EA202092900A2 - Мутационный анализ днк в плазме для детектирования рака - Google Patents

Мутационный анализ днк в плазме для детектирования рака

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Publication number
EA202092900A2
EA202092900A2 EA202092900A EA202092900A EA202092900A2 EA 202092900 A2 EA202092900 A2 EA 202092900A2 EA 202092900 A EA202092900 A EA 202092900A EA 202092900 A EA202092900 A EA 202092900A EA 202092900 A2 EA202092900 A2 EA 202092900A2
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Eurasian Patent Office
Prior art keywords
cancer detection
plasma dna
mutation analysis
dna mutation
cancer
Prior art date
Application number
EA202092900A
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English (en)
Other versions
EA202092900A3 (ru
Inventor
Вай Квунь Росса Чиу
Юйк-Мин Деннис Ло
Квунь Чэ Чань
Пэйюн Цзян
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Те Чайниз Юниверсити Ов Гонконг
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Publication of EA202092900A2 publication Critical patent/EA202092900A2/ru
Publication of EA202092900A3 publication Critical patent/EA202092900A3/ru

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Abstract

Частоту соматических мутаций в биологическом образце (например, в плазме или сыворотке) субъекта, проходящего скрининг или мониторинг на наличие рака, можно сравнить с таковой в конститутивной ДНК того же субъекта. Из данных частот можно получить параметр и применять его для классификации уровня рака. Ложноположительные результаты можно отсеять, требуя, по меньшей мере, определенного количества считываемых последовательностей (маркеров) в любом измененном локусе, что позволяет получить более точный параметр. Относительные частоты различных измененных локусов можно проанализировать для определения уровня гетерогенности опухолей у пациента.
EA202092900A 2012-06-21 2013-06-14 Мутационный анализ днк в плазме для детектирования рака EA202092900A3 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261662878P 2012-06-21 2012-06-21
US201261682725P 2012-08-13 2012-08-13
US201261695795P 2012-08-31 2012-08-31
US201261711172P 2012-10-08 2012-10-08
US13/801,748 US11261494B2 (en) 2012-06-21 2013-03-13 Method of measuring a fractional concentration of tumor DNA

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EA202092900A2 true EA202092900A2 (ru) 2021-03-31
EA202092900A3 EA202092900A3 (ru) 2021-06-30

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EA201500027A EA037292B1 (ru) 2012-06-21 2013-06-14 Способ детектирования рака или предзлокачественного изменения путем мутационного анализа днк в плазме
EA202092900A EA202092900A3 (ru) 2012-06-21 2013-06-14 Мутационный анализ днк в плазме для детектирования рака

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US (3) US11261494B2 (ru)
EP (3) EP3919627A1 (ru)
JP (4) JP6371280B2 (ru)
KR (7) KR102656030B1 (ru)
CN (3) CN104662168B (ru)
AU (4) AU2013278994C1 (ru)
CA (2) CA2876327C (ru)
DK (2) DK3456843T3 (ru)
EA (2) EA037292B1 (ru)
ES (2) ES2687847T3 (ru)
HK (3) HK1204013A1 (ru)
HU (1) HUE056915T2 (ru)
IL (5) IL298810B1 (ru)
MX (3) MX360264B (ru)
PT (1) PT3456843T (ru)
SG (2) SG10201808217WA (ru)
TW (4) TWI803505B (ru)
WO (1) WO2013190441A2 (ru)
ZA (1) ZA201409281B (ru)

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