EA202190725A1 - HETEROCYCLIC AROMATIC COMPOUNDS WITH KINASE INHIBITOR ACTIVITY - Google Patents

HETEROCYCLIC AROMATIC COMPOUNDS WITH KINASE INHIBITOR ACTIVITY

Info

Publication number
EA202190725A1
EA202190725A1 EA202190725A EA202190725A EA202190725A1 EA 202190725 A1 EA202190725 A1 EA 202190725A1 EA 202190725 A EA202190725 A EA 202190725A EA 202190725 A EA202190725 A EA 202190725A EA 202190725 A1 EA202190725 A1 EA 202190725A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kinase inhibitor
aromatic compounds
heterocyclic aromatic
inhibitor activity
jak
Prior art date
Application number
EA202190725A
Other languages
Russian (ru)
Inventor
Лэй Цзян
Цзяньвэнь Ден
Чжиюн Фэн
Шэнъян Лю
Сюйдун Мао
Кэ Шан
Цзяньюн Шоу
Даньи У
Сяопин Се
Юань Сюй
Хайся Чжао
Цзяньхуа Чжан
Минвэй Чжэн
Original Assignee
Шанхай Инновабио Фармасьютикалс Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шанхай Инновабио Фармасьютикалс Ко., Лтд. filed Critical Шанхай Инновабио Фармасьютикалс Ко., Лтд.
Priority claimed from PCT/CN2019/107381 external-priority patent/WO2020057669A1/en
Publication of EA202190725A1 publication Critical patent/EA202190725A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Предложены ингибитор киназы JAK, его получение и применение. В частности, создано соединение формулы I, где каждая группа такая, как описано в описании. Соединение обладает превосходной ингибирующей активностью JAK и поэтому может быть использовано для приготовления фармацевтических композиций для лечения рака и других заболеваний, связанных с активностью JAK.A JAK kinase inhibitor, its preparation and use are proposed. In particular, a compound of Formula I is provided, wherein each group is as described herein. The compound has excellent JAK inhibitory activity and therefore can be used for the preparation of pharmaceutical compositions for the treatment of cancer and other diseases associated with JAK activity.

EA202190725A 2018-09-21 2019-09-23 HETEROCYCLIC AROMATIC COMPOUNDS WITH KINASE INHIBITOR ACTIVITY EA202190725A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811109355.9A CN110938070A (en) 2018-09-21 2018-09-21 Heteroaromatic compound with kinase inhibition activity
PCT/CN2019/107381 WO2020057669A1 (en) 2018-09-21 2019-09-23 Aromatic heterocyclic compound with kinase inhibitory activity

Publications (1)

Publication Number Publication Date
EA202190725A1 true EA202190725A1 (en) 2021-07-14

Family

ID=69904507

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190725A EA202190725A1 (en) 2018-09-21 2019-09-23 HETEROCYCLIC AROMATIC COMPOUNDS WITH KINASE INHIBITOR ACTIVITY

Country Status (2)

Country Link
CN (1) CN110938070A (en)
EA (1) EA202190725A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114081889A (en) * 2020-12-29 2022-02-25 上海岸阔医药科技有限公司 Methods for preventing or treating side effects associated with EGFR dysfunction
CN116655636A (en) * 2022-02-17 2023-08-29 上海轶诺药业有限公司 Five-membered and six-membered heterocyclic compounds and application thereof as protein kinase inhibitors

Also Published As

Publication number Publication date
CN110938070A (en) 2020-03-31

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