ECSP078026A - ANTI-CD40 HUMANIZED ANTIBODIES AND THEIR METHODS OF USE - Google Patents
ANTI-CD40 HUMANIZED ANTIBODIES AND THEIR METHODS OF USEInfo
- Publication number
- ECSP078026A ECSP078026A EC2007008026A ECSP078026A ECSP078026A EC SP078026 A ECSP078026 A EC SP078026A EC 2007008026 A EC2007008026 A EC 2007008026A EC SP078026 A ECSP078026 A EC SP078026A EC SP078026 A ECSP078026 A EC SP078026A
- Authority
- EC
- Ecuador
- Prior art keywords
- methods
- humanized antibodies
- antigen
- antibodies
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided are humanized anti-CD40 antibodies and antigen-binding fragments and methods for treating disease characterized by expression of CD40 antigen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68485305P | 2005-05-26 | 2005-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP078026A true ECSP078026A (en) | 2008-03-26 |
Family
ID=37452957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2007008026A ECSP078026A (en) | 2005-05-26 | 2007-12-17 | ANTI-CD40 HUMANIZED ANTIBODIES AND THEIR METHODS OF USE |
Country Status (19)
Country | Link |
---|---|
US (4) | US8303955B2 (en) |
EP (1) | EP1885399B1 (en) |
JP (1) | JP5027804B2 (en) |
KR (1) | KR100991010B1 (en) |
CN (1) | CN101237882B (en) |
AT (1) | ATE485057T1 (en) |
AU (1) | AU2006249305B2 (en) |
BR (1) | BRPI0610470A2 (en) |
CA (1) | CA2609269C (en) |
CR (1) | CR9562A (en) |
DE (1) | DE602006017690D1 (en) |
EC (1) | ECSP078026A (en) |
ES (1) | ES2354865T3 (en) |
IL (1) | IL187594A0 (en) |
MA (1) | MA29595B1 (en) |
NO (1) | NO341793B1 (en) |
PL (1) | PL1885399T3 (en) |
RU (1) | RU2407544C2 (en) |
WO (1) | WO2006128103A2 (en) |
Families Citing this family (70)
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US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
EP1885399B1 (en) * | 2005-05-26 | 2010-10-20 | Seattle Genetics, Inc. | Humanized anti-cd40 antibodies and their methods of use |
MX2008007140A (en) * | 2005-12-09 | 2009-03-04 | Seattle Genetics Inc | Methods of using cd40 binding agents. |
WO2008091954A2 (en) * | 2007-01-23 | 2008-07-31 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
CN101910414B (en) | 2007-11-07 | 2016-01-13 | 健泰科生物技术公司 | For assessment of the method and composition of the responsiveness of B cell lymphoma antagonism CD40 Antybody therapy |
US8961991B2 (en) | 2009-03-10 | 2015-02-24 | Baylor Research Institute | Anti-CD40 targeted fusion proteins |
FR2942799B1 (en) * | 2009-03-06 | 2011-02-25 | Lfb Biotechnologies | ANTI-RHESUS MONOCLONAL ANTIBODY |
CA3032548C (en) | 2009-03-10 | 2023-05-09 | Baylor Research Institute | Anti-cd40 antibodies and uses thereof |
CN103415534A (en) | 2009-03-10 | 2013-11-27 | 贝勒研究院 | Antigen presenting cell targeted cancer vaccines |
MX2011010938A (en) * | 2009-04-18 | 2012-01-12 | Genentech Inc | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies. |
WO2011084605A1 (en) * | 2009-12-16 | 2011-07-14 | The Trustees Of The University Of Pennsylvania | Anti-prostate cancer antibodies and methods of detection and treatment of prostate cancer using the same |
SI3178851T1 (en) | 2010-03-31 | 2020-09-30 | Boehringer Inhelheim International Gmbh | Anti-cd40 antibodies |
PT3556774T (en) | 2011-03-11 | 2024-02-29 | Beth Israel Deaconess Medical Ct Inc | Anti-cd40 antibodies and uses thereof |
EP2688592A4 (en) | 2011-03-25 | 2015-07-22 | Baylor Res Inst | Compositions and methods to immunize against hepatitis c virus |
CN103635488B (en) * | 2011-04-29 | 2016-12-14 | 埃派斯进有限公司 | Anti-CD 40 antibodies and using method thereof |
GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
ES2819075T3 (en) * | 2011-10-11 | 2021-04-14 | Viela Bio Inc | Support matrices derived from TN3 specific for CD40L and their methods of use |
AR090263A1 (en) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | COMBINED ANTIBODY THERAPY AGAINST HUMAN CSF-1R AND USES OF THE SAME |
CA2888763A1 (en) | 2012-10-30 | 2014-05-08 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
AR097584A1 (en) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R AND ANTIBODIES AGAINST HUMAN PD-L1 |
EP3094652B1 (en) | 2014-01-13 | 2021-09-29 | Baylor Research Institute | Novel vaccines against hpv and hpv-related diseases |
AU2015254526B2 (en) | 2014-04-30 | 2020-04-30 | Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft | Humanized antibodies against CD269 (BCMA) |
SG11201701070WA (en) | 2014-08-12 | 2017-03-30 | Alligator Bioscience Ab | Combination therapies with anti cd40 antibodies |
EP3212230B1 (en) * | 2014-10-29 | 2021-01-20 | Seagen Inc. | Dosage and administration of non-fucosylated anti-cd40 antibodies |
BR112017010303A2 (en) * | 2014-11-18 | 2018-05-15 | Janssen Pharmaceutica Nv | cd47 antibodies, methods and uses |
LT3283527T (en) | 2015-04-13 | 2021-03-25 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
EP3344655B1 (en) * | 2015-09-01 | 2023-07-26 | Boehringer Ingelheim International GmbH | Use of anti-cd40 antibodies for treatment of lupus nephritis |
MX2018002708A (en) | 2015-09-04 | 2018-08-01 | Primatope Therapeutics Inc | Humanized anti-cd40 antibodies and uses thereof. |
AU2016329057A1 (en) | 2015-09-30 | 2018-04-12 | Janssen Biotech, Inc. | Antagonistic antibodies specifically binding human CD40 and methods of use |
US20170101471A1 (en) * | 2015-10-08 | 2017-04-13 | The Board Of Trustees Of The Leland Stanford Junior University | Blockade of tim-1 for treating graft-versus-host disease |
US10894830B2 (en) | 2015-11-03 | 2021-01-19 | Janssen Biotech, Inc. | Antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3 and their uses |
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CN109475603B (en) | 2016-06-20 | 2023-06-13 | 科马布有限公司 | anti-PD-L1 antibodies |
MA45941A (en) | 2016-08-12 | 2019-06-19 | Janssen Biotech Inc | FC-MODIFIED ANTI-TNFR SUPERFAMILY ANTIBODIES WITH IMPROVED AGONIST ACTIVITY AND THEIR USE PROCEDURES |
US10669344B2 (en) | 2016-08-12 | 2020-06-02 | Janssen Biotech, Inc. | Engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions |
JP7138094B2 (en) | 2016-08-25 | 2022-09-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Intermittent administration of anti-CSF-1R antibody in combination with macrophage activator |
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US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
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KR20200103761A (en) * | 2017-12-27 | 2020-09-02 | 브리스톨-마이어스 스큅 컴퍼니 | Anti-CD40 antibody and uses thereof |
CA3103629A1 (en) | 2018-06-15 | 2019-12-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
CN112638944A (en) | 2018-08-23 | 2021-04-09 | 西进公司 | anti-TIGIT antibody |
MX2021003548A (en) | 2018-10-01 | 2021-05-27 | Hoffmann La Roche | Bispecific antigen binding molecules comprising anti-fap clone 212. |
CN112654641A (en) * | 2018-10-01 | 2021-04-13 | 豪夫迈·罗氏有限公司 | Bispecific antigen binding molecules with trivalent binding to CD40 |
EP3860653A1 (en) | 2018-10-05 | 2021-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
MX2021006360A (en) | 2018-11-30 | 2021-08-11 | Jiangsu Hengrui Medicine Co | Cd40 antibody pharmaceutical composition and use thereof. |
WO2020108611A1 (en) | 2018-11-30 | 2020-06-04 | 江苏恒瑞医药股份有限公司 | Anti-cd40 antibody, antigen binding fragment and pharmaceutical use thereof |
WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
WO2020253722A1 (en) * | 2019-06-17 | 2020-12-24 | Eucure (Beijing) Biopharma Co., Ltd | Anti-cd40 antibodies and uses thereof |
US20220370418A1 (en) | 2019-09-09 | 2022-11-24 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
WO2021127217A1 (en) | 2019-12-17 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
TW202206100A (en) | 2020-04-27 | 2022-02-16 | 美商西健公司 | Treatment for cancer |
JP2023532339A (en) | 2020-06-29 | 2023-07-27 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | Viruses engineered to promote sanotransmission and their use in treating cancer |
EP4221751A1 (en) | 2020-09-30 | 2023-08-09 | Seagen Inc. | Uveal melanoma treatment using sea-cd40 |
MX2023004941A (en) | 2020-11-08 | 2023-07-12 | Seagen Inc | Combination-therapy antibody drug conjugate with immune cell inhibitor. |
EP4313109A1 (en) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
TW202314247A (en) | 2021-05-25 | 2023-04-01 | 美商思進公司 | Methods of quantifying anti-cd40 antibodies |
CN115403670A (en) | 2021-05-26 | 2022-11-29 | 安徽瀚海博兴生物技术有限公司 | anti-CD40 antibodies and uses thereof |
CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
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WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
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EP1885399B1 (en) * | 2005-05-26 | 2010-10-20 | Seattle Genetics, Inc. | Humanized anti-cd40 antibodies and their methods of use |
-
2006
- 2006-05-26 EP EP06771453A patent/EP1885399B1/en active Active
- 2006-05-26 WO PCT/US2006/020688 patent/WO2006128103A2/en active Application Filing
- 2006-05-26 KR KR1020077030332A patent/KR100991010B1/en active IP Right Grant
- 2006-05-26 US US11/913,305 patent/US8303955B2/en active Active
- 2006-05-26 RU RU2007148932/10A patent/RU2407544C2/en active
- 2006-05-26 PL PL06771453T patent/PL1885399T3/en unknown
- 2006-05-26 BR BRPI0610470-3A patent/BRPI0610470A2/en not_active IP Right Cessation
- 2006-05-26 CA CA2609269A patent/CA2609269C/en active Active
- 2006-05-26 AT AT06771453T patent/ATE485057T1/en not_active IP Right Cessation
- 2006-05-26 CN CN2006800271172A patent/CN101237882B/en active Active
- 2006-05-26 DE DE602006017690T patent/DE602006017690D1/en active Active
- 2006-05-26 AU AU2006249305A patent/AU2006249305B2/en active Active
- 2006-05-26 JP JP2008513805A patent/JP5027804B2/en active Active
- 2006-05-26 ES ES06771453T patent/ES2354865T3/en active Active
-
2007
- 2007-11-22 IL IL187594A patent/IL187594A0/en unknown
- 2007-12-06 CR CR9562A patent/CR9562A/en not_active Application Discontinuation
- 2007-12-11 MA MA30474A patent/MA29595B1/en unknown
- 2007-12-12 NO NO20076404A patent/NO341793B1/en unknown
- 2007-12-17 EC EC2007008026A patent/ECSP078026A/en unknown
-
2012
- 2012-09-19 US US13/622,517 patent/US8492531B2/en active Active
-
2013
- 2013-06-25 US US13/926,817 patent/US20130315900A1/en not_active Abandoned
-
2014
- 2014-03-10 US US14/202,923 patent/US20140193405A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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CA2609269C (en) | 2014-08-05 |
RU2007148932A (en) | 2009-07-10 |
NO341793B1 (en) | 2018-01-22 |
KR20080030958A (en) | 2008-04-07 |
CR9562A (en) | 2008-03-06 |
EP1885399A2 (en) | 2008-02-13 |
EP1885399B1 (en) | 2010-10-20 |
US20130315900A1 (en) | 2013-11-28 |
AU2006249305B2 (en) | 2012-10-18 |
WO2006128103A3 (en) | 2007-01-18 |
CN101237882A (en) | 2008-08-06 |
AU2006249305A1 (en) | 2006-11-30 |
CA2609269A1 (en) | 2006-11-30 |
NO20076404L (en) | 2008-02-13 |
US20140193405A1 (en) | 2014-07-10 |
MA29595B1 (en) | 2008-07-01 |
EP1885399A4 (en) | 2009-04-22 |
PL1885399T3 (en) | 2011-04-29 |
US8492531B2 (en) | 2013-07-23 |
JP2008541733A (en) | 2008-11-27 |
JP5027804B2 (en) | 2012-09-19 |
BRPI0610470A2 (en) | 2010-06-22 |
US20090181015A1 (en) | 2009-07-16 |
ES2354865T3 (en) | 2011-03-18 |
US20130023047A1 (en) | 2013-01-24 |
WO2006128103A2 (en) | 2006-11-30 |
DE602006017690D1 (en) | 2010-12-02 |
IL187594A0 (en) | 2008-03-20 |
CN101237882B (en) | 2012-08-15 |
KR100991010B1 (en) | 2010-10-29 |
RU2407544C2 (en) | 2010-12-27 |
ATE485057T1 (en) | 2010-11-15 |
US8303955B2 (en) | 2012-11-06 |
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