EE9900264A - Crystallization method of the tetrahydropyridine derivative and formation of crystalline forms - Google Patents

Crystallization method of the tetrahydropyridine derivative and formation of crystalline forms

Info

Publication number: EE9900264A
Authority: EE; Estonia
Prior art keywords: formation; crystalline forms; crystallization method; tetrahydropyridine derivative; tetrahydropyridine
Prior art date: 1996-12-23

Application number

EEP199900264A

Other languages

Estonian (et)

Other versions

EE04188B1 (en

Inventor

Caron Antoine

Franc Bruno

Monnier Olivier

Original Assignee

Sanofi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-23

Filing date

1997-12-23

Publication date

2000-02-15

1997-12-23 Application filed by Sanofi filed Critical Sanofi

2000-02-15 Publication of EE9900264A publication Critical patent/EE9900264A/en

2003-12-15 Publication of EE04188B1 publication Critical patent/EE04188B1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Child & Adolescent Psychology (AREA)
Biochemistry (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP199900264A 1996-12-23 1997-12-23 Crystallization method of the tetrahydropyridine derivative and formation of crystalline forms EE04188B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615904A FR2757543B1 (en)	1996-12-23	1996-12-23	PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED
PCT/FR1997/002393 WO1998028271A1 (en)	1996-12-23	1997-12-23	Method for the crystallisation of a tetrahydopyridin derivative and resulting crystalline forms

Publications (2)

Publication Number	Publication Date
EE9900264A true EE9900264A (en)	2000-02-15
EE04188B1 EE04188B1 (en)	2003-12-15

Family

ID=9499043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900264A EE04188B1 (en)	1996-12-23	1997-12-23	Crystallization method of the tetrahydropyridine derivative and formation of crystalline forms

Country Status (39)

Country	Link
EP (1)	EP0950050B1 (en)
JP (2)	JP4499188B2 (en)
KR (1)	KR100586670B1 (en)
CN (1)	CN1129580C (en)
AR (1)	AR009672A1 (en)
AT (1)	ATE307802T1 (en)
AU (1)	AU736697B2 (en)
BR (1)	BR9714081A (en)
CA (1)	CA2275596C (en)
CO (1)	CO5070688A1 (en)
CZ (1)	CZ296689B6 (en)
DE (1)	DE69734460T2 (en)
DK (1)	DK0950050T3 (en)
DZ (1)	DZ2383A1 (en)
EE (1)	EE04188B1 (en)
EG (1)	EG21567A (en)
ES (1)	ES2251038T3 (en)
FR (1)	FR2757543B1 (en)
HK (1)	HK1024002A1 (en)
HR (1)	HRP970699B1 (en)
HU (1)	HU227425B1 (en)
IL (1)	IL129938A (en)
IN (1)	IN186976B (en)
IS (1)	IS2357B (en)
MY (1)	MY118015A (en)
NO (1)	NO312364B1 (en)
NZ (1)	NZ336130A (en)
PL (1)	PL190494B1 (en)
RS (1)	RS49882B (en)
RU (1)	RU2192416C2 (en)
SA (1)	SA98180971B1 (en)
SI (1)	SI0950050T1 (en)
SK (1)	SK285088B6 (en)
TR (1)	TR199901363T2 (en)
TW (1)	TW518322B (en)
UA (1)	UA60324C2 (en)
UY (1)	UY24825A1 (en)
WO (1)	WO1998028271A1 (en)
ZA (1)	ZA9711576B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2757543B1 (en) *	1996-12-23	1999-04-02	Sanofi Sa	PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED
FR2782082B3 (en) *	1998-08-05	2000-09-22	Sanofi Sa	CRYSTALLINE FORMS OF (R) - (+) - N - [[3- [1-BENZOYL-3- (3,4- DICHLOROPHENYL) PIPERIDIN-3-YL] PROP-1-YL] -4-PHENYLPIPERIDIN-4 - YL] -N-METHYLACETAMIDE (OSANETANT) AND PROCESS FOR THE PREPARATION OF SAID COMPOUND
US9272068B2 (en)	2010-03-12	2016-03-01	Nippon Shokubai Co., Ltd.	Process for producing water-absorbing resin
KR101879468B1 (en) *	2011-04-15	2018-07-17	엠큐어 파마슈티컬즈 리미티드	Process for preparation of rilpivirine intermediate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531707A1 (en) *	1982-08-16	1984-02-17	Midy Spa	SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES WITH ANOREXIGENIC ACTIVITY, A PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS
FR2757543B1 (en) *	1996-12-23	1999-04-02	Sanofi Sa	PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED

1996
- 1996-12-23 FR FR9615904A patent/FR2757543B1/en not_active Expired - Fee Related
1997
- 1997-12-19 AR ARP970106029A patent/AR009672A1/en not_active Application Discontinuation
- 1997-12-22 HR HR970699A patent/HRP970699B1/en not_active IP Right Cessation
- 1997-12-22 MY MYPI97006233A patent/MY118015A/en unknown
- 1997-12-22 DZ DZ970233A patent/DZ2383A1/en active
- 1997-12-23 UA UA99063521A patent/UA60324C2/en unknown
- 1997-12-23 IL IL12993897A patent/IL129938A/en not_active IP Right Cessation
- 1997-12-23 EP EP97952986A patent/EP0950050B1/en not_active Expired - Lifetime
- 1997-12-23 TR TR1999/01363T patent/TR199901363T2/en unknown
- 1997-12-23 CO CO97074792A patent/CO5070688A1/en unknown
- 1997-12-23 CZ CZ0229299A patent/CZ296689B6/en not_active IP Right Cessation
- 1997-12-23 PL PL97334256A patent/PL190494B1/en not_active IP Right Cessation
- 1997-12-23 SI SI9730720T patent/SI0950050T1/en unknown
- 1997-12-23 WO PCT/FR1997/002393 patent/WO1998028271A1/en active IP Right Grant
- 1997-12-23 EG EG138397A patent/EG21567A/en active
- 1997-12-23 ES ES97952986T patent/ES2251038T3/en not_active Expired - Lifetime
- 1997-12-23 BR BR9714081-3A patent/BR9714081A/en not_active Application Discontinuation
- 1997-12-23 DE DE69734460T patent/DE69734460T2/en not_active Expired - Lifetime
- 1997-12-23 RU RU99116597/04A patent/RU2192416C2/en not_active IP Right Cessation
- 1997-12-23 CN CN97180863A patent/CN1129580C/en not_active Expired - Fee Related
- 1997-12-23 AU AU56684/98A patent/AU736697B2/en not_active Ceased
- 1997-12-23 IN IN3761DE1997 patent/IN186976B/en unknown
- 1997-12-23 UY UY24825A patent/UY24825A1/en not_active IP Right Cessation
- 1997-12-23 DK DK97952986T patent/DK0950050T3/en active
- 1997-12-23 CA CA002275596A patent/CA2275596C/en not_active Expired - Fee Related
- 1997-12-23 SK SK828-99A patent/SK285088B6/en not_active IP Right Cessation
- 1997-12-23 HU HU0001387A patent/HU227425B1/en not_active IP Right Cessation
- 1997-12-23 EE EEP199900264A patent/EE04188B1/en not_active IP Right Cessation
- 1997-12-23 RS YUP-289/99A patent/RS49882B/en unknown
- 1997-12-23 NZ NZ336130A patent/NZ336130A/en not_active IP Right Cessation
- 1997-12-23 JP JP52848198A patent/JP4499188B2/en not_active Expired - Fee Related
- 1997-12-23 AT AT97952986T patent/ATE307802T1/en active
- 1997-12-23 KR KR1019997005373A patent/KR100586670B1/en not_active IP Right Cessation
- 1997-12-23 ZA ZA9711576A patent/ZA9711576B/en unknown
1998
- 1998-01-21 TW TW086119629A patent/TW518322B/en not_active IP Right Cessation
- 1998-03-11 SA SA98180971A patent/SA98180971B1/en unknown
1999
- 1999-06-10 IS IS5076A patent/IS2357B/en unknown
- 1999-06-22 NO NO19993076A patent/NO312364B1/en not_active IP Right Cessation
2000
- 2000-06-01 HK HK00103287A patent/HK1024002A1/en not_active IP Right Cessation
2009
- 2009-05-07 JP JP2009112971A patent/JP2009197022A/en active Pending

Also Published As

Publication number	Publication date
NO312364B1 (en)	2002-04-29
HUP0001387A3 (en)	2002-03-28
PL334256A1 (en)	2000-02-14
WO1998028271A1 (en)	1998-07-02
DZ2383A1 (en)	2002-12-28
CN1129580C (en)	2003-12-03
IS2357B (en)	2008-04-15
HUP0001387A2 (en)	2000-09-28
CA2275596A1 (en)	1998-07-02
IL129938A0 (en)	2000-02-29
RS49882B (en)	2008-08-07
EP0950050A1 (en)	1999-10-20
JP2009197022A (en)	2009-09-03
EG21567A (en)	2001-12-31
SK82899A3 (en)	1999-12-10
EE04188B1 (en)	2003-12-15
DE69734460T2 (en)	2006-07-06
FR2757543B1 (en)	1999-04-02
CN1241180A (en)	2000-01-12
MY118015A (en)	2004-08-30
BR9714081A (en)	2000-05-09
ATE307802T1 (en)	2005-11-15
UY24825A1 (en)	1998-04-21
JP2001507012A (en)	2001-05-29
AU5668498A (en)	1998-07-17
HRP970699B1 (en)	2007-03-31
HK1024002A1 (en)	2000-09-29
CA2275596C (en)	2005-10-11
ZA9711576B (en)	1998-06-25
TR199901363T2 (en)	1999-08-23
ES2251038T3 (en)	2006-04-16
HRP970699A2 (en)	1998-10-31
KR20000069504A (en)	2000-11-25
SI0950050T1 (en)	2006-04-30
NO993076D0 (en)	1999-06-22
DK0950050T3 (en)	2006-01-23
CO5070688A1 (en)	2001-08-28
KR100586670B1 (en)	2006-06-07
TW518322B (en)	2003-01-21
EP0950050B1 (en)	2005-10-26
SA98180971B1 (en)	2006-09-13
CZ229299A3 (en)	1999-09-15
DE69734460D1 (en)	2005-12-01
FR2757543A1 (en)	1998-06-26
AU736697B2 (en)	2001-08-02
UA60324C2 (en)	2003-10-15
AR009672A1 (en)	2000-04-26
IN186976B (en)	2001-12-22
IL129938A (en)	2004-06-20
YU28999A (en)	2003-01-31
NZ336130A (en)	2001-01-26
RU2192416C2 (en)	2002-11-10
PL190494B1 (en)	2005-12-30
NO993076L (en)	1999-06-22
SK285088B6 (en)	2006-06-01
CZ296689B6 (en)	2006-05-17
JP4499188B2 (en)	2010-07-07
IS5076A (en)	1999-06-10
HU227425B1 (en)	2011-05-30

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	HC1A	Change of owner name
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2012-08-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20111223

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