EA202091184A1 - Композиции, содержащие тимогидрохинон, и способ их получения - Google Patents
Композиции, содержащие тимогидрохинон, и способ их полученияInfo
- Publication number
- EA202091184A1 EA202091184A1 EA202091184A EA202091184A EA202091184A1 EA 202091184 A1 EA202091184 A1 EA 202091184A1 EA 202091184 A EA202091184 A EA 202091184A EA 202091184 A EA202091184 A EA 202091184A EA 202091184 A1 EA202091184 A1 EA 202091184A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- thymohydroquinone
- disclosed
- preparation
- compositions containing
- nigella sativa
- Prior art date
Links
- OQIOHYHRGZNZCW-UHFFFAOYSA-N 2-methyl-5-propan-2-ylbenzene-1,4-diol Chemical compound CC(C)C1=CC(O)=C(C)C=C1O OQIOHYHRGZNZCW-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 2
- KEQHJBNSCLWCAE-UHFFFAOYSA-N thymoquinone Chemical compound CC(C)C1=CC(=O)C(C)=CC1=O KEQHJBNSCLWCAE-UHFFFAOYSA-N 0.000 abstract 4
- 244000090896 Nigella sativa Species 0.000 abstract 3
- 235000016698 Nigella sativa Nutrition 0.000 abstract 3
- 239000001711 nigella sativa Substances 0.000 abstract 3
- NTWLPZMPTFQYQI-UHFFFAOYSA-N (3alpha)-olean-12-ene-3,23-diol Natural products C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C NTWLPZMPTFQYQI-UHFFFAOYSA-N 0.000 abstract 2
- GCGBHJLBFAPRDB-UHFFFAOYSA-N Hederagenin Natural products CC1(C)CCC2(CCC3(C)C4CCC5C(C)(CO)C(O)CCC5(C)C4CC=C3C2C1)C(=O)O GCGBHJLBFAPRDB-UHFFFAOYSA-N 0.000 abstract 2
- GCGBHJLBFAPRDB-KCVAUKQGSA-N Scutellaric acid Natural products CC1(C)CC[C@@]2(CC[C@@]3(C)[C@@H]4CC[C@H]5[C@@](C)(CO)[C@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2C1)C(=O)O GCGBHJLBFAPRDB-KCVAUKQGSA-N 0.000 abstract 2
- IBAJNOZMACNWJD-HVUPOBLPSA-N beta-Hederin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2C([C@H]3[C@]([C@@H]4[C@@]([C@@]5(CC[C@]6(CCC(C)(C)C[C@H]6C5=CC4)C(O)=O)C)(C)CC3)(C)CC2)(C)C)OC[C@H](O)[C@@H]1O IBAJNOZMACNWJD-HVUPOBLPSA-N 0.000 abstract 2
- IBAJNOZMACNWJD-UOADPIBESA-N beta-Hederin Natural products O=C(O)[C@]12[C@H](C=3[C@](C)([C@@]4(C)[C@@H]([C@]5(C)[C@H](C(C)(C)[C@@H](O[C@@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O)[C@@H](C)O7)[C@H](O)[C@H](O)CO6)CC5)CC4)CC=3)CC1)CC(C)(C)CC2 IBAJNOZMACNWJD-UOADPIBESA-N 0.000 abstract 2
- IBAJNOZMACNWJD-UHFFFAOYSA-N giganteaside D Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C3C(C4C(C5(CCC6(CCC(C)(C)CC6C5=CC4)C(O)=O)C)(C)CC3)(C)CC2)(C)C)OCC(O)C1O IBAJNOZMACNWJD-UHFFFAOYSA-N 0.000 abstract 2
- PGOYMURMZNDHNS-MYPRUECHSA-N hederagenin Chemical compound C1C[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PGOYMURMZNDHNS-MYPRUECHSA-N 0.000 abstract 2
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/065—Diphenyl-substituted acyclic alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0292—Treatment of the solvent
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
Abstract
Раскрыты композиции, обогащенные тимогидрохиноном, дополнительно включающие тимохинон, гедерагенин и/или -гедерин, приготовленные путем смешивания активных молекул, выделенных из семян Nigella sativa. Также раскрыты новые способы выделения биологически активных компонентов тимогидрохинона, тимохинона из семян Nigella sativa. Также раскрыт способ выделения -гедерина и гедерагенина из отработанного материала Nigella sativa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762610565P | 2017-12-27 | 2017-12-27 | |
| PCT/US2018/067478 WO2019133587A1 (en) | 2017-12-27 | 2018-12-26 | Compositions containing thymohydroquinone and their method of preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202091184A1 true EA202091184A1 (ru) | 2020-09-23 |
Family
ID=66949194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202091205A EA202091205A1 (ru) | 2017-12-27 | 2018-12-26 | Композиции для терапии гипергликемии и сопутствующих состояний |
| EA202091184A EA202091184A1 (ru) | 2017-12-27 | 2018-12-26 | Композиции, содержащие тимогидрохинон, и способ их получения |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202091205A EA202091205A1 (ru) | 2017-12-27 | 2018-12-26 | Композиции для терапии гипергликемии и сопутствующих состояний |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10881623B2 (ru) |
| EP (2) | EP3731833A4 (ru) |
| JP (2) | JP7089033B2 (ru) |
| KR (2) | KR102539298B1 (ru) |
| CN (2) | CN111566218B (ru) |
| AU (2) | AU2018397668B2 (ru) |
| BR (2) | BR112020012333A2 (ru) |
| CA (2) | CA3087050C (ru) |
| EA (2) | EA202091205A1 (ru) |
| WO (2) | WO2019133587A1 (ru) |
| ZA (2) | ZA202004531B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214514B (zh) * | 2020-03-10 | 2022-03-22 | 上海中医药大学 | 续断及续断中活性组分在降糖中的应用 |
| WO2022132844A1 (en) * | 2020-12-15 | 2022-06-23 | Muhammed Majeed | Anti-viral compositions |
| KR20230119160A (ko) * | 2020-12-17 | 2023-08-16 | 새미-사빈사 그룹 리미티드 | 만성 염증 상태에서 최종 당화 산물 수용체(rage)를표적화하는 조성물 |
| CN114948915B (zh) * | 2022-07-18 | 2023-10-24 | 广东省农业科学院动物卫生研究所 | 百里醌在制备抗副猪嗜血杆菌药物中的应用 |
| WO2024073699A1 (en) * | 2022-09-29 | 2024-04-04 | Muhammed Majeed | Compositions for the management of hirsutism |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8535740B2 (en) * | 2002-11-22 | 2013-09-17 | Bionexus, Ltd. | Compositions from Nigella sativa |
| US8029831B2 (en) * | 2008-07-29 | 2011-10-04 | Bionexus, Ltd. | Formulations containing thymoquinone for urinary health |
| WO2005009332A2 (en) * | 2003-07-31 | 2005-02-03 | Palsamed (P.B.S.) Ltd. | Compositions-of-matter for lowering serum cholesterol and/or triglyceride level and methods of producing and using same |
| GB0505909D0 (en) * | 2005-03-23 | 2005-04-27 | Univ Leeds | Formulations |
| WO2008017484A1 (en) * | 2006-08-09 | 2008-02-14 | Dsm Ip Assets B.V. | Novel agents for the treatment of disorders connected to impaired neurotransmission |
| CN101781604A (zh) * | 2010-03-11 | 2010-07-21 | 南京农业大学 | 超临界二氧化碳萃取黑种草子油的方法 |
| US20160213727A1 (en) * | 2012-01-26 | 2016-07-28 | William G. Rohlfsen | Methods and Uses of High Thymoquinone and Thymohydroquinone Essential Oil of Monarda |
| CN103948604A (zh) * | 2014-05-20 | 2014-07-30 | 天津理工大学 | 常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备 |
| PL412214A1 (pl) | 2015-05-04 | 2016-11-07 | Biovico Spółka Z Ograniczoną Odpowiedzialnością | Kompozycja roślinna o właściwościach przeciwzapalnych, przeciwalergicznych i/lub przeciwastmatycznych oraz jej zastosowanie |
-
2018
- 2018-12-26 EP EP18893434.3A patent/EP3731833A4/en active Pending
- 2018-12-26 CN CN201880083854.7A patent/CN111566218B/zh active Active
- 2018-12-26 CA CA3087050A patent/CA3087050C/en active Active
- 2018-12-26 CN CN201880083853.2A patent/CN111542313B/zh active Active
- 2018-12-26 BR BR112020012333-1A patent/BR112020012333A2/pt active Search and Examination
- 2018-12-26 BR BR112020012949-6A patent/BR112020012949A2/pt unknown
- 2018-12-26 JP JP2020536250A patent/JP7089033B2/ja active Active
- 2018-12-26 US US16/232,242 patent/US10881623B2/en active Active
- 2018-12-26 AU AU2018397668A patent/AU2018397668B2/en active Active
- 2018-12-26 EA EA202091205A patent/EA202091205A1/ru unknown
- 2018-12-26 CA CA3087042A patent/CA3087042C/en active Active
- 2018-12-26 JP JP2020536249A patent/JP7012857B2/ja active Active
- 2018-12-26 US US16/232,197 patent/US10945969B2/en active Active
- 2018-12-26 KR KR1020207020978A patent/KR102539298B1/ko active IP Right Grant
- 2018-12-26 AU AU2018397667A patent/AU2018397667B2/en active Active
- 2018-12-26 KR KR1020207020094A patent/KR102577863B1/ko active IP Right Grant
- 2018-12-26 EP EP18897769.8A patent/EP3732294A4/en active Pending
- 2018-12-26 WO PCT/US2018/067478 patent/WO2019133587A1/en unknown
- 2018-12-26 EA EA202091184A patent/EA202091184A1/ru unknown
- 2018-12-26 WO PCT/US2018/067480 patent/WO2019133588A1/en unknown
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2020
- 2020-07-22 ZA ZA2020/04531A patent/ZA202004531B/en unknown
- 2020-07-22 ZA ZA2020/04532A patent/ZA202004532B/en unknown
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