ECSP056233A - NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY - Google Patents

NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY

Info

Publication number
ECSP056233A
ECSP056233A EC2005006233A ECSP056233A ECSP056233A EC SP056233 A ECSP056233 A EC SP056233A EC 2005006233 A EC2005006233 A EC 2005006233A EC SP056233 A ECSP056233 A EC SP056233A EC SP056233 A ECSP056233 A EC SP056233A
Authority
EC
Ecuador
Prior art keywords
new
antimicrobial activity
lincomycin
derivatives
lincomycin derivatives
Prior art date
Application number
EC2005006233A
Other languages
Spanish (es)
Inventor
Jason Gustaf Lewis
Sampath-Kumar Anandan
Harwin O'dowd
Mikhail Federovich Gordeev
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/642,807 external-priority patent/US7164011B2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of ECSP056233A publication Critical patent/ECSP056233A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se describen nuevos derivados de lincomicina. Estos derivados de lincomicina exhiben actividad antibacteriana. Los compuestos de la presente invención pueden exhibir actividades potentes contra las bacterias, incluyendo organismos grampositivos, y pueden ser agentes antimicrobianos útiles. También se describen métodos de síntesis y de uso de los compuestos.New derivatives of lincomycin are described. These lincomycin derivatives exhibit antibacterial activity. The compounds of the present invention may exhibit potent activities against bacteria, including gram-positive organisms, and may be useful antimicrobial agents. Methods of synthesis and use of the compounds are also described.

EC2005006233A 2003-06-17 2005-12-16 NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY ECSP056233A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US47929603P 2003-06-17 2003-06-17
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity

Publications (1)

Publication Number Publication Date
ECSP056233A true ECSP056233A (en) 2006-04-19

Family

ID=40203032

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006233A ECSP056233A (en) 2003-06-17 2005-12-16 NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY

Country Status (17)

Country Link
EP (1) EP1644393A2 (en)
JP (1) JP2007516172A (en)
KR (1) KR20060091050A (en)
AU (1) AU2004261550A1 (en)
BR (1) BRPI0411534A (en)
CA (1) CA2528592A1 (en)
EC (1) ECSP056233A (en)
GE (1) GEP20084437B (en)
HK (1) HK1090061A1 (en)
IL (1) IL172183A0 (en)
IS (1) IS8147A (en)
MA (1) MA27860A1 (en)
MX (1) MXPA05013915A (en)
NO (1) NO20055893L (en)
OA (1) OA13179A (en)
RS (1) RS20050931A (en)
WO (1) WO2005012320A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016632A2 (en) 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
EP1654268A2 (en) * 2003-06-17 2006-05-10 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
CA2620600A1 (en) * 2005-08-31 2007-03-08 Wyeth 9-aminocarbonylsubstituted derivatives of glycylcyclines
JP5064237B2 (en) 2005-12-09 2012-10-31 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincomycin derivatives and antibacterial agents containing the same as active ingredients
JP5290166B2 (en) * 2007-05-31 2013-09-18 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincosamide derivative and antibacterial agent comprising the same
EP2151447A4 (en) 2007-05-31 2012-09-05 Meiji Seika Kaisha Lincomycin derivatives and antibacterial agents containing the same as the active ingredient
US8822679B2 (en) * 2011-06-24 2014-09-02 California Institute Of Technology Quaternary heteroatom containing compounds
US20130267699A1 (en) 2011-06-24 2013-10-10 California Institute Of Technology Quaternary heteroatom containing compounds
US10421696B2 (en) 2014-12-18 2019-09-24 California Institute Of Technology Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CN107922373A (en) 2015-03-27 2018-04-17 加利福尼亚技术学院 Use low catalyst concentration and the asymmetry catalysis decarboxylation alkyl-alkyl for the pre-catalyst stablized
US10040784B2 (en) 2016-03-11 2018-08-07 California Institute Of Technology Compositions and methods for acylating lactams
EP3480190B1 (en) 2017-11-01 2023-01-04 California Institute of Technology Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
US11214568B2 (en) 2018-10-18 2022-01-04 California Institute Of Technology Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
CN110357839A (en) * 2019-08-29 2019-10-22 重庆经致制药技术开发有限公司 The preparation method of Bu Waxitan chiral intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128232C (en) * 1964-04-13
US3268556A (en) * 1964-04-13 1966-08-23 Upjohn Co Novel lincomycin derivatives
NL146501C (en) * 1964-07-01
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
NL140527B (en) * 1965-02-08 1973-12-17 Upjohn Co PROCESS FOR PREPARING LINCOMYCIN RELATED COMPOUNDS.
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
US3549615A (en) * 1968-10-17 1970-12-22 Upjohn Co Lincomycin derivatives and process for producing the same
DE2118636A1 (en) * 1970-04-20 1971-11-04 The Upjohn Co., Kalamazoo, Mich. (V.StA.) 3-nucleotides of lincomycin and their analogues, processes for their preparation and their use in therapeutic preparations
US3787390A (en) * 1971-06-23 1974-01-22 Upjohn Co Analogs of lincomycin and process
US3849396A (en) * 1973-01-08 1974-11-19 Upjohn Co Lincomycin and clindamycin 1-o-ethers
US3923602A (en) * 1973-10-25 1975-12-02 Upjohn Co Composition of matter and process
JPS5641239A (en) * 1979-09-13 1981-04-17 Hitachi Cable Ltd Flame-retardant composition
US4278789A (en) * 1979-11-23 1981-07-14 The Upjohn Company Lincomycin compounds
WO2004016632A2 (en) * 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
BRPI0411537A (en) * 2003-06-17 2006-08-01 Vicuron Pharm Inc lincomycin derivatives that have antibacterial activity

Also Published As

Publication number Publication date
MXPA05013915A (en) 2006-07-03
AU2004261550A1 (en) 2005-02-10
OA13179A (en) 2006-12-13
GEP20084437B (en) 2008-07-25
RS20050931A (en) 2008-04-04
IL172183A0 (en) 2011-08-01
WO2005012320A3 (en) 2005-10-20
IS8147A (en) 2005-11-24
EP1644393A2 (en) 2006-04-12
BRPI0411534A (en) 2006-08-22
HK1090061A1 (en) 2006-12-15
WO2005012320A2 (en) 2005-02-10
MA27860A1 (en) 2006-04-03
KR20060091050A (en) 2006-08-17
JP2007516172A (en) 2007-06-21
CA2528592A1 (en) 2005-02-10
NO20055893L (en) 2006-03-14

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