collection container 6 to be transferred to the pressure equalization chamber 19. The valve 18 is then closed. The collection container 6 can now be attached to the ampule 14 via the cannula set 1, 2 and liquid can be transferred to the collection container 6 by moving the plunger 8 downwards away from the rubber stopper 7. When the reduced pressure in the ampule 14 is so large that the pressure equalization chamber 19 is attached to the tube 9. Air can now rise up in the container 6, and be pressed by the plunger 8 up into the ampule 14 and achieve a pressure equalization in it. This procedure can be repeated when necessary.
  • When liquid from one or more ampules 14 has been transferred to the collection container 6 it is uncoupled from the cannula set 1, 2 and possibly also from the valve 18. The coupling member 17 is then connected to an injection needle 20, a vein catheter, infusion apparatus or the like for transfer of the liquid to the intended use, for example to a patient. Of course the valve 18 can remain and the cannula 20 or the equivalent can be attached to the tube 9 via the valve 18.
  • The collection container 6 can be designed as a delivery container for certain medications in powder form, for example freeze dried cell poisons, which are dissolved by teh liquid which is taken from the ampule 14. In order to prevent the powder from blocking the penetrating cannal in the tube 9 a liquid or air pereable filter (not shown) can be placed in teh tube or attached to it. For this application type teh valve 18 is appropriately permanently attached to the tube 9, as well as the pressure equalization chamber 19 to the valve.
  • The invention is not restricted to the exemplifications shown but instead a number of modifications is possible within the framework of the patent claims.

Claims (6)

1. Device for transferring a liquid from a vessel e.g. a bloodvessel, a ampule (14) or the like to a collection container (6), both of which can be attached to each other via a connecting apparatus (1) with a two sided cannula (2), where at least the collection container (6) is closed at one end by a sealing cap (7) which can be penetrated by the cannula (2), the collection container (6) being in the shape of a cylinder for a plunger (8), equipped with a rod (9), both of which are provided with an axial penetrating canal,
characterized by,
that the collection container (6) consists of a cylinder open at both ends, one end of which is sealable by said sealing cap (7) and through which other end the plunger rod (9) is extending, that on the free end of the plunger rod (9) an openable stopper (11) is attached whereby through axial motion of the plunger in the collection container away from the sealing cap (7) reduced pressure is achieved in the collection container for sucking up the liquid in it through the cannula (2), and after opening the stopper (11) the liquid can be brought into the rod (9) by motion of the plunger (8) toward the collection container's (6) sealing cap (7).
2. Device according to claim 1,
characterized by,
the said rod (9) consists of a transparent tube being shaped as a pipette to be used in connection with determination of the sinking reaction for a blood sample.
3. Device according to claim 2,
characterized by,
that a blood filter (12) is attached to the pipette (9) within the stopper (11).
4. Device according to claim 1,
characterized by,
that the rod (9) having a coupling member (17) at the end away from the plunger for attachment of a cannula (20), vein catheter, infusion apparatus or the like.
5. Device according to claim 4,
characterized by,
that a multi-ported valve (18) is connected to the tube (9) or coupling member (17), where a flexible pressure equalization chamber (19) is connectable to one of the valve ports.
6. Device according to one or several of the above claims,
characterized by,
that the two sided cannula's (2) inner and/or outer parts equipped with points (3, 4) being enclosed each in its own self sealing membrane (5, 15) in the form of a rubber cap or the like.
EP86850262A 1985-07-24 1986-07-18 Device for transferring a substance between at least two vessels in a closed system Withdrawn EP0210153A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8503583 1985-07-24
SE8503583A SE8503583L (en) 1985-07-24 1985-07-24 DEVICE FOR TRANSFERING A SUBSTANCE BETWEEN ATMINSTONE TWO KERL IN A CLOSED SYSTEM

Publications (2)

Publication Number Publication Date
EP0210153A2 true EP0210153A2 (en) 1987-01-28
EP0210153A3 EP0210153A3 (en) 1988-06-08

Family

ID=20360960

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86850262A Withdrawn EP0210153A3 (en) 1985-07-24 1986-07-18 Device for transferring a substance between at least two vessels in a closed system

Country Status (3)

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EP (1) EP0210153A3 (en)
JP (1) JPS6331671A (en)
SE (1) SE8503583L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0732766B2 (en) * 1990-09-26 1995-04-12 テルモ株式会社 Blood collection needle
JPH08126630A (en) * 1994-11-01 1996-05-21 Terumo Corp Blood collecting appliance and blood collecting needle

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4037464A (en) * 1974-06-24 1977-07-26 Mediplast Ab Device for transferring blood or a similar fluid to a pipette
US4192320A (en) * 1977-07-28 1980-03-11 Becton, Dickinson And Company Adapter for syringe
WO1980002106A1 (en) * 1979-04-02 1980-10-16 American Hospital Supply Corp Blood sampler
DE3025800A1 (en) * 1980-07-08 1982-02-04 Helga 4130 Moers Ufermann Sampling and sink rate testing of blood - using settling tube connected directly to syringe
US4392497A (en) * 1980-12-02 1983-07-12 Ghaussy Rahmat U Erythrocyte sedimentation rate apparatus and method
WO1985003350A1 (en) * 1984-01-20 1985-08-01 Anders Trell A device for taking and dispensing blood samples for the purpose of determining blood sedimentation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4037464A (en) * 1974-06-24 1977-07-26 Mediplast Ab Device for transferring blood or a similar fluid to a pipette
US4192320A (en) * 1977-07-28 1980-03-11 Becton, Dickinson And Company Adapter for syringe
WO1980002106A1 (en) * 1979-04-02 1980-10-16 American Hospital Supply Corp Blood sampler
DE3025800A1 (en) * 1980-07-08 1982-02-04 Helga 4130 Moers Ufermann Sampling and sink rate testing of blood - using settling tube connected directly to syringe
US4392497A (en) * 1980-12-02 1983-07-12 Ghaussy Rahmat U Erythrocyte sedimentation rate apparatus and method
WO1985003350A1 (en) * 1984-01-20 1985-08-01 Anders Trell A device for taking and dispensing blood samples for the purpose of determining blood sedimentation

Also Published As

Publication number Publication date
SE8503583D0 (en) 1985-07-24
EP0210153A3 (en) 1988-06-08
SE8503583L (en) 1987-01-25
JPS6331671A (en) 1988-02-10

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