ECSP045200A - ACIDS 3- (IMIDAZOLIL) -2-ALCOXIPROPANOICOS - Google Patents
ACIDS 3- (IMIDAZOLIL) -2-ALCOXIPROPANOICOSInfo
- Publication number
- ECSP045200A ECSP045200A EC2004005200A ECSP045200A ECSP045200A EC SP045200 A ECSP045200 A EC SP045200A EC 2004005200 A EC2004005200 A EC 2004005200A EC SP045200 A ECSP045200 A EC SP045200A EC SP045200 A ECSP045200 A EC SP045200A
- Authority
- EC
- Ecuador
- Prior art keywords
- alcoxipropanoicos
- imidazolil
- acids
- alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Los compuestos de acuerdo con la fórmula (I) en la que n es 0-3, R1 es alquilo C1-6 opcionalmente sustituido, alquenilo C2-6 o alquinilo C2-6, heterociclo, heterociclo aromático, arilo o hidrógeno y cada uno de R2, R3, R4, R5, R6, R7, R8 y R9 se selecciona independientemente entre hidrógeno y alquilo C1-6 opcionalmente sustituido, o R5 y R8 son una cadena alquileno, son novedosos. Estos compuestos son útiles en el tratamiento de afecciones trombóticas y otras patologías asociadas con la deposición de fibrina.The compounds according to formula (I) in which n is 0-3, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, heterocycle, aromatic heterocycle, aryl or hydrogen and each of R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from hydrogen and optionally substituted C1-6 alkyl, or R5 and R8 are an alkylene chain, they are novel. These compounds are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0201389A GB0201389D0 (en) | 2002-01-22 | 2002-01-22 | 3-(imidazolyl)-2-alkoxypropanoic acids |
GB0202027A GB0202027D0 (en) | 2002-01-29 | 2002-01-29 | 3-(imidazolyl)-2-alkoxypropanoic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP045200A true ECSP045200A (en) | 2004-08-27 |
Family
ID=27614792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2004005200A ECSP045200A (en) | 2002-01-22 | 2004-07-22 | ACIDS 3- (IMIDAZOLIL) -2-ALCOXIPROPANOICOS |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1467731A1 (en) |
JP (1) | JP2005520811A (en) |
KR (1) | KR20040077775A (en) |
CN (1) | CN1620291A (en) |
AP (1) | AP2004003084A0 (en) |
AR (1) | AR038197A1 (en) |
BR (1) | BR0307016A (en) |
CA (1) | CA2472238A1 (en) |
EA (1) | EA200400716A1 (en) |
EC (1) | ECSP045200A (en) |
HR (1) | HRP20040659A2 (en) |
IL (1) | IL162677A0 (en) |
IS (1) | IS7310A (en) |
MA (1) | MA27167A1 (en) |
MX (1) | MXPA04006573A (en) |
NO (1) | NO20043457L (en) |
OA (1) | OA12756A (en) |
PA (1) | PA8563501A1 (en) |
PE (1) | PE20030929A1 (en) |
PL (1) | PL371487A1 (en) |
TN (1) | TNSN04121A1 (en) |
TW (1) | TW200302094A (en) |
UY (1) | UY27615A1 (en) |
WO (1) | WO2003061652A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005051384A1 (en) * | 2003-11-25 | 2005-06-09 | Pfizer Limited | Stabilised pharmaceutical compositions |
JP2008536923A (en) * | 2005-04-18 | 2008-09-11 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | Use of TAFI inhibitors to enhance myocardial reperfusion and facilitate PCI |
EP2361910A4 (en) | 2008-10-29 | 2012-08-01 | Taisho Pharmaceutical Co Ltd | Compound having tafia inhibitory activity |
US8987242B2 (en) | 2008-12-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXA inhibitors |
US8642582B2 (en) | 2008-12-05 | 2014-02-04 | Merck Sharp & Dohme Corp. | Morpholinone compounds as factor IXa inhibitors |
LT2548871T (en) * | 2010-03-18 | 2017-09-25 | Daiichi Sankyo Company, Limited | Cycloalkyl-substituted imidazole derivative |
CN102884053B (en) * | 2010-03-18 | 2016-03-02 | 第一三共株式会社 | Cyclopropanecarboxylacid acid derivative |
CA2914533A1 (en) | 2013-06-10 | 2014-12-18 | Sanofi | Macrocyclic urea derivatives as inhibitors of tafia, their preparation and their use as pharmaceuticals |
EP3437641A4 (en) | 2016-03-29 | 2019-11-20 | Daiichi Sankyo Company, Limited | Inflammatory intestinal disease therapeutic agent |
TWI802591B (en) | 2017-09-14 | 2023-05-21 | 日商第一三共股份有限公司 | Compound having ring structures |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9901572D0 (en) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
SK1732003A3 (en) * | 2000-08-17 | 2004-08-03 | Pfizer | Substituted imidazoles as TAFIa inhibitors |
-
2003
- 2003-01-10 EP EP03700059A patent/EP1467731A1/en not_active Withdrawn
- 2003-01-10 OA OA1200400190A patent/OA12756A/en unknown
- 2003-01-10 KR KR10-2004-7011370A patent/KR20040077775A/en not_active Application Discontinuation
- 2003-01-10 CN CNA03802599XA patent/CN1620291A/en active Pending
- 2003-01-10 AP APAP/P/2004/003084A patent/AP2004003084A0/en unknown
- 2003-01-10 BR BR0307016-6A patent/BR0307016A/en not_active IP Right Cessation
- 2003-01-10 JP JP2003561596A patent/JP2005520811A/en active Pending
- 2003-01-10 EA EA200400716A patent/EA200400716A1/en unknown
- 2003-01-10 PL PL03371487A patent/PL371487A1/en unknown
- 2003-01-10 CA CA002472238A patent/CA2472238A1/en not_active Abandoned
- 2003-01-10 IL IL16267703A patent/IL162677A0/en unknown
- 2003-01-10 MX MXPA04006573A patent/MXPA04006573A/en unknown
- 2003-01-10 WO PCT/IB2003/000060 patent/WO2003061652A1/en not_active Application Discontinuation
- 2003-01-16 TW TW092100889A patent/TW200302094A/en unknown
- 2003-01-17 PE PE2003000058A patent/PE20030929A1/en not_active Application Discontinuation
- 2003-01-20 UY UY27615A patent/UY27615A1/en not_active Application Discontinuation
- 2003-01-21 AR ARP030100165A patent/AR038197A1/en unknown
- 2003-01-22 PA PA20038563501A patent/PA8563501A1/en unknown
-
2004
- 2004-06-14 IS IS7310A patent/IS7310A/en unknown
- 2004-06-30 TN TNP2004000121A patent/TNSN04121A1/en unknown
- 2004-07-15 MA MA27786A patent/MA27167A1/en unknown
- 2004-07-19 HR HR20040659A patent/HRP20040659A2/en not_active Application Discontinuation
- 2004-07-22 EC EC2004005200A patent/ECSP045200A/en unknown
- 2004-08-19 NO NO20043457A patent/NO20043457L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL162677A0 (en) | 2005-11-20 |
UY27615A1 (en) | 2003-08-29 |
CN1620291A (en) | 2005-05-25 |
WO2003061652A8 (en) | 2004-09-10 |
CA2472238A1 (en) | 2003-07-31 |
JP2005520811A (en) | 2005-07-14 |
MA27167A1 (en) | 2005-01-03 |
OA12756A (en) | 2006-07-03 |
MXPA04006573A (en) | 2004-10-04 |
NO20043457L (en) | 2004-08-19 |
WO2003061652A1 (en) | 2003-07-31 |
IS7310A (en) | 2004-06-14 |
HRP20040659A2 (en) | 2004-10-31 |
TNSN04121A1 (en) | 2006-06-01 |
AR038197A1 (en) | 2005-01-05 |
KR20040077775A (en) | 2004-09-06 |
PA8563501A1 (en) | 2004-08-31 |
PL371487A1 (en) | 2005-06-13 |
EA200400716A1 (en) | 2004-12-30 |
EP1467731A1 (en) | 2004-10-20 |
TW200302094A (en) | 2003-08-01 |
AP2004003084A0 (en) | 2004-09-30 |
BR0307016A (en) | 2004-11-03 |
PE20030929A1 (en) | 2003-11-05 |
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