ECSP056233A - NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY - Google Patents
NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITYInfo
- Publication number
- ECSP056233A ECSP056233A EC2005006233A ECSP056233A ECSP056233A EC SP056233 A ECSP056233 A EC SP056233A EC 2005006233 A EC2005006233 A EC 2005006233A EC SP056233 A ECSP056233 A EC SP056233A EC SP056233 A ECSP056233 A EC SP056233A
- Authority
- EC
- Ecuador
- Prior art keywords
- new
- antimicrobial activity
- lincomycin
- derivatives
- lincomycin derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen nuevos derivados de lincomicina. Estos derivados de lincomicina exhiben actividad antibacteriana. Los compuestos de la presente invención pueden exhibir actividades potentes contra las bacterias, incluyendo organismos grampositivos, y pueden ser agentes antimicrobianos útiles. También se describen métodos de síntesis y de uso de los compuestos.New derivatives of lincomycin are described. These lincomycin derivatives exhibit antibacterial activity. The compounds of the present invention may exhibit potent activities against bacteria, including gram-positive organisms, and may be useful antimicrobial agents. Methods of synthesis and use of the compounds are also described.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47950203P | 2003-06-17 | 2003-06-17 | |
US47929603P | 2003-06-17 | 2003-06-17 | |
US10/642,807 US7164011B2 (en) | 2002-08-15 | 2003-08-15 | Lincomycin derivatives possessing antibacterial activity |
US10/777,455 US7199105B2 (en) | 2002-08-15 | 2004-02-11 | Lincomycin derivatives possessing antibacterial activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP056233A true ECSP056233A (en) | 2006-04-19 |
Family
ID=40203032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005006233A ECSP056233A (en) | 2003-06-17 | 2005-12-16 | NEW LINCOMYCIN DERIVATIVES THAT HAVE ANTIMICROBIAL ACTIVITY |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1644393A2 (en) |
JP (1) | JP2007516172A (en) |
KR (1) | KR20060091050A (en) |
AU (1) | AU2004261550A1 (en) |
BR (1) | BRPI0411534A (en) |
CA (1) | CA2528592A1 (en) |
EC (1) | ECSP056233A (en) |
GE (1) | GEP20084437B (en) |
HK (1) | HK1090061A1 (en) |
IL (1) | IL172183A0 (en) |
IS (1) | IS8147A (en) |
MA (1) | MA27860A1 (en) |
MX (1) | MXPA05013915A (en) |
NO (1) | NO20055893L (en) |
OA (1) | OA13179A (en) |
RS (1) | RS20050931A (en) |
WO (1) | WO2005012320A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016632A2 (en) | 2002-08-15 | 2004-02-26 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
US7199105B2 (en) | 2002-08-15 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
US7199106B2 (en) | 2003-06-17 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antimicrobial activity |
US7256177B2 (en) | 2003-06-17 | 2007-08-14 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
EP1654268A2 (en) * | 2003-06-17 | 2006-05-10 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
US7361743B2 (en) | 2004-02-11 | 2008-04-22 | Pfizer Inc | Lincomycin derivatives possessing antibacterial activity |
CA2620600A1 (en) * | 2005-08-31 | 2007-03-08 | Wyeth | 9-aminocarbonylsubstituted derivatives of glycylcyclines |
JP5064237B2 (en) | 2005-12-09 | 2012-10-31 | Meiji Seikaファルマ株式会社 | Lincomycin derivatives and antibacterial agents containing the same as active ingredients |
JP5290166B2 (en) * | 2007-05-31 | 2013-09-18 | Meiji Seikaファルマ株式会社 | Lincosamide derivative and antibacterial agent comprising the same |
EP2151447A4 (en) | 2007-05-31 | 2012-09-05 | Meiji Seika Kaisha | Lincomycin derivatives and antibacterial agents containing the same as the active ingredient |
US8822679B2 (en) * | 2011-06-24 | 2014-09-02 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US20130267699A1 (en) | 2011-06-24 | 2013-10-10 | California Institute Of Technology | Quaternary heteroatom containing compounds |
US10421696B2 (en) | 2014-12-18 | 2019-09-24 | California Institute Of Technology | Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation |
CN107922373A (en) | 2015-03-27 | 2018-04-17 | 加利福尼亚技术学院 | Use low catalyst concentration and the asymmetry catalysis decarboxylation alkyl-alkyl for the pre-catalyst stablized |
US10040784B2 (en) | 2016-03-11 | 2018-08-07 | California Institute Of Technology | Compositions and methods for acylating lactams |
EP3480190B1 (en) | 2017-11-01 | 2023-01-04 | California Institute of Technology | Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols |
US11214568B2 (en) | 2018-10-18 | 2022-01-04 | California Institute Of Technology | Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same |
CN110357839A (en) * | 2019-08-29 | 2019-10-22 | 重庆经致制药技术开发有限公司 | The preparation method of Bu Waxitan chiral intermediate |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL128232C (en) * | 1964-04-13 | |||
US3268556A (en) * | 1964-04-13 | 1966-08-23 | Upjohn Co | Novel lincomycin derivatives |
NL146501C (en) * | 1964-07-01 | |||
US3282917A (en) * | 1964-08-17 | 1966-11-01 | Upjohn Co | Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor |
NL140527B (en) * | 1965-02-08 | 1973-12-17 | Upjohn Co | PROCESS FOR PREPARING LINCOMYCIN RELATED COMPOUNDS. |
US3496163A (en) * | 1965-02-08 | 1970-02-17 | Upjohn Co | 7-halo-7-deoxylincomycins and process for preparing the same |
US3555007A (en) * | 1968-07-22 | 1971-01-12 | Upjohn Co | 7-deoxy-7-halo lincomycin d derivatives |
US3549615A (en) * | 1968-10-17 | 1970-12-22 | Upjohn Co | Lincomycin derivatives and process for producing the same |
DE2118636A1 (en) * | 1970-04-20 | 1971-11-04 | The Upjohn Co., Kalamazoo, Mich. (V.StA.) | 3-nucleotides of lincomycin and their analogues, processes for their preparation and their use in therapeutic preparations |
US3787390A (en) * | 1971-06-23 | 1974-01-22 | Upjohn Co | Analogs of lincomycin and process |
US3849396A (en) * | 1973-01-08 | 1974-11-19 | Upjohn Co | Lincomycin and clindamycin 1-o-ethers |
US3923602A (en) * | 1973-10-25 | 1975-12-02 | Upjohn Co | Composition of matter and process |
JPS5641239A (en) * | 1979-09-13 | 1981-04-17 | Hitachi Cable Ltd | Flame-retardant composition |
US4278789A (en) * | 1979-11-23 | 1981-07-14 | The Upjohn Company | Lincomycin compounds |
WO2004016632A2 (en) * | 2002-08-15 | 2004-02-26 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
BRPI0411537A (en) * | 2003-06-17 | 2006-08-01 | Vicuron Pharm Inc | lincomycin derivatives that have antibacterial activity |
-
2004
- 2004-06-17 AU AU2004261550A patent/AU2004261550A1/en not_active Abandoned
- 2004-06-17 GE GEAP20049117A patent/GEP20084437B/en unknown
- 2004-06-17 OA OA1200500364A patent/OA13179A/en unknown
- 2004-06-17 EP EP04776816A patent/EP1644393A2/en not_active Withdrawn
- 2004-06-17 WO PCT/US2004/019689 patent/WO2005012320A2/en active Application Filing
- 2004-06-17 RS YUP-2005/0931A patent/RS20050931A/en unknown
- 2004-06-17 MX MXPA05013915A patent/MXPA05013915A/en unknown
- 2004-06-17 CA CA002528592A patent/CA2528592A1/en not_active Abandoned
- 2004-06-17 BR BRPI0411534-1A patent/BRPI0411534A/en not_active IP Right Cessation
- 2004-06-17 KR KR1020057024291A patent/KR20060091050A/en active Search and Examination
- 2004-06-17 JP JP2006517464A patent/JP2007516172A/en active Pending
-
2005
- 2005-11-24 IS IS8147A patent/IS8147A/en unknown
- 2005-11-24 IL IL172183A patent/IL172183A0/en unknown
- 2005-12-12 NO NO20055893A patent/NO20055893L/en not_active Application Discontinuation
- 2005-12-16 EC EC2005006233A patent/ECSP056233A/en unknown
- 2005-12-16 MA MA28672A patent/MA27860A1/en unknown
-
2006
- 2006-09-21 HK HK06110528.4A patent/HK1090061A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA05013915A (en) | 2006-07-03 |
AU2004261550A1 (en) | 2005-02-10 |
OA13179A (en) | 2006-12-13 |
GEP20084437B (en) | 2008-07-25 |
RS20050931A (en) | 2008-04-04 |
IL172183A0 (en) | 2011-08-01 |
WO2005012320A3 (en) | 2005-10-20 |
IS8147A (en) | 2005-11-24 |
EP1644393A2 (en) | 2006-04-12 |
BRPI0411534A (en) | 2006-08-22 |
HK1090061A1 (en) | 2006-12-15 |
WO2005012320A2 (en) | 2005-02-10 |
MA27860A1 (en) | 2006-04-03 |
KR20060091050A (en) | 2006-08-17 |
JP2007516172A (en) | 2007-06-21 |
CA2528592A1 (en) | 2005-02-10 |
NO20055893L (en) | 2006-03-14 |
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