ECSP003672A - SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES - Google Patents

SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES

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Publication number
ECSP003672A
ECSP003672A ECSP003672A ECSP003672A EC SP003672 A ECSP003672 A EC SP003672A EC SP003672 A ECSP003672 A EC SP003672A EC SP003672 A ECSP003672 A EC SP003672A
Authority
EC
Ecuador
Prior art keywords
app
secretase
alzheimer
disease
substrates
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Mark E Gurney
Michael J Bienkowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP003672 priority Critical patent/ECSP003672A/en
Publication of ECSP003672A publication Critical patent/ECSP003672A/en

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  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención proporciona la enzima y los procedimientos enzimáticos para escindir el sitio de escición de a-secretasa de la proteína APP, y los correspondientes ácidos nucleicos, péptidos, vectores, células y aislados celulares y ensayos. También se proporciona una enzima que corta el sitio a-secretasa de APP. La invención además proporciona una proteína APP modificada y sus correspondientes ácidos nucleicos, péptidos, vectores, células y aislados celulares, y ensayos que son esencialmente útiles para identificar sustancias potencialmente terapéuticas en el tratamiento o la prevención de la enfermedad de Alzheimer.The present invention provides the enzyme and enzymatic methods for cleaving the a-secretase cleavage site of the APP protein, and the corresponding nucleic acids, peptides, vectors, cells and cell isolates and assays. An enzyme that cuts the APP-secretase site of APP is also provided. The invention further provides a modified APP protein and its corresponding nucleic acids, peptides, vectors, cells and cell isolates, and assays that are essentially useful for identifying potentially therapeutic substances in the treatment or prevention of Alzheimer's disease.

ECSP003672 2000-09-22 2000-09-22 SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES ECSP003672A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP003672 ECSP003672A (en) 2000-09-22 2000-09-22 SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP003672 ECSP003672A (en) 2000-09-22 2000-09-22 SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES

Publications (1)

Publication Number Publication Date
ECSP003672A true ECSP003672A (en) 2001-04-23

Family

ID=42041266

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP003672 ECSP003672A (en) 2000-09-22 2000-09-22 SECRETASE IN THE DISEASE OF ALZHEIMER, SUBSTRATES OF THE APP AND ITS USES

Country Status (1)

Country Link
EC (1) ECSP003672A (en)

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