EP0124186A3 - Imidazole-ethanol esters - Google Patents

Imidazole-ethanol esters Download PDF

Info

Publication number
EP0124186A3
EP0124186A3 EP84200621A EP84200621A EP0124186A3 EP 0124186 A3 EP0124186 A3 EP 0124186A3 EP 84200621 A EP84200621 A EP 84200621A EP 84200621 A EP84200621 A EP 84200621A EP 0124186 A3 EP0124186 A3 EP 0124186A3
Authority
EP
European Patent Office
Prior art keywords
formula
imidazole
compounds
preparation
acid residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84200621A
Other versions
EP0124186A2 (en
EP0124186B1 (en
Inventor
Petrus Simon Hofman
David William Reid Hall
Kapil Dev Jaitly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brocades-Pharma Bv Te Leiderdorp
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Priority to AT84200621T priority Critical patent/ATE37360T1/en
Publication of EP0124186A2 publication Critical patent/EP0124186A2/en
Publication of EP0124186A3 publication Critical patent/EP0124186A3/en
Application granted granted Critical
Publication of EP0124186B1 publication Critical patent/EP0124186B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Cosmetics (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to the use of 1-H-imidazol-1-ethanol and compounds of the formula <CHEM> in which R represents an organic acid residue which does not bear further carboxyl groups, either in the free or salt form, as sebum synthesis inhibitors. <??>The invention also relates to parmaceutical preparations comprising a compound of formula I, and their preparation and to the compounds of formula I in which R is as defined above except the acetic acid residue, and their preparation.
EP84200621A 1983-05-03 1984-05-02 Imidazole-ethanol esters Expired EP0124186B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84200621T ATE37360T1 (en) 1983-05-03 1984-05-02 ESTERS OF IMIDAZOLAETHANOL.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8301550 1983-05-03
NL8301550A NL8301550A (en) 1983-05-03 1983-05-03 IMIDAZOLETHANOL ESTERS.

Publications (3)

Publication Number Publication Date
EP0124186A2 EP0124186A2 (en) 1984-11-07
EP0124186A3 true EP0124186A3 (en) 1985-05-15
EP0124186B1 EP0124186B1 (en) 1988-09-21

Family

ID=19841793

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84200621A Expired EP0124186B1 (en) 1983-05-03 1984-05-02 Imidazole-ethanol esters

Country Status (17)

Country Link
US (2) US4563473A (en)
EP (1) EP0124186B1 (en)
JP (1) JPH0645542B2 (en)
AT (1) ATE37360T1 (en)
AU (1) AU567936B2 (en)
CA (1) CA1290759C (en)
DE (1) DE3474140D1 (en)
DK (1) DK163185C (en)
ES (1) ES8502976A1 (en)
FI (1) FI84476C (en)
GR (1) GR81602B (en)
HU (1) HU195781B (en)
IE (1) IE57351B1 (en)
NL (1) NL8301550A (en)
NO (1) NO164166C (en)
NZ (1) NZ208022A (en)
PT (1) PT78517B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816589A (en) * 1987-08-06 1989-03-28 W. R. Grace & Co.-Conn. Aminopropylimidazoles
US5433950A (en) * 1990-05-07 1995-07-18 Schering-Plough Healthcare Products, Inc. Flexible collodion compositions
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
US6545163B1 (en) * 1995-10-02 2003-04-08 Napp Technologies Process to prepare 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20030027804A1 (en) * 2001-06-27 2003-02-06 Van Der Hoop Roland Gerritsen Therapeutic combinations for the treatment of hormone deficiencies
US20070088012A1 (en) * 2005-04-08 2007-04-19 Woun Seo Method of treating or preventing type-2 diabetes
EP2450041B1 (en) 2005-10-12 2018-09-26 Unimed Pharmaceuticals, LLC Improved testosterone gel for use in the treatment of hypogonadism
AU2006334107A1 (en) * 2005-12-30 2007-07-12 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
US8846063B2 (en) * 2008-12-16 2014-09-30 Kimberly-Clark Worldwide, Inc. Personal care composition containing a volatile and a terpene alcohol
JP5229337B2 (en) * 2011-02-14 2013-07-03 信越化学工業株式会社 Nitrogen-containing organic compounds
WO2013064153A1 (en) * 2011-10-31 2013-05-10 Claus Selch Larsen Prodrugs of non- steroid anti - inflammatory agents (nsaids)
JP2015221830A (en) * 2015-08-26 2015-12-10 チョンシー ユー Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
JP2019006795A (en) * 2018-08-27 2019-01-17 チョンシー ユー Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates
CN112029074A (en) * 2020-09-03 2020-12-04 广州市固研电子材料有限公司 Latent epoxy resin liquid curing agent and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1486817A (en) * 1965-07-22 1967-06-30 Basf Ag Insecticides
DE3122175A1 (en) * 1981-06-04 1982-12-23 Bayer Ag, 5090 Leverkusen Substituted azolylalkyl phenoxyphenoxyalkanecarboxylates, processes for their preparation, and their use as herbicides and plant growth regulators
EP0082982A2 (en) * 1981-12-15 1983-07-06 BASF Aktiengesellschaft Ammonium salts of hemi-esters of N-hydroxyethyl imidazole, process for their preparation and application as corrosion inhibitors soluble in oil

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542690C3 (en) * 1965-07-22 1981-08-20 Basf Ag, 6700 Ludwigshafen Use of imidazole derivatives as insecticide synergists
SU380652A1 (en) * 1971-05-05 1973-05-15 Иркутский институт органической химии Сибирского отделени USSR Academy of Sciences
JPS504012A (en) * 1972-12-16 1975-01-16
DK471479A (en) * 1978-12-13 1980-06-14 Pfizer PROCEDURE FOR PREPARING IMIDAZOLD DERIVATIVES AND SALTS THEREOF
JPS56140989A (en) * 1980-04-03 1981-11-04 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydrophyridine-3,5-dicarboxylic ester derivative or its salt
DE3122152A1 (en) * 1981-06-04 1982-12-23 Bayer Ag, 5090 Leverkusen Substituted azolylalkyl phenoxybenzoates, processes for their preparation and their use as herbicides
ZA832792B (en) * 1982-05-10 1983-12-28 Hoffmann La Roche Quinazoline derivatives
DE3219821A1 (en) * 1982-05-26 1983-12-01 Bayer Ag, 5090 Leverkusen Substituted diphenyl ethers, processes for their preparation, and their use as herbicides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1486817A (en) * 1965-07-22 1967-06-30 Basf Ag Insecticides
DE3122175A1 (en) * 1981-06-04 1982-12-23 Bayer Ag, 5090 Leverkusen Substituted azolylalkyl phenoxyphenoxyalkanecarboxylates, processes for their preparation, and their use as herbicides and plant growth regulators
EP0082982A2 (en) * 1981-12-15 1983-07-06 BASF Aktiengesellschaft Ammonium salts of hemi-esters of N-hydroxyethyl imidazole, process for their preparation and application as corrosion inhibitors soluble in oil

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 96, No. 23; June 7, 1982, COLUMBUS, OHIO (US), page 677, column 2, abstract nr. 199.719b; & JP-A-56 140 989 (YOSHITOMI) (04-11-1981) *
CHEMICAL ABSTRACTS, Vol.83, No.13, 29-09-1975, COLUMBUS,OHIO (US) Page 602, column 1, abstract nr. 114.815p; & JP-A-50 004 012 (KYORIN) (16-01-1975) *

Also Published As

Publication number Publication date
IE57351B1 (en) 1992-08-12
EP0124186A2 (en) 1984-11-07
PT78517B (en) 1986-07-14
HU195781B (en) 1988-07-28
FI84476C (en) 1991-12-10
NO164166B (en) 1990-05-28
HUT34166A (en) 1985-02-28
DK163185B (en) 1992-02-03
ES532147A0 (en) 1985-02-01
DK218684A (en) 1984-11-04
NO164166C (en) 1990-09-05
DE3474140D1 (en) 1988-10-27
DK163185C (en) 1992-06-29
JPH0645542B2 (en) 1994-06-15
ATE37360T1 (en) 1988-10-15
NZ208022A (en) 1987-09-30
AU567936B2 (en) 1987-12-10
NL8301550A (en) 1984-12-03
FI841738A0 (en) 1984-05-02
FI841738A (en) 1984-11-04
JPS6016925A (en) 1985-01-28
CA1290759C (en) 1991-10-15
FI84476B (en) 1991-08-30
US4563473A (en) 1986-01-07
GR81602B (en) 1984-12-11
PT78517A (en) 1984-06-01
AU2727984A (en) 1984-11-08
IE841086L (en) 1984-11-03
US4710571A (en) 1987-12-01
EP0124186B1 (en) 1988-09-21
DK218684D0 (en) 1984-05-02
NO841744L (en) 1984-11-05
ES8502976A1 (en) 1985-02-01

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