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La presente invención se refiere a procedimientos para la preparación de formas anhidras e hidratadas al mesilato de N-(3-etinilfenil)-6,7-bis (2-metocietoxi)-4-quinazolinamina que son compuestos útiles para el tratamiento de alteraciones hiperproliferativas incluyendo el cáncer, en mamíferos, como el hombre.The present invention relates to processes for the preparation of anhydrous and hydrated forms of N- (3-ethynylphenyl) -6,7-bis (2-methokethoxy) -4-quinazolinamine mesylate which are useful compounds for the treatment of hyperproliferative disorders including cancer, in mammals, such as man.
ECSP9929361999-04-271999-04-27
N- (3- ETHYLPHENYLAMINE) MESYLATE -6,7- BIS (2- METOXYETOXI) -4- QUINOAZOLINAMINE ANHYDROUS AND MONOHYDRATED
ECSP992936A
(en)
Stable polymorph of n-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy)-4- quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof
Substituted homopiperidylbenzimidazole analog compounds as authentic relaxants, process for preparing same, pharmaceutical composition and process for preparing it.