ECSP034699A - NUCLEOSID COMPOUNDS AS VIRAL-DEPENDING RNA RNA POLYMERASE INHIBITORS - Google Patents
NUCLEOSID COMPOUNDS AS VIRAL-DEPENDING RNA RNA POLYMERASE INHIBITORSInfo
- Publication number
- ECSP034699A ECSP034699A ECSP034699A ECSP034699A EC SP034699 A ECSP034699 A EC SP034699A EC SP034699 A ECSP034699 A EC SP034699A EC SP034699 A ECSP034699 A EC SP034699A
- Authority
- EC
- Ecuador
- Prior art keywords
- rna
- viral
- compounds
- dependent
- infection
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El presente invento proporciona compuestos nucleósidos y ciertos de sus derivados que son inhibidores de la polimerasa de ARN viral dependiente del ARN. Estos compuestos son inhibidores de la replicación del ARN viral dependiente del ARN y son útiles para el tratamiento de la infección viral por ARN dependiente del ARN . Son particularmente útiles como inhibidores de la polimerasa NS5B del virus de la hepatitis C (VHC), como inhibidores de la replicación del VHC, y/o para el tratamiento de la infección por hepatitis C. El invento describe también composiciones farmacéuticas que contienen dichos compuestos nucleósidos solos o en combinación con otros agentes con actividad contra la infección viral por ARN dependiente del ARN, en particular la infección, por el VHC. También se divulgan métodos para inhibir la polimerasa de V dependiente del ARN, inhibir la replicación del ARN viral dependiente del V y/o tratar la infección viral por ARN dependiente del ARN con los compuestos nucleósidos del presente invento.The present invention provides nucleoside compounds and certain derivatives thereof that are inhibitors of RNA-dependent viral RNA polymerase. These compounds are inhibitors of RNA-dependent viral RNA replication and are useful for the treatment of RNA-dependent viral RNA infection. They are particularly useful as inhibitors of hepatitis C virus NS5B polymerase (HCV), as inhibitors of HCV replication, and / or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing said compounds. nucleosides alone or in combination with other agents with activity against RNA-dependent RNA viral infection, in particular HCV infection. Methods for inhibiting V-dependent RNA polymerase, inhibiting replication of V-dependent viral RNA and / or treating viral RNA-dependent viral infection with the nucleoside compounds of the present invention are also disclosed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26331301P | 2001-01-22 | 2001-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034699A true ECSP034699A (en) | 2003-08-29 |
Family
ID=33449461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP034699 ECSP034699A (en) | 2001-01-22 | 2003-07-21 | NUCLEOSID COMPOUNDS AS VIRAL-DEPENDING RNA RNA POLYMERASE INHIBITORS |
Country Status (2)
| Country | Link |
|---|---|
| EC (1) | ECSP034699A (en) |
| ZA (1) | ZA200305078B (en) |
-
2003
- 2003-06-30 ZA ZA200305078A patent/ZA200305078B/en unknown
- 2003-07-21 EC ECSP034699 patent/ECSP034699A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200305078B (en) | 2004-05-21 |
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