EA202092900A2 - Мутационный анализ днк в плазме для детектирования рака - Google Patents
Мутационный анализ днк в плазме для детектирования ракаInfo
- Publication number
- EA202092900A2 EA202092900A2 EA202092900A EA202092900A EA202092900A2 EA 202092900 A2 EA202092900 A2 EA 202092900A2 EA 202092900 A EA202092900 A EA 202092900A EA 202092900 A EA202092900 A EA 202092900A EA 202092900 A2 EA202092900 A2 EA 202092900A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cancer detection
- plasma dna
- mutation analysis
- dna mutation
- cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 230000035772 mutation Effects 0.000 title 1
- 206010069754 Acquired gene mutation Diseases 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000037439 somatic mutation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/16—Assays for determining copy number or wherein the copy number is of special importance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2539/00—Reactions characterised by analysis of gene expression or genome comparison
- C12Q2539/10—The purpose being sequence identification by analysis of gene expression or genome comparison characterised by
- C12Q2539/107—Representational Difference Analysis [RDA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Частоту соматических мутаций в биологическом образце (например, в плазме или сыворотке) субъекта, проходящего скрининг или мониторинг на наличие рака, можно сравнить с таковой в конститутивной ДНК того же субъекта. Из данных частот можно получить параметр и применять его для классификации уровня рака. Ложноположительные результаты можно отсеять, требуя, по меньшей мере, определенного количества считываемых последовательностей (маркеров) в любом измененном локусе, что позволяет получить более точный параметр. Относительные частоты различных измененных локусов можно проанализировать для определения уровня гетерогенности опухолей у пациента.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261662878P | 2012-06-21 | 2012-06-21 | |
US201261682725P | 2012-08-13 | 2012-08-13 | |
US201261695795P | 2012-08-31 | 2012-08-31 | |
US201261711172P | 2012-10-08 | 2012-10-08 | |
US13/801,748 US11261494B2 (en) | 2012-06-21 | 2013-03-13 | Method of measuring a fractional concentration of tumor DNA |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202092900A2 true EA202092900A2 (ru) | 2021-03-31 |
EA202092900A3 EA202092900A3 (ru) | 2021-06-30 |
Family
ID=52274459
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500027A EA037292B1 (ru) | 2012-06-21 | 2013-06-14 | Способ детектирования рака или предзлокачественного изменения путем мутационного анализа днк в плазме |
EA202092900A EA202092900A3 (ru) | 2012-06-21 | 2013-06-14 | Мутационный анализ днк в плазме для детектирования рака |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500027A EA037292B1 (ru) | 2012-06-21 | 2013-06-14 | Способ детектирования рака или предзлокачественного изменения путем мутационного анализа днк в плазме |
Country Status (19)
Country | Link |
---|---|
US (3) | US11261494B2 (ru) |
EP (3) | EP3919627A1 (ru) |
JP (4) | JP6371280B2 (ru) |
KR (7) | KR102656030B1 (ru) |
CN (3) | CN104662168B (ru) |
AU (4) | AU2013278994C1 (ru) |
CA (2) | CA2876327C (ru) |
DK (2) | DK3456843T3 (ru) |
EA (2) | EA037292B1 (ru) |
ES (2) | ES2687847T3 (ru) |
HK (3) | HK1204013A1 (ru) |
HU (1) | HUE056915T2 (ru) |
IL (5) | IL298810B1 (ru) |
MX (3) | MX360264B (ru) |
PT (1) | PT3456843T (ru) |
SG (2) | SG10201808217WA (ru) |
TW (4) | TWI803505B (ru) |
WO (1) | WO2013190441A2 (ru) |
ZA (1) | ZA201409281B (ru) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2467691A (en) | 2008-09-05 | 2010-08-11 | Aueon Inc | Methods for stratifying and annotating cancer drug treatment options |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
EP2619329B1 (en) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
KR20190100425A (ko) | 2010-12-30 | 2019-08-28 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
JP6153874B2 (ja) | 2011-02-09 | 2017-06-28 | ナテラ, インコーポレイテッド | 非侵襲的出生前倍数性呼び出しのための方法 |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
WO2014151117A1 (en) | 2013-03-15 | 2014-09-25 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
US20140274738A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
JP6525473B2 (ja) | 2013-11-13 | 2019-06-05 | ニューゲン テクノロジーズ, インコーポレイテッド | 複製物配列決定リードを同定するための組成物および方法 |
ES2784450T3 (es) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Métodos y sistemas para detectar variantes genéticas |
EP3134541B1 (en) * | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
CN106795562B (zh) | 2014-07-18 | 2022-03-25 | 香港中文大学 | Dna混合物中的组织甲基化模式分析 |
EP4358097A1 (en) * | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
US10102337B2 (en) | 2014-08-06 | 2018-10-16 | Nugen Technologies, Inc. | Digital measurements from targeted sequencing |
EP3198026B1 (en) * | 2014-08-07 | 2019-10-09 | Pharmassist Ltd | Method of determining pik3ca mutational status in a sample |
ES2925014T3 (es) | 2014-09-12 | 2022-10-13 | Univ Leland Stanford Junior | Identificación y uso de ácidos nucleicos circulantes |
CA2967447A1 (en) * | 2014-12-05 | 2016-06-09 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
US11072814B2 (en) | 2014-12-12 | 2021-07-27 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
WO2016109452A1 (en) * | 2014-12-31 | 2016-07-07 | Guardant Health , Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
ES2908347T3 (es) | 2015-02-10 | 2022-04-28 | Univ Hong Kong Chinese | Detección de mutaciones para cribado de cáncer y análisis fetal |
CA2983833C (en) * | 2015-05-01 | 2024-05-14 | Guardant Health, Inc. | Diagnostic methods |
WO2016183106A1 (en) | 2015-05-11 | 2016-11-17 | Natera, Inc. | Methods and compositions for determining ploidy |
CN104894268B (zh) * | 2015-06-05 | 2018-02-09 | 上海美吉生物医药科技有限公司 | 定量样本中源自细胞凋亡的dna浓度的方法及其应用 |
CN107849556A (zh) * | 2015-07-01 | 2018-03-27 | 学校法人庆应义塾 | 癌组织的异质性标记物及其使用 |
JP2017016665A (ja) * | 2015-07-03 | 2017-01-19 | 国立大学法人東北大学 | 配列のデータからの変異情報の選択方法、システム、及び、コンピュータプログラム |
ES2911613T3 (es) | 2015-07-20 | 2022-05-20 | Univ Hong Kong Chinese | Análisis de patrones de metilación de haplotipos en tejidos en una mezcla de ADN |
CA2993362A1 (en) * | 2015-07-23 | 2017-01-26 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
AU2016305103C1 (en) * | 2015-08-12 | 2020-06-04 | The Chinese University Of Hong Kong | Single-molecule sequencing of plasma DNA |
EP3341876A4 (en) | 2015-08-25 | 2018-10-10 | Nantomics, LLC | Systems and methods for genetic analysis of metastases |
JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス, インコーポレイテッド | 無細胞dnaの分析による腫瘍遺伝子コピー数を決定するための方法 |
CN109072309B (zh) * | 2016-02-02 | 2023-05-16 | 夸登特健康公司 | 癌症进化检测和诊断 |
US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
KR101810528B1 (ko) * | 2016-03-29 | 2017-12-21 | 한국과학기술원 | 단백질을 변화시키지 않는 암 돌연변이의 기능적 recurrence를 구하는 방법 및 장치 |
WO2017181146A1 (en) | 2016-04-14 | 2017-10-19 | Guardant Health, Inc. | Methods for early detection of cancer |
GB2555765A (en) | 2016-05-01 | 2018-05-16 | Genome Res Ltd | Method of detecting a mutational signature in a sample |
CN105969656B (zh) * | 2016-05-13 | 2019-09-10 | 万康源(天津)基因科技有限公司 | 一种单细胞外显子测序肿瘤体细胞突变检测及分析平台 |
CN105969856B (zh) * | 2016-05-13 | 2019-11-12 | 万康源(天津)基因科技有限公司 | 一种单细胞外显子测序肿瘤体细胞突变检测方法 |
CN106355045B (zh) * | 2016-08-30 | 2019-03-15 | 天津诺禾致源生物信息科技有限公司 | 一种基于扩增子二代测序小片段***缺失检测的方法及装置 |
SG11201811159SA (en) * | 2016-09-30 | 2019-01-30 | Guardant Health Inc | Methods for multi-resolution analysis of cell-free nucleic acids |
CN110100013A (zh) | 2016-10-24 | 2019-08-06 | 香港中文大学 | 用于肿瘤检测的方法和*** |
GB201618485D0 (en) * | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
CN114774520A (zh) * | 2016-11-17 | 2022-07-22 | 领星生物科技(上海)有限公司 | 检测肿瘤发展的***和方法 |
KR20230062684A (ko) | 2016-11-30 | 2023-05-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
US11101019B2 (en) * | 2016-12-08 | 2021-08-24 | Life Technologies Corporation | Methods for detecting mutation load from a tumor sample |
CN106874710A (zh) * | 2016-12-29 | 2017-06-20 | 安诺优达基因科技(北京)有限公司 | 一种用于利用肿瘤ffpe样本检测体细胞突变的装置 |
CN106845153A (zh) * | 2016-12-29 | 2017-06-13 | 安诺优达基因科技(北京)有限公司 | 一种用于利用循环肿瘤dna样本检测体细胞突变的装置 |
CA3051509A1 (en) | 2017-01-25 | 2018-08-02 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
US11342047B2 (en) | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
EP3625341A4 (en) * | 2017-05-16 | 2021-05-19 | Guardant Health, Inc. | IDENTIFICATION OF SOMATIC ORIGIN OR GERMINAL LINE OF CELLLESS DNA |
KR102145417B1 (ko) * | 2017-05-24 | 2020-08-19 | 지니너스 주식회사 | 무세포 핵산으로부터 수득된 서열 분석 데이터에 대한 배경 대립인자의 빈도 분포를 생성하는 방법 및 이를 이용하여 무세포 핵산으로부터 변이를 검출하는 방법 |
EP3658684B1 (en) | 2017-07-26 | 2023-08-30 | The Chinese University Of Hong Kong | Enhancement of cancer screening using cell-free viral nucleic acids |
US20210125683A1 (en) * | 2017-09-15 | 2021-04-29 | The Regents Of The University Of California | Detecting somatic single nucleotide variants from cell-free nucleic acid with application to minimal residual disease monitoring |
CN111357054B (zh) * | 2017-09-20 | 2024-07-16 | 夸登特健康公司 | 用于区分体细胞变异和种系变异的方法和*** |
CN111201572A (zh) * | 2017-10-10 | 2020-05-26 | 南托米克斯有限责任公司 | 用于提高精确度的癌症患者的综合基因组转录组肿瘤-正常样基因组套分析 |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
WO2019090156A1 (en) * | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
JP7013490B2 (ja) * | 2017-11-30 | 2022-02-15 | イルミナ インコーポレイテッド | 配列バリアントコールのためのバリデーションの方法及びシステム |
US20190249229A1 (en) * | 2018-02-12 | 2019-08-15 | Nant Holdings Ip, Llc | Bam signatures from liquid and solid tumors and uses therefor |
US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
EP3781709A4 (en) * | 2018-04-16 | 2022-11-30 | Grail, LLC | SYSTEMS AND METHODS FOR DETERMINING TUMOR FRACTION IN CELL-FREE NUCLEIC ACID |
CA3098321A1 (en) | 2018-06-01 | 2019-12-05 | Grail, Inc. | Convolutional neural network systems and methods for data classification |
WO2019236478A1 (en) * | 2018-06-04 | 2019-12-12 | Guardant Health, Inc. | Methods and systems for determining the cellular origin of cell-free nucleic acids |
SG11202100344WA (en) | 2018-07-23 | 2021-02-25 | Guardant Health Inc | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
EP3874066A1 (en) * | 2018-11-01 | 2021-09-08 | Illumina, Inc. | Methods and compositions for somatic variant detection |
KR20210089240A (ko) * | 2018-11-13 | 2021-07-15 | 미리어드 제네틱스, 인크. | 체세포성 돌연변이를 위한 방법 및 시스템 그리고 그 용도 |
US11581062B2 (en) | 2018-12-10 | 2023-02-14 | Grail, Llc | Systems and methods for classifying patients with respect to multiple cancer classes |
US20200199656A1 (en) | 2018-12-19 | 2020-06-25 | The Chinese University Of Hong Kong | Cell-free dna end characteristics |
US20200219587A1 (en) * | 2018-12-21 | 2020-07-09 | Grail, Inc. | Systems and methods for using fragment lengths as a predictor of cancer |
CN109616198A (zh) * | 2018-12-28 | 2019-04-12 | 陈洪亮 | 仅用于肝癌单一癌种筛查的特异甲基化检测位点组合的选取方法 |
CN109686414A (zh) * | 2018-12-28 | 2019-04-26 | 陈洪亮 | 仅用于肝癌筛查的特异甲基化检测位点组合的选取方法 |
CN109817279B (zh) * | 2019-01-18 | 2022-11-04 | 臻悦生物科技江苏有限公司 | 肿瘤突变负荷的检测方法、装置、存储介质及处理器 |
KR102381252B1 (ko) * | 2019-02-19 | 2022-04-01 | 주식회사 녹십자지놈 | 혈중 무세포 dna 기반 간암 치료 예후예측 방법 |
CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和***及应用 |
CN109920480B (zh) * | 2019-03-14 | 2020-02-21 | 深圳市海普洛斯生物科技有限公司 | 一种校正高通量测序数据的方法和装置 |
CN111755075B (zh) * | 2019-03-28 | 2023-09-29 | 深圳华大生命科学研究院 | 对免疫组库高通量测序样本间序列污染进行过滤的方法 |
WO2020236630A1 (en) * | 2019-05-17 | 2020-11-26 | Ultima Genomics, Inc. | Methods and systems for detecting residual disease |
CN111223525A (zh) * | 2020-01-07 | 2020-06-02 | 广州基迪奥生物科技有限公司 | 一种肿瘤外显子测序数据分析方法 |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
JP7022861B1 (ja) * | 2021-06-25 | 2022-02-18 | 株式会社日立パワーソリューションズ | アレイ型超音波送受信装置 |
CA3224461A1 (en) * | 2021-06-30 | 2023-01-05 | Jonathan Chee Ming WAN | Detection of somatic mutational signatures from whole genome sequencing of cell-free dna |
KR20230085239A (ko) * | 2021-12-06 | 2023-06-14 | 주식회사 지씨지놈 | 혈중 무세포 dna 기반 유방암 치료 예후예측 방법 |
CN115064212B (zh) * | 2022-06-24 | 2023-03-14 | 哈尔滨星云生物信息技术开发有限公司 | 基于wgs数据的预设区域人群肿瘤特异突变识别方法 |
WO2024003936A1 (en) | 2022-06-29 | 2024-01-04 | Raman Govindarajan | Method for detecting cancer susceptibility, early detection and predicting cancer behaviour |
KR20240051739A (ko) * | 2022-10-13 | 2024-04-22 | 인하대학교 산학협력단 | cfDNA의 구조 변이 서열 검출을 통한 미세잔존질환 진단 방법 |
CN117012274B (zh) * | 2023-10-07 | 2024-01-16 | 北京智因东方转化医学研究中心有限公司 | 基于高通量测序识别基因缺失的装置 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1169347B1 (en) | 1999-04-02 | 2008-07-02 | Corixa Corporation | Compounds and methods for therapy and diagnosis of lung cancer |
US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
JP2005514956A (ja) | 2002-01-18 | 2005-05-26 | ジェンザイム・コーポレーション | 胎児dnaの検出および対立遺伝子の定量化のための方法 |
JP4500673B2 (ja) | 2002-05-10 | 2010-07-14 | シティ・オブ・ホープ | 加ピロリン酸分解活性化重合(pap) |
US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
US20060188889A1 (en) * | 2003-11-04 | 2006-08-24 | Christopher Burgess | Use of differentially expressed nucleic acid sequences as biomarkers for cancer |
US8394582B2 (en) | 2003-03-05 | 2013-03-12 | Genetic Technologies, Inc | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
DE60328193D1 (de) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Nicht invasiver Nachweis fötaler genetischer Merkmale |
CA2562310A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
CA2601221C (en) * | 2005-03-18 | 2013-08-06 | The Chinese University Of Hong Kong | A method for the detection of chromosomal aneuploidies |
US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
ES2739484T3 (es) | 2006-02-02 | 2020-01-31 | Univ Leland Stanford Junior | Prueba genética fetal no invasiva mediante análisis digital |
CA2647793C (en) | 2006-02-28 | 2016-07-05 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
WO2008024009A1 (fr) | 2006-08-15 | 2008-02-28 | Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) | Niveau de transcription du gène timp3 utilisé en tant que marqueur servant à diagnostiquer le cancer du poumon non à petites cellules |
MX2009012722A (es) | 2007-05-25 | 2009-12-11 | Decode Genetics Ehf | Variantes geneticas sobre chr 5p12 y 10q26 como marcadores para el uso en la evaluacion del riesgo, diagnostico, pronostico y tratamiento del cancer de mama. |
CA2900927C (en) | 2007-07-23 | 2018-08-14 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
CA3069082C (en) * | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
RU2011143425A (ru) | 2009-03-31 | 2013-05-10 | Оридис Биомаркерс Гмбх | Способ диагностики рака и мониторинга лечения рака |
WO2011038507A1 (en) | 2009-10-02 | 2011-04-07 | Centre For Addiction And Mental Health | Method for analysis of dna methylation profiles of cell-free circulating dna in bodily fluids |
WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
ES2720282T3 (es) | 2009-11-05 | 2019-07-19 | Univ Hong Kong Chinese | Análisis genómico fetal a partir de una muestra biológica materna |
MX357692B (es) | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
EP2848703A1 (en) | 2010-01-19 | 2015-03-18 | Verinata Health, Inc | Simultaneous determination of aneuploidy and fetal fraction |
AU2011207544A1 (en) | 2010-01-19 | 2012-09-06 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
US20130210645A1 (en) | 2010-02-18 | 2013-08-15 | The Johns Hopkins University | Personalized tumor biomarkers |
EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
EP4269623A3 (en) | 2010-11-30 | 2024-03-06 | The Chinese University Of Hong Kong | Analysis of a biological sample of an organism for chromosomal deletions or amplifications associated with cancer |
GB2485635B (en) | 2011-07-26 | 2012-11-28 | Verinata Health Inc | Method for determining the presence or absence of different aneuploidies in a sample |
EP3922731A3 (en) | 2011-10-06 | 2022-01-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10214775B2 (en) | 2011-12-07 | 2019-02-26 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
CA2867293C (en) | 2012-03-13 | 2020-09-01 | Abhijit Ajit PATEL | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
JP2016513959A (ja) | 2013-02-21 | 2016-05-19 | トマ バイオサイエンシーズ, インコーポレイテッド | 核酸分析のための方法、組成物およびキット |
US10017807B2 (en) | 2013-03-15 | 2018-07-10 | Verinata Health, Inc. | Generating cell-free DNA libraries directly from blood |
US10174375B2 (en) | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
-
2013
- 2013-03-13 US US13/801,748 patent/US11261494B2/en active Active
- 2013-06-14 CA CA2876327A patent/CA2876327C/en active Active
- 2013-06-14 JP JP2015517896A patent/JP6371280B2/ja active Active
- 2013-06-14 EP EP21185002.9A patent/EP3919627A1/en active Pending
- 2013-06-14 ES ES13807105.5T patent/ES2687847T3/es active Active
- 2013-06-14 CA CA3080937A patent/CA3080937A1/en active Pending
- 2013-06-14 CN CN201380042981.XA patent/CN104662168B/zh active Active
- 2013-06-14 PT PT18185290T patent/PT3456843T/pt unknown
- 2013-06-14 HU HUE18185290A patent/HUE056915T2/hu unknown
- 2013-06-14 EA EA201500027A patent/EA037292B1/ru unknown
- 2013-06-14 KR KR1020237012164A patent/KR102656030B1/ko active IP Right Grant
- 2013-06-14 DK DK18185290.6T patent/DK3456843T3/da active
- 2013-06-14 KR KR1020247011005A patent/KR20240049635A/ko active IP Right Grant
- 2013-06-14 EP EP18185290.6A patent/EP3456843B1/en active Active
- 2013-06-14 IL IL298810A patent/IL298810B1/en unknown
- 2013-06-14 WO PCT/IB2013/054898 patent/WO2013190441A2/en active Application Filing
- 2013-06-14 KR KR1020157001225A patent/KR101884909B1/ko active IP Right Grant
- 2013-06-14 SG SG10201808217WA patent/SG10201808217WA/en unknown
- 2013-06-14 AU AU2013278994A patent/AU2013278994C1/en active Active
- 2013-06-14 DK DK13807105.5T patent/DK2864501T3/en active
- 2013-06-14 EA EA202092900A patent/EA202092900A3/ru unknown
- 2013-06-14 MX MX2014016058A patent/MX360264B/es active IP Right Grant
- 2013-06-14 KR KR1020217009799A patent/KR102375645B1/ko active IP Right Grant
- 2013-06-14 SG SG11201408113QA patent/SG11201408113QA/en unknown
- 2013-06-14 EP EP13807105.5A patent/EP2864501B1/en active Active
- 2013-06-14 ES ES18185290T patent/ES2894479T3/es active Active
- 2013-06-14 CN CN201711070698.4A patent/CN107779506B/zh active Active
- 2013-06-14 CN CN202110493949.XA patent/CN113151474A/zh active Pending
- 2013-06-14 KR KR1020207009028A patent/KR102237923B1/ko active IP Right Grant
- 2013-06-14 IL IL311127A patent/IL311127A/en unknown
- 2013-06-14 KR KR1020187021883A patent/KR102096611B1/ko active IP Right Grant
- 2013-06-14 KR KR1020227008276A patent/KR102521842B1/ko active IP Right Grant
- 2013-06-20 TW TW107128593A patent/TWI803505B/zh active
- 2013-06-20 TW TW102122036A patent/TWI636255B/zh active
- 2013-06-20 TW TW111143054A patent/TW202328458A/zh unknown
- 2013-06-20 TW TW109127987A patent/TWI786428B/zh active
-
2014
- 2014-11-27 IL IL235967A patent/IL235967B/en active IP Right Grant
- 2014-12-17 ZA ZA2014/09281A patent/ZA201409281B/en unknown
- 2014-12-19 MX MX2018013085A patent/MX2018013085A/es unknown
- 2014-12-19 MX MX2023001154A patent/MX2023001154A/es unknown
-
2015
- 2015-05-06 HK HK15104321.5A patent/HK1204013A1/xx unknown
- 2015-06-24 HK HK15105992.0A patent/HK1205533A1/xx unknown
-
2017
- 2017-07-04 AU AU2017204558A patent/AU2017204558B2/en active Active
- 2017-12-22 US US15/853,288 patent/US20180202003A1/en active Pending
-
2018
- 2018-05-15 HK HK18106285.1A patent/HK1246830A1/zh unknown
- 2018-07-12 JP JP2018132118A patent/JP6930948B2/ja active Active
-
2019
- 2019-05-08 US US16/406,715 patent/US20190264291A1/en active Pending
- 2019-08-12 IL IL26864519A patent/IL268645A/en active IP Right Grant
-
2020
- 2020-01-08 AU AU2020200122A patent/AU2020200122B2/en active Active
- 2020-11-19 IL IL278867A patent/IL278867B2/en unknown
-
2021
- 2021-08-12 JP JP2021131682A patent/JP7408161B2/ja active Active
-
2022
- 2022-07-28 AU AU2022209294A patent/AU2022209294A1/en active Pending
-
2023
- 2023-12-13 JP JP2023210140A patent/JP2024026360A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202092900A2 (ru) | Мутационный анализ днк в плазме для детектирования рака | |
WO2020023420A3 (en) | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage | |
CY1121741T1 (el) | Χρηση του μεγεθους θραυσματων εξωκυτταριου dna για τον προσδιορισμο παραλλαγης αριθμου αντιγραφων | |
GB2525804A (en) | Methods and compositions for classification of samples | |
MX2016016902A (es) | Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas. | |
GB2552267A (en) | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results | |
EP4279612A3 (en) | Analysis of fragmentation patterns of cell-free dna | |
MY195999A (en) | Molecular Detection/Diagnosis Reagent for Tumor | |
EP4282405A3 (en) | Detection of cancer biomarkers using nanoparticles | |
GB2526736A (en) | Methods, compositions, and kits for nucleic acid analysis | |
MX2017003790A (es) | Detección de secuencias diana por percepción de nanoporos de sondas sintéticas. | |
WO2015109263A3 (en) | Biomarkers for detecting and monitoring colon cancer | |
WO2015094995A3 (en) | Gene signature biomarkers of tumor response to pd-1 antagonists | |
MX2016006455A (es) | Dispositivo integrado de fuente-pixel activo para el analisis rapido de especimenes biologicos y quimicos. | |
MX2019007814A (es) | Algoritmo de perfil de expresion genica y prueba para determinar la prognosis de cancer de prostata. | |
EA201491833A1 (ru) | Основанные на клетках перекрестные анализы и их применение | |
EP2472425A3 (en) | System and method for detecting unknown malware | |
BR112015023769A2 (pt) | sistemas de instrumento analítico | |
EP2908132A3 (en) | Prediction of drug sensitivity of lung tumors based on molecular and genetic signatures | |
EA201691505A1 (ru) | Детектирование экспрессии простатического специфического мембранного антигена (psma) на циркулирующих опухолевых клетках (ctc) | |
EP2977467A3 (en) | Method, use of marker, and determination device for obtaining information on plural types of cancers | |
PH12020500156A1 (en) | Enhancement of cancer screening using cell-free viral nucleic acids | |
WO2016034715A3 (fr) | Methode de prediction de l'evolution clinique du cancer colorectal | |
IN2015DN01608A (ru) | ||
EP2808397A3 (en) | Method for obtaining information on colon cancer and marker and kit for obtaining information on colon cancer |