ECSP11011454A - 5-ALQUINIL-PIRIDINAS - Google Patents

5-ALQUINIL-PIRIDINAS

Info

Publication number
ECSP11011454A
ECSP11011454A EC2011011454A ECSP11011454A ECSP11011454A EC SP11011454 A ECSP11011454 A EC SP11011454A EC 2011011454 A EC2011011454 A EC 2011011454A EC SP11011454 A ECSP11011454 A EC SP11011454A EC SP11011454 A ECSP11011454 A EC SP11011454A
Authority
EC
Ecuador
Prior art keywords
piridinas
alquinil
medicine
excessive
prepare
Prior art date
Application number
EC2011011454A
Other languages
Spanish (es)
Inventor
Tobias Wunberg
Der Veen Lars Anders Van
Siegfried Schneider
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40719954&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011454(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP11011454A publication Critical patent/ECSP11011454A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

La presente invención comprende compuestos de fórmula general (1)en la que R1 a R4, m y n se definen como en la reivindicación 1, que son adecuados para el tratamiento de enfermedades caracterizadas por una proliferación celular excesiva o anormal, y el uso de los mismos para preparar un medicamento que tenga las propiedades mencionadas anteriormenteThe present invention comprises compounds of general formula (1) in which R1 to R4, m and n are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof to prepare a medicine that has the properties mentioned above

EC2011011454A 2009-04-21 2011-11-11 5-ALQUINIL-PIRIDINAS ECSP11011454A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09158327 2009-04-21

Publications (1)

Publication Number Publication Date
ECSP11011454A true ECSP11011454A (en) 2011-12-30

Family

ID=40719954

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011454A ECSP11011454A (en) 2009-04-21 2011-11-11 5-ALQUINIL-PIRIDINAS

Country Status (23)

Country Link
US (2) US20110098275A1 (en)
EP (1) EP2421846B1 (en)
JP (1) JP5635592B2 (en)
KR (1) KR20120004529A (en)
CN (1) CN102459224A (en)
AP (1) AP2011005894A0 (en)
AR (1) AR076332A1 (en)
AU (1) AU2010240963A1 (en)
BR (1) BRPI1013716A2 (en)
CA (1) CA2759368A1 (en)
CL (1) CL2011002625A1 (en)
CO (1) CO6460762A2 (en)
EA (1) EA201101517A1 (en)
EC (1) ECSP11011454A (en)
IL (1) IL215161A0 (en)
MA (1) MA33222B1 (en)
MX (1) MX2011011021A (en)
PE (1) PE20120637A1 (en)
SG (1) SG175272A1 (en)
TN (1) TN2011000531A1 (en)
TW (1) TW201103905A (en)
UY (1) UY32565A (en)
WO (1) WO2010122069A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA108069C2 (en) 2009-03-23 2015-03-25 Гленмарк Фармасьютікалс, С.А. Fused pyrimidinedione derivatives as trpa1 modulators
AU2010227225A1 (en) 2009-03-23 2011-09-15 Glenmark Pharmaceuticals, S.A. Furopyrimidinedione derivatives as TRPA1 modulators
US8466162B2 (en) * 2011-01-26 2013-06-18 Boehringer Ingelheim International Gmbh 5-alkynyl-pyridines
WO2013177092A1 (en) * 2012-05-23 2013-11-28 Sunshine Lake Pharma Co., Ltd. Substituted alkynyl pyridine compounds and methods of use
CN107108581B (en) 2014-08-21 2020-06-23 百时美施贵宝公司 Tieback benzamide derivatives as potent ROCK inhibitors
CA3033752C (en) * 2016-08-15 2022-05-31 Purdue Research Foundation 4-substituted aminoisoquinoline derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
UA85087C2 (en) * 2004-04-23 2008-12-25 Бристол-Майэрс Сквибб Компани Monocyclic heterocycles as kinase inhibitors
US7915443B2 (en) * 2006-11-16 2011-03-29 Allergan, Inc. Sulfoximines as kinase inhibitors
US7776869B2 (en) * 2004-10-18 2010-08-17 Amgen Inc. Heteroaryl-substituted alkyne compounds and method of use
JP2008528663A (en) * 2005-02-01 2008-07-31 アストラゼネカ アクチボラグ Pyrimidine compounds having Ties (TEK) inhibitory activity
PL2323992T3 (en) 2008-07-29 2017-01-31 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
EP2327704A4 (en) 2008-08-29 2012-05-09 Shionogi & Co Ring-fused azole derivative having pi3k-inhibiting activity

Also Published As

Publication number Publication date
KR20120004529A (en) 2012-01-12
UY32565A (en) 2010-11-30
EA201101517A1 (en) 2012-05-30
TN2011000531A1 (en) 2013-05-24
BRPI1013716A2 (en) 2016-04-05
EP2421846B1 (en) 2016-01-06
JP5635592B2 (en) 2014-12-03
AR076332A1 (en) 2011-06-01
AP2011005894A0 (en) 2011-10-31
CO6460762A2 (en) 2012-06-15
CN102459224A (en) 2012-05-16
US20130196975A1 (en) 2013-08-01
MA33222B1 (en) 2012-04-02
MX2011011021A (en) 2011-11-02
US9090564B2 (en) 2015-07-28
CL2011002625A1 (en) 2012-04-20
US20110098275A1 (en) 2011-04-28
AU2010240963A1 (en) 2011-10-13
PE20120637A1 (en) 2012-05-26
TW201103905A (en) 2011-02-01
IL215161A0 (en) 2011-12-29
JP2012524750A (en) 2012-10-18
WO2010122069A1 (en) 2010-10-28
SG175272A1 (en) 2011-11-28
CA2759368A1 (en) 2010-10-28
EP2421846A1 (en) 2012-02-29

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