EE200100437A - C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine - Google Patents
C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamineInfo
- Publication number
- EE200100437A EE200100437A EEP200100437A EEP200100437A EE200100437A EE 200100437 A EE200100437 A EE 200100437A EE P200100437 A EEP200100437 A EE P200100437A EE P200100437 A EEP200100437 A EE P200100437A EE 200100437 A EE200100437 A EE 200100437A
- Authority
- EE
- Estonia
- Prior art keywords
- epothiolones
- modified
- preparation
- modified epothiolones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999107588 DE19907588A1 (de) | 1999-02-22 | 1999-02-22 | C-21 Modifizierte Epothilone |
DE1999130111 DE19930111A1 (de) | 1999-07-01 | 1999-07-01 | C-21 Modifizierte Epothilone |
PCT/US2000/004068 WO2000050423A1 (en) | 1999-02-22 | 2000-02-17 | C-21 modified epothilones |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200100437A true EE200100437A (et) | 2002-12-16 |
EE04852B1 EE04852B1 (et) | 2007-06-15 |
Family
ID=26051995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200100437A EE04852B1 (et) | 1999-02-22 | 2000-02-17 | C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine ja ravimkoostise kasutamine vähkkasvajate või teiste proliferatiivsete haiguste ravimisel |
Country Status (37)
Country | Link |
---|---|
US (1) | US6262094B1 (et) |
EP (1) | EP1157023B1 (et) |
JP (1) | JP4598957B2 (et) |
KR (1) | KR100685336B1 (et) |
CN (1) | CN1205208C (et) |
AR (1) | AR028815A1 (et) |
AT (1) | ATE254615T1 (et) |
AU (1) | AU771089B2 (et) |
BG (1) | BG64987B1 (et) |
BR (1) | BR0008379A (et) |
CA (1) | CA2360452C (et) |
CO (1) | CO5140093A1 (et) |
CZ (1) | CZ301498B6 (et) |
DE (1) | DE60006649T2 (et) |
DK (1) | DK1157023T3 (et) |
EE (1) | EE04852B1 (et) |
ES (1) | ES2209831T3 (et) |
GE (1) | GEP20033067B (et) |
HK (1) | HK1038923B (et) |
HU (1) | HUP0200076A3 (et) |
ID (1) | ID29829A (et) |
IL (1) | IL144501A0 (et) |
LT (1) | LT4944B (et) |
LV (1) | LV12755B (et) |
MX (1) | MXPA01008374A (et) |
MY (1) | MY120601A (et) |
NO (1) | NO320806B1 (et) |
NZ (1) | NZ513629A (et) |
PE (1) | PE20001546A1 (et) |
PL (1) | PL212545B1 (et) |
PT (1) | PT1157023E (et) |
RU (1) | RU2253652C2 (et) |
SK (1) | SK287200B6 (et) |
TR (1) | TR200102401T2 (et) |
TW (1) | TWI270546B (et) |
UY (1) | UY26024A1 (et) |
WO (1) | WO2000050423A1 (et) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1367057B1 (de) * | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilone E und F |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
US6589968B2 (en) * | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
AU9187601A (en) | 2000-09-22 | 2002-04-02 | Biotechnolog Forschung Gmbh | Triazolo-epothilones |
US6989450B2 (en) * | 2000-10-13 | 2006-01-24 | The University Of Mississippi | Synthesis of epothilones and related analogs |
EP1353667A1 (en) * | 2001-01-25 | 2003-10-22 | Bristol-Myers Squibb Company | Parenteral formulations containing epothilone analogs |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
MXPA03007394A (es) | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Tratamiento de tumores refractarios mediante uso de derivados de epotilona. |
JP2004522771A (ja) * | 2001-02-20 | 2004-07-29 | ブリストル−マイヤーズ スクイブ カンパニー | 治療抵抗性腫瘍の処置用エポチロン誘導体 |
WO2002072085A1 (en) * | 2001-03-14 | 2002-09-19 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
MXPA04006822A (es) * | 2002-01-14 | 2004-12-08 | Novartis Ag | Combinaciones que comprenden epotilonas y anti-metabolitos. |
TW200303202A (en) | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
AU2003212457A1 (en) * | 2002-03-01 | 2003-09-16 | University Of Notre Dame | Derivatives of epothilone b and d and synthesis thereof |
CN1939299A (zh) * | 2002-03-08 | 2007-04-04 | 诺瓦提斯公司 | 包含埃坡霉素衍生物和烷化剂的组合 |
EP1854464A3 (en) * | 2002-03-08 | 2008-06-04 | Novartis AG | Combinations comprising epothilone derivatives and alkylating agents |
ATE452896T1 (de) | 2002-03-12 | 2010-01-15 | Bristol Myers Squibb Co | C3-cyanoepothilonderivate |
AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
WO2003092683A1 (en) * | 2002-05-01 | 2003-11-13 | Novartis Ag | Epothilone derivative for the treatment of hepatoma and other cancer diseases |
TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4791183B2 (ja) | 2002-08-23 | 2011-10-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体、類似体の合成およびその使用 |
RS20050235A (en) | 2002-09-23 | 2007-06-04 | Bristol Myers Squibb Company, | Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b |
CA2499682A1 (en) * | 2002-10-09 | 2004-04-22 | Kosan Biosciences, Inc. | Epo d + 5-fu/gemcitabine |
US7169771B2 (en) | 2003-02-06 | 2007-01-30 | Bristol-Myers Squibb Company | Thiazolyl-based compounds useful as kinase inhibitors |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
EP1559447A1 (en) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism |
GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
CA2588400A1 (en) * | 2004-11-18 | 2006-05-26 | Bristol-Myers Squibb Company | Enteric coated bead comprising ixabepilone, and preparation thereof |
JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Birドメイン結合化合物 |
CN101360494A (zh) * | 2005-11-22 | 2009-02-04 | 斯克里普斯研究学院 | 高效埃博霉素的化学合成 |
US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
CN101535300B (zh) | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
WO2008109075A2 (en) * | 2007-03-05 | 2008-09-12 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to ctla-4 antagonists |
WO2008147941A1 (en) * | 2007-05-25 | 2008-12-04 | Bristol-Myers Squibb Company | Processes for making epothilone compounds and analogs |
CN101909693A (zh) | 2008-01-08 | 2010-12-08 | 百时美施贵宝公司 | 用于治疗增殖性疾病的抗-ctla4抗体与微管蛋白调节剂的组合 |
ES2501565T3 (es) * | 2008-04-24 | 2014-10-02 | Bristol-Myers Squibb Company | Uso de epotilona D en el tratamiento de enfermedades asociadas a Tau incluyendo enfermedad de Alzheimer |
MX2010012579A (es) * | 2008-05-29 | 2010-12-20 | Squibb Bristol Myers Co | Metodos para predecir respuesta de pacientes a modulacion de la via co-estimuladora. |
WO2010014784A2 (en) * | 2008-08-01 | 2010-02-04 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases |
DK2769737T3 (en) | 2009-07-20 | 2017-07-24 | Bristol Myers Squibb Co | COMBINATION OF ANTI-CTLA4 ANTIBODY WITH ETOPOSIDE FOR SYNERGISTIC TREATMENT OF PROLIFERATIVE DISEASES |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
MY173795A (en) | 2009-11-05 | 2020-02-24 | Incozen Therapeutics Pvt Ltd | Novel benzopyran kinase modulators |
WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
EP2571577A1 (en) | 2010-05-17 | 2013-03-27 | Bristol-Myers Squibb Company | Improved immunotherapeutic dosing regimens and combinations thereof |
JP5960688B2 (ja) | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規3,5−二置換−3h−[1,2,3]トリアゾロ[4,5−b]ピリジン化合物 |
AU2011255647A1 (en) | 2010-05-18 | 2012-11-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
MY168757A (en) | 2011-05-04 | 2018-12-04 | Rhizen Pharmaceuticals S A | Novel compounds as modulators of protein kinases |
CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
WO2013144737A2 (en) | 2012-03-30 | 2013-10-03 | Rhizen Pharmaceuticals Sa | Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases |
US9725477B2 (en) | 2012-11-17 | 2017-08-08 | Beijing Fswelcome Technology Development Co., Ltd | Platinum compounds of malonic acid derivative having leaving group containing amino or alkylamino |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
US20160264670A1 (en) | 2013-11-06 | 2016-09-15 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
EA201791049A1 (ru) | 2014-12-04 | 2017-10-31 | Бристол-Майерс Сквибб Компани | Комбинация анти-cs1 и анти-pd1 антител для лечения рака (миеломы) |
ES2886657T3 (es) | 2015-06-29 | 2021-12-20 | Bristol Myers Squibb Co | Regímenes de dosificación inmunoterapéutica que comprenden pomalidomida y un anticuerpo anti-CS1 para el tratamiento de cáncer |
CN105153177B (zh) * | 2015-09-28 | 2017-08-08 | 湖南大学 | 呋喃并色满肟烯/炔丙基醚及其制备方法与应用 |
WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE301115C (et) | ||||
DE75883C (de) | W. schulte in Siegen und F. A. SAPP in Hillnhütten, Kreis Siegen | Ofen zur Erzeugung von Cyanammonium | ||
DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
WO1997019086A1 (de) | 1995-11-17 | 1997-05-29 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilonderivate, herstellung und verwendung |
DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
EP1367057B1 (de) * | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilone E und F |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
DE19707303B4 (de) | 1997-02-11 | 2006-05-11 | Mitteldeutsches Bitumenwerk Gmbh | Verfahren zur Gewinnung von Mikrowachsen, Paraffinen und Ölen aus Altkunststoffen oder Altkunststoffgemischen |
WO1998038192A1 (de) | 1997-02-25 | 1998-09-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Seitenkettenmodifizierte epothilone |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
ATE225783T1 (de) | 1997-04-18 | 2002-10-15 | Studiengesellschaft Kohle Mbh | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
ATE224882T1 (de) | 1997-07-16 | 2002-10-15 | Schering Ag | Thiazolderivate, verfahren zur herstellung und verwendung |
AU9340998A (en) | 1997-08-09 | 1999-03-01 | Schering Aktiengesellschaft | New epothilone derivatives, method for producing same and their pharmaceutical use |
US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
WO2000039276A2 (en) * | 1998-12-23 | 2000-07-06 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
-
2000
- 2000-02-17 AU AU32348/00A patent/AU771089B2/en not_active Ceased
- 2000-02-17 CN CNB008039461A patent/CN1205208C/zh not_active Expired - Fee Related
- 2000-02-17 HU HU0200076A patent/HUP0200076A3/hu unknown
- 2000-02-17 BR BR0008379-8A patent/BR0008379A/pt not_active IP Right Cessation
- 2000-02-17 WO PCT/US2000/004068 patent/WO2000050423A1/en active IP Right Grant
- 2000-02-17 EP EP00910219A patent/EP1157023B1/en not_active Expired - Lifetime
- 2000-02-17 DK DK00910219T patent/DK1157023T3/da active
- 2000-02-17 GE GEAP20006055A patent/GEP20033067B/en unknown
- 2000-02-17 PL PL350179A patent/PL212545B1/pl unknown
- 2000-02-17 US US09/506,481 patent/US6262094B1/en not_active Expired - Lifetime
- 2000-02-17 TR TR2001/02401T patent/TR200102401T2/xx unknown
- 2000-02-17 ES ES00910219T patent/ES2209831T3/es not_active Expired - Lifetime
- 2000-02-17 EE EEP200100437A patent/EE04852B1/et unknown
- 2000-02-17 AT AT00910219T patent/ATE254615T1/de active
- 2000-02-17 CA CA2360452A patent/CA2360452C/en not_active Expired - Fee Related
- 2000-02-17 TW TW089102732A patent/TWI270546B/zh not_active IP Right Cessation
- 2000-02-17 SK SK1078-2001A patent/SK287200B6/sk not_active IP Right Cessation
- 2000-02-17 NZ NZ513629A patent/NZ513629A/xx unknown
- 2000-02-17 ID IDW00200101797A patent/ID29829A/id unknown
- 2000-02-17 IL IL14450100A patent/IL144501A0/xx not_active IP Right Cessation
- 2000-02-17 KR KR1020017010421A patent/KR100685336B1/ko not_active IP Right Cessation
- 2000-02-17 RU RU2001125435/04A patent/RU2253652C2/ru not_active IP Right Cessation
- 2000-02-17 PT PT00910219T patent/PT1157023E/pt unknown
- 2000-02-17 JP JP2000601003A patent/JP4598957B2/ja not_active Expired - Fee Related
- 2000-02-17 MX MXPA01008374A patent/MXPA01008374A/es active IP Right Grant
- 2000-02-17 DE DE60006649T patent/DE60006649T2/de not_active Expired - Lifetime
- 2000-02-17 CZ CZ20012991A patent/CZ301498B6/cs not_active IP Right Cessation
- 2000-02-21 MY MYPI20000629A patent/MY120601A/en unknown
- 2000-02-22 CO CO00012008A patent/CO5140093A1/es unknown
- 2000-02-22 AR ARP000100744A patent/AR028815A1/es unknown
- 2000-02-22 PE PE2000000140A patent/PE20001546A1/es not_active Application Discontinuation
- 2000-02-22 UY UY26024A patent/UY26024A1/es not_active Application Discontinuation
-
2001
- 2001-08-17 NO NO20014017A patent/NO320806B1/no not_active IP Right Cessation
- 2001-08-17 BG BG105830A patent/BG64987B1/bg unknown
- 2001-08-23 LV LV010126A patent/LV12755B/xx unknown
- 2001-08-24 LT LT2001086A patent/LT4944B/lt not_active IP Right Cessation
-
2002
- 2002-01-22 HK HK02100498.5A patent/HK1038923B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE200100437A (et) | C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine | |
HUP0203425A3 (en) | Quinazoline derivatives, process for their preparation and their use | |
EE05223B1 (et) | Triasoloprimidiini hendid, meetod nende valmistamiseks ning nende kasutamine | |
EE200200704A (et) | Uued ühendid, meetod nende valmistamiseks ning nende kasutamine | |
EE200200470A (et) | Uued ühendid, meetod nende valmistamiseks ning nende kasutamine | |
EE05109B1 (et) | Sulfoonamiidi derivaadid, nende kasutamine meditsiinis ning meetod nende valmistamiseks | |
MXPA02008801A (es) | Derivados de indol, proceso para la preparacion de los mismos y su uso. | |
GB9823873D0 (en) | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents | |
HK1048999A1 (zh) | 氮雜䓬吲衍生物,它們的製備和應用 | |
EE200100574A (et) | Uued ühendid, nende valmistamise meetod ning kasutamine | |
HUP0203225A3 (en) | Benzodiazepin derivatives, the production and use thereof | |
EE04739B1 (et) | Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ning vaheühend ja selle valmistamismeetod | |
HUP9900163A2 (en) | Process for the preparation of sterol-and stanol-esters, and use thereof | |
EE04721B1 (et) | Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine | |
EE9800302A (et) | Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat | |
HUP0302295A3 (en) | Thienodibenzoazulene derivatives, process for their preparation and use thereof | |
EE03682B1 (et) | Asendatud bensimidasooli derivaadid, protsessid nende valmistamiseks ning nende kasutamine | |
DE50002417D1 (de) | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung | |
EE200200697A (et) | Uued ühendid, meetod nende valmistamiseks ning nende kasutamine | |
PL351616A1 (en) | Polyolefin compositions, method for the production and use thereof | |
EE200100573A (et) | Uued ühendid, nende valmistamise meetod ning kasutamine | |
HUP0100146A3 (en) | 3-(1-hydroxy-pentylidene)-5-nitro-3h-benzofuran-2-one, process for its preparation and use thereof | |
AU2796602A (en) | Coniosetin and derivatives thereof, method for producing the same and use thereof | |
EP1273657A4 (en) | NOVEL PROTEIN, METHOD FOR PRODUCTION AND USE | |
DE50005841D1 (de) | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |