ECSP055871A - TETRAHYDROQUINOLINE DERIVATIVES - Google Patents

TETRAHYDROQUINOLINE DERIVATIVES

Info

Publication number
ECSP055871A
ECSP055871A EC2005005871A ECSP055871A ECSP055871A EC SP055871 A ECSP055871 A EC SP055871A EC 2005005871 A EC2005005871 A EC 2005005871A EC SP055871 A ECSP055871 A EC SP055871A EC SP055871 A ECSP055871 A EC SP055871A
Authority
EC
Ecuador
Prior art keywords
alkoxy
alkylamino
derivatives
heterocycloalkyl
heteroaryl
Prior art date
Application number
EC2005005871A
Other languages
Spanish (es)
Inventor
Cornelis Marius Timmers
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ECSP055871A publication Critical patent/ECSP055871A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de tetrahidroquinolina de la fórmula general (I) o a su sal farmacéuticamente aceptable, en donde R1 y R2 son H o Me; R3 es H, hidroxi, (1-4C)alcoxi, (di)(1-4C)alquilamino(2-4C)alcoxi o (2-6)heterocicloalquil(2-4C)alcoxi; R4 es H, OH, (1-4C)alcoxi o R7; R5 es H, OH, (1-4C)alcoxi o R7, con la condición de que si R4 es H, R5 no es H, OH o (1-4C)alcoxi y si R5 es H, R4 no es H, OH o (1-4C)alcoxi; R6 es (2-5C)heteroarilo, (6C)arilo, (3-8)cicloalquilo, (2-6C)heterocicloalquilo o (1-6C)alquilo; R7 es amino, (di)(1-4C)alquilamino, (6C)arilcarbonilamino, (6C)arilcarboniloxi, (2-5C)heteroarilcarbonilamino, (2-5C)heteroarilcarboniloxi, R8-(2-4C)alquilamino, R8-(2-4C)alcoxi, R9-metilamino o R9-metoxi; R8 es hidroxi, amino, (1-4C)alcoxi, (di)(1-4C)alquilamino, (2-6C)heterocicloalquilo, (2-6C)heterocicloalquilcarbonilamino, (di)(1-4C)alquilaminocarbonilamino o (1-4C)alcoxicarbonilamino y R9 es aminocarbonilo, (di)(1-4C)alquilaminocarbonilo, (2-5C)heteroarilo o (6C)arilo. La presente invención también se refiere a composiciones farmacéuticas que comprenden dichos derivados y al uso de estos derivados para regular la fertilidad.The present invention relates to tetrahydroquinoline derivatives of the general formula (I) or their pharmaceutically acceptable salt, wherein R1 and R2 are H or Me; R3 is H, hydroxy, (1-4C) alkoxy, (di) (1-4C) alkylamino (2-4C) alkoxy or (2-6) heterocycloalkyl (2-4C) alkoxy; R4 is H, OH, (1-4C) alkoxy or R7; R5 is H, OH, (1-4C) alkoxy or R7, with the proviso that if R4 is H, R5 is not H, OH or (1-4C) alkoxy and if R5 is H, R4 is not H, OH or (1-4C) alkoxy; R6 is (2-5C) heteroaryl, (6C) aryl, (3-8) cycloalkyl, (2-6C) heterocycloalkyl or (1-6C) alkyl; R7 is amino, (di) (1-4C) alkylamino, (6C) arylcarbonylamino, (6C) arylcarbonyloxy, (2-5C) heteroarylcarbonylamino, (2-5C) heteroarylcarbonyloxy, R8- (2-4C) alkylamino, R8- ( 2-4C) alkoxy, R9-methylamino or R9-methoxy; R8 is hydroxy, amino, (1-4C) alkoxy, (di) (1-4C) alkylamino, (2-6C) heterocycloalkyl, (2-6C) heterocycloalkylcarbonylamino, (di) (1-4C) alkylaminocarbonylamino or (1- 4C) alkoxycarbonylamino and R9 is aminocarbonyl, (di) (1-4C) alkylaminocarbonyl, (2-5C) heteroaryl or (6C) aryl. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.

EC2005005871A 2002-12-20 2005-06-20 TETRAHYDROQUINOLINE DERIVATIVES ECSP055871A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43504002P 2002-12-20 2002-12-20
EP02102866 2002-12-20

Publications (1)

Publication Number Publication Date
ECSP055871A true ECSP055871A (en) 2005-09-20

Family

ID=32683821

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005871A ECSP055871A (en) 2002-12-20 2005-06-20 TETRAHYDROQUINOLINE DERIVATIVES

Country Status (10)

Country Link
KR (1) KR20050084341A (en)
CO (1) CO5590903A2 (en)
DE (1) DE60326390D1 (en)
EC (1) ECSP055871A (en)
EG (1) EG24958A (en)
HK (1) HK1077577A1 (en)
HR (1) HRP20050576A2 (en)
IS (1) IS2647B (en)
MX (1) MXPA05006767A (en)
NO (1) NO330612B1 (en)

Also Published As

Publication number Publication date
IS2647B (en) 2010-08-15
CO5590903A2 (en) 2005-12-30
NO20052727L (en) 2005-07-13
EG24958A (en) 2011-02-28
HK1077577A1 (en) 2006-02-17
IS7871A (en) 2005-05-26
NO330612B1 (en) 2011-05-30
DE60326390D1 (en) 2009-04-09
KR20050084341A (en) 2005-08-26
NO20052727D0 (en) 2005-06-07
HRP20050576A2 (en) 2005-10-31
MXPA05006767A (en) 2005-09-08

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