EA201992798A2 - ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS - Google Patents

ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS

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Publication number
EA201992798A2
EA201992798A2 EA201992798A EA201992798A EA201992798A2 EA 201992798 A2 EA201992798 A2 EA 201992798A2 EA 201992798 A EA201992798 A EA 201992798A EA 201992798 A EA201992798 A EA 201992798A EA 201992798 A2 EA201992798 A2 EA 201992798A2
Authority
EA
Eurasian Patent Office
Prior art keywords
antibodies
therapeutic
application
antibodies against
diagnostic means
Prior art date
Application number
EA201992798A
Other languages
Russian (ru)
Other versions
EA201992798A3 (en
Inventor
Цзин Сун
Кан Ли
Тун Чжан
Ланьлань Сюй
Ци Лю
Хао Пэн
Original Assignee
Бейджин Свитзерланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бейджин Свитзерланд Гмбх filed Critical Бейджин Свитзерланд Гмбх
Priority to EA201992798A priority Critical patent/EA201992798A3/en
Publication of EA201992798A2 publication Critical patent/EA201992798A2/en
Publication of EA201992798A3 publication Critical patent/EA201992798A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Предложены антитела, которые специфично связываются с белком программируемой смерти-1 (PD-1, Pdcd-1 или CD279) и ингибируют PD1-опосредованную клеточную сигнализацию и активности в клетках иммунной системы, антитела связываются с набором аминокислотных остатков, необходимых для связывания его лиганда, и применение данных антител для лечения или диагностики рака, инфекционных заболеваний или других патологических расстройств, модулируемых PD1-опосредованными функциями.Antibodies are proposed that specifically bind to a programmed death-1 protein (PD-1, Pdcd-1 or CD279) and inhibit PD1-mediated cell signaling and activity in the cells of the immune system, antibodies bind to a set of amino acid residues necessary for binding of its ligand, and the use of these antibodies for the treatment or diagnosis of cancer, infectious diseases or other pathological disorders modulated by PD1-mediated functions.

EA201992798A 2013-09-13 2013-09-13 ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS EA201992798A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA201992798A EA201992798A3 (en) 2013-09-13 2013-09-13 ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EA201992798A EA201992798A3 (en) 2013-09-13 2013-09-13 ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS

Publications (2)

Publication Number Publication Date
EA201992798A2 true EA201992798A2 (en) 2020-03-31
EA201992798A3 EA201992798A3 (en) 2020-06-30

Family

ID=69942870

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992798A EA201992798A3 (en) 2013-09-13 2013-09-13 ANTIBODIES AGAINST PD1 AND THEIR APPLICATION AS A THERAPEUTIC AND DIAGNOSTIC MEANS

Country Status (1)

Country Link
EA (1) EA201992798A3 (en)

Also Published As

Publication number Publication date
EA201992798A3 (en) 2020-06-30

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