ECSP19008417A - Anticuerpos con inmunogenicidad baja y usos de estos - Google Patents
Anticuerpos con inmunogenicidad baja y usos de estosInfo
- Publication number
- ECSP19008417A ECSP19008417A ECSENADI20198417A ECDI201908417A ECSP19008417A EC SP19008417 A ECSP19008417 A EC SP19008417A EC SENADI20198417 A ECSENADI20198417 A EC SENADI20198417A EC DI201908417 A ECDI201908417 A EC DI201908417A EC SP19008417 A ECSP19008417 A EC SP19008417A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibodies
- low immunogenicity
- antigen
- methods
- binding fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
En la presente se proporcionan anticuerpos y fragmentos de unión al antígeno de estos con inmunogenicidad baja o nula en seres humanos y opcionalmente con características de fabricación deseables. También se proporcionan composiciones que comprenden dichos anticuerpos o fragmentos de unión al antígeno, métodos para utilizar dichos anticuerpos, y métodos para elaborar dichos anticuerpos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359150P | 2016-07-06 | 2016-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP19008417A true ECSP19008417A (es) | 2019-02-28 |
Family
ID=60913146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI20198417A ECSP19008417A (es) | 2016-07-06 | 2019-02-05 | Anticuerpos con inmunogenicidad baja y usos de estos |
Country Status (19)
Country | Link |
---|---|
US (1) | US11427632B2 (es) |
EP (1) | EP3481862A4 (es) |
JP (1) | JP7120989B2 (es) |
KR (1) | KR20190035737A (es) |
CN (1) | CN109689684B (es) |
AR (1) | AR108975A1 (es) |
AU (1) | AU2017292752B2 (es) |
BR (1) | BR112019000166A2 (es) |
CA (1) | CA3029977A1 (es) |
CL (1) | CL2019000019A1 (es) |
CO (1) | CO2019001112A2 (es) |
EA (1) | EA201990218A1 (es) |
EC (1) | ECSP19008417A (es) |
IL (1) | IL264009A (es) |
MX (1) | MX2019000172A (es) |
SG (1) | SG11201811788SA (es) |
TW (1) | TW201811824A (es) |
WO (1) | WO2018009499A1 (es) |
ZA (1) | ZA201900070B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11401329B2 (en) | 2017-08-02 | 2022-08-02 | Phanes Therapeutics, Inc. | Anti-CD47 antibodies and uses thereof |
KR102115300B1 (ko) * | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법 |
TW202045550A (zh) * | 2019-04-05 | 2020-12-16 | 美商西建公司 | 腫瘤選擇性結合cd47之抗體之工程 |
EP3980747A1 (en) | 2019-06-07 | 2022-04-13 | ALX Oncology Inc. | Methods and reagents for reducing the interference of drugs that bind cd47 in serological assays |
CN116685348A (zh) | 2020-10-07 | 2023-09-01 | 细胞基因公司 | 淋巴恶性肿瘤病状的双特异性抗体治疗 |
EP4256336A1 (en) | 2020-12-06 | 2023-10-11 | ALX Oncology Inc. | Multimers for reducing the interference of drugs that bind cd47 in serological assays |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE768377T1 (de) | 1988-09-02 | 1998-01-02 | Dyax Corp | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
GB9026912D0 (en) | 1990-12-11 | 1991-01-30 | Wessex Instrumentation Limited | Reaction detection equipment |
WO1992018619A1 (en) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
EP0590067A1 (en) | 1991-06-14 | 1994-04-06 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
PT1696031E (pt) | 1991-12-02 | 2010-06-25 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
PT859841E (pt) | 1995-08-18 | 2002-11-29 | Morphosys Ag | Bibliotecas de proteinas/ (poli) peptidos |
US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
KR101224235B1 (ko) * | 2003-04-11 | 2013-01-25 | 메디뮨 엘엘씨 | 재조합 il9 항체 및 그의 용도 |
US20060228350A1 (en) | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
SI1673398T1 (sl) | 2003-10-16 | 2011-05-31 | Micromet Ag | Multispecifiäśne deimunizirajoäśe cd3 povezovalne molekule |
US7354854B2 (en) | 2005-05-24 | 2008-04-08 | Texas Instruments Incorporated | Nickel silicide method and structure |
US7964707B2 (en) * | 2005-06-01 | 2011-06-21 | Micromet Ag | Anti-IL2 antibodies |
MX2008012485A (es) | 2006-03-30 | 2008-10-10 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de c-met. |
WO2008076487A2 (en) | 2006-12-20 | 2008-06-26 | Verenium Corporation | Antibodies and methods for making and using them |
EP2014681A1 (en) * | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
AU2010335950B2 (en) | 2009-12-23 | 2014-08-21 | Novartis Ag | Method for decreasing immunogenicity |
LT2536764T (lt) | 2010-02-18 | 2018-10-25 | Ose Immunotherapeutics | Anti-cd28 humanizuoti antikūnai |
MX360772B (es) * | 2012-02-06 | 2018-11-15 | Inhibrx Inc | Anticuerpos cd47 y metodos de uso de los mismos. |
SI2859017T1 (sl) | 2012-06-08 | 2019-05-31 | Sutro Biopharma, Inc. | Protitelesa, ki vsebujejo specifične nenaravne aminokislinske ostanke, postopki njihove priprave in postopki njihove uporabe |
ES2907763T3 (es) | 2012-08-31 | 2022-04-26 | Sutro Biopharma Inc | Aminoácidos modificados que comprenden un grupo azido |
EP4137518A1 (en) | 2013-02-06 | 2023-02-22 | Inhibrx, Inc. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
WO2016073879A2 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
CN107406503B (zh) | 2014-11-18 | 2021-07-16 | 詹森药业有限公司 | Cd47抗体、方法和用途 |
BR112017014258A2 (pt) * | 2014-12-30 | 2018-03-06 | Celgene Corp | anticorpos anti-cd47 e usos dos mesmos |
AU2016326423A1 (en) * | 2015-09-21 | 2018-04-26 | Erasmus University Medical Center | Anti-CD47 antibodies and methods of use |
-
2017
- 2017-07-05 WO PCT/US2017/040653 patent/WO2018009499A1/en unknown
- 2017-07-05 CN CN201780054156.XA patent/CN109689684B/zh active Active
- 2017-07-05 US US16/315,141 patent/US11427632B2/en active Active
- 2017-07-05 CA CA3029977A patent/CA3029977A1/en active Pending
- 2017-07-05 EA EA201990218A patent/EA201990218A1/ru unknown
- 2017-07-05 MX MX2019000172A patent/MX2019000172A/es unknown
- 2017-07-05 EP EP17824773.0A patent/EP3481862A4/en active Pending
- 2017-07-05 BR BR112019000166A patent/BR112019000166A2/pt not_active Application Discontinuation
- 2017-07-05 AR ARP170101865A patent/AR108975A1/es unknown
- 2017-07-05 KR KR1020197003635A patent/KR20190035737A/ko not_active Application Discontinuation
- 2017-07-05 SG SG11201811788SA patent/SG11201811788SA/en unknown
- 2017-07-05 TW TW106122515A patent/TW201811824A/zh unknown
- 2017-07-05 AU AU2017292752A patent/AU2017292752B2/en not_active Expired - Fee Related
- 2017-07-05 JP JP2019500244A patent/JP7120989B2/ja active Active
-
2018
- 2018-12-28 IL IL264009A patent/IL264009A/en unknown
-
2019
- 2019-01-04 CL CL2019000019A patent/CL2019000019A1/es unknown
- 2019-01-04 ZA ZA2019/00070A patent/ZA201900070B/en unknown
- 2019-02-05 EC ECSENADI20198417A patent/ECSP19008417A/es unknown
- 2019-02-05 CO CONC2019/0001112A patent/CO2019001112A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2018009499A1 (en) | 2018-01-11 |
IL264009A (en) | 2019-01-31 |
AU2017292752B2 (en) | 2023-07-27 |
AR108975A1 (es) | 2018-10-17 |
JP2019524087A (ja) | 2019-09-05 |
CL2019000019A1 (es) | 2019-06-28 |
SG11201811788SA (en) | 2019-01-30 |
EP3481862A1 (en) | 2019-05-15 |
BR112019000166A2 (pt) | 2019-10-01 |
ZA201900070B (en) | 2023-08-30 |
US11427632B2 (en) | 2022-08-30 |
CN109689684A (zh) | 2019-04-26 |
TW201811824A (zh) | 2018-04-01 |
JP7120989B2 (ja) | 2022-08-17 |
US20190241654A1 (en) | 2019-08-08 |
CN109689684B (zh) | 2022-09-23 |
EA201990218A1 (ru) | 2019-07-31 |
EP3481862A4 (en) | 2020-08-12 |
CO2019001112A2 (es) | 2019-02-19 |
AU2017292752A1 (en) | 2019-01-24 |
MX2019000172A (es) | 2019-09-26 |
KR20190035737A (ko) | 2019-04-03 |
CA3029977A1 (en) | 2018-01-11 |
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