EP0191438A2 - Double capsule for receiving medicines - Google Patents

Double capsule for receiving medicines Download PDF

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Publication number
EP0191438A2
EP0191438A2 EP86101626A EP86101626A EP0191438A2 EP 0191438 A2 EP0191438 A2 EP 0191438A2 EP 86101626 A EP86101626 A EP 86101626A EP 86101626 A EP86101626 A EP 86101626A EP 0191438 A2 EP0191438 A2 EP 0191438A2
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EP
European Patent Office
Prior art keywords
capsule
web
capsules
bodies
another
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86101626A
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German (de)
French (fr)
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EP0191438A3 (en
Inventor
Josef Hofer
Friedrich Stanislaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of EP0191438A2 publication Critical patent/EP0191438A2/en
Publication of EP0191438A3 publication Critical patent/EP0191438A3/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Definitions

  • the invention relates to a capsule, in particular made of hard gelatin, for taking medication.
  • capsules allow an exact dosage of the drug. They are also preferably used to apply unpleasant tasting or smelling drugs orally.
  • additives are added to the capsule material, such as preservatives, plasticizers, flavors or colors.
  • Known capsules made of hard gelatin consist of two parts, namely a capsule body and a capsule cap, which are inserted into one another after filling.
  • the sizes of such hard gelatin capsules are standardized and have a capacity between 0.13 ml and about 1.4 ml.
  • the invention has for its object to provide a capsule arrangement with which the drug dosage can be varied in a simple manner.
  • this object is achieved in that two capsule bodies, each of which can be closed with a capsule cap, are connected to one another by a breakable web.
  • the separation according to the invention into two contiguous but separately ingestible capsules enables a larger amount of medicament to be distributed over two capsules which are taken one after the other. By connecting the capsules, the patient is reminded that two capsules - but no longer - should be taken.
  • the double capsule according to the invention also makes it possible to save dosage forms for certain medications, the dose of which is typically increased in the course of therapy. Instead of having to provide different capsule sizes and corresponding packs, the patient can be prescribed to take only one capsule at the start of therapy and to increase the dose to the entire double capsule at a certain time. Different filling quantities for the two capsule bodies connected to one another can further increase the variation possibilities with regard to the dosage.
  • the invention also enables the combination of two incompatible dosage forms, which can be taken by the patient with practically one grip, without confusion or mistakes being possible. The same applies to the combination of two different dosage forms.
  • chronobiologically constructed pharmaceutical forms can be simplified with the double capsule in a very sensible way, for example by taking the first partial capsule in the morning and the second partial capsule in the evening.
  • Retard and initial pellets can also be combined with one another without mixing problems according to the teaching of the invention.
  • the web connects opposite bottoms of two capsule bodies and is provided with a predetermined breaking point.
  • the web is preferably made of hard gelatin and integrally formed with both capsule bodies.
  • a plurality of capsule bodies in a row are each connected to one another by frangible webs.
  • the preferred embodiments of the webs described with the aid of the double capsule can also be transferred to the capsule series.
  • FIG. 1 schematically shows a double capsule 10, which is composed of two capsule bodies 12, 12 'and the associated capsule caps 14, 14'.
  • a web 16 connects coaxially the longitudinal axes of both capsule bodies 12, 12 'the bottoms 18, 18' of the capsule body.
  • a predetermined breaking point 20 is formed in the web 16 so that the two capsule bodies 12, 12 'can be separated from one another.
  • the double capsule 10 according to the invention can e.g. in a further development of the well-known immersion process for the production of individual capsules.
  • immersion sticks arranged in rows on metal slats are immersed in gelatin solution. So that a uniform gelatin layer forms, the slats are turned around after being pulled out of the solution.
  • This process can be modified in order to produce the double capsules according to the invention in such a way that the drop extension which is formed when the dip sticks are pulled out of the solution in the middle of the subsequent capsule base is used to form the web according to the invention.
  • two capsules can be joined together, depending on the dry state, if necessary with heating.
  • the capsules are also filled similarly to conventional capsules. After filling the upper capsule body and sealing it by means of the capsule cap, a rotation of 180 ° takes place and the process is repeated.
  • FIG. 2 shows two capsules 22, 22 'which are produced in a conventional manner by immersion and which are connected to one another in the area of the drop extension 24, 24' in such a way that a continuous, integral double capsule is formed.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The capsule, consisting in particular of hard gelatine, has two capsule bodies (12,12') which can in each case be closed off by means of a capsule cap (14,14') and are connected to one another by a breakable branch (16). <IMAGE>

Description

Die Erfindung betrifft eine Kapsel, insbesondere aus Hartgelatine, zur Aufnahme von Medikamenten.The invention relates to a capsule, in particular made of hard gelatin, for taking medication.

Es ist bekannt, Arzneimittel in Kapseln aus Gelatine darzureichen. Derartige Kapseln ermöglichen eine genaue Dosierung des Arzneistoffes. Sie werden auch bevorzugt eingesetzt, um unangenehm schmeckende oder riechende Arzneimittel peroral anzuwenden. Je nach Herstellungs- und Anwendungsart werden dem Kapselmaterial Zusatzstoffe beigemischt, wie beispielsweise Konservierungsmittel, Weichmacher, Geschmacksstoffe oder Farbstoffe.It is known to administer drugs in gelatin capsules. Such capsules allow an exact dosage of the drug. They are also preferably used to apply unpleasant tasting or smelling drugs orally. Depending on the type of manufacture and application, additives are added to the capsule material, such as preservatives, plasticizers, flavors or colors.

Bekannte Kapseln aus Hartgelatine (auch Steckkapseln genannt) setzen sich aus zwei Teilen, nämlich einem Kapsel-Körper und einer Kapsel-Kappe zusammen, welche nach dem Füllen eineinander gesteckt werden. Die Größen derartiger Hartgelatinekapseln sind genormt und haben ein Fassungsvermögen zwischen 0,13 ml und etwa 1,4 ml.Known capsules made of hard gelatin (also called plug capsules) consist of two parts, namely a capsule body and a capsule cap, which are inserted into one another after filling. The sizes of such hard gelatin capsules are standardized and have a capacity between 0.13 ml and about 1.4 ml.

Bei der Applikation von Arzneimitteln ist häufig eine sehr individuelle Dosierung erforderlich. Die Dosierung hängt nicht nur vom Patienten, wie dessen Alter, Geschlecht, Gewicht oder Krankheitszustand etc. ab, sondern auch vom zeitlichen Verlauf der Therapie. So können am Anfang der Therapie geringere Dosen eingenommen werden, die sich allmählich steigern oder auch umgekehrt. Die herkömmlichen, einstückigen Kapseln, eröffnen nur sehr geringe Möglichkeiten, die Dosierung individuell einzustellen. Bei einer Vielzahl von Therapien ist es erforderlich, daß der Patient regelmäßig mehr als ein Arzneimittel in Kombination einnimmt. Um hierbei Verwechslungen und andere Irrtümer seitens des Patienten auszuschließen, sind Verpackungen entwikkelt worden, denen der Patient jeweils die vorgeschriebene Kombination an Einzeltabletten und/oder Kapseln entnehmen kann. Diese Verpackungen mit einzelnen Fächern sind aber relativ aufwendig und nur für sehr komplizierte Therapien gebräuchlich.When applying drugs, a very individual dosage is often required. The dosage depends not only on the patient, such as his age, gender, weight or disease status etc., but also on the course of therapy over time. At the beginning of therapy, lower doses can be taken, which gradually increase, or vice versa. The conventional, one-piece capsules only open up very few possibilities to adjust the dosage individually. A variety of therapies require that the patient regularly take more than one drug in combination. To avoid confusion and other errors on the part of the patient, packaging has been developed from which the patient can take the prescribed combination of individual tablets and / or capsules. However, this packaging with individual subjects is relatively complex and only used for very complicated therapies.

Der Erfindung liegt die Aufgabe zugrunde, eine Kapsel-Anordnung zu schaffen, mit welcher die Arzneimitteldosierung in einfacher Weise variiert werden kann.The invention has for its object to provide a capsule arrangement with which the drug dosage can be varied in a simple manner.

Erfindungsgemäß wird diese Aufgabe dadurch gelöst, daß zwei jeweils mit einer Kapsel-Kappe verschließbare Kapsel-Körper miteinander durch einen brechbaren Steg verbunden sind.According to the invention, this object is achieved in that two capsule bodies, each of which can be closed with a capsule cap, are connected to one another by a breakable web.

Die erfindungsgemäße Auftrennung in zwei zusammenhängende, aber getrennt einnehmbare Kapseln ermöglicht eine größere Arzneimittelmenge auf zwei Kapseln zu verteilen, welche nacheinander eingenommen werden. Durch die Verbindung der Kapseln wird der Patient daran erinnert, daß zwei Kapseln - aber auch nicht mehr - eingenommen werden sollen.The separation according to the invention into two contiguous but separately ingestible capsules enables a larger amount of medicament to be distributed over two capsules which are taken one after the other. By connecting the capsules, the patient is reminded that two capsules - but no longer - should be taken.

Auch ermöglicht die erfindungsgemäße Doppel-Kapsel eine Einsparung von Darreichungsformen für bestimmte Arzneien, deren Dosis typischerweise im Verlaufe einer Therapie gesteigert wird. Anstatt unterschiedliche Kapselgrößen und entsprechende Packungen bereitstellen zu müssen, kann dem Patienten vorgeschrieben werden, am Beginn der Therapie nur eine Kapsel einzunehmen und zu einem bestimmten Zeitpunkt die Dosis auf die ganze Doppel-Kapsel zu erhöhen. Durch unterschiedliche Füllmengen für die beiden miteinander verbundenen Kapsel-Körper lassen sich die Variationsmöglichkeiten hinsichtlich der Dosierung noch erhöhen.The double capsule according to the invention also makes it possible to save dosage forms for certain medications, the dose of which is typically increased in the course of therapy. Instead of having to provide different capsule sizes and corresponding packs, the patient can be prescribed to take only one capsule at the start of therapy and to increase the dose to the entire double capsule at a certain time. Different filling quantities for the two capsule bodies connected to one another can further increase the variation possibilities with regard to the dosage.

Darüberhinaus ermöglicht die Erfindung auch die Kombination von zwei inkompatiblen Arzneiformen, welche vom Patienten mit praktisch einem Griff eingenommen werden können, ohne daß Verwechslungen oder Fehlgriffe möglich sind. Entsprechendes gilt auch bei der Kombination von zwei verschiedenen Arzneiformen.In addition, the invention also enables the combination of two incompatible dosage forms, which can be taken by the patient with practically one grip, without confusion or mistakes being possible. The same applies to the combination of two different dosage forms.

Die Darreichung von chronobiologisch aufgebauten Arzneiformen läßt sich mit der Doppel-Kapsel in sehr sinnfälliger Weise vereinfachen, indem beispielsweise die erste Teil-Kapsel am Morgen eingenommen wird und die zweite Teil-Kapsel am Abend.The administration of chronobiologically constructed pharmaceutical forms can be simplified with the double capsule in a very sensible way, for example by taking the first partial capsule in the morning and the second partial capsule in the evening.

Auch können nach der Lehre der Erfindung Retard- und Initial-Pellets ohne Mischungsprobleme miteinander kombiniert werden.Retard and initial pellets can also be combined with one another without mixing problems according to the teaching of the invention.

In einer bevorzugten Ausführungsform der Erfindung verbindet der Steg gegenüberliegende Böden von zwei Kapsel-Körpern und ist mit einer Soll-Bruchstelle versehen. Der Steg ist vorzugsweise wie die Kapseln aus Hartgelatine und integral mit beiden Kapsel-Körpern ausgeformt.In a preferred embodiment of the invention, the web connects opposite bottoms of two capsule bodies and is provided with a predetermined breaking point. Like the capsules, the web is preferably made of hard gelatin and integrally formed with both capsule bodies.

In einer Variante der Erfindung ist vorgesehen, daß eine Vielzahl von Kapsel-Körpern in einer Reihe jeweils miteinander durch brechbare Stege verbunden sind. Die anhand der Doppel-Kapsel beschriebenen bevorzugten Ausgestaltungen der Stege lassen sich auch auf die Kapsel-Reihe übertragen.In a variant of the invention it is provided that a plurality of capsule bodies in a row are each connected to one another by frangible webs. The preferred embodiments of the webs described with the aid of the double capsule can also be transferred to the capsule series.

Nachfolgend ist ein Ausführungsbeispiel der Erfindung anhand der Zeichnung näher erläutert. Es zeigt:

  • Fig. 1 einen schematischen Schnitt durch eine Doppel-Kapsel und
  • Fig. 2 ein weiteres Ausführungsbeispiel einer Doppel-Kapsel
An exemplary embodiment of the invention is explained in more detail below with reference to the drawing. It shows:
  • Fig. 1 shows a schematic section through a double capsule and
  • Fig. 2 shows another embodiment of a double capsule

Die Figur 1 zeigt schematisch eine Doppel-Kapsel 10, welche aus zwei Kapsel-Körpern 12, 12' und den zugehörigen Kapsel-Kappen 14, 14' zusammengesetzt ist. Ein Steg 16 verbindet koaxial mit den Längsachsen beider Kapsel-Körper 12, 12' die Böden 18, 18' der Kapsel-Körper.FIG. 1 schematically shows a double capsule 10, which is composed of two capsule bodies 12, 12 'and the associated capsule caps 14, 14'. A web 16 connects coaxially the longitudinal axes of both capsule bodies 12, 12 'the bottoms 18, 18' of the capsule body.

Im Steg 16 ist eine Soll-Bruchstelle 20 ausgeformt, so daß die beiden Kapsel-Körper 12, 12' voneinander getrennt werden können.A predetermined breaking point 20 is formed in the web 16 so that the two capsule bodies 12, 12 'can be separated from one another.

Die erfindungsgemäße Doppel-Kapsel 10 läßt sich z.B. in einer Weiterentwicklung des bekannten Tauchverfahrens zur Herstellung von Einzel-Kapseln zusammensetzen. Bei dem bekannten Tauchverfahren werden auf Metall-Latten reihenweise angeordnete Tauchstifte in Gelatine-Lösung getaucht. Damit sich eine gleichmäßige Gelatine-Schicht bildet, werden die Latten nach dem Herausziehen aus der Lösung herumgedreht. Dieser Vorgang kann zur Herstellung der erfindungsgemäßen Doppel-Kapseln derart modifiziert werden, daß der sich beim Herausziehen der Tauchstifte aus der Lösung in der Mitte des späteren Kapsel-Bodens bildende Tropfen-Fortsatz zur Bildung des erfindungsgemäßen Steges herangezogen wird. Vor dem vollständigen Trocknen können zwei Kapseln, je nach Trockenzustand gegebenenfalls unter Erwärmung, miteinander verbunden werden.The double capsule 10 according to the invention can e.g. in a further development of the well-known immersion process for the production of individual capsules. In the known immersion method, immersion sticks arranged in rows on metal slats are immersed in gelatin solution. So that a uniform gelatin layer forms, the slats are turned around after being pulled out of the solution. This process can be modified in order to produce the double capsules according to the invention in such a way that the drop extension which is formed when the dip sticks are pulled out of the solution in the middle of the subsequent capsule base is used to form the web according to the invention. Before drying is complete, two capsules can be joined together, depending on the dry state, if necessary with heating.

Auch das Füllen der Kapseln erfolgt ähnlich wie bei herkömmlichen Kapseln. Nach Füllung des oberen Kapsel-Körpers und dessen Verschluß mittels der Kapsel-Kappe erfolgt eine Drehung um 180° und der Vorgang wird wiederholt.The capsules are also filled similarly to conventional capsules. After filling the upper capsule body and sealing it by means of the capsule cap, a rotation of 180 ° takes place and the process is repeated.

In Fig. 2 sind zwei in herkömmlicher Weise im Tauchverfahren hergestellte Kapseln 22, 22' gezeigt, die im Bereich des Tropfenfortsatzes 24, 24' miteinander derart verbunden sind, daß eine durchgehende, integrale Doppel-Kapsel gebildet wird.2 shows two capsules 22, 22 'which are produced in a conventional manner by immersion and which are connected to one another in the area of the drop extension 24, 24' in such a way that a continuous, integral double capsule is formed.

Claims (8)

1. Kapsel, insbesondere aus Hartgelatine, zur Aufnahme von Medikamenten, dadurch gekennzeichnetdaß zwei jeweils mit einer Kapsel-Kappe (14, 14') verschließbare Kapsel-Körper (12, 12') miteinander durch einen brechbaren Steg (16) verbunden sind.1. capsule, in particular made of hard gelatin, for taking medicaments, characterized in that two capsule bodies (12, 12 ') which can each be closed with a capsule cap (14, 14') are connected to one another by a breakable web (16). 2. Kapsel nach Anspruch 1, dadurch gekennzeichnet, daß der Steg (16) die den Kapsel-Kappen (14, 14') gegenüberliegenden Böden (18, 18') der Kapsel-Körper (12, 12') miteinander verbindet.2. Capsule according to claim 1, characterized in that the web (16) connects the capsule caps (14, 14 ') opposite bottoms (18, 18') of the capsule body (12, 12 ') with each other. 3. Kapsel nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, daß der Steg (16) integral mit beiden Kapsel-Körpern (12, 12') ausgeformt ist.3. Capsule according to one of claims 1 or 2, characterized in that the web (16) is integrally formed with two capsule bodies (12, 12 '). 4. Kapsel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß der Steg (16) mit einer Soll-Bruchstelle (20) in Form einer Querschnittsverringerung versehen ist.4. Capsule according to one of the preceding claims, characterized in that the web (16) is provided with a predetermined breaking point (20) in the form of a reduction in cross section. 5. Kapsel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß der Steg (16) zumindest annähernd kreisförmigen Querschnitt aufweist.5. Capsule according to one of the preceding claims, characterized in that the web (16) has at least approximately circular cross section. 6. Kapsel nach einem der Ansprüche 1-4, dadurch gekennzeichnet, daß der Steg (16) etwa rechteckförmigen Querschnitt aufweist.6. Capsule according to one of claims 1-4, characterized in that the web (16) has an approximately rectangular cross section. 7. Kapsel nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß ein Kapsel-Körper (12) eine größere Füllmenge aufnimmt als der andere Kapsel-Körper (12').7. Capsule according to one of the preceding claims, characterized in that a capsule body (12) holds a larger filling quantity than the other capsule body (12 '). 8. Kapsel, insbesondere aus Hartgelatine, zur Aufnahme von Medikamenten, dadurch gekennzeichnet, daß eine Mehrzahl von jeweils mit einer Kapsel-Kappe verschließbaren Kapsel-Körpern miteinander durch einen brechbaren Steg verbunden sind.8. capsule, in particular made of hard gelatin, for taking medication, characterized in that a plurality of capsule bodies, each of which can be closed with a capsule cap, are connected to one another by a breakable web.
EP86101626A 1985-02-11 1986-02-07 Double capsule for receiving medicines Withdrawn EP0191438A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19858503747 DE8503747U1 (en) 1985-02-11 1985-02-11 Double capsule for holding medication
DE8503747U 1985-02-11

Publications (2)

Publication Number Publication Date
EP0191438A2 true EP0191438A2 (en) 1986-08-20
EP0191438A3 EP0191438A3 (en) 1987-09-23

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EP86101626A Withdrawn EP0191438A3 (en) 1985-02-11 1986-02-07 Double capsule for receiving medicines

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JP (1) JPS61217166A (en)
DE (1) DE8503747U1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225565A2 (en) * 1985-12-06 1987-06-16 Boehringer Ingelheim Kg Divisible capsule
EP0274345B1 (en) * 1986-11-13 1991-08-07 Warner-Lambert Company Dividable capsule

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283566C (en) *
DE1516488A1 (en) * 1964-10-16 1970-01-08 Lilly Co Eli Push-in capsule
DE2024841A1 (en) * 1969-06-18 1971-04-22 Scherer G C Ltd , Windsor, Ontario (Kanada) Capsule case for medications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283566C (en) *
DE1516488A1 (en) * 1964-10-16 1970-01-08 Lilly Co Eli Push-in capsule
DE2024841A1 (en) * 1969-06-18 1971-04-22 Scherer G C Ltd , Windsor, Ontario (Kanada) Capsule case for medications

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225565A2 (en) * 1985-12-06 1987-06-16 Boehringer Ingelheim Kg Divisible capsule
EP0225565A3 (en) * 1985-12-06 1988-06-15 Boehringer Ingelheim Kg Divisible capsule
EP0274345B1 (en) * 1986-11-13 1991-08-07 Warner-Lambert Company Dividable capsule

Also Published As

Publication number Publication date
EP0191438A3 (en) 1987-09-23
DE8503747U1 (en) 1985-05-09
JPS61217166A (en) 1986-09-26

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