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Application filed by Ридженерон Фармасьютикалз, Инк.filedCriticalРидженерон Фармасьютикалз, Инк.
Priority claimed from PCT/US2020/026445external-prioritypatent/WO2020206162A1/en
Publication of EA202192703A1publicationCriticalpatent/EA202192703A1/en
Предложены способы и композиции для интеграции кодирующих последовательностей для антигенсвязывающих белков, таких как нейтрализующие антитела широкого спектра действия, в локус "безопасная гавань", такой как локус альбумина у животного in vivo.Methods and compositions are provided for integrating coding sequences for antigen-binding proteins, such as broad spectrum neutralizing antibodies, into a safe harbor locus, such as the albumin locus in an animal in vivo.
EA202192703A2019-08-162020-04-02
METHODS AND COMPOSITIONS FOR INSERTING ANTIBODY ENCODING SEQUENCES INTO "SAFE HARBOR" LOCUS
EA202192703A1
(en)
Anti-tigit antibodies and antigen-binding fragments; pharmaceutical composition comprising them; polynenucleotide encoding said antibody; vector comprising them, host cell; method of producing said antibody or antigen-binding fragment thereof; and use in the treatment of cancer. (Divisional Application 310-2017).