ECSP19020141A - Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino - Google Patents
Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalinoInfo
- Publication number
- ECSP19020141A ECSP19020141A ECSENADI201920141A ECDI201920141A ECSP19020141A EC SP19020141 A ECSP19020141 A EC SP19020141A EC SENADI201920141 A ECSENADI201920141 A EC SENADI201920141A EC DI201920141 A ECDI201920141 A EC DI201920141A EC SP19020141 A ECSP19020141 A EC SP19020141A
- Authority
- EC
- Ecuador
- Prior art keywords
- steroid
- disustituted
- pirazolyl
- crystaline
- formula
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title 1
- 239000007787 solid Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- -1 19-nor-C21-C3,3-disubstituted pyrazolyl steroid Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
Esta invención se refiere a un esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) y formas sólidas cristalinas y composiciones del mismo. También se describen en la presente métodos de preparación de formas sólidas cristalinas del esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) y métodos de uso del esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) o formas sólidas cristalinas, sales farmacéuticamente aceptables, y composiciones farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662378582P | 2016-08-23 | 2016-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP19020141A true ECSP19020141A (es) | 2019-04-30 |
Family
ID=59772778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201920141A ECSP19020141A (es) | 2016-08-23 | 2019-03-22 | Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11236121B2 (es) |
| EP (2) | EP3981763A1 (es) |
| JP (2) | JP2019524853A (es) |
| KR (2) | KR20190040043A (es) |
| CN (4) | CN115974954A (es) |
| AR (3) | AR109393A1 (es) |
| AU (3) | AU2017315682B2 (es) |
| BR (1) | BR112019003637A2 (es) |
| CA (1) | CA3034262A1 (es) |
| CL (2) | CL2019000477A1 (es) |
| CO (1) | CO2019002596A2 (es) |
| EA (1) | EA201990565A1 (es) |
| EC (1) | ECSP19020141A (es) |
| IL (1) | IL302480A (es) |
| JO (1) | JOP20190022B1 (es) |
| MA (1) | MA46042A (es) |
| MX (2) | MX2019002193A (es) |
| PE (1) | PE20190915A1 (es) |
| PH (1) | PH12019500375A1 (es) |
| SG (1) | SG11201901445TA (es) |
| TW (2) | TW202342059A (es) |
| WO (1) | WO2018039378A1 (es) |
| ZA (1) | ZA201901051B (es) |
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| SG10201802389SA (en) | 2013-04-17 | 2018-04-27 | Sage Therapeutics Inc | 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof |
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| PT3224269T (pt) | 2014-11-27 | 2020-06-01 | Sage Therapeutics Inc | Composições e métodos para tratamento de distúrbios do snc |
| SI3250210T1 (sl) | 2015-01-26 | 2021-07-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
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| EP4302764A2 (en) | 2016-07-11 | 2024-01-10 | Sage Therapeutics, Inc. | C17, c20, and c21 substituted neuroactive steroids and their methods of use |
| CN115974954A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
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| US20210338692A1 (en) * | 2018-06-12 | 2021-11-04 | Sage Therapeutics, Inc. | A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid and methods of use thereof |
| US20230322846A9 (en) | 2018-12-05 | 2023-10-12 | Sage Therapeutics, Inc. | Neuroactive steroids and their methods of use |
| CN111454318A (zh) * | 2019-01-20 | 2020-07-28 | 浙江易众化工有限公司 | 抗抑郁药物sage-217的晶型及其制备方法 |
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-
2017
- 2017-08-23 CN CN202210890024.3A patent/CN115974954A/zh active Pending
- 2017-08-23 KR KR1020197008069A patent/KR20190040043A/ko not_active Application Discontinuation
- 2017-08-23 EP EP21190443.8A patent/EP3981763A1/en active Pending
- 2017-08-23 PE PE2019000416A patent/PE20190915A1/es unknown
- 2017-08-23 AR ARP170102330A patent/AR109393A1/es unknown
- 2017-08-23 KR KR1020237017309A patent/KR20230079470A/ko not_active Application Discontinuation
- 2017-08-23 TW TW112101437A patent/TW202342059A/zh unknown
- 2017-08-23 JP JP2019510657A patent/JP2019524853A/ja not_active Withdrawn
- 2017-08-23 BR BR112019003637A patent/BR112019003637A2/pt active Search and Examination
- 2017-08-23 JO JOP/2019/0022A patent/JOP20190022B1/ar active
- 2017-08-23 CN CN202210890054.4A patent/CN115974956A/zh active Pending
- 2017-08-23 AU AU2017315682A patent/AU2017315682B2/en active Active
- 2017-08-23 MA MA046042A patent/MA46042A/fr unknown
- 2017-08-23 CN CN202210890025.8A patent/CN115974955A/zh active Pending
- 2017-08-23 US US16/326,977 patent/US11236121B2/en active Active
- 2017-08-23 CN CN201780063826.4A patent/CN110088091A/zh active Pending
- 2017-08-23 EA EA201990565A patent/EA201990565A1/ru unknown
- 2017-08-23 WO PCT/US2017/048267 patent/WO2018039378A1/en active Application Filing
- 2017-08-23 MX MX2019002193A patent/MX2019002193A/es unknown
- 2017-08-23 SG SG11201901445TA patent/SG11201901445TA/en unknown
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2019
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2021
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