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Application filed by Ccam Therapeutics LtdfiledCriticalCcam Therapeutics Ltd
Publication of ECSP16090450ApublicationCriticalpatent/ECSP16090450A/en
Se proporcionan anticuerpos humanizados, capaces de unión específica a moléculas de CEACAM1 humana que contienen mutaciones restauradoras de humano a murino en regiones variables distintas de CDR, y sus secuencias codificadoras de polinucleótidos; también se proporcionan composiciones farmacéuticas que comprenden estos anticuerpos, así como sus métodos de su uso para tratar y diagnosticar cáncer y otras condiciones.Humanized antibodies are provided, capable of specific binding to human CEACAM1 molecules containing human to murine restorative mutations in variable regions other than CDRs, and their polynucleotide coding sequences; Pharmaceutical compositions comprising these antibodies are also provided, as well as methods of their use to treat and diagnose cancer and other conditions.
ECIEPI201690450A2014-04-272016-11-24
HUMANIZED ANTIBODIES AGAINST THE CELLULAR ADHESION MOLECULE RELATED TO CARCINOEMBRIONIC ANTIGEN 1 (CEACAM1)
ECSP16090450A
(en)