EA202090453A2 - ANTIBODIES TO CD40 - Google Patents

ANTIBODIES TO CD40

Info

Publication number
EA202090453A2
EA202090453A2 EA202090453A EA202090453A EA202090453A2 EA 202090453 A2 EA202090453 A2 EA 202090453A2 EA 202090453 A EA202090453 A EA 202090453A EA 202090453 A EA202090453 A EA 202090453A EA 202090453 A2 EA202090453 A2 EA 202090453A2
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
fcriib
antigen
bind
antibody
Prior art date
Application number
EA202090453A
Other languages
Russian (ru)
Other versions
EA202090453A3 (en
Inventor
Брайан С. Барнхарт
Бригитт Дево
Аарон П. Ямнюк
Шэннон Л. Окада
Бренда Л. Стивенс
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA202090453A2 publication Critical patent/EA202090453A2/en
Publication of EA202090453A3 publication Critical patent/EA202090453A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

В изобретении предоставлены агонистические антитела или их антигенсвязывающие части, которые связываются с CD40 человека. Такие антитела необязательно содержат Fc-области с увеличенной специфичностью к FcRIIb. Изобретение также относится к способам лечения злокачественной опухоли или хронической инфекции посредством введения нуждающемуся в этом индивидууму антител по изобретению.The invention provides agonistic antibodies or antigen-binding parts thereof that bind to human CD40. Such antibodies optionally contain Fc regions with increased specificity for FcRIIb. The invention also relates to methods for treating a malignant tumor or a chronic infection by administering to a needy individual an antibody of the invention.

EA202090453A 2015-11-09 2016-06-28 ANTIBODIES TO CD40 EA202090453A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562252615P 2015-11-09 2015-11-09

Publications (2)

Publication Number Publication Date
EA202090453A2 true EA202090453A2 (en) 2020-06-30
EA202090453A3 EA202090453A3 (en) 2020-09-30

Family

ID=71138781

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090453A EA202090453A3 (en) 2015-11-09 2016-06-28 ANTIBODIES TO CD40

Country Status (1)

Country Link
EA (1) EA202090453A3 (en)

Also Published As

Publication number Publication date
EA202090453A3 (en) 2020-09-30

Similar Documents

Publication Publication Date Title
EA201890162A1 (en) ANTIBODIES TO CD40 WITH ENHANCED AGONISTIC ACTIVITY
EA201890175A1 (en) ANTIBODIES TO CD40
EA201890131A1 (en) IMMUNOMODULATION AND TREATMENT OF SOLID TUMORS BY ANTIBODIES THAT SPECIFICALLY CONNECT CD38
CY1124033T1 (en) DOSAGE AND ADMINISTRATION OF NON-FUCOSYLATED ANTI-CD40 ANTIBODIES
EA201891925A1 (en) ANTIBODIES TO CD40 WITH STRENGTHENED AGONISTIC ACTIVITY
EA201892294A1 (en) ANTIBODIES AND COMPOSITIONS AGAINST TIM-3
EA201892362A1 (en) AGONISTIC ANTIBODIES THAT ARE BINDING HUMAN CD40, AND THEIR OPTIONS
EA201990912A1 (en) ANTI-LAG-3 ANTIBODIES AND THEIR COMPOSITIONS
EA201792589A1 (en) ANTIBODIES AGAINST CD123 AND CONJUGATES OF INDICATED ANTIBODIES
EA201890305A1 (en) HUMANIZED OR CHIMERIC CD3 ANTIBODIES
MX370818B (en) Anti-b7-h1 antibodies for treating tumors.
EA201790288A1 (en) ANTI-CTLA4 MONOCLONAL ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT, PHARMACEUTICAL COMPOSITION AND APPLICATION
EA201791208A1 (en) Antibodies to CD38 for the treatment of acute myeloid leukemia
PH12017500493A1 (en) Combination therapy
EA201791050A1 (en) CONJUGATES OF ANTIBODIES AND MEDICINES
EA201690007A1 (en) METALLIC ENZYME INHIBITING COMPOUNDS
EA201691541A1 (en) NEW ANTI-BAFF ANTIBODIES
MX2018012493A (en) Methods for monitoring and treating cancer.
NZ730186A (en) Humanized anti-hepcidin antibodies and uses thereof
EA201891299A1 (en) THERAPEUTIC ANTIBODIES TO CD9
EA201992318A1 (en) COMPOSITIONS AND METHODS FOR DIAGNOSTIC AND TREATMENT OF PROSTATE CANCER USING A MOLECULE BINDING PROGASTRIN
WO2018089807A3 (en) Anti-cd46 antibodies and methods of use
EA201791970A1 (en) METHOD FOR TREATING PRIMARY SCLEROSED HOLANGITIS
MX2019014090A (en) Methods for the treatment of chronic pouchitis.
EA201792282A1 (en) METHODS OF TREATMENT OF DISEASES